Clinical trials: sponsored by University of Minnesota
Fanconi Anemia, Severe Aplastic Anemia
Alpha/Beta TCD HCT in Patients With Inherited BMF Disorders
This is a phase II trial of T cell receptor alpha/beta depletion (α/β TCD) peripheral blood stem cell (PBSC) transplantation in patients with inherited bone marrow failure (BMF) disorders to eliminate the need for routine…
- Conditions
- Fanconi Anemia, Severe Aplastic Anemia, Myelodysplastic Syndromes, T Cell Receptor Alpha/Beta Depletion
- Trial name
- NCT03579875
- Testing
- Total Body Irradiation (TBI) (Plan 1), Cyclophosphamide (CY) (Plan 1), Fludarabine (FLU)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Essential Tremor
Algorithms for Programming DBS Systems for ET
Deep brain stimulation (DBS) targeting the Vim thalamus (ventralis intermedius nucleus) is an FDA-approved neuromodulation therapy for treating postural and action tremor in individuals with essential tremor (ET).
- Trial name
- NCT03984643
- Testing
- Vim-Deep Brain Stimulation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Minnesota
Parkinson's Disease
Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease
This protocol will characterize the effects of deep brain stimulation (DBS) location (both adverse and beneficial) on motor signs in people with Parkinson's disease (PD).
- Trial name
- NCT05557864
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Minnesota
Parkinson Disease
Circuit-Based Deep Brain Stimulation for Parkinson's Disease P1A2&3 Catalyst
This study will help us better understand how the brain works in people with Parkinson's disease (PD). PD is a brain disease that gets worse over time, and affects over 10 million people world-wide.
- Trial name
- NCT05658302
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Alopecia Areata
DPCP for the Treatment of Alopecia Areata
This is an open labeled study to determine the response and characteristics, safety and efficacy, of the proprietary DPCP ointment composition as a topical immunotherapeutic agent for the treatment of extensive alopecia areata.
- Trial name
- NCT03651752
- Testing
- Diphenylcyclopropenone (DPCP) Ointment
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Minnesota
Obesity
Prolonged Daily Fasting as a Viable Alternative to Caloric Restriction in At-Risk Obese Humans
Purpose: Obesity is reaching epidemic proportions, affecting 36% of the adult population in the United States. There is intense interest in dietary management to treat obesity and its associated complications.
- Trial name
- NCT04259632
- Testing
- Time Restricted Eating (TRE), Caloric Restriction (CR)
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- University of Minnesota
Acute Lymphoblastic Leukemia, Large B-cell Lymphoma
MT2017-45: CAR-T Cell Therapy for Heme Malignancies
This is a phase II study of FDA-approved CAR-T products for patients with hematologic malignancies. Patients will be assigned to Arm A and B based on age and diagnosis.
- Trial name
- NCT03642626
- Testing
- KYMRIAH, YESCARTA, Fludarabine 30mg/m2 4 doses
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Social Stress, Adolescent Behavior
Affective Social Buffering
The purpose of this experiment is to determine the mechanisms through which parental buffering of stress physiology during affective stimulus presentation diminishes with pubertal development and whether this diminution of…
- Trial name
- NCT04312945
- Testing
- Questionnaires, MRI
- Where
- United States
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cystic Fibrosis, Cystic Fibrosis-related Diabetes
Semaglutide in CFRD
This open label, single arm pilot study, will examine the safety and tolerability of GLP-1RA semaglutide as an add-on therapy to insulin for overweight/obese adult patients with cystic fibrosis related diabetes (CFRD).
- Trial name
- NCT05788965
- Testing
- Semaglutide
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Minnesota
Cystic Fibrosis, Pregnancy
Pharmacokinetics of CFTR Modulators in Pregnant Individuals and in Postpartum Breastfeeding Mothers
This study aims to evaluate the pharmacokinetic changes during pregnancy, postpartum, and in breast milk in cystic fibrosis patients receiving a cystic fibrosis transmembrane conductance regulator (CTFR) modulator, including…
- Trial name
- NCT04940533
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Refractive Errors
Seeing to Learn in Sierra Leone
The main objective of the Sierra Leone Sees to Learn (SL2) trial is to assess the educational impact of providing free eyeglasses to students aged 9-20 years with uncorrected refractive error in Sierra Leone.
