Clinical trials: sponsored by University of Edinburgh
Chronic Low Back Pain (Non-specific, Uncomplicated)
Aquatic and Land Exercises for Chronic Low Back Pain
This study aims to learn about the effects of aquatic and land exercises on managing chronic low back pain in adults aged 18-65. The participants engage in a 12-week supervised land and water-based exercise program.
- Trial name
- AquaLand-CLBP (NCT06874881)
- Testing
- Aquatic Exercises, Land Exercises
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University of Edinburgh
Fertility Disorders, Childhood Cancer
Cryopreservation of Prepubertal Testicular Tissue for Preservation of Fertility in Young Boys With Cancer
Prepubertal boys treated for cancer are at risk of infertility as a result of their treatment. At present there are no options to preserve fertility in these boys.
- Trial name
- NCT06063551
- Testing
- Testicular Biopsy
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Edinburgh
Cauda Equina Syndrome
Understanding Cauda Equina Syndrome
Cauda equina syndrome is a potentially devastating condition caused by compression of the cauda equina nerve roots. This can result in bowel, bladder and sexual dysfunction plus lower limb weakness, numbness, and pain.
- Trial name
- UCES (NCT07235579)
- Where
- United Kingdom
- Volunteers
- 621 people
- Sponsor
- University of Edinburgh
Coronary Artery Disease
DIAMOND - Dual Antiplatelet Therapy to Reduce Myocardial Injury
Heart attacks are most commonly caused by rupture of fatty deposits (plaques) within the wall of heart blood vessels. It appears that this process can also frequently occur without causing any symptoms and these events likely…
- Trial name
- DIAMOND (NCT02110303)
- Testing
- Ticagrelor
- Where
- United Kingdom
- Volunteers
- 220 people
- Sponsor
- University of Edinburgh
Coronary Artery Disease, Primary Prevention
Effect of the SCOT-HEART 2 Trial on Lifestyle.
This study will recruit 400 participants who are taking part in the Computed Tomography Coronary Angiography for the Prevention of Myocardial Infarction (SCOT-HEART 2) trial.
- Trial name
- NCT04156061
- Testing
- Delivery of CT scan results
- Where
- United Kingdom
- Volunteers
- 400 people
- Sponsor
- University of Edinburgh
Renal Transplant Rejection, Renal Transplant Failure
Heme Arginate in Transplantation Study
Organ shortage for transplant has necessitated use of kidneys from older donors, increasing the chance that the kidney will not work immediately or for as long as expected.
- Trial name
- HOT2 (NCT03646344)
- Testing
- Heme Arginate 25 MG/ML, 0.9% Sodium-chloride
- Where
- 2 sites in United Kingdom
- Volunteers
- 47 people
- Sponsor
- University of Edinburgh
Anticholinesterase Insecticide Poisoning, Pesticide Poisoning
Effectiveness of Calcium Channel Blockade for OP and Carbamate Pesticide Poisoning
This study evaluates whether the addition of intravenous magnesium sulphate or nimodipine to standard therapy (supportive care plus for all patients atropine and, for OP insecticide poisoned patients, pralidoxime) benefits…
- Trial name
- CCBOC (NCT03925025)
- Testing
- Magnesium Sulfate, Nimodipine
- Where
- 7 sites in Bangladesh
- Volunteers
- 1,728 people
- Sponsor
- University of Edinburgh
Ischaemic Heart Diseases
Rotigaptide in Endothelial Dysfunction?
Arterial occlusion can lead to tissue ischemia and, if prolonged, end organ infarction. Clinical and experimental data would suggest that restoration of blood flow might trigger additional injury beyond that induced by the…
- Trial name
- NCT07192744
- Testing
- Forearm vascular study
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Microbial Keratitis
Microbial Keratitis Sampling for Biomarker Discovery
The goal of this observational study is to identify prognostic and/or diagnostic signatures (biomarkers) related to microbial keratitis outcomes.
- Trial name
- NCT05888883
- Where
- United Kingdom
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
COVID-19
DEFINE - Evaluating Therapies for COVID-19
COVID-19 is a community acquired pneumonia caused by infection with a novel coronavirus, SARS CoV2 and is a serious condition with high mortality in hospitalised patients, for which there is no currently approved treatment other…
- Trial name
- DEFINE (NCT04473053)
- Testing
- Nafamostat Mesilate, TD139, Standard care
- Where
- United Kingdom
- Volunteers
- 71 people
- Sponsor
- University of Edinburgh
Pancreatic Fistula, Pancreatectomy
Distal Pancreatectomy Pancreatic Fistula Risk Prediction Model Validation Study
Distal pancreas resection is a relatively rare procedure with a known risk of postoperative pancreatic fistula. Until quite recently, no valid risk prediction models for this have been available.
