Clinical trials: sponsored by University of Manitoba
Dementia
Investigating Different Frequencies of Transcranial Electrical Stimulations in Dementia Population
Dementia is a prevalent condition with no known cure. It affects not only the person with dementia but also the family. This study will investigate the effects of applying different transcranial electrical stimulation (tES)…
- Trial name
- NCT06547021
- Testing
- Transcranial Direct Current Stimulation (tDCS), Gamma Transcranial Alternating Current Stimulation (tACS), Theta Transcranial Alternating Current Stimulation (tACS)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of Manitoba
Prevention, Type2Diabetes
Dialectal Behaviour Therapy to Enhance Health Behaviour Change for Adolescents Living With Obesity (DIRECTION Trial)
This research is being conducted to evaluate emotion-focused therapy that incorporates elements of mindfulness, distress tolerance, and relationship support.
- Trial name
- NCT05338944
- Testing
- Dialectical behavioral therapy, Lifestyle
- Where
- 3 sites in Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Scrotum Disease, Hydrocele Male
Efficacy of Inhaled Methoxyflurane (Penthrox) as Adjunct for Urologic Procedures Under Local Anesthetic: A Pilot Study
We wish to perform a prospective randomized controlled pilot study at the Men's Health Clinic and Health Science's Centre to assess whether or not the use of Penthrox as an adjunct to LA is associated with improved pain tolerance…
- Conditions
- Scrotum Disease, Hydrocele Male, Spermatocele, Scrotal Hematocele
- Trial name
- NCT07192198
- Testing
- Methoxyflurane, Control
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Loneliness, Social Isolation
Evaluating and Implementing The CONNECT Program - a Group-Based Telehealth Intervention to Reduce Social Isolation, Loneliness, and Mental Health Symptoms in Adults Ages 55+, Compared to Routine Community-Based Programming
Older adults in Canada are experiencing increasing levels of social isolation, loneliness, and mental health challenges, including anxiety and depression - trends that have worsened during and following the COVID-19 pandemic.
- Conditions
- Loneliness, Social Isolation, Depression Disorders, Anxiety
- Trial name
- NCT07107906
- Testing
- The CONNECT Program, Community Participation as Usual (Service as Usual)
- Where
- Canada
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Suicide, Suicide, Attempted
Living With Hope: A Preliminary Investigation of a Skills Class
This study will determine whether Living with Hope, a novel, 12-week coping skills class, reduces suicidal thoughts and behaviors among individuals who have made a recent suicide attempt.
- Conditions
- Suicide, Suicide, Attempted, Suicidal Ideation
- Trial name
- NCT04140149
- Testing
- Living with Hope
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- University of Manitoba
Metabolic Syndrome
Effects of Canola Oil on Vascular and Metabolic Parameters in Individuals With Metabolic Syndrome
MetS is an early stage of CVD and is an appropriate target for dietary interventions. MetS is a clustering of risk factors (abdominal obesity, elevated serum triglycerides, low HDL-cholesterol, hypertension, elevated fasting…
- Trial name
- METCO-2013 (NCT01890330)
- Testing
- Canola Oil 25 g/d, Non-Canola Oil Mixture 25 g/d
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University of Manitoba
Mental Disorder, Pharmacogenetics
Pharmacogenomics-Supported Psychotropic Prescribing Trial
Investigate the feasibility and utility of implementing pharmacogenetic testing for adults (aged 18 and older) seeking care for mental illness in Manitoba.
- Conditions
- Mental Disorder, Pharmacogenetics, Adverse Drug Reaction (ADR), Effectiveness
- Trial name
- PGx-SUPPORT (NCT06929533)
- Testing
- Pharmacogenetic Testing
- Where
- 2 sites in Canada
- Volunteers
- 200 people
- Sponsor
- University of Manitoba
Post Traumatic Stress Disorder
Written Exposure Therapy for PTSD in a Virtual, Group-based Format
The purpose of this study is to examine whether Written Exposure Therapy (WET) can be effectively delivered virtually and in a group format for the treatment of Post-Traumatic Stress Disorder in a military and police population.
- Trial name
- NCT05553249
- Testing
- Written Exposure Therapy
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- University of Manitoba
Croup
Croup Dosing Study
Croup is a common childhood respiratory disease that often leads to frequent emergency department visits. It is a viral infection that causes cough, throat, and airway swelling, making breathing difficult.
