Clinical trials: sponsored by University of Edinburgh
Anemia
Non-invasive Identification of Preoperative Anaemia
Approximately 20% of patients undergoing elective orthopaedic surgery are anaemic. When not identified and treated before surgery, this can lead to requiring blood transfusions, which brings additional expenses, time and…
- Trial name
- NIPPA (NCT04247178)
- Where
- United Kingdom
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Covid19
Case Fatalities in Hospitalised COVID-19 Patients in the UK
This study will investigate how the case fatality in hospitalised patients with COVID-19 has changed throughout the pandemic. It will also explore possible mechanisms that could be driving these changes.
- Trial name
- NCT04527458
- Testing
- Patient Characteristics, COVID-19 treatments, Differences in triage
- Where
- United Kingdom
- Volunteers
- 70,000 people
- Sponsor
- University of Edinburgh
Intellectual Disability
Study of Mindfulness Course for Parents of Adults With Intellectual Disabilities
Being a parent to an adult person with learning disabilities can be very stressful, and can lead to experiencing mental health problems.
- Trial name
- NCT04294082
- Testing
- Mindfulness based intervention
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Edinburgh
Post Traumatic Stress Disorder
Post-traumatic Stress Disorder (PTSD) Symptoms in Later Life
Older adults are becoming a growing proportion of people utilising mental health services. However, the needs of this population are poorly understood despite the evidence that mental health conditions are manifested differently…
- Trial name
- NCT03821259
- Testing
- Psychological measures
- Where
- United Kingdom
- Volunteers
- 88 people
- Sponsor
- University of Edinburgh
Dental Trauma
Factors Affecting the Pulpal Prognosis of Injured Teeth
Factors affecting the pulpal prognosis of injured teeth. Dental injuries may affect the survival of teeth. It is recommended to monitor the injured teeth at regular intervals to ensure that the appropriate treatment is delivered…
- Trial name
- TRAUMA (NCT03845426)
- Testing
- Root canal treatment.
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Bronchiectasis
Bacterial Load Guided Therapy for Severe Bronchiectasis Exacerbations
From the British Thoracic Guidelines1 and a PUBMED search there are no randomised controlled trials exploring optimum antibiotic duration for chest infections.
- Trial name
- BLTBrIV (NCT02047773)
- Testing
- Duration, Colomycin, Meropenem
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- University of Edinburgh
Cauda Equina Syndrome, Functional Neurological Disorder
BLB Study Back or Leg Pain and Bladder Symptoms Study
The research focuses on Cauda Equina Syndrome (CES) which describes damage to the nerves in the lower back which supply bladder, bowels, sexual function and the legs usually from slipped discs in the spine.
- Trial name
- BLB (NCT03325374)
- Testing
- Questionnaires and examination
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Edinburgh
Alzheimer's Dementia
European Prevention of Alzheimer's Dementia (EPAD) Longitudinal Cohort Study (LCS)
Brain changes associated with Alzheimer's disease may precede symptoms of Alzheimer's Dementia by over 20 years. The Investigators hope to be able to identify Alzheimer's disease at its very earliest stages when in theory…
- Trial name
- EPAD-LCS (NCT02804789)
- Where
- 30 sites in Belgium, France and 7 more
- Volunteers
- 2,095 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Respiratory Infections
Exploratory Study of Intrapulmonary Microdosing of Gram-negative Optical Imaging Detection Probe
Critically ill patients are often ventilated in dedicated critical care units to provide respiratory support. Despite best practice patients can often develop a condition called adult respiratory distress syndrome (ARDS), which…
- Trial name
- BAC TWO (NCT02491164)
- Testing
- BAC TWO, FE and Cellvizio viewer software
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of Edinburgh
Bacterial Respiratory Infections
Microdosing of BAC ONE to the Distal Lung
Critically ill patients are often ventilated in dedicated critical care units to provide respiratory support. Despite best practice patients can often develop a condition called adult respiratory distress syndrome (ARDS), which…
- Trial name
- BAC ONE (NCT02558062)
- Testing
- BAC ONE administration
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- University of Edinburgh
Intellectual Disabilities With Other Behavioral Symptoms, Acceptance Processes
Evaluation of an ACT and PBS Group for Parents and Education Staff
Parents and education staff who work with children with intellectual disabilities (ID) are known to be at a higher risk of experiencing psychological distress.
