Clinical trials: sponsored by University of Massachusetts, Worcester
Perinatal Anxiety, Anxiety Sensitivity
Reaching Calm: A Digital Intervention to Prevent Perinatal Anxiety Disorders
The goal of this clinical trial is to find out if a digital program called Reaching Calm can help prevent anxiety in women who are pregnant.
- Conditions
- Perinatal Anxiety, Anxiety Sensitivity, Perinatal Depression
- Trial name
- NCT07458698
- Testing
- Digital mental health intervention
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Massachusetts, Worcester
Alcohol Use Disorder, Risky Health Behavior
A Female-Specific CBT Group for Veteran Women With Alcohol Use Disorder in VA Primary Care Settings
The purpose of this study is to evaluate a Female-Specific Cognitive Behavioral Therapy (CBT) Group as treatment for Alcohol Use Disorder among Veteran women.
- Trial name
- NCT06118346
- Testing
- Female-Specific Cognitive Behavioral Therapy (FS-CBT), Usual Care
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- University of Massachusetts, Worcester
Hidradenitis Suppurativa (HS)
Botulinum Toxin Blockade of Neuronal Signals to Immune Cells as a Novel Treatment for Hidradenitis Suppurativa
This study will build on data from mice and humans implicating TRPV1 nociceptors in the pathogenesis of the type-17 chronic inflammatory skin disease hidradenitis suppurativa (HS).
- Trial name
- Botox in HS (NCT07756346)
- Testing
- Botulinum Toxin A (Allergan, Inc, Irvine CA)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Massachusetts, Worcester
Weight Management Counseling
Medical Residents Learning Weight Management Counseling Skills
The goal of this study is to addresses the lack of weight management training physicians receive during their residency training.
- Trial name
- MRWeight (NCT06529666)
- Testing
- Didatic Session 1: Core Foundation Course, The 3Ps Program, Didactic session 2
- Where
- 8 sites in United States
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Hidradenitis Suppurativa, Hyperhidrosis
Targeting Nociceptors in Hidradenitis Suppurativa
This study will build on data from mice and humans implicating TRPV1 nociceptors in the pathogenesis of the type-17 chronic inflammatory skin disease Hidradenitis Suppurativa (HS).
- Trial name
- HS (NCT05403710)
- Testing
- Botulinum toxin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Massachusetts, Worcester
Breast Cancer
MIRAI-MRI: Comparing Screening MRI for Patients at High Risk for Breast Cancer Identified by Mirai and Tyrer-Cuzick
Accurate risk assessment is essential for the success of population screening programs and early detection efforts in breast cancer. Mirai is a new deep learning model based on full resolution mammograms.
- Trial name
- NCT05968157
- Testing
- Breast MRI, MIRAI
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- University of Massachusetts, Worcester
Idiopathic Pulmonary Fibrosis
Metformin to Attenuate Progressive Respiratory Decline in Idiopathic Pulmonary Fibrosis
This is a randomized, placebo-controlled trial of metformin in 400 participants with idiopathic pulmonary fibrosis (IPF) who are at high risk of adverse clinical outcomes based on a proteomic classifier.
- Trial name
- MAVRIC (NCT07520110)
- Testing
- Metformin
- Where
- 15 sites in United States
- Volunteers
- 800 people
- Sponsor
- University of Massachusetts, Worcester
Pre-Exposure Prophylaxis
Developing mHealth to Promote PrEP Use Among Thai Young Vulnerable Adolescents and Emerging Adults
The main aim of this study is to develop technology-based interventions to improve HIV pre-exposure prophylaxis (PrEP) uptake and adherence among Thai young transgender women.
- Trial name
- NCT05262426
- Testing
- Behavioral: Motivational Enhancement System for PrEP Uptake and Adherence (MES-PrEP), Enhanced YaCool, Standard PrEP Counseling
- Where
- 3 sites in Thailand
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Type 2 Diabetes
A Community Health Worker/Pharmacist Team to Improve Blood Sugars in Diabetes Care Using Continuous Glucose Monitoring
Continuous glucose monitoring (CGM) can help improve blood sugar management in type 2 diabetes. A sequential, multiple assignment, randomized trial will evaluate clinical pharmacists, community health workers, and telehealth in…
- Trial name
- TEAM-CGM (NCT05911256)
- Testing
- Pharmacist Only, Continuous Glucose Monitor (CGM), Community Health Worker (CHW)
- Where
- United States
- Volunteers
- 318 people
- Sponsor
- University of Massachusetts, Worcester
Cancer, Cardiovascular Diseases
ActivityChoice: Implementing Clinic-Based Physical Activity Program Choices for Cancer Survivors
Cardiovascular disease, the number one leading cause of death in the United States, is highly prevalent in cancer survivors. Physical activity can reduce risk, and referrals to programs addressing survivors' choices are highly…
- Conditions
- Cancer, Cardiovascular Diseases, Physical Inactivity
- Trial name
- NCT05870176
- Testing
- Enhanced Referral, Standard Referral
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Pre-Exposure Prophylaxis
Thailand HIV and Stigma Reduction Study
This project will develop a multi-component, technology-delivered intervention designed to reduce HIV and intersectional stigma and improve the use of HIV pre-exposure prophylaxis (PrEP) among HIV-negative Thai vulnerable…
- Trial name
- NCT06576648
- Testing
- Mobile Healthy Choices (mHC), Finding Respect and Ending Stigma around HIV (FRESH), Standard PrEP Counseling
- Where
- 3 sites in Thailand
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Pre-Exposure Prophylaxis
Zambia Healthy Choices Project for Emerging Adults Living With HIV
This project will develop and implement a multi-component intervention using mobile health technology to improve HIV self-management and reduce substance use.
