Clinical trials: sponsored by University of Edinburgh
Critical Illness
Development and Evaluation of Strategies to Improve Sedation Quality in InTensive Care
Intensive Care Units (ICUs) across Scotland are working with the Scottish Patient Safety Programme (SPSP) to reduce healthcare associated infections (HAls). This is being done through implementation of "care bundles".
- Trial name
- DESIST (NCT01634451)
- Testing
- Bespoke on-line sedation education package, Sedation specific outcome process feedback, Responsiveness monitoring; novel sedation monitor
- Where
- United Kingdom
- Volunteers
- 1,637 people
- Sponsor
- University of Edinburgh
Healthy
Cardiovascular Effects of Apelin In Healthy Volunteers
Apelin is an endogenous peptide with physiological actions in the cardiovascular system. Apelin can modulate vasomotor tone and is a potent endogenous inotrope.
- Trial name
- NCT02259686
- Testing
- Apelin 1mg subcutaneous, Apelin 1mg intravenous, Apelin 5mg subcutaneous
- Where
- 2 sites in United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Graft Failure, Ischemia-reperfusion Injury
Induction of HO-1; a Therapeutic Approach to Reduce Ischaemia Reperfusion Injury (IRI) Following Deceased Donor Renal Transplantation
This is a blinded, placebo-controlled, randomised controlled trial looking at the effects of Heme arginate (HA) on cadaveric renal transplantation.
- Trial name
- HOT (NCT01430156)
- Testing
- Heme arginate (Normosang), 0.9% sodium chloride
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Edinburgh
Postoperative Pain
Comparison of Analgesic Methods, and Their Effects on Patient Recovery, Following Liver Surgery
The provision of adequate pain relief following major liver surgery is essential, not only for patient comfort, but for the prevention of complications, such as chest infection.
- Trial name
- LIVER (NCT01042054)
- Testing
- Standard optimised recovery protocol., Wound catheter plus patient-controlled analgesia.
- Where
- United Kingdom
- Volunteers
- 65 people
- Sponsor
- University of Edinburgh
Myocardial Infarction
Ferumoxytol for Magnetic Resonance Imaging of Myocardial Infarction
The investigators wish to examine whether a novel 'nanoparticle' of iron oxide, administered intravenously allows an area of heart muscle damage after heart attack to be visualised using a magnetic resonance scanner.
- Trial name
- NCT01323296
- Testing
- Ferumoxytol
- Where
- 2 sites in United Kingdom
- Volunteers
- 15 people
- Sponsor
- University of Edinburgh
Angina Pectoris, Coronary Heart Disease
Effects of Ambient Air Pollution Exposure in Patients With Stable Angina Pectoris During Normal Daily Activities
The purpose of this study is to identify whether exposure to ambient levels of air pollution during normal daily activities has a functional impact on patients with coronary heart disease
- Trial name
- NCT00738491
- Where
- 2 sites in United Kingdom
- Volunteers
- 1 people
- Sponsor
- University of Edinburgh
Endothelial Dysfunction
The Role of Nitric Oxide Synthase Isoforms in the Cardiovascular Effects of Air Pollution
Exposure to air pollution has been linked to increased cardiorespiratory morbidity and mortality. The exact component of air pollution that mediates this effect is unknown, but the link is strongest for fine combustion derived…
- Trial name
- NCT00845169
- Testing
- Forearm vascular study
- Where
- Sweden
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Neonatal Sepsis
Neurodevelopmental Outcomes After Suspected or Proven Sepsis: Secondary Analysis of INIS Trial Database
Neonatal sepsis is an important determinant of adverse neurodevelopmental outcome. The investigators seek to investigate whether neurodevelopmental outcome following neonatal sepsis differs according to whether or not the…
- Trial name
- NCT02281890
- Testing
- Proven sepsis
- Volunteers
- 3,493 people
- Sponsor
- University of Edinburgh
Liver Resection, Paracetamol Administration
Paracetamol Metabolism After Liver Surgery
This observational study will assess the metabolic pathways of paracetamol that are utilised after liver resection.
- Trial name
- PETALS (NCT01770041)
- Testing
- Paracetamol (observation of routine administration)
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- University of Edinburgh
Liver Resection
Energy Expenditure and Regeneration Following Liver Resection Resection
This observational study will measure resting energy expenditure in patients who have undergone liver resection and compare methods of measuring resting energy expenditure.
