Clinical trials: sponsored by University of Edinburgh
Functional Neurological Disorder
Psychoeducation Group Intervention for FND
This study aims to assess the feasibility of running a brief psychoeducation group intervention in an outpatient setting to assess the practicalities and benefits of offering this type of intervention for both clinicians and…
- Trial name
- NCT03857347
- Testing
- Psychoeducation Group for FND
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Edinburgh
Liver Cancer, Surgery
HepaT1ca: Quantifying Liver Health in Surgical Candidates for Liver Malignancies
This observational clinical cohort study aims to evaluate the clinical utility of LiverMultiScan in quantifying liver health prior to liver resection or TACE.
- Conditions
- Liver Cancer, Surgery, Liver Regeneration, Colorectal Cancer Metastatic
- Trial name
- Hepatica (NCT03213314)
- Testing
- Multiparameter magnetic resonance imaging
- Where
- 2 sites in United Kingdom
- Volunteers
- 149 people
- Sponsor
- University of Edinburgh
Blood Pressure
PAracetamol Treatment in Hypertension: Effect on Blood Pressure (PATH-BP) Study
The purpose of this study is to examine if chronic paracetamol dosing increases blood pressure in patients with known high blood pressure.
- Trial name
- PATH-BP (NCT01997112)
- Testing
- Paracetamol
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Edinburgh
Pain
Paracetamol Versus Placebo in Conjunction With Strong Opioids for Cancer Pain
National guidelines advocate the use of paracetamol in conjunction with strong opioids for cancer pain, despite a lack of evidence for its efficacy.
- Trial name
- PaSO (NCT02706769)
- Testing
- Paracetamol
- Where
- United Kingdom
- Volunteers
- 34 people
- Sponsor
- University of Edinburgh
Sleep Deprivation, Sleep
Sleep Headphones and HDU: a Novel Intervention and Sound Evaluation
It is well established that patients sleep poorly in the Intensive Care Unit (ICU), and excessive noise is considered to be a modifiable cause of this.
- Trial name
- SHH: Noise! (NCT03774212)
- Testing
- Active noise cancelling headphones
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- University of Edinburgh
Pesticide Poisoning
A Community Trial to Determine Whether 'Safe Storage' Reduces Pesticide Self-poisoning in Rural Asia
A major global public health priority is to identify effective methods for preventing deaths from pesticide self-poisoning. The aim of this work is to determine whether the provision of lockable storage containers to poor…
- Trial name
- NCT01146496
- Testing
- Ultraviolet light-resistant plastic in-ground pesticide storage container
- Where
- Sri Lanka
- Volunteers
- 223,861 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Deliberate Self-Harm
Mentalization-Based Group Therapy for Adolescents
This is a prospective parallel group design of group-based Mentalization-Based Therapy for Adolescents (MBT-A) through a pilot randomised controlled trial comparing group-based MBT-A plus treatment as usual (TAU) to TAU alone.
- Trial name
- NCT02771691
- Testing
- Mentalization-Based Group Therapy for Adolescents
- Where
- United Kingdom
- Volunteers
- 53 people
- Sponsor
- University of Edinburgh
Osteoarthritis of the Knee
Targeted Rehabilitation to Improve Outcome After Knee Replacement- A Physiotherapy Study
The TRIO-physio study is looking at how well patients with osteoarthritis recover after knee replacement surgery (also known as Total Knee Arthroplasty (TKA)). Currently around 20% of patients are not satisfied after TKA.
- Trial name
- TRIO-Physio (NCT01849445)
- Testing
- Intensive physiotherapy, Home physiotherapy exercises
- Where
- 6 sites in United Kingdom
- Volunteers
- 334 people
- Sponsor
- University of Edinburgh
Liver Cirrhosis, Variceal Haemorrhage
Early Use of TIPSS in Patients With Cirrhosis and Variceal Bleeding
Gastro-oesophageal varices (swollen veins in the gullet and stomach) are present in 50% of patients with liver cirrhosis and are its most serious complication as their rupture results in potentially life threatening bleeding.
- Trial name
- EarlyTIPSS (NCT02377141)
- Testing
- Endoscopic Variceal Band Ligation, Transjugular Intrahepatic Porto-Systemic Stent Shunt
- Where
- 2 sites in United Kingdom
- Volunteers
- 59 people
- Sponsor
- University of Edinburgh
Coronary Heart Disease
Myocardial Blood Flow by 15O Water PET
Coronary heart disease is a very common condition caused by narrowings in the blood vessel supplying the heart. the investigators are studying new tests to diagnose heart disease.
