Clinical trials: sponsored by University of Minnesota
Post-Acute Sequelae of COVID-19
Diaphragmatic Breathing Exercises for Post-COVID-19 Diaphragmatic Dysfunction (DD)
Diaphragm is the principal muscle of inspiration. Diaphragmatic dysfunction is seen in many conditions including following intubation, lung disease, prolonged ventilation, neuromuscular disease, phrenic nerve injury.
- Trial name
- NCT06330376
- Testing
- Usual care of traditional treatment, Specific DB program/Diaphragmatic manipulation program
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Limbal Stem-cell Deficiency, Congenital Aniridia
Treatment of LSCD With DM
Limbal Stem Cell Deficiency (LSCD) is a blinding disease that accounts for an estimated 15-20% of corneal blindness worldwide. Current treatments are limited.
- Trial name
- NCT05909735
- Testing
- transplantation of a Descemet's Membrane corneal onlay, partial LSCD, transplantation of a Descemet's Membrane corneal onlay, total/near-total LSCD
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Minnesota
Hypertension, Menopause, Premature
Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women
This is a cross-sectional study in which the investigators will determine the impact of premature/early menopause on MSNA, BP and baroreflex sensitivity in younger (≤49 yr old) and older (≥50 yr old) women.
- Conditions
- Hypertension, Menopause, Premature, Menopause, Blood Pressure
- Trial name
- NCT04439370
- Testing
- Microneurography to measure muscle sympathetic nerve activity (MSNA), Baroreflex sensitivity testing, Sympathoexcitatory Maneuvers
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Anesthesia
Poke and a Placebo
To discover if a positive description of the procedure for an epidural can reduce the overall pain score associated with the procedure.
- Trial name
- NCT04497220
- Testing
- Negative Connotation Langauge, Positive Connotation Language
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Lymphoma
Neurotoxicity Prophylaxis With Intrathecal Dexamethasone and Simvastatin Post Axi-Cel
Open-label, single-arm, single center pilot study to assess safety and feasibility of administering dexamethasone intrathecally and simvastatin orally during axicabtagene ciloleucel (axi-cel) treatment.
- Trial name
- NCT04514029
- Testing
- Simvastatin, Dexamethasone
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Premature Infant
Ultrasound Assessment of BC in the NICU
The overall objective of the proposal is to evaluate the ability of ultrasound to predict and routinely (weekly) monitor changes in the body composition of healthy preterm infants in the neonatal intensive care unit (NICU) in…
- Trial name
- NCT03241082
- Testing
- ultrasound
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Minnesota
Healthy Subjects, Lean Trained Subjects
Training Effects on Fuel Metabolism
The investigators are interested in how skeletal muscle processes fat and how this may affect insulin resistance. This is an important question since insulin resistance predates and predicts type 2 diabetes.
- Conditions
- Healthy Subjects, Lean Trained Subjects, Overweight and Obesity
- Trial name
- TrainMeUpMN (NCT02150889)
- Testing
- Running Program, Yoga Program
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Rotator Cuff Tears
Tuberoplasty Versus Balloon Spacer
The purpose of this study is to examine bone-to-bone contact between the tuberosity as compared to a subacromial balloon spacer procedure.
- Trial name
- NCT06735170
- Testing
- biologic tuberoplasty, subacromial balloon spacer
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Minnesota
Central Airway Obstruction
To Investigate Airway Oxygen Concentrations During Rigid Bronchoscopy Procedures Performed With High Frequency Jet Ventilation
Thermal ablation (use of treatment modalities that generate heat) has become a widely used tool for treatment of central airway obstruction (e.g. laser, electrocautery, radiofrequency, and argon plasma coagulation).
- Trial name
- NCT05881863
- Testing
- No intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Minnesota
Adenocarcinoma of Pancreas
Adenovirus (RGDCRAdCOX2F)
This is a single center, Phase I dose finding study of a single direct tumor injection of an RGD modified conditionally replicative adenovirus (RGDCRAdcox2F) in persons with adenocarcinoma of the pancreas.
- Trial name
- NCT06693986
- Testing
- Replicative Adenovirus Vector (RGDCRAdCOX2F)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Epidural Placement
CompuFlo CathCheck
The purpose of this study is to determine if the Compuflo CathCheck system is equivalent to an epidurogram in determining epidural catheter location (in or outside the epidural space), using the epidurogram as the gold standard.