- Trial name
- EAGLE (NCT02031094)
- Testing
- Observational study: Sense Wear armband and indirect calorimetry used to measure resting energy expenditure
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- University of Edinburgh
Open Liver Resection
The Effects of Local Infiltration Versus Epidural Following Liver Resection 2
The investigators plan to compare epidurals versus wound catheters for effects on pain relief and recovery following open liver surgery.
- Trial name
- LIVER 2 (NCT01747122)
- Testing
- Wound catheter, Epidural
- Where
- United Kingdom
- Volunteers
- 97 people
- Sponsor
- University of Edinburgh
Contraceptive Use After Emergency Contraception
Initiating Contraception After Emergency Contraception From Pharmacy
Pharmacists do not provide immediate contraception to women after emergency contraception (EC); they can only give advice on local contraceptive services.
- Trial name
- NCT01738971
- Testing
- rapid access, one month progestogen only pill
- Where
- United Kingdom
- Volunteers
- 168 people
- Sponsor
- University of Edinburgh
Premature Birth, Perinatal Mortality
Assessing the Impact of Smoke-free Legislation on Perinatal Health in the Netherlands
The purpose of this study is to investigate whether there has been a change in perinatal outcomes following the phased smoking ban introduction (January 2004 for workplaces; July 2008 for bars and restaurants) workplaces in the…
- Conditions
- Premature Birth, Perinatal Mortality, Infant, Low Birth Weight, Stillbirth
- Trial name
- NCT02189265
- Testing
- Smoke-free legislation
- Where
- 2 sites in Netherlands, United Kingdom
- Volunteers
- 2,069,695 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Chronic Obstructive Pulmonary Disease (COPD)
HELPing Older People With Very Severe Chronic Obstructive Pulmonary Disease Towards the End of Their Lives: Developing, Piloting and Refining a Practical Intervention (HELP-COPD)
The purpose of this study is to develop, refine and pilot a novel complex (HELP-COPD) assessment, undertaken during or immediately after a hospital admission, which addresses the holistic care needs of people with severe chronic…
- Trial name
- HELP-COPD (NCT01650480)
- Testing
- HELP-COPD action plan
- Where
- United Kingdom
- Volunteers
- 44 people
- Sponsor
- University of Edinburgh
Appendicitis
A Comparison of Appendicectomy Outcomes in Children Between Paediatric and General Surgical Centres in Scotland
Introduction Appendicectomy (or appendectomy in US usage) is the single most commonly performed emergency surgical operation performed on British children.
- Trial name
- NCT02047786
- Where
- United Kingdom
- Volunteers
- 4,000 people
- Sponsor
- University of Edinburgh
Non Alcoholic Fatty Liver Disease
The Effect Of Omega-3 Fatty Acids on Non-alcoholic Fatty Liver Disease
There is preliminary evidence that Omega 3, a compound naturally found in fish oil, reduces the amount of fat stored in the liver and improves liver function.
- Trial name
- NCT01277237
- Testing
- Omacor, lactose tablet
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Edinburgh
Stillbirth, Infant Mortality
Impact of Smoke-free Legislation on Early-life Mortality and Low Birth Weight in England
The purpose of this study is to investigate whether there has been a change in low birth weight and perinatal and infant mortality following the July 2007 introduction of a ban on smoking in public places and workplaces in…
- Conditions
- Stillbirth, Infant Mortality, Sudden Infant Death, Infant, Low Birth Weight
- Trial name
- NCT02039583
- Testing
- Smoke-free legislation
- Where
- United Kingdom
- Volunteers
- 10,291,118 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Abdomen, Acute
Geographic Influences on Emergency Laparotomy Outcomes
Introduction 'Emergency Laparotomy' is an umbrella term for a set of commonly performed procedures which are known to carry a significant risk of mortality and morbidity.
- Trial name
- NCT02017977
- Where
- United Kingdom
- Volunteers
- 40,000 people
- Sponsor
- University of Edinburgh
Autism Spectrum Disorder
A Clinical Trial of a New Computer Based Intervention for Children With Autism.
The CLICK-EAST research project is an investigation of the efficacy of a computer based learning programme which aims to teach the fundamental components of social attention to young children with autism spectrum disorder (ASD).
- Trial name
- Click-East (NCT01493609)
- Testing
- Click-East app
- Where
- 2 sites in United Kingdom
- Volunteers
- 54 people
- Sponsor
- University of Edinburgh
Bronchiectasis
A Trial of Atorvastatin as an Anti-Inflammatory Agent in Non-Cystic Fibrosis Bronchiectasis
The investigators hypothesise that long term statin treatment will improve patients' symptoms through its anti-inflammatory effect.
- Trial name
- NCT01299181
- Testing
- Atorvastatin
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Edinburgh