Clinical trials: sponsored by University of Edinburgh
Inflammatory Bowel Diseases
Mitochondrial DAMPs as Mechanistic Biomarkers of Mucosal Inflammation in Crohn's Disease and Ulcerative Colitis
The MUSIC study is a multi-centre, longitudinal study set in the real world IBD clinical setting to investigate and develop a new biomarker approach that aims to inform both patients and clinicians of the current state of the…
- Trial name
- MUSIC (NCT04760964)
- Where
- 3 sites in United Kingdom
- Volunteers
- 250 people
- Sponsor
- University of Edinburgh
COVID-19
Community Perception on COVID-19 Prevention and Control
In times whereby COVID-19 is rapidly spreading, research on the epidemiological, diagnostic, clinical and social aspects of the illness has been highlighted as important as there is very limited information of this disease in all…
- Trial name
- NCT06452108
- Where
- Pakistan
- Volunteers
- 2,651 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Endometriosis
A Clinical Trial to Evaluate Dichloroacetate (DCA) as a Treatment for Endometriosis-associated Pain
This is a single-arm open label exploratory clinical trial to evaluate dichloroacetate (DCA) as a possible treatment for treatment of endometriosis-associated pain
- Trial name
- EPiC (NCT04046081)
- Testing
- Dichloroacetate
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Edinburgh
Pancreatic Cancer
Whipples Resection in Octogenarians
Whipples resection is an operation that has a burden of high morbidity and mortality. It is performed for a variety of disorders of the pancreas, duodenum and ampulla.
- Trial name
- NCT03813368
- Testing
- Whipples pancreatico-duodenectomy
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- University of Edinburgh
Endometriosis, Pelvic Pain
The Effectiveness of Laparoscopic Treatment of Superficial Endometriosis for Managing Chronic Pelvic Pain
Endometriosis is a chronic, incurable condition that affects about 10% of women of reproductive age. It is defined as a growth of cells similar to the womb lining outside of the womb in the pelvis, and is associated with chronic…
- Trial name
- ESPriT1 (NCT04081532)
- Testing
- surgical removal of superficial peritoneal endometriosis
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- University of Edinburgh
Pneumonia, Childhood Pneumonia
Online Learning Portal on Under Five Pneumonia
Despite the availability of standard pneumonia management guidelines and multiple global efforts, pneumonia continues to be the leading killer of children under five, accounting to around 17% of the total under five deaths…
- Conditions
- Pneumonia, Childhood Pneumonia, Infectious Disease, Acute Respiratory Infection
- Trial name
- NCT04495361
- Testing
- E-learning portal
- Where
- Pakistan
- Volunteers
- 600 people
- Sponsor
- University of Edinburgh
Aortic Stenosis, Transthyretin Amyloidosis
Positron Emission Tomography / Magnetic Resonance Imaging in Aortic Stenosis
Aortic stenosis is the most common valve disease requiring surgery in the Western world. It is defined by progressive calcification and fibrosis of the valve leaflets and restricted valve opening.
- Trial name
- PASS (NCT03352089)
- Where
- United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Post Partum, Pregnancy Related
Effects of Second-hand Smoke on a Pregnant Woman
More than 40% of all pregnant women in Pakistan are exposed to second-hand smoke - causing approximately 17,000 still births in a year.
- Trial name
- NCT04488276
- Testing
- In-depth interviews
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- University of Edinburgh
Prion Disease, Dementia
Enhanced CJD Surveillance in the Older Population
The purpose of this study to investigate if cases of Creutzfeldt-Jakob Disease (CJD) and other forms of prion disease are being missed in older adults living within Lothian.
