Clinical trials: sponsored by University of Minnesota
Childhood Cancer, Hematoietic Cell Transplant
Green Exercise for Cancer - Creating Opportunities for Survivors
The purpose of this study is to assess feasibility and acceptability for a trial to evaluate exercise behaviors, fatigue and exercise motivation in adolescent and young adult survivors of childhood cancer who participate in an…
- Trial name
- GECCOS (NCT03852758)
- Testing
- Outdoor Exercise, Indoor Exercise
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Minnesota
Tic Disorders, Tics
Transcranial Magnetic Stimulation to Augment Behavior Therapy for Tics
The study will examine whether combining Comprehensive Behavioral Intervention for Tics (CBIT) with inhibition of the supplementary motor area (SMA) using transcranial magnetic stimulation (TMS) normalizes activity in the…
- Conditions
- Tic Disorders, Tics, Tic, Motor, Tic Disorder, Childhood
- Trial name
- NCT04578912
- Testing
- Comprehensive Behavioral Intervention for Tics (CBIT), Repetitive Transcranial Magnetic Stimulation (rTMS), Continuous Theta Burst Stimulation (cTBS)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Minnesota
Sickle Cell Disease, Transfusion Dependent Alpha- or Beta- Thalassemia
Hematopoietic Stem Cell Transplant for High Risk Hemoglobinopathies
This is a study to collect the outcomes of stem cell transplantation for patients with hematologic diseases other than cancer.
- Conditions
- Sickle Cell Disease, Transfusion Dependent Alpha- or Beta- Thalassemia, Diamond Blackfan Anemia, Paroxysmal Nocturnal Hemoglobinuria
- Trial name
- NCT02179359
- Testing
- Reduced Toxicity Ablative Regimen, Reduced Intensity Preparative Regimen, Myeloablative Preparative Regimen
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Adolescent Behavior, Social Stress
Does Social Buffering Continue to be Effective Over the Peripubertal Period When Friends Share the Stressor Experience?
The purpose of this experiment is to determine whether social buffering by friends of stress physiology remains effective later in puberty when friends share the load versus when they provide support but are not undergoing the…
- Trial name
- NCT04311996
- Testing
- Friend and target, Friend support, unfamiliar peer and target
- Where
- United States
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Prematurity
Ultrasound, Peds Body Composition, and Neurodevelopmental Outcomes
The overall objective of the proposal is to evaluate the ability of ultrasound to predict the body composition of toddlers in the outpatient clinical setting and to evaluate the relationship between body composition and…
- Trial name
- NCT03479515
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Minnesota
Brain Tumor-Glioma
Spectroscopic Magnetic Resonance Imaging of Glioma
The study is designed to develop and test new Magnetic Resonance Imaging methods that can improve the characterization of brain cancer and facilitate improved clinical care of these participants.
- Trial name
- MEGA-PRESS (NCT03677999)
- Testing
- MEGA-PRESS sequence Magnetic Resonance Spectroscopy
- Where
- United States
- Sponsor
- University of Minnesota
Lichen Planopilaris of Scalp, Alopecia Areata
Mechanical Intervention on the Scalp Microbiome: Setting the Stage for the Future Management of Cicatricial Alopecias
The objective of this study is to assess the effect of standardized scalp care, specifically mechanical cleansing with the Venus Glow™ Device and water, on the scalp microbiome.
- Trial name
- NCT06357169
- Testing
- Venus Glow
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Secondary Progressive Multiple Sclerosis, Primary Progressive Multiple Sclerosis
ACTH in Progressive Forms of MS
This is a phase II, randomized, double-blind, placebo-controlled, multi-center study to evaluate the safety, tolerability, and efficacy of adrenocorticotropic hormone (ACTH, Acthar gel) administered as a pulsed regimen consisting…
- Conditions
- Secondary Progressive Multiple Sclerosis, Primary Progressive Multiple Sclerosis, Progressive Relapsing Multiple Sclerosis
- Trial name
- NCT01950234
- Testing
- ACTH
- Where
- 3 sites in United States
- Volunteers
- 59 people
- Sponsor
- University of Minnesota
Functional Dysphonia, Voice Disorders
Dysphonia, Distress, and Perceived Control: Technology Based Assessment and Intervention
The purpose of this study is to pilot test a version of the intervention that has been tailored for participants with dysphonia.
