Clinical trials: sponsored by University of Edinburgh
Ischaemic Heart Diseases
The Effect of Ischaemic-Reperfusion and Remote Ischaemic Preconditioning in Man - A Bradykinin Dependent Pathway
Heart attacks are usually caused by a blood clot blocking an artery supplying blood to the heart. Current treatments are designed at relieving this blockage as quickly as possible to minimize damage to the heart muscle.
- Trial name
- NCT00965393
- Testing
- Forearm vascular study, bradykinin receptor antagonist (HOE-140)
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Fibroid, Leiomyoma
Novel MRI Strategies as a Non-invasive Biomarker in Women With Uterine Fibroids
Fibroids are present in up to 80% of women of reproductive age. Associated heavy menstrual bleeding is often an indication for surgery. At present there are no long-term medical treatments for fibroids.
- Trial name
- NCT00746031
- Testing
- GnRH analogue (Zoladex), GnRH antagonist-Cetrorelix
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Edinburgh
Hepatic Insufficiency, Liver Insufficiency
Liver Transplantation and Reticuloendothelial Clearance Capacity
Study summary: "Liver transplantation and the reticuloendothelial clearance capacity." The purpose of this study is to evaluate the effect of liver transplantation on the immune system.
- Trial name
- NCT00929032
- Testing
- Nanocoll®
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Edinburgh
Renin Angiotensin System
Interaction of Apelin and Angiotensin in the Systemic Circulation
The apelin-APJ system is a relatively new discovery. It has generated interest in part due to it's apparent ability to counteract the renin-angiotensin system, which is frequently overactive in many cardiovascular disease.
- Trial name
- NCT01049646
- Testing
- Angiotensin II, Saline
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Heart Disease, Vasodilation
Interaction of Apelin and Angiotensin in the Human Forearm Circulation
The apelin-APJ system is a relatively new discovery. It has generated interest in part due to it's apparent ability to counteract the renin-angiotensin system, which is frequently overactive in many cardiovascular disease.
- Trial name
- NCT00901888
- Testing
- Apelin infusion, Sodium nitroprusside infusion
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Bronchiectasis
Long Term Nebulised Gentamicin in Patients With Bronchiectasis
The hypothesis of this randomized placebo controlled trial is that targeted nebulized gentamicin to the airways will reduce bacterial burden and limit neutrophil airways inflammation.
- Trial name
- NCT00749866
- Testing
- Gentamicin, Saline
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Edinburgh
Heart Disease, Vasodilation
Interaction of Apelin and Angiotensin in the Human Forearm Circulation
The apelin-APJ system is a relatively new discovery. It has generated interest in part due to it's apparent ability to counteract the renin-angiotensin system, which is frequently overactive in many cardiovascular disease.
- Trial name
- NCT00901745
- Testing
- Angiotensin II, Noradrenaline infusion
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Heart Disease, Heart Failure
Investigating Systemic and Local Vascular Responses to Apelin in the Context of Renin-angiotensin Upregulation
The apelin-APJ system is a relatively new discovery. It has generated interest in part due to it's apparent ability to counteract the renin-angiotensin system, which is frequently overactive in many cardiovascular disease.
- Conditions
- Heart Disease, Heart Failure, Vasodilatation
- Trial name
- NCT00901719
- Testing
- Apelin, Acetylcholine, Sodium nitroprusside
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Hypertension
Sildenafil and Exercise Capacity in Hypertension
Hypertension (persistently elevated blood pressure) is a major risk factor for heart disease and stroke. Hypertensive individuals show a reduced exercise capacity, which is present from a very early stage and contributes to their…
- Trial name
- NCT00599235
- Testing
- sildenafil, hydralazine
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Angina Pectoris, Coronary Heart Disease
Reducing the Pro-ischaemic Effects of Air Pollution Exposure Using a Simple Face Mask
Air pollution is a major cause of cardiorespiratory morbidity and mortality. The exact components of air pollution that underlie the cardiovascular effects are not yet known, but combustion-derived particulate matter is suspected…
- Conditions
- Angina Pectoris, Coronary Heart Disease, Blood Pressure, Heart Rate Variability
- Trial name
- NCT00809653
- Testing
- No Face Mask, Face Mask
- Where
- China
- Volunteers
- 100 people
- Sponsor
- University of Edinburgh
Coronary Heart Disease, Angina Pectoris
The Effects of Diesel Exhaust Inhalation On Exercise Capacity In Patients With Stable Angina Pectoris
The purpose of this study is to determine whether exposure to diesel exhaust (air pollution) has a functional impact on patients with stable angina pectoris.
