Clinical trials: sponsored by University of Edinburgh
Respiratory Tract Infections, Upper Respiratory Tract Infections
Smoking Ban and Paediatric Hospital Admissions for Respiratory Tract Infections in England
The purpose of this study is to investigate whether there has been a change in the number of hospital admissions for respiratory tract infections among children following the July 2007 introduction of a ban on smoking in public…
- Conditions
- Respiratory Tract Infections, Upper Respiratory Tract Infections, Lower Respiratory Tract Infections
- Trial name
- NCT01920165
- Testing
- Smoke-free legislation
- Where
- United Kingdom
- Volunteers
- 1,660,652 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Overdose
Scottish and Newcastle Anti-emetic Pre-treatment for Paracetamol Poisoning Study (SNAP)
This study is designed to assess the impact of new approaches to therapy for paracetamol poisoning. Standard therapy is currently acetylcysteine by intravenous infusion over 20.25h.
- Trial name
- SNAP (NCT01050270)
- Testing
- Ondansetron, acetylcysteine
- Where
- 3 sites in United Kingdom
- Volunteers
- 222 people
- Sponsor
- University of Edinburgh
Healthy
A Phase I Study of Oral UE2343 in Healthy Subjects
A randomised, double-blind, placebo-controlled, phase I study in healthy subjects. Safety, pharmacokinetic and pharmacodynamic data will be collected.
- Trial name
- UE2343 (NCT01770886)
- Testing
- UE2343
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Heart Failure, Endothelium
Effect of Urocortins in Patients With Heart Failure
Despite modern advances in treatment, heart failure continues to carry a poor prognosis with high morbidity and mortality rates.
- Trial name
- NCT01599728
- Testing
- Urocortin 2, Urocortin 3 and Substance P
- Where
- United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Coronary Disease
320 Multidetector Computed Tomography Prior to Coronary Artery Bypass Surgery
Recent advances in technology have resulted in the development of scanners that can n image the heart arteries within 10 to 20 minutes but without the need for admission to hospital or insertion of catheters.
- Trial name
- NCT01169948
- Testing
- Computed tomography scan
- Where
- United Kingdom
- Sponsor
- University of Edinburgh
Hypertension
Does Ultraviolet Irradiation Reduce Platelet Reactivity and Improve Coronary Microvascular Function in Man?
Endothelium derived nitric oxide (NO) regulates vascular tone and blood pressure in man. NO also inhibits platelet aggregation and mediates a variety of beneficial anti-inflammatory and repair mechanisms.
- Trial name
- NCT01785511
- Testing
- UVA Radiation
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Healthy
Tracking Inflammatory Cells Using Superparamagnetic Particles of Iron Oxide (SPIO) and Magnetic Resonance Imaging (MRI)
Treatment of a wide range of diseases using stem cells and other types of cell appears promising. Following administration of cells it is often not clear where exactly the cells have gone and how many of them have reached the…
- Trial name
- NCT01169935
- Testing
- Administration of intra-dermal Endorem, Mantoux test, Autologous Endorem-labelled mononuclear cells
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Abdominal Aortic Aneurysm
Magnetic Resonance Imaging To Predict Outcomes In Aortic Aneurysms
The aorta is the main blood vessel that comes out of the heart and distributes blood to the whole body. In some people, the aorta becomes swollen (aneurysm) and bursts, especially as it passes through the abdomen.
- Trial name
- NCT01749280
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University of Edinburgh
Cancer
Edinburgh Pain Assessment Tool (EPAT©) Study
To determine if the institutionalisation of a regular systematic approach to the assessment of pain in inpatient cancer units using the Edinburgh Pain Assessment Tool (EPAT©) leads to better control of pain than that achieved by…
- Trial name
- EPAT© (NCT00595777)
- Testing
- EPAT© Educational Package
- Where
- 19 sites in United Kingdom
- Volunteers
- 1,928 people
- Sponsor
- University of Edinburgh
Respiratory Inflammation, Systemic Inflammation
Woodsmoke Exposure and Cardiovascular Function
Air pollution is linked to respiratory and cardiovascular disease. Wood smoke is a common air in many parts of the world and previous studies indicate that wood smoke induce oxidative stress in the respiratory tract.
