Clinical trials: sponsored by University of Edinburgh
Liver Diseases, Pancreas Disease
Enhanced Recovery After Surgery for Hepatobiliary-Pancreatic Surgery
ERAS protocols have been utilized extensively in abdominal and non abdominal surgery over the past 20 years. These protocols incorporate evidence based, multi-disciplinary peri-operative care components.
- Trial name
- NCT03772392
- Testing
- HPB resection
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Edinburgh
Cardiopulmonary Bypass
Blood Isoflurane Concentration and the Oxygenator
This study compares two oxygenators commonly in use to establish whether they effect the amount of isoflurane in the patient's blood.
- Trial name
- NCT03146949
- Testing
- Sorin Inspire Oxygenator, Medtronic Affinity Fusion
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- University of Edinburgh
Myocarditis, Takotsubo Cardiomyopathy
Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) in Ischaemic, Inflammatory and Takotsubo Cardiomyopathy (MEMORY)
Manganese is a calcium analogue which actively enters viable cells with intact calcium-handling mechanisms and its uptake is evident by an increase in MRI-detectable T1 relaxivity of tissues.
- Conditions
- Myocarditis, Takotsubo Cardiomyopathy, Reversible Coronary Ischaemia
- Trial name
- MEMORY (NCT04623788)
- Testing
- Cardiac MRI
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Surgical Site Infection
Tracking Wound Infection With Smartphone Technology
This study aims to evaluate if a smartphone-delivered tool can help assess for wound infections, and if this improves access to care and results in earlier treatment. Participants will be randomised to one of two groups.
- Trial name
- TWIST (NCT02704897)
- Testing
- Wound Assessment Tool
- Where
- 2 sites in United Kingdom
- Volunteers
- 492 people
- Sponsor
- University of Edinburgh
Liver Cancer
The Effect of Analgesic Modalities on Long Term Outcomes Following Open Liver Resection
The LIVER (Local Infiltration Versus Epidural after Liver Resection) and LIVER 2 (Local Infiltration Versus Epidural after Liver Resection 2) studies were randomised controlled trials that compared epidural analgesia with local…
- Trial name
- LIVER 3 (NCT03813953)
- Testing
- Liver resection
- Where
- United Kingdom
- Volunteers
- 160 people
- Sponsor
- University of Edinburgh
Surgical Wound Infection
Determining the Worldwide Epidemiology of Surgical Site Infections After Gastrointestinal Surgery
Surgical site infection (SSI) is the most common complication following major gastrointestinal surgery, affecting between 25-40% of patients.
- Trial name
- GlobalSurg 2 (NCT02662231)
- Testing
- Emergency, or elective gastrointestinal resection
- Where
- 2 sites in United Kingdom
- Volunteers
- 12,539 people
- Sponsor
- University of Edinburgh
Acute Kidney Injury
PREdicting RENAL Injury In Patient After Hip Fracture Surgery
To determine whether MALDI, a type of Mass-Spectometry, can use protein pattern detection within urine to predict postoperative (after an operation) kidney damage in adults who have undergone emergency hip fracture surgery?
- Trial name
- PRE-RENAL (NCT03049150)
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Edinburgh
Depression, Diabetes Mellitus Type 2
Pilot Study of a Self-help Intervention for Depression in Patients With a Chronic Disease
A feasibility pilot trial of the self-help, "Cognitive behavioural therapy" based "Living Life to the Full" Materials for use by patients with diabetes type 2 and / or coronary heart disease.
- Conditions
- Depression, Diabetes Mellitus Type 2, Coronary Heart Disease
- Trial name
- NCT00854984
- Testing
- Living Life to the Full
- Where
- 2 sites in United Kingdom
- Volunteers
- 49 people
- Sponsor
- University of Edinburgh
Surgical Procedures, Operative
Determining Universal Processes Related to Best Outcome in Emergency Gastrointestinal Surgery: an International Evaluation
A multicentre, international evaluation of emergency abdominal surgery to establish surgical outcomes and identify common, modifiable best practice processes.
- Trial name
- GlobalSurg-1 (NCT02179112)
- Testing
- Emergency Abdominal Surgery
- Where
- United Kingdom
- Volunteers
- 10,745 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
MRI, PET Scan
Validation of PET-MRI for Cardiovascular Disease
To determine whether PET-MRI can obtain comparable images to PET-CT in those with coronary artery disease.