- Trial name
- SLII (NCT06065631)
- Testing
- Eyeglasses, Prescription slip
- Where
- Sierra Leone
- Volunteers
- 1,821 people
- Sponsor
- University of Minnesota
Fetal Alcohol Spectrum Disorders
CIFASD 5 tDCS and Cognitive Training
This is a randomized placebo-controlled trial of cognitive training with transcranial direct current stimulation (tDCS) for children and adolescents (ages 8 - 17 years) with prenatal alcohol exposure (PAE).
- Trial name
- NCT05456321
- Testing
- Active tDCS, Cognitive Training
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Minnesota
DLBCL, Diffuse Large B Cell Lymphoma
Ph I/II Study of E7777 Prior to CAR-T for R/R LBCL
This is a multicenter Phase I study to determine the maximum tolerated dose (MTD) of E7777 when given prior to cyclophosphamide/fludarabine (CY/Flu) lymphodepletion (LD) chemotherapy and an FDAapproved CAR-T product…
- Conditions
- DLBCL, Diffuse Large B Cell Lymphoma, High-grade B-cell Lymphoma, DLBCL Arising From Follicular Lymphoma
- Trial name
- NCT04855253
- Testing
- E7777, Fludarabine, Cyclophosphamide
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Visual Snow Syndrome, Migraine
Investigating Brain Function in People With and Without Visual Snow Syndrome Using Adaptation to Visual Stimuli
The goal of this study is to learn more about the brain pathways and activity involved in creating Visual Snow Syndrome (VSS). The main questions it aims to answer are: Does VSS arise from spontaneous activity in brain pathways?…
- Conditions
- Visual Snow Syndrome, Migraine, Healthy
- Trial name
- VPVSS (NCT06961864)
- Testing
- Visual Adaptation, Assessments and Questionnaires, Functional Magnetic Resonance Imaging (fMRI)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Staphylococcus Aureus Colonization, Surgical Site Infections
Effectiveness of Screening and Decolonization of S. Aureus to Prevent S. Aureus Surgical Site Infections in Surgery Outpatients
The purpose of the study is to determine the effectiveness, safety, and health-care utilization and costs of a preoperative Staphylococcus aureus (SA) screening and decolonization bundle, (5 days of nasal mupirocin ointment…
- Conditions
- Staphylococcus Aureus Colonization, Surgical Site Infections, Healthcare Associated Infections
- Trial name
- NCT06378359
- Testing
- Screening and decolonization for SA carriers with the 3 drug bundle, No screening for SA, no screening
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Minnesota
Postpartum, Hypertension
HOPE-BP 2.0: Evaluating the Optimal Duration of Postpartum Remote Blood Pressure Monitoring
Postpartum remote blood pressure monitoring programs for patients with hypertensive disorders of pregnancy (HDP) are becoming part of standard postpartum management.
- Conditions
- Postpartum, Hypertension, Hypertensive Disorder of Pregnancy
- Trial name
- NCT07204756
- Testing
- 2-Week Home Monitoring, 6-Week Home Monitoring
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Minnesota
Physical Activity
Neighborhood Park Youth Sports Program Fee Waiver and Intensive Family Outreach
To evaluate a park-level intervention to increase child moderate/vigorous physical activity (MVPA), and decrease sedentary time among low-income racially/ethnically diverse children ages 6-12 yrs.
- Trial name
- PARKS (NCT05231837)
- Testing
- Experimental: Fee Waiver, Fee Waiver Plus Intensive Outreach
- Where
- United States
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Perception of Things Changing Color, Adaptive Behavior
Visual Mode Switching in Color Perception
Participants will be given experience wearing colored lenses that add a tint to the environment. Changes in visual perception and neural processing that arise as a result of this experience will be measured.
- Trial name
- NCT05779228
- Testing
- Mode Switching Training
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Minnesota
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
Evaluation of Early Identification of Cognitive Side Effects of Immunotherapy
This clinical trial evaluates the use of a tool kit, Stress, Affect, Language and Speech Analysis (SALSA), for early identification of cognitive side effects of immunotherapy compared to the standard of care assessment.
- Trial name
- NCT06414278
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Glenohumeral Arthritis, Rotator Cuff Arthropathy
Corticosteroid Injection Versus Nerve Block
The purpose of this study is to evaluate conservative pain relief measures for patients suffering from glenohumeral arthritis or rotator cuff arthropathy.
- Trial name
- NCT06735027
- Testing
- intraarticular corticosteroid injection (IACI), suprascapular nerve block (SSNB)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Minnesota
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