- Trial name
- NCT01805193
- Testing
- Computed tomography myocardial perfusion imaging, Oxygen 15 labelled water positron emission tomography
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Edinburgh
Heavy Menstrual Bleeding
Dexamethasone for Excessive Menstruation
This study builds on previous research which has provided compelling evidence that deficient activity of glucocorticoids in the endometrium is a cause of increased menstrual bleeding.
- Trial name
- dexFEM (NCT01769820)
- Testing
- Dexamethasone
- Where
- United Kingdom
- Volunteers
- 123 people
- Sponsor
- University of Edinburgh
Schistosomiasis
Childhood Schistosomiasis: a Novel Strategy Extending the Benefits/Reach of Antihelminthic Treatment
Objective and Hypotheses: This project has the overall objective of implementing and evaluating new approaches to reducing the current and future burden of urinary schistosomiasis in young children using the antihelminthic drug…
- Trial name
- NCT02495909
- Where
- Zimbabwe
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Anxiety Disorders, Stroke
Treating Anxiety After Stroke (TASK)
The TASK (Treating Anxiety after StroKe) trial is a feasibility randomized controlled trial. It aims to evaluate the feasibility of i) web-enabled trial procedures, and ii) the TASK intervention in stroke and TIA patients
- Conditions
- Anxiety Disorders, Stroke, Transient Ischemic Attack
- Trial name
- TASK (NCT03439813)
- Testing
- TASK-CBT, TASK-Relax
- Where
- United Kingdom
- Volunteers
- 27 people
- Sponsor
- University of Edinburgh
Liver Cirrhosis, Hypertension, Portal
Serelaxin To Lower Portal Pressure
Portal hypertension (an increase in blood pressure in the portal vein that carries the blood from the intestine and spleen to the liver) underlies most of the serious complications of liver cirrhosis.
- Trial name
- STOPP (NCT02669875)
- Testing
- Serelaxin
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- University of Edinburgh
One-Lung Ventilation
Estimating Blood Concentrations of Anaesthetics During One-Lung Ventilation (OLV)
The aims of the study is to determine if end-tidal concentrations of the anaesthetic gases isoflurane and sevoflurane as measured by a standard gas monitor are related to the blood levels during one-lung ventilation.
- Trial name
- NCT02821455
- Testing
- Lung Surgery with One-Lung Ventilation
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- University of Edinburgh
Acute Kidney Injury, Liver Cirrhoses
Prognostic Biomarkers For Acute Kidney Injury In Liver Cirrhosis
Acute kidney injury (AKI) is a common and under-diagnosed problem in patients with liver cirrhosis, and is associated with significant illness and preventable death.
- Conditions
- Acute Kidney Injury, Liver Cirrhoses, Biomarkers
- Trial name
- NCT03156426
- Testing
- Event of interest: Acute kidney injury
- Where
- United Kingdom
- Volunteers
- 52 people
- Sponsor
- University of Edinburgh
Non-alcoholic Fatty Liver Disease
Breath Analysis Using an Electronic Nose in Non Alcoholic Fatty Liver Disease
The purpose of this is to analyse human exhaled breath by means of a device called electronic nose(eNose) in patients with non-alcoholic fatty liver disease (NAFLD) as a way to non-invasive assessment of liver disease.This device…
- Trial name
- BEN (NCT02950610)
- Testing
- Breath analysis - electronic signature "Breath-print"
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Aortic Stenosis
The Role of Myocardial Fibrosis in Patients With Aortic Stenosis
Aortic stenosis is the most common adult valvular heart disease in the western world. Heart failure and sudden cardiac death are complications associated with aortic stenosis.
- Trial name
- NCT01755936
- Testing
- Cardiac Magnetic Resonance Imaging, Echocardiography, 72 hour Holter Monitor
- Where
- United Kingdom
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Aortic Stenosis
Role of Active Valvular Calcification and Inflammation in Patients With Aortic Stenosis
The aortic valve is the main outlet valve from the heart. This valve can become diseased and narrowed when it needs to be replaced with an artificial valve.
- Trial name
- NCT01358513
- Where
- United Kingdom
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Stroke
Reproducibility Study of Transcranial Doppler
Hardening of the neck vessels (carotid arteries) caused by fatty deposits called 'plaques' is a common cause of strokes. Over time plaques can burst or may lead to a severe narrowing (stenosis) of the neck artery.
- Trial name
- NCT03050567
- Testing
- Transcranial Doppler Ultrasound
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh