Clinical trials: sponsored by University of Iowa
Healthy
Impact of Transcranial Direct Current Stimulation Intensity on Leg Muscle Fatigability in Healthy Adults
Transcranial direct current stimulation (tDCS) is a painless,non-invasive means of increasing brain excitability. It has been used for several years and in many populations to improve physical and psychological outcomes.
- Trial name
- NCT04321304
- Testing
- Transcranial direct current stimulation at 2 mA, Transcranial direct current stimulation at 4 mA
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Cognitive Measures, Driving Simulator Performance
Phenytoin and Driving Safety: A Randomized, Controlled Cross-Over Study
Automobile driving is a crucial aspect of everyday life, yet vehicular crashes represent a serious public health problem. Patients with epilepsy are at elevated risk for automobile crashes, causing great personal suffering and…
- Trial name
- NCT00581893
- Testing
- Phenytoin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Cervical Cancer
Quality of Life Interventions During Cervical Cancer Treatment
The proposed project will examine the effects of a healing touch intervention in women receiving chemotherapy and radiation for advanced cervical cancer.
- Trial name
- NCT04905576
- Testing
- Relaxation training, Therapeutic touch, Questionnaire administration
- Volunteers
- 60 people
- Sponsor
- University of Iowa
Text Messaging
Text Messaging Follow-up From ED
Ensuring follow-up for patients after discharge from the emergency department (ED) has long been a concern for ED care providers. The current technology of text messaging may be able to assist us in improving follow-up rates.
- Trial name
- NCT03370978
- Testing
- Text Messaging
- Where
- United States
- Sponsor
- University of Iowa
Obstructive Sleep Apnea
Inorganic Nitrate and OSA
The main purpose of this study is to determine if acute beetroot juice supplementation reduces peripheral chemoreflex sensitivity in patients with obstructive sleep apnea.
- Trial name
- NCT03930563
- Testing
- Pre-beetroot juice supplementation, Post-beetroot juice supplementation
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Iowa
AKI
The Impact of CRRT Modality on Filter Life
The investigators plan to start patients who need CRRT on either CVVH or CVVHD by block randomization, and then to measure filter life.
- Trial name
- NCT04762524
- Testing
- CVVH vs CVVHD
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- University of Iowa
Healthy
Racial/Ethnic Differences in Microneedle Response
The study to be performed will define the rate of skin barrier recovery following microneedle treatment of the skin in healthy subjects of differing racial/ethnic backgrounds.
- Trial name
- NCT03332628
- Testing
- Microneedle patch
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Hip Osteoarthritis, Knee Osteoarthritis
Acceptance and Commitment Therapy Delivered by Automated Software Messaging
This study aims to 1) observe the course of pain, 2) mental status, and 3) possible effect of a behavioral intervention delivered via an automated mobile phone messaging robot in patients were indicated and/or scheduled to…
- Conditions
- Hip Osteoarthritis, Knee Osteoarthritis, Mental Stress, Coronavirus
- Trial name
- NCT04329897
- Testing
- Software Messaging
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Endothelial Function, Hyperglycemia
Hyperglycemia, Exercise, and Endothelial Function
The main purpose of this study is to determine if exercise preserves vascular function during hyperglycemia. All subjects will consume a sugary beverage three times daily for seven days.
- Trial name
- NCT03651713
- Testing
- GLU+EX, GLU
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Bacterial Transmission, S.Aureus Transmission
Impact of Germicidal Light
Visible light at 405nm has been shown to be germicidal. The hypothesis is that use of this light (Indigo-Clean Lights) in operating rooms will reduce S.
- Conditions
- Bacterial Transmission, S.Aureus Transmission, Operating Room Exposure to S. Aureus, 90-day Postoperative Surgical Site Infections, Superficial and Deep
- Trial name
- NCT03886337
- Testing
- Germicidal lighting
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Iowa
Carcinoma, Adenoid Cystic, Head and Neck Neoplasms
Nelfinavir in Recurrent Adenoid Cystic Cancer of the Head and Neck
The purpose of this study is to evaluate the FDA-approved drug nelfinavir (NFV) as an oncologic agent for adenoid cystic cancers of the head and neck.