- Trial name
- NCT01488500
- Testing
- Bronchoscopy
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Vascular Disease, Heart Disease
Effects of Urocortins on Forearm Arterial Blood Flow in Healthy Volunteers (Protocol 3)
Impairment of the heart's pumping capacity (heart failure) remains a major clinical problem with a poor prognosis and the search for novel treatments remains an important area of research.
- Trial name
- NCT01096706
- Testing
- NO clamp, Saline, Fluconazole
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Vascular Function in Healthy Volunteers
Diesel Exhaust Inhalation, Systemic Nitric Oxide Inhibition and Cardiac Output
Exposure to combustion-derived fine particulate air pollution is associated with cardiovascular mortality and morbidity. In previous studies, exposure to diesel exhaust (a major constituent of urban particulate air pollution) has…
- Trial name
- DISCO (NCT01060930)
- Testing
- Intravenous infusion of L-NMMA and Nor-epinephrine
- Where
- Sweden
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Healthy
Biodiesel Exhaust, Acute Vascular and Endothelial Responses
Exposure to particulate air pollution has been shown to increase cardiovascular mortality and morbidity, and in previous controlled exposure studies has been shown to have acute cardiovascular and respiratory effects.
- Trial name
- BEAVER (NCT01337882)
- Testing
- Forearm venous occlusion plethysmography study
- Where
- Sweden
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Cardiovascular Disease, Heart Failure
Effects of Urocortins on Forearm Arterial Blood Flow in Healthy Volunteers - Protocol 4
Impairment of the heart's pumping capacity (heart failure) remains a major clinical problem with a poor prognosis and the search for novel treatments remains an important area of research.
- Trial name
- NCT01296607
- Testing
- Urocortin 2, Urocortin 3
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Intensive Care, Blood Transfusion
Restrictive and Liberal Transfusion Strategies in Intensive Care
The most effective transfusion practice in critically ill ICU patients is unknown. Currently the data is unclear as to whether a liberal or restrictive transfusion policy is of most benefit to patients in the short and longer…
- Conditions
- Intensive Care, Blood Transfusion, Anemia
- Trial name
- RELIEVE (NCT00944112)
- Testing
- Restrictive RBC Transfusion, Liberal RBC Transfusion
- Where
- 6 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Edinburgh
Vascular Disease, Heart Disease
Effects of Urocortins on Forearm Arterial Blood Flow in Healthy Volunteers
Impairment of the heart's pumping capacity (heart failure) remains a major clinical problem with a poor prognosis and the search for novel treatments remains an important area of research.
- Trial name
- NCT01049542
- Testing
- Astressin 2B
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Colorectal Liver Metastases
Optimised Recovery With Accelerated Nutrition and GI Enhancement
Factors which delay recovery following uncomplicated abdominal surgery include uncontrolled pain, intolerance of diet and poor mobility.
- Trial name
- ORANGE (NCT00538954)
- Testing
- Post operative laxation (Magnesium Oxide), Preoperative metabolic conditioning postoperative nutritional supplementation, Standard ERAS group
- Where
- 2 sites in Netherlands, United Kingdom
- Volunteers
- 64 people
- Sponsor
- University of Edinburgh
Ischaemic Heart Diseases
The Effect of Ischaemic-Reperfusion in Man - A Bradykinin Dependent Pathway
Heart attacks are usually caused by a blood clot blocking an artery supplying blood to the heart. Current treatments are designed to relieve this blockage as quickly as possible to minimize damage to the heart muscle.
- Trial name
- NCT00965120
- Testing
- Forearm vascular study, bradykinin receptor antagonist (HOE-140)
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Ischaemic Heart Diseases
The Effect of Ischaemic-reperfusion on the Endogenous Fibrinolysis in Man
Heart attacks are usually caused by a blood clot blocking an artery supplying blood to the heart. Current treatments are designed at relieving this blockage as quickly as possible to minimise damage to the heart muscle.
- Trial name
- NCT00789451
- Testing
- Forearm vascular study
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Ischaemic Heart Diseases
The Effect of Ischaemic-Reperfusion and Ischaemic Preconditioning on the Endogenous Fibrinolysis in Man
Heart attacks are usually caused by a blood clot blocking an artery supplying blood to the heart. Current treatments are designed at relieving this blockage as quickly as possible to minimise damage to the heart muscle.
- Trial name
- NCT00789243
- Testing
- Forearm vascular study
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh