Clinical trials: sponsored by University of Edinburgh
Asthma Childhood, Asthma Attack
Remote Monitoring of Asthma in Children and Young People
The objective of this study is to determine whether healthcare data and remotely collected patient data can accurately predict asthma attacks in children and young people aged 5-17 years.
- Conditions
- Asthma Childhood, Asthma Attack, Remote Monitoring, Risk Assessment
- Trial name
- NCT07129616
- Where
- United Kingdom
- Volunteers
- 900 people
- Sponsor
- University of Edinburgh
Aortic Valve Stenosis, Hypertrophy, Left Ventricular
Early Valve Replacement Guided by Biomarkers of LV Decompensation in Asymptomatic Patients With Severe AS
Aortic stenosis is the most common valvular disease in the Western world. It is caused by progressive narrowing of the aortic valve leading to increased strain on the heart muscle which has to work increasingly hard to pump blood…
- Trial name
- EVoLVeD (NCT03094143)
- Testing
- Aortic valve intervention
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- University of Edinburgh
Atrial Fibrillation (AF)
Mechanisms of Myocardial Injury and Ischemia in Patients With Rapid Atrial Fibrillation
The goal of this observational study is to better understand the role of measuring troponin (a protein measured by a blood test) and coronary imaging in patients presenting with rapid atrial fibrillation (AF) The main questions…
- Trial name
- Mi-AF (NCT06951100)
- Testing
- CT coronary angiography
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- University of Edinburgh
Coronary Artery Disease
Troponin in Acute Chest Pain to Risk Stratify and Guide EffecTive Use of Computed Tomography Coronary Angiography
Most patients presenting to hospital with symptoms of a heart attack are sent home without further tests once a heart attack has been ruled out.
- Trial name
- TARGET-CTCA (NCT03952351)
- Testing
- CT Coronary Angiography (CTCA)
- Where
- 9 sites in United Kingdom
- Volunteers
- 3,170 people
- Sponsor
- University of Edinburgh
Decay, Dental
General Dentists' Knowledge, Attitudes and Clinical Usage of SDF
This study will look at how dentists in the UK are using Silver Diamine Fluoride (SDF) in their everyday practice. SDF is a liquid treatment that helps stop tooth decay.
- Trial name
- GDPKAUSDF (NCT07405437)
- Where
- United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Systemic Lupus Erythematosus
Fatigue in Lupus Intervention Programmes (FLIP)
Systemic Lupus Erythematosus (SLE) is an autoimmune rheumatic disease. Patients report that fatigue has a significant impact on their quality of life but is often not discussed in healthcare settings.
- Trial name
- FLIP (NCT06308770)
- Testing
- Standard Care, 4 week FMP, 7 week FMP
- Where
- United Kingdom
- Volunteers
- 261 people
- Sponsor
- University of Edinburgh
Critical Illness
Alpha 2 Agonists for Sedation to Produce Better Outcomes From Critical Illness (A2B Trial)
Many patients in intensive care (ICU) need help to breathe on a breathing machine and need pain killers and sedatives to keep them comfortable and pain free.
- Trial name
- A2B (NCT03653832)
- Testing
- Dexmedetomidine, Clonidine, Propofol
- Where
- 38 sites in United Kingdom
- Volunteers
- 1,404 people
- Sponsor
- University of Edinburgh
Lynch Syndrome
Protocol for Non-invasive Gynaecological Surveillance in Lynch Syndrome
Lynch syndrome is the most common inherited condition that raises a person's risk of getting certain cancers. It happens because of changes in genes that normally fix damaged DNA.
- Trial name
- PREDI-ENDO (NCT07877779)
- Where
- United Kingdom
- Volunteers
- 1,450 people
- Sponsor
- University of Edinburgh
Endometriosis
Retinal Imaging for Systemic Inflammation in Endometriosis
There is increasing evidence that examining our eyes can tell us a lot of information about our health, and systemic diseases. Our plan is to compare the images taken of the back of eyes of women who have endometriosis with those…
- Trial name
- RISE (NCT07232485)
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Malnutrition (Calorie), Colorectal Cancer
Optimizing Patient Treatment With EPA-enriched Nutrition, a Randomised Control Trial
Malnutrition is a common and serious issue for people living with cancer. Many cancer patients experience weight loss, muscle weakness, and poor quality of life due to malnutrition.
