Clinical trials: sponsored by University of Edinburgh
Stroke
Reproducibility Study of Transcranial Doppler
Hardening of the neck vessels (carotid arteries) caused by fatty deposits called 'plaques' is a common cause of strokes. Over time plaques can burst or may lead to a severe narrowing (stenosis) of the neck artery.
- Trial name
- NCT03050567
- Testing
- Transcranial Doppler Ultrasound
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Delirium, Dementia
Validating Studies to Assess the Diagnostic Accuracy of a Software Application for Detection and Monitoring of Attentional Deficits in Delirium
The study has two phases: Phase B and Phase C. The purpose of the Phase B study is to determine the performance (sensitivity and specificity) of a smartphone application (DelApp) to identify delirium in the whole inpatient…
- Trial name
- NCT02590796
- Testing
- No intervention given to participants
- Where
- 2 sites in United Kingdom
- Volunteers
- 907 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Placenta, Retained
GOT-IT Trial: Glyceryl Trinitrate for Retained Placenta
A retained placenta (RP) is a complication after a normal birth, which affects nearly 11,000 women in the UK per year. This is where the placenta is not delivered spontaneously after giving birth.
- Trial name
- GOT-IT (NCT02085213)
- Testing
- Glyceryl Trinitrate
- Where
- United Kingdom
- Volunteers
- 1,107 people
- Sponsor
- University of Edinburgh
Schizophrenia
Promoting Physical Activity in People With Schizophrenia.
People with schizophrenia die approximately 20 years earlier than those in the general population, and this is mostly due to cardiovascular disease (CVD) and related poor physical health.
- Trial name
- ProActiveS (NCT03514212)
- Testing
- ProActiveS
- Volunteers
- 20 people
- Sponsor
- University of Edinburgh
Multiple Sclerosis, Psychological Distress
The Impact of Positive Mental Training in Multiple Sclerosis
Depression and anxiety are common in MS and often go untreated. Even symptoms which do not meet the threshold for a psychiatric diagnosis can have a significant impact on quality of life.
- Trial name
- PosMTMS (NCT02524093)
- Testing
- Positive Mental Training, treatment as usual
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Edinburgh
Decreased Fetal Movements Affecting Care of Mother, Pregnancy
Promoting Awareness Fetal Movements to Reduce Fetal Mortality Stillbirth, a Stepped Wedge Cluster Randomised Trial.
Rates of stillbirth in Scotland are among the highest in resource rich countries. The majority of stillbirths occur in normally formed infants, with (retrospective) evidence of placental insufficiency being the commonest clinical…
- Conditions
- Decreased Fetal Movements Affecting Care of Mother, Pregnancy, Stillbirth
- Trial name
- AFFIRM (NCT01777022)
- Testing
- A package of interventions
- Where
- 29 sites in Ireland, United Kingdom
- Volunteers
- 430,830 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Cerebral Small Vessel Diseases, Cognitive Impairment
Lacunar Intervention Trial 1 (LACI-1)
Phase II pilot randomised, factorial, short term dose escalation, open label, blinded intermediary endpoint trial, in two hospital centres in the UK, of tolerability and safety of cilostazol, isosorbide mononitrate, both or…
- Conditions
- Cerebral Small Vessel Diseases, Cognitive Impairment, Stroke
- Trial name
- Prevent-SVD (NCT02481323)
- Testing
- isosorbide mononitrate, cilostazol
- Where
- 2 sites in United Kingdom
- Volunteers
- 57 people
- Sponsor
- University of Edinburgh
Anorexia Nervosa, Bulimia Nervosa
Eating Disorders: Online Self-help & Usual Treatment (TAU) vs TAU Only
A pilot study exploring whether individuals receiving usual treatment (CBT) from the specialist NHS Tayside Eating Disorders Service and accessing the online self-help "Smart Eating" programme have improved treatment outcomes…
- Conditions
- Anorexia Nervosa, Bulimia Nervosa, Binge Eating Disorder, Other Specified Feeding or Eating Disorder
- Trial name
- NCT03107221
- Testing
- "Smart Eating" internet-based self-help programme
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Edinburgh
Chronic Kidney Disease
Arterial Stiffness in Chronic Kidney Disease
Diurnal variations in the cardiovascular system apparent in healthy individuals, are different in chronic kidney disease patients.
