Clinical trials: sponsored by University of Miami
Prostate Cancer
Radiation Hypofractionation Via Extended Versus Accelerated Therapy (HEAT) For Prostate Cancer
Accelerated Hypofractionation Radiotherapy for prostate cancer of 36.25 Gy delivered in 5 fractions will not be inferior to the standard treatment of 70.2 Gy given in 26 fractions with respect to four-year biochemical failure…
- Trial name
- HEAT (NCT01794403)
- Testing
- Extended Hypofractionation Radiotherapy, Accelerated Hypofractionation Radiotherapy
- Where
- 3 sites in United States, Australia and 1 more
- Volunteers
- 161 people
- Sponsor
- University of Miami
Hepatocellular Carcinoma, Cholangiocarcinoma
Targeted Navigation in Hepatocellular Carcinoma (HCC)
The investigators are trying to learn more about the personal perceptions and experiences regarding the needs of patients with liver cancer to help improve the care of all patients.
- Conditions
- Hepatocellular Carcinoma, Cholangiocarcinoma, Hepatobiliary Cancer
- Trial name
- NCT06260943
- Testing
- Target Navigation Pilot Program
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- University of Miami
Prostate Cancer, Hypogonadism, Male
Testosterone Replacement Therapy in Hypogonadal Patients With Prostate Cancer Under Active Surveillance
The purpose of this study is evaluate the safety of testosterone replacement therapy in men with newly diagnosed low-risk prostate cancer and hypogonadism on active surveillance.
- Trial name
- NCT07278362
- Testing
- Testosterone cypionate
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- University of Miami
Crohn Disease
Glucagon-like Peptide-1 Receptor Agonist (GLP-1 RA) and Diet in Inflammatory Bowel Disease (IBD) Patients
The purpose of this study is to use diet and an injectable medication called tirzepatide (Zepbound) glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist (GIP-GLP-1 RA) medication as adjunctive…
- Trial name
- NCT06774079
- Testing
- Tirzepatide, Mediterranean diet
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Miami
HIV/AIDS, HPV Infection
ORCHID: An Online Intervention for Persons With HIV (Miami)
The purpose of this research is to test ORCHID (Optimizing Resilience \& Coping with HIV through Internet Delivery), a skills-building intervention that improves mental health status for persons with HIV, who are at-risk for…
- Trial name
- ORCHID-Miami (NCT05935644)
- Testing
- ORCHID
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Miami
Spinal Cord Injuries
Cuneiform Nucleus (CnF) Deep Brain Stimulation for Gait Facilitation Following Spinal Cord Injury
This is a study about deep brain stimulation (DBS) as an investigational treatment for walking impairment following spinal cord injury (SCI).
- Trial name
- NCT07109804
- Testing
- Deep Brain Stimulation (DBS), Deep Brain Stimulation (DBS) Device Implant Procedure, Training Sessions
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- University of Miami
Urinary Tract Infections, Stress Urinary Incontinence
Prophylactic Antibiotics for Outpatient Urethral Bulking
The purpose of this study is to evaluate whether taking prophylactic (preventative) antibiotics at the time of standard of care clinic-based urethral bulking reduces the risk of post-procedural urinary tract infection (UTI).
- Conditions
- Urinary Tract Infections, Stress Urinary Incontinence, Urinary Incontinence
- Trial name
- NCT07501065
- Testing
- Bactrim (800/160 mg), Keflex (500 mg), Cipro (250 mg), or Macrobid (100mg)
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of Miami
Cerebral Aneurysm
Effect of Sirolimus on Molecular Alterations in Cerebral Aneurysms
The objective of this study is to explore the effects of Sirolimus on the underlying molecular alterations of cerebral aneurysms.
- Trial name
- NCT04141020
- Testing
- Microsurgical clipping, Endovascular treatment, Sirolimus
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Miami
Heart Diseases
Understanding Decentralized Trial Engagement and Clinical Impediments Through Digital Efforts (UDECIDE) Among Unrepresented Groups With Poor Cardiovascular and Cardiometabolic Health
The objective of the UDECIDE study is to demonstrate adherence to decentralized clinical trials among underrepresented groups with cardiometabolic conditions .
- Trial name
- NCT06587204
- Testing
- Control Group, Decentralized Group, Digital Literacy Navigation Group
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of Miami
Dementia, Mild Cognitive Impairment (MCI)
Combating Alzheimer's Through Sleep and Exercise
The Combating Alzheimer's through Sleep and Exercise (CASE) study is an exploratory, hypothesis-generating trial designed to: (1) assess whether improvements in sleep are associated with improvements in cognitive performance and…
- Conditions
- Dementia, Mild Cognitive Impairment (MCI), Cognitively Unimpaired, Alzheimer's Dementia (AD)
- Trial name
- CASE (NCT04855630)
- Testing
- Elemind Neuromodulation Headband, Exercise Routine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Miami
Colorectal Cancer
Guardant Shield Colorectal Cancer Screening
The purpose of this research is to identify individuals overdue for colon cancer screening and send them a reminder to complete their screening, which includes standard of care colonoscopy or stool-based testing.
- Trial name
- NCT07436637
- Testing
- Screening Reminder, Blood Sample Collection
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Miami
Depression, Anxiety
Preventing Anxiety and Depression in Older Hispanics
The purpose of this study is to look at the best ways to prevent anxiety and depression in older Latino adults who are at risk for developing anxiety and depression.
- Trial name
- HOLAA&D (NCT03870360)
- Testing
- HOLA Component 1, HOLA Component 2, HOLA Component 3
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of Miami
Major Depression, Generalized Anxiety
Neural Mechanisms of Real-world Emotions and Internalizing
This study utilizes mobile health methods, including smartphone technology, subjective self-reports measures of emotion, behavioral tasks, functional Magnetic Resonance Imaging (fMRI), physiological measures of attention and…
- Conditions
- Major Depression, Generalized Anxiety, Emotions
- Trial name
- NCT07891624
- Testing
- Academic Performance Feedback
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Miami
Prostate Cancer
Exercise-induced Steroid Changes in Active Surveillance for Prostate Cancer
The purpose of this research study is to understand how a short session of a home-based bodyweight high-intensity interval training (HIIT) affects steroid hormone levels in men on active surveillance for low-grade prostate cancer.
- Trial name
- ESCAPE (NCT07518888)
- Testing
- High-Intensity Interval Training (HIIT) Exercise
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Miami
Gastrointestinal Stromal Tumors
ctDNA-Guided Sunitinib And Regorafenib Therapy for GIST
The purpose of this research is to test if mutations (changes in DNA) in exons (segment of DNA or RNA containing information that has the instructions for making proteins) in the KIT gene can be used to predict the body's…
- Trial name
- NCT05366816
- Testing
- Sunitinib, Regorafenib
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Miami
Leptomeningeal Metastasis, Breast Cancer
BRain-AVOidant Proton Craniospinal Irradiation for Leptomeningeal Metastases From Solid Tumor Malignancies
The purpose of this study is to determine the efficacy of BRain-AVOidant proton craniospinal irradiation (BRAVO pCSI) in adult participants with leptomeningeal metastases from solid tumors.
- Conditions
- Leptomeningeal Metastasis, Breast Cancer, Lung Cancer (NSCLC)
- Trial name
- BRAVO-LM (NCT07789912)
- Testing
- Radiation Treatments Using Brain- Avoidant Proton Craniospinal Irradiation (BRAVO- pCSI)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Miami
Kidney Cancer, Renal Cancer
NSAID Use After Robotic Partial Nephrectomy
The purpose of this study is to see how effective non-steroidal anti-inflammatory drugs (NSAIDs) are at controlling pain without side effects in participants after robotic-assisted partial nephrectomy.
- Conditions
- Kidney Cancer, Renal Cancer, Renal Neoplasm
- Trial name
- No-PAIN (NCT05842044)
- Testing
- Ketorolac, Acetaminophen, Oxycodone
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- University of Miami
Asthma
Ventilation and Perfusion in Asthmatics
Assess regional changes to perfusion and ventilation from inhaled corticosteroid (ICS) and Fast-acting beta-antagonist (FABA) among adult asthmatics using radiographically derived estimates of regional ventilation…
- Trial name
- NCT07426458
- Testing
- Albuterol Sulfate, Albuterol-Budesonide
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Miami
Glaucoma
VGFTe-(HD)-OD-2566: Adjunctive Aflibercept Ahmed Glaucoma Valve (AAA) Study
The purpose of this study is to determine if injections of aflibercept into the eye given at the end of the Ahmed tube surgery as well as at postoperative months one and two would improve eye pressure control compared to standard…
- Trial name
- NCT07891182
- Testing
- Aflibercept Injection, Ahmed Tube Surgery
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Miami
HIV Infections
Advancing Access to HIV/HCV Testing for People Who Inject Drugs (PWID)
The purpose of this study is to test the effectiveness of the ACCESS strategy: an organizational-level intervention that uses funding and practice facilitation to improve the organizational capacity of syringe services programs…
- Trial name
- ACCESS (NCT06730555)
- Testing
- ACCESS Intervention, Control Group
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Miami