- Conditions
- Malnutrition (Calorie), Colorectal Cancer, Lung Cancer
- Trial name
- OPT-EPA (NCT07255066)
- Testing
- Fortimel Forticare Sensations
- Where
- 4 sites in Norway, United Kingdom
- Volunteers
- 118 people
- Sponsor
- University of Edinburgh
Eczema, Psoriasis
Evidencing Vibroacoustic Sensing for Inflammatory Skin Disease Monitoring
Over 300 million people around the world struggle with skin conditions like eczema and psoriasis, which cause ongoing discomfort and emotional stress.
- Trial name
- NCT07846813
- Testing
- Vibroacoustic sensing device
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Edinburgh
Skin Conditions and Traditional Medicine
Public Attitudes Towards Traditional Medicine in Dermatological Care Within Blantyre, Malawi: Insights From Subject Matter Experts
This study aims to understand how people in Blantyre, Malawi recognise and manage common skin problems, and what role traditional medicine plays in their care.
- Trial name
- PATTMIDC (NCT07812844)
- Volunteers
- 13 people
- Sponsor
- University of Edinburgh
Cognitive Impairment, Cognitive Impairment, Mild
Cognitive Assessment And Post-Operative Complications After Surgery: Linking Anaesthesia And Risk
Many older people can experience confusion, memory problems, or a decline in their thinking after major surgery. These problems are sometimes called 'postoperative neurocognitive disorders' or PND and can affect recovery and a…
- Conditions
- Cognitive Impairment, Cognitive Impairment, Mild, Cognitive Impairment, Progressive, Anesthesia
- Trial name
- CAPSULAR (NCT07470216)
- Testing
- Montreal Cognitive Assessment, biomarkers
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Cardiovascular Risk Factor, Blood Pressure
Diurnal BP Patterns in Those at Increased Risk of CVD
In health, blood pressure (BP) falls at night by >10% compared with day-time values. This natural dipping pattern is important as without it there is an increased risk of cardiovascular disease (CVD).
- Conditions
- Cardiovascular Risk Factor, Blood Pressure, Arterial Stiffness, Chronic Kidney Diseases
- Trial name
- NCT04522765
- Testing
- Assessment of 24 hour blood pressure and arterial stiffness
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Heart Failure, Diabetic Cardiomyopathies
The DAPA-MEMRI Trial
Diabetes mellitus is among the top 10 causes of death worldwide with an increasing incidence. Patients with diabetes are at risk of developing heart failure which is characterised by significant changes in the heart muscle…
- Trial name
- DAPA-MEMRI (NCT04591639)
- Testing
- Dapagliflozin 10 milligrams [Farxiga]
- Where
- United Kingdom
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Respiratory Disease
Procedural Skills Transfer in Bronchoscopy
Brief summary The goal of this Feasibility study is to capture bronchoscopy data from patients (Group1) and bronchoscopists (Group 2) over a period of three years.
- Trial name
- NCT07168408
- Where
- United Kingdom
- Volunteers
- 320 people
- Sponsor
- University of Edinburgh
Aortic Stenosis
The Scottish Aortic Stenosis LongiTudinal Imaging and biomarkeR (SALTIRE) Programme
The goal of this observational study is to understand the processes of what causes and accelerates the disease progress in aortic stenosis and following aortic valve replacement.
- Trial name
- SALTIRE (NCT06047561)
- Testing
- PET-CT
- Where
- United Kingdom
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Crohn Disease
Fibrosis Associated Protein Inhibitor (FAPI) Radiotracer-based Imaging to Identify Fibrotic Intestinal Crohn's Disease
Crohn's Disease (CD) is a chronic inflammatory condition that can affect any part of the intestine and currently has no cure. It affects 6.8 million people worldwide with UK healthcare costs in excess of £1 billion per year.
- Trial name
- FATE-CD (NCT07152431)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Edinburgh
Takotsubo Cardiomyopathy
Manganese-enhanced Magnetic Resonance Imaging in Takotsubo Cardiomyopathy
The goal of this research study is to further understand the physiological mechanisms involved in a heart condition called takotsubo cardiomyopathy, also known as broken heart syndrome.
- Trial name
- TAKO MEMRI (NCT07491718)
- Testing
- Bisoprolol, Valsartan, sacubitril/ valsartan
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Peripheral Arterial Disease, Chronic Limb Threatening Ischemia
Symptomatic and Systemic Atherosclerotic Plaque Activity in Patients With Peripheral Arterial Disease Using Novel Imaging
The goal of this observational study is to characterise the relationships between inflammation, microcalcification and thrombus activity in atherosclerotic plaques in peripheral and systemic vascular territories in patients with…
- Trial name
- SISYPHUS (NCT07472049)
- Testing
- Whole body [68Ga]DOTATATE PET-CT, Whole body [18F]GP1 PET-CT, Whole body [18F]NaF PET-CT
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Edinburgh