Clinical trials: sponsored by University of Edinburgh
Hypoglycaemia
Effect of Hypoglycaemia on Social Cognition and Cardiac Conduction
It is known that hypoglycaemia affects various domains of cognitive function. One aspect of cognitive function is 'social cognition', which is our ability to interpret facial expressions, gestures and speech.
- Trial name
- NCT02347553
- Testing
- This is not an interventional study
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University of Edinburgh
Atherosclerosis
Radial Artery Function Following Trans-radial Cardiac Catheterisation
The investigators will study Radial artery injury and endothelial function following trans-radial cardiac catheterisation. Radial artery injury will be quantified pre- and post- angiography using Optical Coherence Tomography.
- Trial name
- NCT02147119
- Testing
- Coronary angiography
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- University of Edinburgh
Postoperative Pain, Postoperative Nausea and Vomiting
A Comparison of Targinact vs. Oxycodone on Gut Function After Colorectal Surgery
Two key requirements for discharge from hospital after major abdominal surgery are adequate oral analgesia and resumption of oral nutrition.
- Trial name
- TACS (NCT02109640)
- Testing
- Targinact, Oxycodone, Laparoscopic segmental colectomy
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Edinburgh
Coagulopathy in Patients Having Thoraco-Abdominal Aneurysm Repair
Fibrinogen as an Alternative to FFP in Aortic Surgery.
Thoracoabdominal aneurysm (TAAA) repair is a major elective vascular operation associated with a large blood loss and potentially life-threatening clotting abnormalities.
- Trial name
- NCT00994045
- Testing
- Fibrinogen concentrate, Fresh Frozen Plasma
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Edinburgh
Pregnancy, Gestational Diabetes
A Feasibility Study Looking at the Use of Glibenclamide and metfoRmin Versus stAndard Care in gEstational diabeteS
The aim of this open label feasibility study is to determine recruitment rates to a randomised trial of glibenclamide compared with insulin (both in addition to maximum tolerated metformin) for the treatment of Gestational…
- Trial name
- GRACES (NCT02080377)
- Testing
- Glibenclamide, Insulin
- Where
- 5 sites in United Kingdom
- Volunteers
- 23 people
- Sponsor
- University of Edinburgh
Cardiac Surgery
The Levels of Anaesthetics in Heart Muscle During Heart Surgery
In the last few years, anaesthetic agents, Isoflurane used in heart surgery have shown some benefits to reduce the risk of heart muscle damage.
- Trial name
- TLAHMHS (NCT02471001)
- Testing
- Blood samples
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- University of Edinburgh
Organophosphate Poisoning
A Pilot Study Using Rocuronium to Prevent Intermediate Syndrome After Organophosphorus Insecticide Poisoning
Organophosphate pesticide poisoning causes close to 300 000 deaths per year worldwide. Many patients who ingest organophosphates require ventilation; of these patients approximately 50% die.
- Trial name
- NCT02147054
- Testing
- Rocuronium, Sugammadex
- Where
- Sri Lanka
- Volunteers
- 45 people
- Sponsor
- University of Edinburgh
Sepsis, Septic Shock
Immune Failure in Critical Therapy (INFECT) Study
Patients admitted to intensive care units (ICU) are at high risk of developing secondary infections, and this is in part due to dysfunction or failure of their 'germ killing' functions (the immune system).
- Trial name
- INFECT (NCT02186522)
- Where
- 4 sites in United Kingdom
- Volunteers
- 168 people
- Sponsor
- University of Edinburgh
Sepsis
Early PREdiction of Severe Sepsis I (ExPRES-Sepsis I) Study
Between 6 and 16% of patients presenting to hospital emergency departments have infections, with half of these having signs of systemic inflammation (known as 'sepsis').