- Trial name
- NCT02629640
- Testing
- Medical history questionnaire, Clinical assessment and review, Participant follow-up
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Edinburgh
Pneumonia, Childhood Pneumonia
mHealth for Pneumonia Prevention
In Pakistan, pneumonia and recurrent wheeze in children under five pose significant threats to children's health. Despite being preventable, more than 90,000 children die each year due to pneumonia in Pakistan, making it one of…
- Conditions
- Pneumonia, Childhood Pneumonia, Infectious Disease, Acute Respiratory Infection
- Trial name
- NCT04493047
- Testing
- Mobile health (mHealth) for pneumonia
- Where
- Pakistan
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Pneumonia, Childhood Pneumonia
Pneumonia Policy Formation in Pakistan
In Pakistan, numerous policies have been formulated in the past on pneumonia management translated into various programs. However, despite completion, the state of pneumonia mortality remains unchanged as no sustainable solutions…
- Trial name
- NCT03784274
- Testing
- Stakeholder analysis
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- University of Edinburgh
Malnutrition, Surgery
CRANE Feasibility Study: Nutritional Intervention for Patients Undergoing Cancer Surgery in Low- and Middle-Income Countries
Aims: The CRANE feasibility study (A mixed methods study of malnutrition and sustainable nutritional intervention for patients undergoing cancer surgery in low- and middle-income countries) aims to investigate the identification…
- Conditions
- Malnutrition, Surgery, Cancer
- Trial name
- CRANE (NCT04448041)
- Testing
- Malnutrition screening
- Where
- 11 sites in Ghana, India and 1 more
- Volunteers
- 168 people
- Sponsor
- University of Edinburgh
Breast Neoplasms, Gastric Cancer
GlobalSurg 3: Quality and Outcomes in Global Cancer Surgery
Aim The aim is to determine the variation in quality of cancer surgery worldwide. Quality will be determined using measures covering infrastructure, care processes, and outcomes.
- Conditions
- Breast Neoplasms, Gastric Cancer, Colon Cancer
- Trial name
- GS3 (NCT03471494)
- Testing
- Exposure: human development index of country
- Where
- United Kingdom
- Volunteers
- 15,958 people
- Sponsor
- University of Edinburgh
Perinatal Mental Health, Antenatal Depression
Enjoy Your Bump : Online Cognitive Behavioural Therapy in Pregnancy
A feasibility study evaluating how acceptable women experiencing low mood or anxiety during their pregnancy find an online Cognitive Behavioural Therapy course called 'Enjoy Your Bump'.
- Conditions
- Perinatal Mental Health, Antenatal Depression, Antenatal Anxiety
- Trial name
- NCT03373734
- Testing
- Enjoy Your Bump
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Edinburgh
Surgical Site Infection
ImplementatioN of Remote Surgical wOund Assessment During the coviD-19 pandEmic
This is a implementation research study of a surgical wound tele-monitoring online tool developed at the University of Edinburgh and demonstrated in the "Tracking wound infection with smartphone technology" (TWIST) randomised…
- Trial name
- INROADE (NCT05069103)
- Testing
- Intervention
- Where
- 2 sites in United Kingdom
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Angina Pectoris, Coronary Heart Disease
Scottish COmputed Tomography of the HEART Trial
The primary objective of the study is to see if coronary artery calcium score and computed tomography coronary angiogram alters the proportion of patients diagnosed with angina due to coronary heart disease.
- Trial name
- SCOT-HEART (NCT01149590)
- Testing
- Computer Tomography Angiography
- Where
- 12 sites in United Kingdom
- Volunteers
- 4,138 people
- Sponsor
- University of Edinburgh
Cervical Cancer
Scottish Cervical Screening and Ethnicity Project
To identify important ethnic inequalities in cervical cancer screening participation in Scotland, and explore possible reasons for these.
- Trial name
- SCREEN (NCT06440382)
- Where
- United Kingdom
- Volunteers
- 600,000 people
- Sponsor
- University of Edinburgh
Ganglion Cysts
An Assessment of Intra-lesional 3% Polidocanol Solution in the Treatment of Digital Myxoid Cyst
Digital myxoid cysts arise from degeneration in the connective tissue of the digit joint, usually the last joint of the finger or toe, often due to underlying joint arthritis. They may connect with the joint.
- Trial name
- NCT02154789
- Testing
- polidocanol, infra-red coagulation, cryotherapy
- Where
- 2 sites in United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Diabetes Mellitus, Type 2
The Effects of Lipoic Acid on Glycaemic Control in Type 2 Diabetes
Hypothesis: that lipoic acid supplements taken orally will improve control of blood sugar levels in people with type 2 diabetes.
- Trial name
- NCT00398892
- Testing
- Lipoic acid
- Where
- United Kingdom
- Sponsor
- University of Edinburgh
Acute Coronary Syndrome, Acute Myocardial Infarction
Switching From Cardiac Troponin I to T
Cardiac troponin is central to the diagnosis of myocardial infarction and high-sensitivity cardiac troponin (hs-cTn) assays are the preferred choice for the assessment of patients with suspected acute coronary syndrome.
- Conditions
- Acute Coronary Syndrome, Acute Myocardial Infarction, Acute Myocardial Ischemia, Myocardial Injury
- Trial name
- TWITCH-ED (NCT05748691)
- Testing
- Clinical implementation of hs-cTnT
- Where
- United Kingdom
- Volunteers
- 26,000 people
- Sponsor
- University of Edinburgh