Clinical trials: sponsored by University of Iowa
Vaccination, Vaccination Hesitancy
Comparing Relative Strengths of Statistical Associations Between Psychological Traits and Vaccination-Related Outcomes I
The goal of this study was to identify psychological motives that had the strongest statistical associations with vaccine outcomes in order to identify novel intervention targets to be used in vaccine promotion efforts.
- Conditions
- Vaccination, Vaccination Hesitancy, Vaccination Promotion, Psychological Aspects
- Trial name
- NCT07172074
- Testing
- General Psych Trait Measure, Vaccine-Specific Psych Trait Measures
- Where
- United States
- Volunteers
- 1,786 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Hypertension
A Pharmacist Intervention to Improve Mother and Child Health
The goal of this clinical trial is to learn if a research pharmacist can improve the health of new mothers and their babies. The main questions it aims to answer are: Will postpartum women who had elevated blood pressure during…
- Trial name
- NCT06073054
- Testing
- Research Pharmacist
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Iowa
Apical Periodontitis
Effectiveness of GentleWave on the Healing of Apical Periodontitis: A Prospective Cohort Study
The purpose of this 12-month prospective cohort study is to evaluate post-operatory pain, patient satisfaction, and treatment outcomes (i.e., healing) when the newly-developed, 510k FDA-approved multisonic energy GentleWAve…
- Trial name
- NCT04966169
- Testing
- GentleWave System
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Iowa
Tuberculosis in Children, Chronic Lung Disease
Paediatric Post-TB Pulmonary Rehab Study
The goal of this clinical trial is to learn if a home-based pulmonary rehabilitation program is feasible and acceptable for children ages 6-15 who have recently completed treatment for pulmonary tuberculosis.
- Conditions
- Tuberculosis in Children, Chronic Lung Disease, Post Tuberculosis
- Trial name
- PPT Rehab (NCT07097961)
- Testing
- Pulmonary Rehabilitation
- Where
- Uganda
- Volunteers
- 40 people
- Sponsor
- University of Iowa
Hypertension, Systolic, Stiffness, Aortic
Sympathetic Regulation of Large Artery Stiffness in Humans With ISH
Stiffening of your blood vessels, particularly the large vessels from your heart (called the aorta and carotids) you age contributes to the development of cardiovascular disease (CVD) such as heart attack and stroke.
- Trial name
- SELECT (NCT04423627)
- Testing
- Clonidine, Hydrochlorothiazide
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Coronary Artery Disease, Vascularization
Acceptance and Commitment Therapy for Patients Undergoing Coronary Artery Bypass Graft Surgery
Heart disease is the leading cause of death globally, accounting for 16% of the world's total deaths. The number of cases is expected to increase as our population ages. Heart disease also results in large economic burden.
- Trial name
- ACT for CABG (NCT06207318)
- Testing
- Acceptance and commitment therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Iowa
Diabetes in Pregnancy
Incentives and Glucose Adherence in Diabetes
Diabetes in pregnancy carries significant pregnancy specific risks and requires frequent glucose monitoring to reduce these risks.
- Trial name
- NCT03338829
- Testing
- Positive incentive, Loss aversion
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Neuroendocrine Tumors, Neuroendocrine Tumor Grade 1
177Lu-DOTATATE Modified Delivery Based on Individualized Dosimetry
The goal of this study is to learn if individualized dosimetry-based prescribing of Lutetium-177 DOTATATE (Lutathera, Novartis Pharmaceuticals) improves treatment outcomes for adults with unresectable neuroendocrine tumors.
- Conditions
- Neuroendocrine Tumors, Neuroendocrine Tumor Grade 1, Neuroendocrine Tumor Grade 2
- Trial name
- LUMOD-ID (NCT06395402)
- Testing
- Lutetium Lu 177 dotatate therapy
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Iowa
Care Giving Burden, Dementia
E-Tailored Pain Management Support for Dementia Family Caregivers: Feasibility of the PACE-app
The goal of this clinical trial is to test whether a web-based application called the Pain Control Enhancement App (PACE-app) can support family caregivers in managing pain for their care recipients with dementia.
