Clinical trials: sponsored by University of Iowa
Abdominal Abscess
Antibiotic Irrigations for Intra-Abdominal Drains
Intra-abdominal abscesses are pus-filled pouches in the abdominal cavity. Current standard of care includes drain placement in the abscess cavity to reach source control as well as administration of systemic antibiotics.
- Trial name
- AID (NCT03476941)
- Testing
- Gentamicin Sulfate Inj 20mg/2ml vial for injection, Clindamycin phosphate 6 mg/1ml for injection
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Tooth Loss
Healing Dynamics in Human Extraction Sockets Grafted With Bio-Oss Collagen®
The purpose of this study is to clinically, radiographically and histologically evaluate the healing sequence of post-extraction sockets grafted with Bio-Oss Collagen® at 3, 6 and 9 months following tooth extraction in…
- Trial name
- NCT03659617
- Testing
- xenograft (BioOss Collagen)
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Smoking Cessation
Pharmacist Intervention to Improve Smoking Cessation
The goal of this study is to assess the effectiveness of a remote pharmacist intervention to help smokers quit. The main questions it aims to answer are: Will smokers being screened for lung cancer with low-radiation-level chest…
- Trial name
- NCT06943287
- Testing
- Pharmacist Intervention
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Iowa
Neonatal Anemia
Optimized Erythropoietin (EPO) Treatment
Neonatal anemia is the most commonly encountered hematologic problem among all neonates cared for in the neonatal intensive care unit (NICU).
- Trial name
- OETNA (NCT02075970)
- Testing
- Epoetin Alpha
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Iowa
Pancreatic Neoplasms, Cancer of Pancreas
A Phase 2 Trial of High-dose Ascorbate for Pancreatic Cancer (PACMAN 2.1)
This clinical trial adds high-dose ascorbate (vitamin C) to the standard of care regimen for metastatic pancreatic adenocarcinoma (a type of pancreatic cancer).
- Conditions
- Pancreatic Neoplasms, Cancer of Pancreas, Cancer of the Pancreas, Neoplasms, Pancreatic
- Trial name
- NCT02905578
- Testing
- Gemcitabine, nab-paclitaxel, Pharmacological ascorbate
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Iowa
Obesity, Knee Osteoarthritis
Wearable Bioimpedance Analyzer for Tracking Body Composition Changes
Obesity, namely at body mass index (BMI) levels exceeding 40kg/m2 (class III obesity), is a risk factor for many diseases including osteoarthritis (OA).
- Trial name
- NCT05986617
- Testing
- InBody Band 2
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Iowa
Pain, Function
Preventing Persistent Post-Surgical Pain and Dysfunction
Primary Aim: To examine the superior efficacy of ACT versus Attention Control (AC) on postoperative pain intensity and functioning in at-risk Veterans undergoing TKA.
- Conditions
- Pain, Function, Anxiety, Depression
- Trial name
- PrePARE (NCT03965897)
- Testing
- Acceptance and Commitment Therapy (ACT), Attention Control (AC)
- Where
- United States
- Volunteers
- 402 people
- Sponsor
- University of Iowa
Pregestational Diabetes
Does the Use of Continuous Glucose Monitoring (CGM) in the Immediate Postpartum Period in Women With Pregestational Diabetes Admitted to the Hospital Decrease Hypoglycemic Episodes
This study will examine whether continuous glucose monitoring in patients hospitalized in the immediate postpartum period is more effective than traditional point of care glucose testing in identifying patients with hypoglycemia.
- Trial name
- NCT06141941
- Testing
- CGM
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Obesity, Metabolic Syndrome X
Drug Therapy Induced Weight Loss to Improve Blood Vessel Function in Subjects With Obesity
Obesity is common (>30% of US adults), contributes to substantial morbidity and mortality, but is difficult to treat. Partly this is due to the transient, arduous and modest nature of lifestyle interventions.
- Trial name
- REVIVE (NCT01351753)
- Testing
- Metformin, Orlistat, Topiramate
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- University of Iowa
Ankle Fractures, Post-traumatic Osteoarthritis
Iterative Design of Custom Dynamic Orthoses to Reduce Articular Contact Stress
The proposed study evaluates the effect of carbon fiber brace design on forces across the ankle joint. Research suggests that ankle arthritis develops after ankle fracture, in part, due to elevated forces on the cartilage.