- Trial name
- ExPRES (NCT02188992)
- Where
- 3 sites in United Kingdom
- Volunteers
- 401 people
- Sponsor
- University of Edinburgh
Aortic Stenosis, Fibrosis
Angiogenesis and Fibrosis in Aortic Stenosis
Angiogenesis and fibrosis lie at the heart of a number of fundamental processes responsible for cardiovascular disease. In this proposal, the investigators intend to build upon a highly successful programme of studies exploring…
- Conditions
- Aortic Stenosis, Fibrosis, Neovascularization, Pathologic
- Trial name
- NCT01837160
- Testing
- Cardiac MRI scan, CT-PET scan, Echocardiogram
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Myocardial Infarction, Fibrosis
Angiogenesis and Fibrosis in Myocardial Infarction
Angiogenesis and fibrosis lie at the heart of a number of fundamental processes responsible for cardiovascular disease. In this proposal, the investigators intend to build upon a highly successful programme of studies exploring…
- Conditions
- Myocardial Infarction, Fibrosis, Neovascularization, Pathologic
- Trial name
- NCT01813045
- Testing
- Cardiac MRI scan, CT-PET scan, CT-coronary angiogram
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Edinburgh
Body Temperature Changes
Development of a Head Cooling Device
This study is testing a head-cooling device on volunteers to assess temperature reduction.
- Trial name
- NCT02226614
- Testing
- University of Edinburgh head cooling device
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Type 1 Diabetes
An ACT Based Application for Young People With Type 1 Diabetes
Study Objectives: This study aims to assess the feasibility and acceptability of an application utilising Acceptance and Commitment Therapy in young people with type 1 diabetes.
- Trial name
- ACT (NCT02526069)
- Testing
- Acceptance and Commitment Therapy
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Multiple Sclerosis
Neuroretinal Biomarkers in Neurodegenerative Diseases
There is increasing evidence that examining our eyes can tell us a lot of information about our health, and systemic diseases. We want to study what eyes can reveal about serious neurodegenerative diseases like multiple…
- Trial name
- NCT02047760
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Post Traumatic Stress Disorder
Recording Heart Rate Variability During Eye Movement Desensitisation Reprocessing With or Without Eye Movement
The purpose of the study is to gain greater insight into Eye Movement Desensitisation Reprocessing (EMDR). EMDR is an NHS recommended treatment, which can significantly reduce trauma symptoms.
- Trial name
- EMDR;PTSD (NCT02565563)
- Testing
- Eye Movement Desensitisation Reprocessing, HeartMath measuring Heart Rate Variability (HRV)
- Sponsor
- University of Edinburgh
Conversion Disorder
TMS and Attentional Bias in Functional Motor Disorder
Functional motor disorders, also called motor conversion disorder, are common reasons for attendance at neurology outpatient clinics.
- Trial name
- NCT02102906
- Testing
- Transcranial magnetic stimulation
- Where
- 2 sites in United Kingdom
- Volunteers
- 13 people
- Sponsor
- University of Edinburgh
Acute Coronary Syndrome, Congestive Cardiac Failure
Palliative Care for Patients With Advanced Heart Disease
Patients admitted as an unscheduled hospital admission with either a acute heart failure syndrome (ACF) or acute coronary syndrome (ACS) will be eligible if their 6-12 month mortality risk is estimated to be 20% or greater at the…
- Conditions
- Acute Coronary Syndrome, Congestive Cardiac Failure, Palliative Care
- Trial name
- FLAME (NCT02302014)
- Testing
- Palliative Care Intervention
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Edinburgh
Chronic Pain
Electro-acupuncture (EA) and Chronic Pelvic Pain (CPP)
Chronic pelvic pain (CPP) is a debilitating condition that affects over 1 million women in the United Kingdom. The annual healthcare costs are estimated at over £150 million.
- Trial name
- BMEA (NCT02295111)
- Testing
- EA treatment, TCM health consult, Usual Care
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Edinburgh
Delirium
Feasibility of a Software App for Testing Inattention in Delirium
This qualitative study aims to evaluate the usability of a smartphone application called DelApp. The study will assess usability and acceptability of the software app by asking 40 clinicians to administer the DelApp assessment to…
- Trial name
- NCT02603380
- Testing
- No intervention
- Volunteers
- 48 people
- Sponsor
- University of Edinburgh
Pulmonary Arterial Hypertension, Vasodilation
Role of Endothelin-A (ETA) and Endothelin-B (ETB) Receptors in the Vasodilatory Response to Endothelin-3 (ET-3)
Endothelin-1 (ET-1) has been linked to a number of conditions including pulmonary arterial hypertension (PAH). ET-1 acts via 2 receptors, ETA and ETB.
- Conditions
- Pulmonary Arterial Hypertension, Vasodilation, Vasoconstriction
- Trial name
- NCT01100736
- Testing
- Bosentan, Sitaxsentan, Endothelin-3
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh