Clinical trials: sponsored by University of Edinburgh
Chronic Respiratory Conditions
Pulmonary Rehabilitation in African Countries
Chronic Respiratory Diseases (CRDs) are common disabling conditions worldwide with high prevalence, morbidity and mortality. More than half of the CRD patients live in low- and middle-income countries (LMICs) where resources for…
- Trial name
- NCT07602673
- Testing
- Centre-based Pulmonary Rehabilitation, Community-based Pulmonary Rehabilitation
- Where
- 3 sites in Cameroon, Nigeria and 1 more
- Volunteers
- 150 people
- Sponsor
- University of Edinburgh
Endometriosis
Whole-Body Cryotherapy as a Non-Pharmacological Treatment to Reduce Chronic Pelvic Pain and Improve Quality of Life in People With Endometriosis
The aim of this study is to investigate whether whole-body cryotherapy (a brief exposure to very cold temperatures) can help reduce pain and improve quality of life in people living with endometriosis, and whether it may…
- Trial name
- CHILL-Endo (NCT07603960)
- Testing
- Whole-Body Cryotherapy
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Edinburgh
Iron Deficiency Anaemia
The Use of Robot Assisted Magnetically Controlled Capsule Endoscopy in Patients With Iron Deficiency Anaemia
In this study the investigators will recruit patients who have already had an upper gastrointestinal (GI) tract endoscopy (OGD) and lower GI tract investigations which did not identify the source of iron deficiency anaemia, and…
- Trial name
- NCT07197424
- Testing
- Robot assisted magnetically controlled capsule endoscopy
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Edinburgh
Health, Hypertension
Optical Coherence Tomography And NEphropathy: The OCTANE Study
Patients with high blood pressure (hypertension) and chronic kidney disease are at an increased risk of developing heart disease and strokes.
- Conditions
- Health, Hypertension, Chronic Kidney Disease
- Trial name
- NCT02132741
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Multiple Sclerosis
Multiple Sclerosis: FutureMS-2 - an Observational Cohort and Scottish Precision Medicine Study
FutureMS is a project created in direct response to frequent questions people with MS ask their doctors. Every person newly diagnosed wants to know how MS will affect them over their life and what can be done to stop the disease…
- Trial name
- NCT06001138
- Where
- 5 sites in United Kingdom
- Volunteers
- 440 people
- Sponsor
- University of Edinburgh
Acute Coronary Syndrome
Point of Care Evaluation of High-sensitivity Cardiac Troponin
In this observational research project the investigators wish to test new technologies that could allow them to either detect or rule out heart attacks earlier.
- Trial name
- POC-ET (NCT05665127)
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- University of Edinburgh
Emotionally Unstable Personality Disorder, Borderline Type
Empathy Anomalies in Emotionally Unstable (Borderline) Personality Disorder
Emotionally unstable (borderline) personality disorder (BPD) is characterised by changeable and extreme emotions and difficulty maintaining relationships. It is often associated with self-harm.
- Trial name
- NCT05381649
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Edinburgh
Palliative Care, Primary Care
Latin America Network for Primary Palliative Care
Palliative care is the holistic care provided to individuals and their families who experience health related suffering related to life-limiting conditions.
- Conditions
- Palliative Care, Primary Care, Primary Care Physician
- Trial name
- LANPPC (NCT07436026)
- Where
- Argentina
- Volunteers
- 50 people
- Sponsor
- University of Edinburgh
Coronary Artery Bypass, Graft Failure
Graft Failure and Consequences of Coronary Artery Bypass Graft Surgery
Coronary artery bypass graft (CABG) surgery is the commonest type of heart operation performed. During this, arteries or veins (termed 'grafts') are used to supply blood around blockages within the blood vessels that supply the…
- Conditions
- Coronary Artery Bypass, Graft Failure, Coronary Artery Bypass Graft, Coronary Artery Bypass Graft Surgery (CABG)
- Trial name
- NCT06800430
- Testing
- Hybrid [18F]-GP1, [68Ga]-DOTATATE, [68Ga]-FAPI total-body positron emission tomography and coronary computed tomography coronary angiography
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University of Edinburgh
Parkinson Disease
Bacillus Subtilis in Parkinson's Disease
The aim of this study is to evaluate whether the administration of Bacillus Subtilis influences gut and blood biomarkers relevant to the proposed mechanism(s) of action, as well as being acceptable as a regular supplement for…
- Trial name
- NCT06487975
- Testing
- Bacillus Subtilis
- Where
- 2 sites in Norway, United Kingdom
- Volunteers
- 26 people
- Sponsor
- University of Edinburgh
Angina, Stable, Coronary Artery Disease
Objective Risk Assessment in Patients With Possible Anginal Chest Pain Using Leading Technology
The ORACLE study is an observational cohort study designed to explore the feasibility of providing an assessment of chest pain for patients with suspected angina within one working day of referral to specialist services.