- Conditions
- Intellectual Disabilities With Other Behavioral Symptoms, Acceptance Processes, Psychological Distress, Burnout, Professional
- Trial name
- NCT03917329
- Testing
- ACT and PBS group workshop
- Where
- 2 sites in United Kingdom
- Volunteers
- 37 people
- Sponsor
- University of Edinburgh
Twin Pregnancy With Antenatal Problem
An Open Randomised Trial of the Arabin Pessary to Prevent Pre-term Birth in Twin Pregnancy
This study aims to determine whether the Arabin cervical pessary prevents preterm birth in women with a twin pregnancy and a short cervix.
- Trial name
- STOPPIT-2 (NCT02235181)
- Testing
- Arabin Cervical Pessary
- Where
- 57 sites in Belgium, United Kingdom
- Volunteers
- 2,228 people
- Sponsor
- University of Edinburgh
Cachexia; Cancer, Diet Modification
Exercise and Nutritional Rehabilitation in Patients With Cancer
In patients with incurable cancer, general deterioration in their ability to walk, exercise and care for themselves is often regarded as an inevitable consequence of this.
- Conditions
- Cachexia; Cancer, Diet Modification, Physical Activity, Advanced Cancer
- Trial name
- ENeRgy (NCT03316157)
- Testing
- ProSure, Physical Exercise
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Functional Disorder
Investigating Drop Attacks
The aim of this project is to better understand the experiences of people who have idiopathic drop attacks. These falls have no identified medical cause but can cause people injuries such as bruising, facial injuries and, in some…
- Trial name
- NCT03694769
- Testing
- Semi-structured interview, Drop attack diary
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- University of Edinburgh
Pneumonia, Childhood Pneumonia
Pneumonia Case Management Practices in Pakistan
Pneumonia in Pakistan continues to be the leading killer of children under five. Although various national and provincial programs have tried to tackle this but they have not been able to achieve the desired outcomes.
- Conditions
- Pneumonia, Childhood Pneumonia, Infectious Disease, Acute Respiratory Infection
- Trial name
- NCT03869099
- Testing
- Pneumonia Case Management Practices
- Where
- Pakistan
- Volunteers
- 160 people
- Sponsor
- University of Edinburgh
Fibrosis, Lung Cancer
Imaging FIB ONE in the Human Lung Using Endomicroscopy
While the process of fibrosis is essential for normal wound healing, an excessive and uncontrolled 'fibrotic' response can result in impaired tissue structure and function.
- Trial name
- FIB ONE (NCT02604862)
- Testing
- FIB ONE, AZD1236
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of Edinburgh
Stroke, Carotid Stenosis
PET-MRI Imaging in Patients With Symptomatic Carotid Artery Stenosis
Ischaemic stroke is a major cause of death and disability worldwide. In patients with recent stroke, the 18F-fluoride positron emission tomography-computed tomography highlights high-risk culprit carotid plaque and is more…
- Trial name
- NCT03215550
- Testing
- CEA, 18F PET-MRI, Transcranial Doppler
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Edinburgh
Stroke, Carotid Stenosis
PET-MRI Imaging in Patients With Acute Neurovascular Syndrome
Ischaemic stroke is a major cause of death and disability worldwide. In patients with recent stroke, the 18F-fluoride positron emission tomography-computed tomography highlights high-risk culprit carotid plaque and is more…
- Trial name
- NCT03215563
- Testing
- 18F PET-MRI, Transcranial Doppler
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Edinburgh
Acute Lung Injury
Exploratory Clinical Study of Neutrophil Activation Probe (NAP) for Optical Molecular Imaging in Human Lungs
Seriously ill patients may develop a complication called acute lung injury (ALI), a form of inflammation in which lung tissue is filled by fluid containing white blood cells called neutrophils.
- Trial name
- NAP (NCT01532024)
- Testing
- Microdose of NAP
- Where
- 3 sites in United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Type 1 Diabetes
Energy Balance Following Islet Transplantation
Islet transplantation may be appropriate in up to 10% of adults with Type 1 diabetes who suffer repeated episodes of hypoglycaemia with severely impaired awareness of hypoglycaemia (IAH) (1).
- Trial name
- EBFIT (NCT03063229)
- Testing
- Accelerometer, Anthropomentry, Blood tests
- Where
- United Kingdom
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh