Clinical trials: sponsored by University of Minnesota
Covid19, SARS-CoV Infection
COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19)
1. The purpose of this trial is to conduct a 2x3 factorial randomized trials, which efficiently allows the parallel conduct of three randomized trials to understand whether metformin, ivermectin, or fluvoxamine, is superior to…
- Trial name
- NCT04510194
- Testing
- Metformin, Fluvoxamine, Ivermectin
- Where
- 7 sites in United States
- Volunteers
- 1,323 people
- Sponsor
- University of Minnesota
Type2Diabetes
TRE in Type 2 Diabetes (See Food Study 3)
Hyperglycemia in patients with Type 2 Diabetes Mellitus is initially treated with metformin coupled with intentional caloric restriction, which is difficult to sustain due to multiple barriers, including acquiring the necessary…
- Trial name
- SFS3 (NCT05290246)
- Testing
- Time restricted eating, Caloric reduction
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Alzheimer Disease, Dementia
Utilizing Senior Companions to Enhance Dementia Care
The inability of healthcare systems to effectively manage Alzheimer's disease and related dementias (ADRD) often results in families remaining unaware of important community-based, long-term services and supports (LTSS) that…
- Trial name
- NCT03667924
- Testing
- PorchLight Project
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Social Stress, Adolescent Behavior
Neural Correlates of the Shift in Social Buffering of Social Evaluative Threat
The purpose of this experiment is to determine the mechanisms through which parental buffering of stress physiology in response to social evaluative threat diminishes with pubertal development and whether this diminution of…
- Trial name
- NCT04211155
- Testing
- Questionnaires, MRI
- Where
- United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Spinal Cord Injuries, Neuropathic Pain
Brivaracetam to Reduce Neuropathic Pain in Chronic SCI: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Spinal cord injury (SCI) is associated with severe neuropathic pain that is often refractory to pharmacological intervention. Preliminary data suggest brivaracetam is a mechanism-based pharmacological intervention for neuropathic…
- Trial name
- NCT05639946
- Testing
- brivaracetam
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Minnesota
Self-Injurious Behavior, Deliberate Self-Harm
A Study Examining Adolescents With Non-Suicidal Self-Injury
This study will examine longitudinal brain development in young adolescent girls with a history of Non-Suicidal Self-Injury (NSSI).
- Trial name
- RDoC (NCT02947308)
- Where
- 3 sites in United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Suicide, Attempted, Suicide, Ideation
Teen Brain Training (TBT)
A non invasive treatment study including participants at risk for suicide attempts and undergoing neurofeedback training. Neurofeedback is controlling your brain activity in real time inside the scanner.
- Conditions
- Suicide, Attempted, Suicide, Ideation, Depression
- Trial name
- NCT06183580
- Testing
- neurofeedback training involving dACC, neurofeedback training involving amygdala
- Where
- United States
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Tobacco Use
Sugars in Cigarettes
The aim of this study is to investigate the impact of sugar levels in cigarette tobacco on cigarette abuse liability and appeal.
- Trial name
- NCT05308316
- Testing
- Cigarettes with added sucrose
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Hearing Loss
A System and Process to Improve the Satisfaction With Hearing Health Products
Innovative Design Labs Inc. (IDL) and its collaborators, proposes to create a cloud-based system which integrates advances and techniques from Health and Wellness Coaching (HWC) into the Hearing Aid (HA) fitting and trial process.
- Trial name
- NCT04926636
- Testing
- Health and Wellness Coaching
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Minnesota
Behavior Problem, Behavior, Child
Effectiveness of an Online Parenting Training
Child and adolescent behavioral health problems are related to the leading causes of youth morbidity and mortality. Parent-focused preventive interventions, such as GenerationPMTO (GenPMTO), effectively prevent behavioral health…
- Conditions
- Behavior Problem, Behavior, Child, Parents, Parent-Child Relations
- Trial name
- NCT05111886
- Testing
- Communication Skills Training, eHealth GenPMTO, Written Referral Process
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Alopecia Areata
DPCP for the Treatment of Alopecia Areata
This is an open labeled study to determine the response and characteristics, safety and efficacy, of the proprietary DPCP ointment composition as a topical immunotherapeutic agent for the treatment of extensive alopecia areata.