- Conditions
- Ankle Fractures, Post-traumatic Osteoarthritis, Osteoarthritis Ankle
- Trial name
- PRMRP-FPA2 (NCT04562896)
- Testing
- Custom Carbon Fiber Dynamic Orthosis (CDO)
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Adult ALL, Healthy
Iterative Design of Custom Dynamic Orthoses
The proposed study evaluates the effect of carbon fiber brace design on forces across the ankle joint. It is expected that carbon fiber braces can be designed to reduce forces in the ankle.
- Trial name
- PRMRP-Norms (NCT04800510)
- Testing
- Carbon Fiber Custom Dynamic Orthosis (CDO)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Iowa
Covid19
Symptom-Based Markers for COVID-19 Transmission
In this study, COVID-19 positive patients will be added to a bidirectional texting program to receive daily surveys about their symptoms with the infection.
- Trial name
- NCT04665245
- Where
- United States
- Volunteers
- 214 people
- Sponsor
- University of Iowa
Edentulous Jaw, Edentulous Mouth
Use of Two Dissolvable Therapeutics Under Removable Partial Dentures
Older removable denture wearing adults suffer from a complex set of oral health challenges, with relatively few solutions identified at this time.
- Trial name
- NCT05441527
- Testing
- MI Paste, then, Biotene Dry Mouth Gel, Biotene Dry Mouth Gel, then, MI Paste
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Tooth Extraction, Immediate Implant Placement
Ultrasound-based Imaging to Detect Early Changes of Hard and Soft Tissue Around Immediately Placed Implants With or Without Soft Tissue Augmentation
Mid-facial recession following immediate implant placement (IIP) in the place of a tooth poses a significant challenge for clinicians to treat.
- Trial name
- NCT05330702
- Testing
- Xenogeneic Volume-Stable Collagen Matrix (VCMX) graft No Intervention: No Soft Tissue Augmentation, Tuberosity Connective Tissue Graft (CTG)
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Hypertension
A Pharmacist Intervention to Improve Mother and Child Health
The goal of this clinical trial is to learn if a research pharmacist can improve the health of new mothers and their babies. The main questions it aims to answer are: Will postpartum women who had elevated blood pressure during…
- Trial name
- NCT06073054
- Testing
- Research Pharmacist
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Iowa
Diabetes in Pregnancy
Incentives and Glucose Adherence in Diabetes
Diabetes in pregnancy carries significant pregnancy specific risks and requires frequent glucose monitoring to reduce these risks.
- Trial name
- NCT03338829
- Testing
- Positive incentive, Loss aversion
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Preeclampsia
Angiotensin II and Chronic Inflammation in Persistent Microvascular Dysfunction Following Preeclampsia
Women who develop preeclampsia during pregnancy are more likely to develop cardiovascular disease later in life, even if they are otherwise healthy.
- Trial name
- NCT03482440
- Testing
- Salsalate Oral Tablet
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Diabetic Retinopathy With Macular Edema of Both Eyes (Diagnosis), Central Retinal Vein Occlusion With Macular Edema
Cool vs Room-temperature Artificial Tears
Background and Objective: To evaluate the efficacy of cooled versus room temperature artificial tears in reducing post intravitreal injection (IVI) ocular discomfort.
- Conditions
- Diabetic Retinopathy With Macular Edema of Both Eyes (Diagnosis), Central Retinal Vein Occlusion With Macular Edema, Exudative Age-Related Macular Degeneration, Unspecified Eye, Cystoid Macular Edema
- Trial name
- NCT05832996
- Testing
- Refresh Plus Preservative-free Lubricant Eye Drops
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Osteo Arthritis Knee, Central Nervous System Sensitization
Pregabalin for Central Sensitization in TKA
The study purpose is to determine if giving pregabalin before and after total knee arthroplasty (TKA) can improve pain and meaningful function after surgery in patients that have central sensitization (CS).
- Trial name
- NCT05460871
- Testing
- Pregabalin 75mg
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Foot Injuries and Disorders
SCANREP: Reliability of 3D Lower Limb Scanning
3D limb scanning systems have recently been implemented for the clinical fitting of prosthetic and orthotic devices due to substantial decreases in costs.
- Trial name
- NCT04032041
- Testing
- Structure Sensor, Caliper
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Iowa