- Trial name
- NCT06272383
- Testing
- 0.15 mg/kg dexamethasone
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Behavioral Activation, Major Depressive Disorder
Pharmacogenomics of Selective Serotonin Reuptake Inhibitor (SSRI)-Induced Behavioural Activation
The purpose of this study is to identify and validate a panel of genetic markers associated with selective serotonin reuptake inhibitors (SSRI)-induced behavioural activation in children and youth with major depressive disorder…
- Conditions
- Behavioral Activation, Major Depressive Disorder, Anxiety Disorders, Antidepressant Drug Adverse Reaction
- Trial name
- PGx-SImBA (NCT06763081)
- Testing
- Not applicable- observational study
- Where
- 2 sites in Canada
- Volunteers
- 160 people
- Sponsor
- University of Manitoba
Phimosis, Paraphimosis
Evaluating the Efficacy of 2-Octyl Cyanoacrylate (2-OCA) With Four Interrupted Sutures in Adult Male Circumcision
This study aims to determine whether cyanoacrylate glue is a non-inferior alternative to continuous suturing for wound closure following adult circumcision.
- Trial name
- NCT06487494
- Testing
- Circumcision wound closure using 2-octyl cyanoacrylate glue with four interrupted sutures, Circumcision wound closure using continuous sutuing
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Obesity
Pea Protein and Muscle Mass During Weight Loss
A pilot study comparing the effects of pea protein versus whey protein on the preservation of muscle mass and functionality in individuals undertaking a weight loss regimen.
- Trial name
- NCT04123938
- Testing
- Pea Protein, Whey Protein, Maltodextrin
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Kidney Disease, Chronic
Virtual Kidney Check and Follow-up
The goal of this clinical trial is to determine the most effective way to complete population-based screening for chronic kidney disease (CKD) in First Nations adults in Manitoba.
- Trial name
- NCT06223750
- Testing
- population-based screening for chronic kidney disease
- Where
- Canada
- Volunteers
- 3,356 people
- Sponsor
- University of Manitoba
Mechanical Ventilation Complication, Vascular Injury
Vascular Injury in Mechanical Ventilation: a Proof-of-Concept Study
Investigation of the effect of mechanical ventilation on biomarkers of microvascular damage
- Conditions
- Mechanical Ventilation Complication, Vascular Injury, Endothelial Dysfunction
- Trial name
- NCT05538858
- Testing
- Mechanical Ventilation
- Where
- Canada
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Sepsis, Shock
Microvascular Monitoring in Circulatory Shock and Sepsis (MiMICSS)
Investigation of the feasibility of using near-infrared spectroscopy (NIRS) to monitor microvascular function in critically ill patients.
- Conditions
- Sepsis, Shock, Critical Illness
- Trial name
- MiMICSS (NCT05985525)
- Testing
- Skeletal muscle and cerebral NIRS (research device)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of Manitoba
Right Ventricular Dysfunction, Cardiac Arrest
Emergency Department Assessment of Right Ventricular Function and Size in the Post Cardiac Arrest Patient
The right side of the heart of often overlooked in patients who are acutely unwell, as the main area of focus when performing echocardiography tends to be the left ventricle.
- Trial name
- NCT03309852
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- University of Manitoba
Septic Shock
Therapeutic Plasma Exchange in Septic Shock: A Pilot Study
The investigators propose to conduct a multi-center randomized pilot feasibility trial comparing therapeutic plasma exchange to standard of care in patients diagnosed with septic shock.
- Trial name
- PLEXSIS (NCT05093075)
- Testing
- Therapeutic Plasma Exchange
- Where
- 11 sites in Canada
- Volunteers
- 80 people
- Sponsor
- University of Manitoba
Mental Health Disorder, Mental Health Impairment
An Innovative Mental Health Virtual Ward: Evaluation of Patient-Centered Outcomes
The goal of this study is to evaluate if admission to the Mental Health Virtual Ward (MH vWard) for mental health crisis stabilization is having a meaningful positive impact on patient reported outcomes and healthcare…
- Conditions
- Mental Health Disorder, Mental Health Impairment, Psychiatric Emergency, Crisis; Emotional
- Trial name
- NCT06526026
- Testing
- Virtual crisis stabilization support with a multi-disciplinary team
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- University of Manitoba
Gestational Diabetes, Prediabetes; Complicating Pregnancy
Predicting Dysglycemia in Individuals With Gestational Diabetes Immediately Postpartum Using Continuous Glucose Monitoring
Gestational diabetes is one of the most common medical disorders in pregnancy and is a major risk factor for the postpartum development of dysglycemia.
- Conditions
- Gestational Diabetes, Prediabetes; Complicating Pregnancy, Type 2 Diabetes, Pregnancy Related
- Trial name
- PREDISPOSE (NCT04972955)
- Testing
- Freestyle Libre 2
- Where
- 4 sites in Canada
- Volunteers
- 240 people
- Sponsor
- University of Manitoba
Healthy Participants
Pilot Assessment of the Safety of a Combination of Curcumin, Omega-3, and Vitamin D Supplements in ACPA+ Individuals
The goal of this clinical trial is to determine if the level of Anti-cyclic citrullinated peptide antibody (ACPA) is altered after taking curcumin, omega-3, and vitamin D supplements (COD) for 3 months.
- Trial name
- PASCOD3 (NCT06478290)
- Testing
- curcumin, omega-3, and vitamin D (COD)
- Where
- 2 sites in Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Manitoba