Clinical trials: sponsored by University of Iowa
Outpatient Parenteral Antibiotic Therapy
Mobile-health Approach to Gather Clinical Information From Patients Following Hospital Discharge
The purpose of this study is to assess the feasibility of using a mobile-health approach to gather clinical data from patients following discharge from the hospital on outpatient parenteral antibiotic therapy (OPAT).
- Trial name
- NCT04709939
- Testing
- OPAT, Focus Group
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- University of Iowa
Oral Cancer
The Oral Microbiome in OSCC
Previous work by a number of scientific teams has revealed that the types of bacteria that colonize the mouth differ between health and pre-cancerous or cancerous oral lesions.
- Trial name
- NCT04925700
- Testing
- ProDentis Lozenge
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Iowa
Central Venous Pressure
Internal Jugular Vein Cross Sectional Area
The Trendelenburg position is used to distend the central veins, improving both success and safety of vascular cannulation. The purpose of this study is to measure the cross-sectional area of the internal jugular vein (IJV) in…
- Trial name
- NCT01099254
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Iowa
Nurse Delivered Counseling, Emotional Distress
Listening Visits for Emotionally Distressed Mothers of Hospitalized Newborns
The proposed research has potential to dramatically improve care for emotionally distressed mothers of newborns hospitalized on the neonatal intensive care unit (NICU).
- Trial name
- NCT03704948
- Testing
- RCT Treatment -Listening Visits delivered by NICU nurse in person, RCT Control Usual mental health care delivered by NICU social workers, Open trial: Listening Visits delivered by a NICU nurse via zoom
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Iowa
Flatfoot, Bone Resorption
Bio-Integrative Versus Metallic Screws for Calcaneus Osteotomies
The use of bio-integrative implants in orthopedic surgery is growing exponentially. As many biomechanical and histological studies were able to sustain its structural and biological properties, few clinical studies are available…
- Conditions
- Flatfoot, Bone Resorption, Cavus Deformity, Osteolysis
- Trial name
- NCT05018130
- Testing
- Calcaneus Osteotomy (Metallic), Calcaneus Osteotomy (Bio-integrative)
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Iowa
Pregnancy Related, Exercise
INcreasing Steps in PREgnancy Study
This pilot study will test the feasibility, acceptability, and efficacy of a remotely-delivered intervention for increasing daily physical activity levels and reducing sedentary behavior during pregnancy among women who are…
- Conditions
- Pregnancy Related, Exercise, Sedentary Behavior, Behavior and Behavior Mechanisms
- Trial name
- INSPiRE (NCT05455008)
- Testing
- Remotely-delivered health coaching intervention
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Post Partum Depression, Perinatal Depression
Efficacy of Brief Acceptance and Commitment Therapy (ACT) for Perinatal Anxiety
This protocol will test the hypothesis that Acceptance and Commitment Therapy (ACT) is effective in reducing anxiety and depressive symptoms during the perinatal and postpartum periods.
- Conditions
- Post Partum Depression, Perinatal Depression, Post Partum Anxiety, Perinatal Anxiety
- Trial name
- NCT03837392
- Testing
- Baseline Assessment (18-26 weeks pregnant), Online Intervention and Phone Coaching Interventions, Follow Up Assessments: 34-36 weeks pregnant and 4-week postpartum
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Iowa
Surgical Site Infection
Nasal Decolonization for Orthopedic Trauma Patients
Many surgical site infections are caused by bacteria that is transferred from a patient's nose to their open surgical wound. Some small studies have shown that putting povidone-iodine in a patient's nose reduces this risk.
- Trial name
- NCT04146116
- Testing
- intranasal povidone-iodine
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Iowa
Adult ALL, Healthy
Effects of Malleo-Lok Stiffness on Lower Limb Mechanics
The primary purpose of this research study is to determine if the stiffness of a commercially available ankle foot orthosis (Malleo-Lok, Bio-Mechanical Composites, Des Moines IA) impacts gait biomechanics and overall joint level…
- Trial name
- MalleoLokStiff (NCT04806100)
- Testing
- Malleo-Lok
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Stroke, Occlusion Carotid
Endovascular Revascularization of Symptomatic Chronically Occluded Internal Carotid Artery
This is a phase 2 randomized single-center open label clinical trial with randomization of 1:1 to either best medical management vs. best medical management and endovascular revascularization of chronically occluded ICA (COICA).