- Trial name
- NCT03651752
- Testing
- Diphenylcyclopropenone (DPCP) Ointment
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Minnesota
Acute Lymphoblastic Leukemia, Large B-cell Lymphoma
MT2017-45: CAR-T Cell Therapy for Heme Malignancies
This is a phase II study of FDA-approved CAR-T products for patients with hematologic malignancies. Patients will be assigned to Arm A and B based on age and diagnosis.
- Trial name
- NCT03642626
- Testing
- KYMRIAH, YESCARTA, Fludarabine 30mg/m2 4 doses
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Obesity
Prolonged Daily Fasting as a Viable Alternative to Caloric Restriction in At-Risk Obese Humans
Purpose: Obesity is reaching epidemic proportions, affecting 36% of the adult population in the United States. There is intense interest in dietary management to treat obesity and its associated complications.
- Trial name
- NCT04259632
- Testing
- Time Restricted Eating (TRE), Caloric Restriction (CR)
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- University of Minnesota
Social Stress, Adolescent Behavior
Affective Social Buffering
The purpose of this experiment is to determine the mechanisms through which parental buffering of stress physiology during affective stimulus presentation diminishes with pubertal development and whether this diminution of…
- Trial name
- NCT04312945
- Testing
- Questionnaires, MRI
- Where
- United States
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cystic Fibrosis, Cystic Fibrosis-related Diabetes
Semaglutide in CFRD
This open label, single arm pilot study, will examine the safety and tolerability of GLP-1RA semaglutide as an add-on therapy to insulin for overweight/obese adult patients with cystic fibrosis related diabetes (CFRD).
- Trial name
- NCT05788965
- Testing
- Semaglutide
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Minnesota
Acute Myeloid Leukemia, Acute Lymphocytic Leukemia
Trial Evaluating MGTA-456 in Patients With High-Risk Malignancy
This is an single arm, open label, interventional phase II trial evaluating the efficacy of umbilical cord blood (UCB) hematopoietic stem and progenitor cells (HSPC) expanded in culture with stimulatory cytokines (SCF, Flt-3L…
- Conditions
- Acute Myeloid Leukemia, Acute Lymphocytic Leukemia, Biphenotypic/Undifferentiated Leukemia, Chronic Myelogenous Leukemia
- Trial name
- NCT03674411
- Testing
- Fludarabine (FLU), Cyclophosphamide (CY), Total Body Irradiation (TBI)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Acute Leukemia, Myelodysplastic Syndromes
PTCy + Sirolimus/VIC-1911 as GVHD Prophylaxis in Myeloablative PBSC Transplantation
This is a single-arm, phase I/II, study of PTCy/sirolimus plus VIC-1911 to prevent GVHD and relapse after Allogeneic Hematopoietic Cell Transplantation (alloHCT).
- Conditions
- Acute Leukemia, Myelodysplastic Syndromes, Myeloproliferative Neoplasm, Lymphoma
- Trial name
- NCT05120570
- Testing
- VIC- 1911
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Acute Pain
Pec Infiltration With Liposomal Bupivacaine for Breast Surgery
The purpose of this study is to compare pain control after breast surgery using either liposomal bupivacaine or bupivacaine when infiltrated during an ultrasound guided pectoralis 1 and 2 block.
- Trial name
- NCT03599635
- Testing
- liposomal bupivacaine, Bupivacaine
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- University of Minnesota
Approach/Avoidance Behavior
Theta Phase-specific TMS to Modulate Prefrontal Activity
The purpose of this study is to evaluate the causal link between the phase of ongoing theta oscillations in the prefrontal cortex and approach/avoidance (Ap/Av) behavior in adults using theta phase-specific transcranial magnetic…
- Trial name
- NCT05416138
- Testing
- Transcranial magnetic stimulation (TMS)
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Aphasia, Non-fluent Aphasia
Combining tDCS and CILT in Non-fluent Aphasia
The long-term goal of this work is to determine if combining a highly intensive, task-specific behavioral language intervention with modulation of the efferent cerebellar-cortical pathway using transcranial direct current…
- Conditions
- Aphasia, Non-fluent Aphasia, Stroke, Brain Injuries
- Trial name
- NCT05561400
- Testing
- tDCS
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Minnesota