- Trial name
- NCT06415357
- Testing
- Mobile Healthy Choices (mHC), Motivational Text Messaging (MTM), Standard ART Counseling
- Where
- Zambia
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Built Environment
Neighborhood Connect
The study is evaluating the effectiveness of an implementation strategy called Neighborhood Connect, which is designed to support residents' engagement in activities that improve the attractiveness, safety and livability of…
- Trial name
- NCT07780825
- Testing
- Neighborhood Connect
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Progressive Pulmonary Fibrosis, Interstitial Lung Disease
PRospective phenotypIng and Multi-omic Endotyping of Progressive Pulmonary Fibrosis
This is a prospective, observational cohort study. Participants with non-idiopatic pulmonary fibrosis, interstitial lung disease (ILD) will be followed for 24 months to systematically collect clinical, imaging, and biospecimen…
- Trial name
- PRIME-PPF (NCT06855329)
- Where
- 24 sites in United States, Australia and 11 more
- Volunteers
- 500 people
- Sponsor
- University of Massachusetts, Worcester
Cytomegalovirus Infections
Cytomegalovirus (CMV) Transmission and Immune Tracking (TransmIT) Study
The goal of STAGE I of the CMV TransmIT Study is to determine the prevalence of CMV shedding in children up to and including 36 months of age in large group childcare centers and in staff who regularly work at the center.
- Trial name
- NCT06522880
- Testing
- CMV PCR on saliva
- Where
- United States
- Sponsor
- University of Massachusetts, Worcester
Gestational Diabetes, Type 2 Diabetes
Preventing T2DM After GDM With Immediate Postpartum Screening
The overall goal of this proposal is to create and test an implementation protocol for in-hospital immediate postpartum diabetes screening for postpartum patients with pregnancies affected by GDM.
- Trial name
- NCT06457139
- Testing
- Glucose tolerance test (2 hour), Active Comparator
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- University of Massachusetts, Worcester
Lung Cancer Screening
Facilitation of Information eXchange for Shared Decision Making for Lung Cancer Screening
The goal of this pilot clinical trial is to learn whether the patient and provider support program, called FIX-SDM, helps patients and providers engage in shared decision-making for lung cancer screening during primary care…
- Trial name
- FIX-SDM LCS (NCT07517692)
- Testing
- FIX-SDM, Usual Care
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Massachusetts, Worcester
Tuberculosis, Pulmonary Tuberculosis
Safety and Tolerability of Metformin in People With Tuberculosis (TB) and Human Immunodeficiency Virus (HIV)
The METHOD study will examine whether adding metformin to standard antibiotic treatment for tuberculosis (TB) in people with HIV is safe and well tolerated.
- Conditions
- Tuberculosis, Pulmonary Tuberculosis, HIV Coinfection
- Trial name
- METHOD (NCT04930744)
- Testing
- Isoniazid, Rifampicin, Ethambutol
- Where
- 2 sites in South Africa
- Volunteers
- 112 people
- Sponsor
- University of Massachusetts, Worcester
Type 2 Diabetes Treated With Insulin, Pregnancy, High Risk
Continuous Glucose Monitor Use in Pregnancy
The purpose of this study is to perform a randomized controlled trial among 180 pregnant women with type 2 diabetes mellitus (T2DM) comparing continuous glucose monitor (CGM) use to the standard of care of multiple daily…
- Trial name
- NCT05317585
- Testing
- Continuous Glucose Monitor, Routine Capillary Blood Glucose Monitoring (Fingerstick Glucose)
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Massachusetts, Worcester
Binge Drinking, Suicidal Ideation
Open Pilot Trial Evaluating an Avatar-Guided Intervention for Emerging Adults With Alcohol Use Problems and Suicide Risk
This study is an open pilot usability trial to test the 1) usability of a newly developed mobile health intervention to help manage suicidal ideation and alcohol use problems and 2) feasibility of research protocols with emerging…
- Trial name
- EA-Avatar (NCT06595862)
- Testing
- EA-Avatar
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Massachusetts, Worcester