- Trial name
- ORACLE (NCT06325020)
- Testing
- The assessment of patients with possible angina using the ORACLE pathway
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- University of Edinburgh
Metabolic Acidosis
A Study on Bedside Formate Assay as a Diagnostic Tool in Methanol Poisoning
Methanol poisoning is a serious issue, particularly in low- and middle-income countries (LMICs), where outbreaks can devastate communities.
- Trial name
- NCT06881641
- Where
- 6 sites in Bangladesh, India
- Volunteers
- 6,120 people
- Sponsor
- University of Edinburgh
Left Ventricular Thrombus, Thrombosis
The "MyoThrombus" Study
Left ventricular thrombus is a recognised complication of acute myocardial infarction, associated with stroke, recurrent myocardial infarction and adverse cardiac remodelling.
- Conditions
- Left Ventricular Thrombus, Thrombosis, STEMI, Stroke
- Trial name
- NCT04829825
- Testing
- 18F-GP1 PET/MR
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Edinburgh
Oropharyngeal Squamous Cell Carcinoma, Human Papillomavirus (HPV)
The Role of Circulating Tumour DNA in Head and Neck Cancer
Cancers of the throat, oropharyngeal squamous cell carcinoma (OPSCC), are highly prevalent across Scotland. Over the past 10 years, both global and Scottish cases of OPSCC have increased, particularly those associated with human…
- Trial name
- NCT05539638
- Where
- 5 sites in United Kingdom
- Volunteers
- 250 people
- Sponsor
- University of Edinburgh
Hypoxic Ischemic Encephalopathy of Newborn, Neonatal Encephalopathy
Investigating Cerebral Oxygenation in the Newborn
The goal of this single centre observational study is to use near-infrared spectroscopy (NIRS) monitoring to investigate cerebral oxygenation in two groups of newborn infants who are at high risk of brain injury.
- Conditions
- Hypoxic Ischemic Encephalopathy of Newborn, Neonatal Encephalopathy, Premature Infant Disease
- Trial name
- ICON (NCT05588960)
- Testing
- Near-infrared spectroscopy monitoring (Masimo O3 Regional Oximeter with Neonatal Sensor)
- Where
- United Kingdom
- Volunteers
- 99 people
- Sponsor
- University of Edinburgh
Motor Neuron Disease, Amyotrophic Lateral Sclerosis
Motor Neurone Disease - Systematic Multi-Arm Adaptive Randomised Trial
MND-SMART is investigating whether selected drugs can slow down the progression of motor neuron disease (MND) and improve survival. The study is 'multi-arm' meaning more than one treatment will be tested at the same time.
- Trial name
- MND-SMART (NCT04302870)
- Testing
- Memantine Hydrochloride Oral Solution, Trazodone Hydrochloride oral solution, Amantadine Hydrochloride Oral Solution
- Where
- 22 sites in United Kingdom
- Volunteers
- 1,150 people
- Sponsor
- University of Edinburgh
Cerebral Small Vessel Diseases, Lacunar Stroke
Retinal Vessel Leakage in Cerebral Small Vessel Disease
The goal of this observational study is to learn about leakage from retinal vessels in cerebral small vessel disease. The main questions it aims to answer are: Does retinal vessel leakage occur in cerebral small vessel disease?…
- Conditions
- Cerebral Small Vessel Diseases, Lacunar Stroke, Vascular Dementia
- Trial name
- NCT06416371
- Testing
- Fundus fluorescein angiography, with ultrawide field retinal imaging
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Edinburgh
Frailty, Age-Related Macular Degeneration
Visual Frailty in Ageing
The goal of this observational study is to define visual frailty and refine monitoring for an ageing population. It involves piloting a visual frailty assessment tool in a cohort of patients aged 60 and above with a known…
- Conditions
- Frailty, Age-Related Macular Degeneration, Functional Status, Mental Health
- Trial name
- VFiA (NCT06604104)
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Upper Respiratory Tract Infections, Virus
Hypertonic Saline Nasal Irrigation and Gargling in Suspected or Confirmed COVID-19 (ELVIS COVID-19)
ELVIS COVID-19 is a pragmatic web-based Bayesian adaptive randomised controlled, parallel group trial of hypertonic saline nasal irrigation and gargling (HSNIG) compared to standard care in participants with clinically suspected…
- Conditions
- Upper Respiratory Tract Infections, Virus, COVID, Virus Shedding
- Trial name
- NCT04382131
- Testing
- NaCl Solution
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University of Edinburgh
Corneal Ulcer (Diagnosis)
Diagnosing Corneal Infection
Microbial keratitis is a common and serious eye disease in Edinburgh. Prompt treatment with antibiotics can prevent sight loss, and identification of the micro-organism and its antibiotic sensitivities are key to appropriate…
- Trial name
- NCT04230811
- Testing
- Corneal impression membrane (Millicell Cell Culture Insert, 12mm, hydrophilic PTFE 0.4µm (PICM01250))
- Where
- United Kingdom
- Sponsor
- University of Edinburgh