- Trial name
- NCT06460155
- Testing
- 3 methods intervention
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Minnesota
Breast Cancer
Physical Rehabilitation Evaluation and Optimal Physical Therapy (PRE-OPT)
Phase 1: The investigators will conduct a prospective study to quantify the association between axillary web syndrome (AWS) and metastatic disease and chronic morbidities such as lymphedema, shoulder dysfunction, and pain…
- Trial name
- NCT04225572
- Testing
- Physical Therapy: Dependent on Patient's Needs
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Child Sexual Abuse
Tertiary Prevention of Child Sexual Abuse
This is a feasibility study designed to inform the development of a multinational study of the effectiveness of a tertiary prevention program for child sexual abuse.
- Trial name
- NCT06126926
- Testing
- group therapy, Treatment as usual
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Minnesota
Temporomandibular Disorder, TMJ Disc Displacement With Reduction
Telerehabilitation for TMD
This study will compare after physical therapy for Temporomandibular Disorders (TMD) performed either in-person or virtually using telerehabilitation.
- Conditions
- Temporomandibular Disorder, TMJ Disc Displacement With Reduction, TMJ Disc Displacement Without Reduction, Masticatory Myofascial Pain
- Trial name
- NCT05318313
- Testing
- Telerehabilitation
- Where
- United States
- Volunteers
- 207 people
- Sponsor
- University of Minnesota
Primary Graft Failure, Secondary Graft Failure
Treatment of Graft Failure After Hematopoietic Stem Cell Transplantation
This is a guideline for the treatment of graft failure after hematopoietic stem cell transplant (HSCT). This regimen, consisting of cyclophosphamide and fludarabine with low dose total body irradiation (TBI) is designed to…
- Trial name
- NCT02161783
- Testing
- Fludarabine, Cyclophosphamide, Total Body Irradiation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Acute Myeloid Leukemia, Acute Lymphocytic Leukemia
Trial Evaluating MGTA-456 in Patients With High-Risk Malignancy
This is an single arm, open label, interventional phase II trial evaluating the efficacy of umbilical cord blood (UCB) hematopoietic stem and progenitor cells (HSPC) expanded in culture with stimulatory cytokines (SCF, Flt-3L…
- Conditions
- Acute Myeloid Leukemia, Acute Lymphocytic Leukemia, Biphenotypic/Undifferentiated Leukemia, Chronic Myelogenous Leukemia
- Trial name
- NCT03674411
- Testing
- Fludarabine (FLU), Cyclophosphamide (CY), Total Body Irradiation (TBI)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Trigeminal Neuralgia, Temporomandibular Disorder
Comorbid Painful TMD Among Trigeminal Neuralgia
An observational study following up with trigeminal neuralgia patients to understand their comorbid facial pain condition, specifically temporomandibular disorder.
- Conditions
- Trigeminal Neuralgia, Temporomandibular Disorder, Myofascial Pain, Trigeminal Neuropathy
- Trial name
- TNTMD (NCT05914558)
- Testing
- Clinical appointment
- Where
- 2 sites in United States
- Sponsor
- University of Minnesota
Acute Leukemia, Myelodysplastic Syndromes
PTCy + Sirolimus/VIC-1911 as GVHD Prophylaxis in Myeloablative PBSC Transplantation
This is a single-arm, phase I/II, study of PTCy/sirolimus plus VIC-1911 to prevent GVHD and relapse after Allogeneic Hematopoietic Cell Transplantation (alloHCT).
- Conditions
- Acute Leukemia, Myelodysplastic Syndromes, Myeloproliferative Neoplasm, Lymphoma
- Trial name
- NCT05120570
- Testing
- VIC- 1911
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Caregiver Burden, Caregiver Stress Syndrome
Traumatic Brain Injury and Alzheimer's Disease/Related Dementias Caregiver Support Intervention
The TBI-AD/ADRD Caregiver Support Intervention (TACSI) incorporates psychosocial and psychoeducational approaches with the objective of: a) identifying stressors associated with caregiving for family members who have the dual…
- Conditions
- Caregiver Burden, Caregiver Stress Syndrome, Caregiver Burnout
- Trial name
- TACSI (NCT05465109)
- Testing
- TBI-AD/ADRD Caregiver Support Intervention (TACSI)
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Relapsed Neuroblastoma, Metastatic Pheochromocytoma
MIBG for Refractory Neuroblastoma and Pheochromocytoma
This is a best available therapy/compassionate use single institution study designed to determine the palliative benefit and toxicity of 131I-MIBG in patients with progressive neuroblastoma and metastatic pheochromocytoma who are…
- Trial name
- NCT01850888
- Testing
- 131 I-Metaiodobenzylguanidine (131I-MIBG), Potassium iodide solution, G-CSF
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
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