- Conditions
- Care Giving Burden, Dementia, Chronic Pain, Pain Management
- Trial name
- PACE-app (NCT07032350)
- Testing
- Web-based pain management support tool, Usual Pain Management Care
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Cancer
Feasibility, Acceptability, and Preliminary Efficacy of a Remotely-delivered Health Coaching Intervention for Cancer Survivors
This study aimed to evaluate the feasibility, acceptability, and preliminary efficacy of an 8-week, remotely delivered health coaching intervention designed to improve: 1) targeted psychosocial mechanisms of action (behavioral…
- Trial name
- NCT07026214
- Testing
- Vitalis Cancer
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Surgical Procedure, Unspecified
Reducing ESKAPE Transmission in the Operating Room
This study is designed to examine the impact of a personalized, body worn alcohol dispenser on the epidemiology of ESKAPE transmission in the anesthesia work area for patients undergoing surgery requiring general anesthesia.
- Trial name
- NCT06274918
- Testing
- Personalized Body-Worn Alcohol Dispenser
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Preeclampsia
Angiotensin II and Chronic Inflammation in Persistent Microvascular Dysfunction Following Preeclampsia
Women who develop preeclampsia during pregnancy are more likely to develop cardiovascular disease later in life, even if they are otherwise healthy.
- Trial name
- NCT03482440
- Testing
- Salsalate Oral Tablet
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Major Depressive Disorder, Suicide
Accelerated iTBS for Depression and Suicidality
The overall objective of this current study is to evaluate the feasibility, safety, and tolerability of "high dose" aiTBS in psychiatric inpatient and outpatients with treatment-refractory unipolar, non-psychotic major depressive…
- Trial name
- RAPID (NCT04441008)
- Testing
- Accelerated Intermittent Theta Burst (aiTBS), Electroconvulsive therapy (ECT)
- Volunteers
- 50 people
- Sponsor
- University of Iowa
COVID-19
COVID-19 Coagulopathy Extension Study
At the University of Iowa, the investigators led a multicenter randomized clinical trial comparing standard prophylactic dose to intermediate dose enoxaparin in hospitalized patients with COVID-19 (NCT04360824).
- Trial name
- NCT05334615
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Iowa
Colorectal Cancer Metastatic, Colon Cancer
Immunotherapy With Y90-RadioEmbolization for Metastatic Colorectal Cancer
This clinical trial will be conducted as a single-center, open-label, Phase I/2 trial to evaluate the feasibility and safety of Yttrium-90 radioembolization (Y90-RE) in combination with a fixed dose of of immunotherapy…
- Conditions
- Colorectal Cancer Metastatic, Colon Cancer, Metastatic Colorectal Cancer, Rectal Cancer
- Trial name
- iRE-C (NCT04108481)
- Testing
- Durvalumab, Yttrium-90 RadioEmbolization
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Iowa
Developmental Language Disorder
Language Outcomes, Mechanisms, and Trajectories in Adults With and Without Developmental Language Disorder
The investigators' overall objective is to characterize the long-term outcomes of Developmental Language Disorder (DLD) in adulthood and to identify specific cognitive mechanisms mediating these outcomes.
- Trial name
- NCT06898671
- Testing
- Eye-Tracking in Visual World Paradigm
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Post-Concussion Syndrome
Cerebellar TDCS for SRPCS Treatment
This study is investigating the immediate and long-term effects of bilateral cerebellar transcranial direct current stimulation on cognition, balance, and symptom severity in people with sports-related post-concussion syndrome.
- Trial name
- NCT04760899
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Diabetic Retinopathy With Macular Edema of Both Eyes (Diagnosis), Central Retinal Vein Occlusion With Macular Edema
Cool vs Room-temperature Artificial Tears
Background and Objective: To evaluate the efficacy of cooled versus room temperature artificial tears in reducing post intravitreal injection (IVI) ocular discomfort.
- Conditions
- Diabetic Retinopathy With Macular Edema of Both Eyes (Diagnosis), Central Retinal Vein Occlusion With Macular Edema, Exudative Age-Related Macular Degeneration, Unspecified Eye, Cystoid Macular Edema
- Trial name
- NCT05832996
- Testing
- Refresh Plus Preservative-free Lubricant Eye Drops
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Osteo Arthritis Knee, Central Nervous System Sensitization
Pregabalin for Central Sensitization in TKA
The study purpose is to determine if giving pregabalin before and after total knee arthroplasty (TKA) can improve pain and meaningful function after surgery in patients that have central sensitization (CS).
- Trial name
- NCT05460871
- Testing
- Pregabalin 75mg
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Healthy
Target Engagement of Terazosin in Healthy Adults
The purpose of the study is to assess the target engagement of Terazosin (TZ) in a single cohort of 6 healthy adult participants.
- Trial name
- NCT04551040
- Testing
- Terazosin
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Iowa