- Conditions
- MRI, PET Scan, Positron-Emission Tomography, Cardiovascular Disease
- Trial name
- NCT02988531
- Testing
- PET/MR scan
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Edinburgh
Abdomen, Acute
The Hospital Volume Relationship in Emergency Laparotomy Outcomes
Introduction 'Emergency Laparotomy' is an umbrella term for a set of commonly performed procedures which are known to carry a significant risk of mortality and morbidity.
- Trial name
- NCT02047812
- Where
- United Kingdom
- Volunteers
- 40,000 people
- Sponsor
- University of Edinburgh
Gout
Gout Self-Monitoring Aiming to Reach Target
This study evaluates whether a supported self-management approach to gout is able to achieve target levels of serum urate, and better control of gout flares.
- Trial name
- Gout-SMART (NCT03274063)
- Testing
- Supported self-management, Usual care
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Edinburgh
Coronary Artery Disease
PET MRI in Coronary Artery Disease
This study will assess the use of position emission tomography/magnetic resonance imaging (PET/MRI) using ultra-small-superparamagnetic particles of iron oxide (USPIO) as a contrast agent in patients with coronary artery disease.
- Trial name
- NCT03451448
- Testing
- PET/MRI, MRI
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Pregnancy
Vascular Responses to UV Exposure in Pregnancy
Season of birth influences pregnancy for reasons that remain unclear however the answer may lie in the amount of sunshine pregnant women are exposed to.
- Trial name
- NCT02482363
- Testing
- UVA radiation
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Appendicitis
Geographic Influences on Appendicectomy Outcomes
Introduction Appendicitis is a common condition which represents a significant resource burden for the Scottish National Health Service (NHS).
- Trial name
- NCT02017951
- Where
- United Kingdom
- Volunteers
- 40,000 people
- Sponsor
- University of Edinburgh
Heart Diseases, Ischemic
PET-MR Imaging of Coronary Atherothrombosis
Heart attacks remain a common cause of death throughout the world. The most common initiating event is the formation of a blood clot within the coronary arteries occluding blood supply to the heart.
- Trial name
- NCT03618303
- Testing
- PET-MRI scan
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- University of Edinburgh
Drug-Induced Liver Injury, Anti-Tuberculous Drug Reaction
Assessing Antibiotic Induced Liver Injury for Stratification of Tuberculosis Patients
A panel of highly sensitive circulating biomarkers for acute liver injury have been identified and demonstrated to identify liver injury on first presentation to hospital before standard tests are elevated in patients with…
- Conditions
- Drug-Induced Liver Injury, Anti-Tuberculous Drug Reaction, Tuberculosis
- Trial name
- ALISTER (NCT03211208)
- Where
- United Kingdom
- Volunteers
- 194 people
- Sponsor
- University of Edinburgh
Appendicitis
The Hospital Volume Relationship in Appendicectomy Outcomes
Background Appendicitis is a common condition which represents a significant resource burden for the Scottish National Health Service (NHS).
- Trial name
- NCT02018016
- Where
- United Kingdom
- Volunteers
- 40,000 people
- Sponsor
- University of Edinburgh
Blood Biomarkers, Vasodilation
The Role of Eicosanoids in the Cardiovascular Actions of Inhaled Nanoparticles
Nanoparticles (NPs) are minute pieces of material to which we are exposed every day in the air we breathe. Some are naturally occurring and have no impact on health, whereas others are produced from urban air pollution and can…
- Conditions
- Blood Biomarkers, Vasodilation, Blood Clotting, Lung Function
- Trial name
- ECOARM (NCT03659864)
- Testing
- diesel exhaust particulate, carbon nanoparticles, small graphene oxide
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Heart; Complications, Valve, Prosthesis
18F-Fluoride Assessment of Aortic Bioprosthesis Durability and Outcome
This study will evaluate the two main types of replacement tissue heart valve used in current practice, comparing outcomes from surgical aortic valve replacement (AVR) with that of the more recently introduced "key-hole"…
- Trial name
- 18F-FAABULOUS (NCT02304276)
- Testing
- 18F-Fluoride PET-CT, CT calcium score of aortic valve
- Volunteers
- 105 people
- Sponsor
- University of Edinburgh