- Trial name
- NCT00737958
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- University of Edinburgh
Endothelial Dysfunction
The Cardiovascular Effects of Air Pollution: the Role of Nitric Oxide
Exposure to air pollution has been linked to increased cardiorespiratory morbidity and mortality. The exact component of air pollution that mediates this effect is unknown, but the link is strongest for fine combustion derived…
- Trial name
- NCT00845767
- Testing
- Forearm Vascular Study
- Where
- Sweden
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Endothelial Dysfunction
The Cardiovascular Effects of Nitrogen Dioxide Exposure
Exposure to air pollution has been linked to increased cardiorespiratory morbidity and mortality. The exact component of air pollution that mediates this effect is unknown, but the link is strongest for fine combustion derived…
- Trial name
- NCT00774514
- Testing
- Forearm Vascular Study
- Where
- Sweden
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Blood Pressure, Heart Rate Variability
The Cardiovascular Benefits of Reducing Personal Exposure to Air Pollution
Exposure to air pollution is an important risk factor for cardiovascular morbidity and mortality, and is associated with increased blood pressure, reduced heart rate variability, endothelial dysfunction and myocardial ischaemia.
- Trial name
- NCT00809432
- Testing
- Face mask (Dust Respirator), No Face mask
- Where
- China
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Endothelial Dysfunction
Combustion Derived Air Pollution and Vascular Function
Air pollution is a major cause of cardiovascular morbidity and mortality. The components of air pollution responsible and the mechanisms through which they might mediate these harmful effects remain only partially understood.
- Trial name
- NCT00775099
- Testing
- Forearm Vascular Study, Badimon Chamber
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Heart Disease
The Effect of a Retrofit Particle Trap on the Vascular Effects of Diesel Exhaust Inhalation
The purpose of this study is to determine whether a retrofit particle trap can reduce the adverse vascular responses to diesel exhaust inhalation
- Trial name
- NCT00745446
- Testing
- Forearm Venous Occlusion Plethysmography
- Where
- Sweden
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Premature Ovarian Failure
Evaluation of Physiologic and Standard Sex Steroid Replacement Regimens in Women With Premature Ovarian Failure
The aim of the study is to determine whether physiological sex steroid replacement improves parameters of skeletal, cardiovascular and reproductive health of women treated with current sex steroid replacement regimens.
- Trial name
- NCT00732693
- Testing
- Ethinylestradiol / Norethisterone, Estradiol / Progesterone
- Where
- 2 sites in United Kingdom
- Volunteers
- 42 people
- Sponsor
- University of Edinburgh
Chronic Kidney Disease, Proteinuria
Endothelin Receptor Antagonism in Proteinuric Nephropathy
The number of people with kidney problems is increasing rapidly, related in part to the increasing prevalence of diabetes. Patients with kidney problems tend to have protein leaking into the urine (proteinuria).
- Trial name
- NCT00722215
- Testing
- BQ-123 (selective endothelin A receptor antagonist), 0.9 % saline, Nifedipine
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Edinburgh
Angina Pectoris
Blood Pressure Interaction Between Sildenafil and Sublingual Glyceryl Trinitrate (GTN) in Men With Angina
The purpose of the study is to determine for how long sildenafil potentiates the blood pressure reduction that occurs with glyceryl trinitrate in men with angina.
- Trial name
- NCT00479908
- Testing
- Sildenafil citrate, Glyceryl trinitrate
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Edinburgh
Coronary Heart Disease
Controlled Exposures to Air Pollution in Patients With Coronary Heart Disease
Air pollution is a major cause of cardiovascular morbidity and mortality. The components of air pollution responsible and the mechanisms through which they might mediate these harmful effects remain only partially understood.
- Trial name
- NCT00437138
- Testing
- Exposure to dilute diesel exhaust (300µg/m3) or filtered air
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- University of Edinburgh