- Trial name
- DPFValid (NCT05737875)
- Where
- United Kingdom
- Volunteers
- 2,284 people
- Sponsor
- University of Edinburgh
Abdominal Aortic Aneurysm, Endoleak
Predicting Endoleaks Following Endovascular Aortic Aneurysm Repair Using 18F-Sodium Fluoride
The purpose of the study is to describe Sodium Fluoride uptake (using Positron Emission Tomography-Computed Tomography - PET-CT) following Endovascular Aneurysm Repair (EVAR) and to determine whether Sodium Fluoride PET-CT can…
- Conditions
- Abdominal Aortic Aneurysm, Endoleak, Stent-Graft Endoleak
- Trial name
- PET-EVAR (NCT04577716)
- Testing
- 18F Sodium Fluoride Positron Emission Tomography / Computed Tomography, CT Aortic Angiogram, 12-month CT Aortic Angiogram
- Where
- 4 sites in United Kingdom
- Volunteers
- 102 people
- Sponsor
- University of Edinburgh
Sepsis
Mechanistic Inflammatory Sub-study Embedded Within the Albumin vs Balanced Crystalloid Trial
MIS-ABC Sepsis is a sub-study looking to understand how the immune response in patients with infection changes during the early stages of the illness, as well as after intravenous fluid treatment.
- Trial name
- MIS-ABC Sepsis (NCT04963569)
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University of Edinburgh
Coronary Artery Disease, Myocardial Infarction
Prediction of Recurrent Events With 18F-Fluoride
This is a multi-centre observational study. It will make use of the positron emission tomography (PET) tracer 18F-sodium fluoride (18F-NaF) as a marker of coronary plaque vulnerability to detect culprit and non-culprit unstable…
- Trial name
- PREFFIR (NCT02278211)
- Where
- United Kingdom
- Volunteers
- 995 people
- Sponsor
- University of Edinburgh
Gallstone, Gallbladder Cancer
Global Evaluation of Cholecystectomy Knowledge and Outcomes
Cholecystectomy is amongst the most common surgical operations performed worldwide. Surgical candidates are treated for biliary pathologies, such as biliary colic, cholecystitis and gallstone pancreatitis.
- Conditions
- Gallstone, Gallbladder Cancer, Bile Duct Injury
- Trial name
- GECKO (NCT06223061)
- Where
- United Kingdom
- Volunteers
- 53,708 people
- Sponsor
- University of Edinburgh
Infective Endocarditis
PET/MR Imaging In Patients With Infective Endocarditis
PET scanning (positron emission tomography) is a well-established technique used to identify areas of interest within the body. It involves injecting a radioactive tracer which highlights abnormal areas.
- Trial name
- NCT03626571
- Testing
- 18F-FDG
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- University of Edinburgh
Chronic Kidney Disease, Proteinuria
Sitaxsentan in Proteinuric Chronic Kidney Disease
Patients with chronic kidney disease (CKD) have higher blood pressures than the general population. They also tend to have protein leaking into the urine (proteinuria).
- Conditions
- Chronic Kidney Disease, Proteinuria, Blood Pressure
- Trial name
- NCT00817037
- Testing
- Sitaxsentan, Nifedipine
- Where
- United Kingdom
- Volunteers
- 27 people
- Sponsor
- University of Edinburgh
Colorectal Cancer, Colorectal Neoplasms
Molecular Effects of Aspirin & Metformin on Colonic Epithelium
Bowel cancer, a significant problem in the United Kingdom (UK) with ~ 41,000 diagnoses and ~ 16,000 deaths annually, has a large preventable component (~54%).
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Adenoma
- Trial name
- NCT05158374
- Testing
- Aspirin tablet, Metformin, Aspirin and Metformin
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Edinburgh
Post-operative Pain, Quality of Life
Post-operative Pain and QoL After RCT
This study is a prospective clinical study, which evaluates pain following the completion of non-surgical root canal treatment and re-treatment cases.
- Trial name
- NCT06412263
- Testing
- Routine root canal treatment/ retreatment
- Where
- United Kingdom
- Volunteers
- 162 people
- Sponsor
- University of Edinburgh
GENE EXPRESSION, Colorectal Cancer
Scottish Vitamin D Intervention Study
AIMS To identify the underlying mechanism by which Vitamin D reduces colorectal cancer risk. OBJECTIVES To demonstrate the effects of vitamin D supplementation on serum vitamin D levels.
- Trial name
- (SCoViDS) (NCT04868227)
- Testing
- FULTIUM D3 VITAMIN D3
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh