Clinical trials: open to volunteers, sponsored by University of Michigan
Cigarette Smoking
Remote Interventions for Menthol Cigarette Use
The purpose of this study is to evaluate whether a digital, incentive-based program, used in conjunction with traditional quitline (QL) services, can be beneficial to quitline callers who smoke menthol cigarettes.
- Trial name
- NCT07356297
- Testing
- Quitline (QL), Mobile incentive-based intervention
- Volunteers
- 1,200 people
- Sponsor
- University of Michigan
Cannabis Use
Activity-Based Intervention to Address Cannabis Use
This study is being completed to test a method to promote patient-centered outcomes among people who use cannabis behaviors.
- Trial name
- NCT07813442
- Testing
- Motivational and Behavioral Economics Informed Intervention, Enhanced Usual Care
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Michigan
Diabetic Foot Ulcer, Diabetic Foot
DFC 004 Biomarkers for Active Diabetic Foot Ulcers
This study is a platform study designed to efficiently test multiple biomarkers to identify diabetic foot ulcers (DFUs) with a higher potential for healing versus not healing that ultimately could be applied at the point of care…
- Conditions
- Diabetic Foot Ulcer, Diabetic Foot, Diabetes
- Trial name
- NCT06104969
- Where
- 9 sites in United States
- Volunteers
- 5,000 people
- Sponsor
- University of Michigan
Endogenous Cushing Syndrome, Adrenal Insufficiency
A Block-and-Replace Therapy With Osilodrostat and Concomitant Glucocorticoid Replacement
The major goal of this study is to determine the incidence of adrenal insufficiency in patients with endogenous Cushing syndrome receiving osilodrostat treatment combined with a replacement of glucocorticoid (block-and-replace…
- Conditions
- Endogenous Cushing Syndrome, Adrenal Insufficiency, Hypercortisolism
- Trial name
- NCT06430528
- Testing
- Osilodrostat
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Michigan
Delirium, Neurocognitive Disorders
Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized Elders
The goal of this clinical trial is to compare the Hospital Elder Life Program (HELP) with a family-augmented version of HELP (FAM-HELP), that includes family members and care partners, for the prevention of delirium in older…
- Conditions
- Delirium, Neurocognitive Disorders, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- ENHANCE (NCT05929703)
- Testing
- HELP, FAM-HELP
- Where
- 7 sites in United States
- Volunteers
- 1,900 people
- Sponsor
- University of Michigan
Hypothyroidism
Optimizing Care for Older Adults Through Thyroid Hormone Deprescribing
The proposed study focuses on testing a novel adapted evidence-based multilevel intervention, Deprescribing Thyroid Hormone In Older Adults (D-THIO), to support thyroid hormone deprescribing (dose de-escalation and/or…
- Trial name
- NCT06629272
- Testing
- D-THIO (Deprescribing Thyroid Hormone In Older Adults), Enhanced usual care
- Where
- 3 sites in United States
- Volunteers
- 900 people
- Sponsor
- University of Michigan
Pregnant Patients at Risk of Gestational Diabetes
A Randomized Controlled Trial of Prepared vs. Unprepared Food
The goal of this study is to assess the feasibility of different food interventions, delivered through insurance providers, for addressing food insecurity in patients at risk of gestational diabetes (diabetes in pregnancy).
- Trial name
- NCT07800182
- Testing
- Prepared meals, Unprepared Pantry/Produce box
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Pre-diabetes, Type 2 Diabetes
Mechanisms of Fatigability With Diabetes
Pre-diabetes (Pre-D) is a precursor to type 2 diabetes (T2D) and characterized by increased exercise fatigability of lower limb muscles, that can impede exercise performance.
- Trial name
- NCT04442451
- Testing
- Control Exercise, Blood Flow Restriction Exercise
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Michigan
Peri-Implantitis
Regenerative Treatment of Peri-implantitis
The purpose of this study is to study the use of a new type of d-PTFE membrane called reinforced PTFE Mesh (RPM) with dental surgery.
- Trial name
- NCT06153212
- Testing
- Membrane placement with bone grafting
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Michigan
Violence, Adolescent
Addressing Root Causes for Gun Violence Prevention (ARC-GVP)
The goal of this study is to help build the evidence base for a locally-relevant youth firearm violence prevention program in Washington D.C., a city experiencing disparities in youth firearm violence outcomes.
- Conditions
- Violence, Adolescent, Firearm Injury, Aggression
- Trial name
- NCT05887973
- Testing
- The T.R.I.G.G.E.R Project
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Older Adults (65 Years and Older), Living Alone
Home-based Monitoring & Enabled Medication Independence With New Digital Tools
This clinical trial is studying an online tool that may help older adults safely manage their medications at home. The study focuses on older adults who live alone and have memory concerns or mild changes in thinking.
- Conditions
- Older Adults (65 Years and Older), Living Alone, Mild Cognitive Decline, Polypharmacy (People Under Treatment With 5 or More Drugs)
- Trial name
- HOME-MIND (NCT07659548)
- Testing
- HOME-MIND
- Volunteers
- 60 people
- Sponsor
- University of Michigan
Opioid Use Disorder
The ConCERN Intervention for Loved Ones of Those With Opioid Use Disorder
Evidence suggests that friends and family play an important role in supporting loved ones that are addicted to opioids. However, there are limited unique resources available for this population of friends and family.
- Trial name
- ConCERN (NCT07795840)
- Testing
- ConCERN intervention, Treatment as Usual
- Where
- 2 sites in United States
- Volunteers
- 700 people
- Sponsor
- University of Michigan
Healthy, Halitosis
Effectiveness of Aquamin® in Mitigating Halitosis
The purpose of this study is to assess whether Aquamin®, a multi-mineral natural product from red marine algae, can help reduce halitosis when taken for 90 days.
- Trial name
- NCT05058638
- Testing
- Aquamin
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Surgery, Pain, Postoperative
Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial
This trial is being completed to compare two commonly used options to treat pain after surgery. Participants that undergo gallbladder removal, hernia repair, and breast lump removal will be eligible to enroll.
- Trial name
- CARES (NCT05722002)
- Testing
- NSAID, Opioid, Acetaminophen
- Where
- 8 sites in United States, Canada
- Volunteers
- 900 people
- Sponsor
- University of Michigan
Depression and Quality of Life, Sexual Violence
Empowerment Self Defense Program for Adult Native Women Survivors of Sexual Violence
The purpose of this study is to culturally adapt and evaluate an empowerment self-defense (ESD) program (i.e., IMpower) for AI/AN women who have experienced SV in their lifetime and currently experiencing moderate to severe…
- Conditions
- Depression and Quality of Life, Sexual Violence, PTSD, Suicidal Ideation
- Trial name
- ESD (NCT07712796)
- Testing
- Empowerment self-defense training
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Michigan
Obstructive Sleep Apnea, Hypertonia, Muscle
Self-Supporting Nasopharyngeal Airway (ssNPA) Treating Upper Airway Obstruction in Hypotonia
The researchers are investigating if the Self-Supporting Nasopharyngeal Airway (ssNPA) device can be used in the treatment of obstructive sleep apnea in children with Hypotonic Upper Airway Obstruction (HUAO).
- Conditions
- Obstructive Sleep Apnea, Hypertonia, Muscle, Nasal Airway Obstruction, Tolerance
- Trial name
- NCT05527652
- Testing
- Self-Supporting Nasopharyngeal Airway (ssNPA)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Amputation Neuroma, Amputation
Short-term Implanted Electrodes Following Regenerative Peripheral Nerve Surgery for Improving Prosthetic Limb Control Signals
The device, a bipolar percutaneous intramuscular electromyography electrode, is intended for use in upper-limb amputation patients who have received the regenerative peripheral nerve interface surgical procedure, in order to…
- Trial name
- NCT03260400
- Testing
- a bipolar percutaneous intramuscular electromyography electrode
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Michigan
PSA, Prostate Cancer
EDRN Prostate MRI Biomarker Study
The commercialization of MRI fusion biopsies has resulted in a dramatic increase in the use of MRI imaging for prostate cancer. How best to use MRI in the initial prostate biopsy setting given the availability of validated…
- Trial name
- P-MRI (NCT03784924)
- Testing
- MRI prostate
- Where
- United States
- Volunteers
- 950 people
- Sponsor
- University of Michigan
Mass Screening
Using Consumer-grade Wearable Devices for Fall Risk Evaluation and Alerts
Creation and use of a smartphone application for older adults to assess the participants' risk of fall. Phase 1: Compare the accuracy and validity of accelerometer and gyroscopic data from a smartphone and gold-standard, wearable…
- Trial name
- NCT06508892
- Testing
- risk of fall
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Drinking Behavior
Social Media Intervention for Risky Drinking
This study is being completed to test prevention methods to promote wellness and reduce risky behaviors, including the use of substances such as alcohol and other drugs.
- Trial name
- NCT07251192
- Testing
- Social media messaging
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- University of Michigan