- Trial name
- NCT03176420
- Testing
- angioplasty and stenting of occluded cervical ICA
- Sponsor
- University of Iowa
Healthy
iWalk Hands Free Crutch
The proposed study evaluates the effects of a hands free crutch (iWalkFree, Inc.) on walking balance and stability compared to standard crutches.
- Trial name
- HFC (NCT04978363)
- Testing
- BOOT, HFC, SAC
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Anesthesia
Regional Anesthesia in Cardiac Pediatric Patients Less Than 5 Years Old
This retrospective review presents a comparison of pediatric patients less than 5 years old undergoing cardiac surgery with general anesthesia with spinal, caudal epidural, or caudal epidural with catheter anesthesia from July…
- Trial name
- NCT02652117
- Volunteers
- 545 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Low Cardiac Output
Hemodynamic Survey Cardiac Surgical Scenarios
The purpose of this study is to find out the Lidco Rapid ( monitoring tool gives cardiac output) is as equivalent in determining the hemodynamic assessment in cardiac surgical scenarios as the most often used pulmonary artery…
- Trial name
- NCT02529033
- Testing
- LIDCO Rapid, Pulmonary artery catheter
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Sedentary Behavior
Residential MapTrek- Increasing Physical Activity Among Older Adults in a Residential-Living
Older adults are a growing population, with projections to reach 83.7 million by 2050. Furthermore, older adults are the most sedentary and least physically active adult population.
- Trial name
- NCT04041869
- Testing
- MapTrek
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Physical Inactivity, Sedentary Behavior
Feasibility, Acceptability, and Efficacy of the Sleep Move Stand Study
The overarching goal for this project is to develop a service-learning program that provides students excellent hands on training and patients with an excellent service that advances their health and well-being.
- Conditions
- Physical Inactivity, Sedentary Behavior, Sleep, Cognitive Function
- Trial name
- SMS (NCT05498415)
- Testing
- Education, Health coaching, Activity Monitor
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Coronary Artery Disease
Aortic-Radial Pressure Gradients Post CPB
This study will examine whether pre-operative, non-invasive arterial stiffness measurements can be used to predict which patients will develop an aortic-to-radial pressure gradient after coronary artery bypass graft (CABG)…
- Trial name
- NCT03142815
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Iowa
Healthy
4 mA tDCS, Estrogen, and Leg Muscle Fatigability
The majority of transcranial direct current stimulation (tDCS) studies have failed to consider sex as a modulating factor. This neglect may partly account for the high inter-subject variability bemoaned by many tDCS investigators…
- Trial name
- NCT04471805
- Testing
- Transcranial direct current stimulation 4 mA
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Problem;Behaviour;Child
Precision-Based Approach to Matching Evidence-Based Interventions to Students With Externalizing Behaviors
Although prevalent across schools in the US, the "One-Size-Fits-All" (OSFA) approach to selecting evidence-based interventions (EBIs) for student externalizing behaviors often yields lackluster outcomes, due to the mismatch…
- Trial name
- SIMSRCT (NCT05752942)
- Testing
- Student Intervention Matching System (SIMS), group-based social skills training
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Iowa
COVID 19 Associated Coagulopathy
Covid-19 Associated Coagulopathy
This prospective, randomized, open-label, multi-center interventional study is designed to compare the safety and efficacy of two LMWH dosing protocols in patients admitted to the University of Iowa Hospitals with COVID-19 who…
- Trial name
- NCT04360824
- Testing
- Intermediate dose thromboprophylaxis, Standard of Care thromboprophylaxis
- Where
- 2 sites in United States
- Volunteers
- 176 people
- Sponsor
- University of Iowa
Chronic Kidney Diseases, Blood Pressure
Curcumin and Exercise in Chronic Kidney Disease
Chronic kidney disease (CKD) is associated with a pro-oxidative and pro-inflammatory state, and this is thought to contribute to a decrease in vascular function leading to greater cardiovascular disease (CVD) risk.
- Conditions
- Chronic Kidney Diseases, Blood Pressure, Hyperemia, Vasoconstriction
- Trial name
- NCT04132648
- Testing
- Curcumin
- Sponsor
- University of Iowa