- Trial name
- NCT01770847
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Anxiety, Depression
An ACT Manual-based, Guided Self-help Intervention Pilot
This study aims to evaluate the effectiveness of a guided self-help intervention using Acceptance and Commitment Therapy (ACT). Half of the participants will receive the self-help manual whilst on a waiting list for individual…
- Trial name
- ACT (NCT02449759)
- Testing
- ACT Intervention Group
- Where
- United Kingdom
- Volunteers
- 52 people
- Sponsor
- University of Edinburgh
CKDu, Arterial Stiffness
An Investigation Into the Cardiovascular Risk and Aetiology of CKDu in Sri Lanka
1. We hypothesise that CKDu patients will have increased arterial stiffness and thus increased all-cause and cardiovascular mortality.
- Conditions
- CKDu, Arterial Stiffness, Proteinuria, Serum Creatinine
- Trial name
- NCT02226055
- Testing
- Arterial Stiffness Assessment
- Where
- Sri Lanka
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Stroke
A Rehabilitation Therapy for Post-stroke Fatigue
Stroke is a leading cause of adult disability in the community. Fatigue affects about a third of stroke survivors. It results in difficulty taking part in everyday activities, and increases risk of hospitalization and death after…
- Trial name
- NCT02131532
- Testing
- A brief psychological intervention
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Edinburgh
Schistosomiasis
Health Benefits of Repeated Treatment in Pediatric Schistosomiasis
Objective and Hypotheses: This project has the overall objective of implementing and evaluating new approaches to reducing the current and future burden of urinary schistosomiasis in young children using the antihelminthic drug…
- Trial name
- NCT01424410
- Where
- Zimbabwe
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Cancer, Pain
Two Step Versus the Standard Three Step Approach of the WHO Analgesic Ladder for Cancer Pain Relief.
The World Health Organization analgesic ladder for cancer pain relief is an internationally used approach to managing cancer pain. Patients generally start on Step 1 of the ladder (paracetamol).
- Trial name
- TVT (NCT01493635)
- Testing
- analgesic ladder
- Where
- United Kingdom
- Volunteers
- 152 people
- Sponsor
- University of Edinburgh
Abdominal Aortic Aneurysm
Sodium Fluoride Imaging of Abdominal Aortic Aneurysms
The purpose of this study is to determine whether Sodium Fluoride imaging (using Positron Emission Tomography-Computed Tomography - PET-CT) is able to help predict the rate of abdominal aortic aneurysm expansion.
- Trial name
- SoFIA3 (NCT02229006)
- Testing
- 18F-NaF PET-CT
- Where
- United Kingdom
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Tuberculosis
Virtual Observed Therapy for Patients With Tuberculosis
Using modern technology, investigators will observe participants taking their TB tablets three times per week using a mobile phone, iPod or computer with camera facilities in the participants home environment.
- Trial name
- NCT02680470
- Testing
- Virtual observed therapy
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Edinburgh
Epilepsy
Preliminary Testing of a Novel Device to Detect Epileptic Seizures
Official statistics report around 1000 deaths due to epilepsy in the UK each year (Hanna et al 2002). Most of these deaths are un-witnessed and in many cases are believed to have been avoidable with timely assistance (Langan et…
- Trial name
- PTEpD (NCT02286271)
- Where
- 2 sites in United Kingdom
- Volunteers
- 117 people
- Sponsor
- University of Edinburgh
BRONCHIECTASIS
Atorvastatin in Bronchiectasis in Patients With Pseudomonas Aeruginosa
Statins are a class of drug used to prevent heart attacks and strokes by lowering blood cholesterol levels. They have also been found to have a beneficial "side effect" of lowering the level of inflammation in the body.
- Trial name
- NCT01299194
- Testing
- ATORVASTATIN
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University of Edinburgh
Cardiac Transplant, Cardiac Sarcoid
DEtection of Cellular Inflammation With FERumoxytol in the HEART
To non-invasively image myocardial accumulation of ultrasmall superparamagnetic particles of iron oxide (USPIOs) by an increase in R2* values (compared to controls) within the myocardium of patients with: i.
- Conditions
- Cardiac Transplant, Cardiac Sarcoid, Myocarditis, Healthy Volunteers
- Trial name
- DECIFER (NCT02319278)
- Testing
- Ferumoxytol
- Where
- 3 sites in United Kingdom
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Chronic Obstructive Pulmonary Disease
Physical Activity Enhancing Programme in COPD
Patients with Chronic Obstructive Pulmonary Disease are characterised by a sedentary lifestyle. This contributes to increase the number of hospitalizations and mortality.
- Trial name
- PAEP (NCT02347566)
- Testing
- Physical activity enhancing programme, Usual care
- Where
- United Kingdom
- Volunteers
- 46 people
- Sponsor
- University of Edinburgh