- Trial name
- NCT01065844
- Testing
- Nelfinavir
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Iowa
Adverse Reaction to Drug, Health Behavior
Personal Health Records and Elder Medication Use Quality
Purpose: To examine the impact of a personal health record (PHR) on medication use safety among older adults. Background: Online PHRs have potential as tools to manage health information.
- Conditions
- Adverse Reaction to Drug, Health Behavior, Medication Adherence, Physician-Patient Relations
- Trial name
- NCT02012712
- Testing
- Personal Health Record (PHR)
- Where
- United States
- Volunteers
- 1,163 people
- Sponsor
- University of Iowa
Mouth Neoplasms, Oropharyngeal Neoplasms
F-18 Fluorothymidine PET Imaging for Early Evaluation of Response to Therapy in Head & Neck Cancer Patients
This is an imaging protocol only, not a therapeutic study. The primary goal of the proposed study is to examine the utility of a new imaging study, Positron Emission Tomography with F-18 Fluorothymidine (FLT PET), in the early…
- Conditions
- Mouth Neoplasms, Oropharyngeal Neoplasms, Laryngeal Neoplasms, Head and Neck Neoplasms
- Trial name
- NCT00721799
- Testing
- 18F-Fluorothymidine PET scan
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Iowa
Stroke
Thrombolytic Care During Inter-hospital Transfer
Evaluation of ischemic stroke patients receiving tissue plasminogen activator (rtPA) during air ambulance transfer
- Trial name
- NCT02752256
- Testing
- Tissue Plasminogen Activator
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Anxiety
Does Treating Anxiety Symptoms With ACT Improve Vascular Inflammation and Function?
The goal of this study is to evaluate the effectiveness of a brief, intensive 1-day psychotherapy group intervention (Acceptance and Commitment Therapy, ACT), compared to a 12 week time control group on anxiety symptoms, vascular…
- Trial name
- ACT on Anxiety (NCT02915874)
- Testing
- Acceptance and Commitment Therapy
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Iowa
There is no Focus on Any Specific Condition
Antegrade Versus Retrograde IV for Blood Draws
The purpose of this study is to compare success rates of antegrade and retrograde intravenous (IV) catheters in their ability to aspirate 20 milliliter blood sample within a 2 minute time frame, 3 hours after initial insertion.
- Trial name
- NCT03533777
- Testing
- Peripheral intravenous catheter placement, Blood draw, Peripheral intravenous catheter
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Peripheral Artery Disease
Dietary Nitrates and Vascular Function in Patients With Peripheral Artery Disease
The overarching question addressed in the current project is: Does dietary nitrate supplementation (8 weeks) improve physiological function in patients with peripheral arterial disease (PAD)? The investigators will specifically…
- Trial name
- NCT01983826
- Testing
- Sodium Nitrate
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Iowa
Veterans, Obesity
An M-Health Intervention in Rural Veterans
MapTrek is a mobile-phone-based web app that allows participants to take a virtual walk in interesting locations around the world while tracking their progress against the progress of other veterans on an interactive map.
- Conditions
- Veterans, Obesity, Overweight
- Trial name
- NCT03720054
- Testing
- MapTrek, Fitbit
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- University of Iowa
Hypotension, Arterial Stiffness
Arterial Stiffness and General Anesthesia Induced Hypotension in Patients on Angiotensin-converting Enzyme Inhibitors
Induction of general anesthesia to the patient could be a challenging period of anesthesia management. Due to autonomic system suppression, hemodynamic fluctuation, such as hypotension or hypertension, is commonly seen during…
- Trial name
- NCT02416024
- Testing
- SphygmoCor system
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Iowa
Charcot Marie Tooth Disease, Inherited Peripheral Neuropathy
Disability Severity Scale (DSI) and Hereditary Motor and Sensory Neuropathy Overall Disability Scale (HMSN-R-ODS)
The purpose of this research study is to create and validate two patient reported outcome (PRO) questionnaires. PRO questionnaires ask questions that help to measure disability in patients with inherited neuropathies.
- Trial name
- DSI and HMSN (NCT02194010)
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 563 people
- Sponsor
- University of Iowa