- Conditions
- Functional Dysphonia, Voice Disorders, Dysphonia
- Trial name
- NCT03576365
- Testing
- VOICE Intervention Arm, Information-Only Arm
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- University of Minnesota
Premature Birth
US and Neurodevelopmental Outcomes in the Neonatal Intensive Care Unit (NICU)
The objective of the project is to identify clinical factors (nutritional and non-nutritional) which are associated with ultrasound measurements of muscle and adipose tissue and to determine whether these ultrasound measurements…
- Trial name
- NCT05071508
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Minnesota
Stroke
Finding an Optimal Latency for Paired Associative Stimulation in People With Chronic Stroke
After a stroke, there is an exaggerated inhibitory influence from the non-stroke hemisphere to the stroke hemisphere. Brain stimulation using repetitive transcranial magnetic stimulation (rTMS) to the non-stroke hemisphere can…
- Trial name
- NCT02188420
- Testing
- Transcranial Magnetic Stimulation will be applied to the primary motor cortex at the interstimulus interval of ("Latency" - 3ms), Transcranial Magnetic Stimulation will be applied to the primary motor cortex at the interstimulus interval of ("Latency" - 5ms), ranscranial Magnetic Stimulation will be applied to the primary motor cortex at the interstimulus interval of ("Latency" - 7ms)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Minnesota
Right Ventricular Dysfunction
Hemodynamic Assessment of the Right Ventricle Using Pressure-volume Loop Catheter and Pulmonary Artery Catheter in Patients Undergoing Left Ventricular Assist Device Placement
This study will include the placement of a pressure volume (PV) loop catheter in the right atrium of patients undergoing left ventricular assist device (LVAD) placement and measure relevant PV loop data.
- Trial name
- NCT04478890
- Testing
- Hemodynamic assessment
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Minnesota
Pulmonary Disease, Chronic Obstructive
An Observational Study of Beta-Blocker Use in Patients With COPD and Acute MI
The study is a prospective, observational study of patients admitted to the BLOCK COPD network hospitals with acute AMI and Chronic Obstructive Pulmonary Disease (COPD) to determine the prevalence of COPD in patients admitted to…
- Trial name
- BLOCK2 (NCT04717492)
- Testing
- Observational
- Where
- 24 sites in United States
- Volunteers
- 584 people
- Sponsor
- University of Minnesota
Tobacco Toxicant Exposure
Metabolism of Deuterated NNN in Smokeless Tobacco Users
The purpose of this study is to better understand how people break down a tobacco specific cancer-causing toxin called N'-nitrosonornicotine (NNN) that is present in smokeless tobacco and cigarettes.
- Trial name
- NCT02414477
- Testing
- Deuterated NNN
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Opioid-use Disorder, Opioid Use
PRescribing INterventions for Chronic Pain Via the Electronic Health Record Study - Current Opioid-User Population
The objective of this research is to assess the effects of electronic health record (EHR)-based decision support tools on primary care provider (PCP) decision-making around pain treatment and opioid prescribing.
- Conditions
- Opioid-use Disorder, Opioid Use, Opioid Abuse
- Trial name
- PRINCE (NCT04601480)
- Testing
- Choice Architecture Nudge, PMP Integration & Nudge
- Where
- United States
- Volunteers
- 309 people
- Sponsor
- University of Minnesota
Acute Respiratory Distress Syndrome, ARDS (Moderate or Severe)
Multiple Dosing of Mesenchymal Stromal Cells in Patients With ARDS (COVID-19)
This is a multi-center, randomized, placebo controlled, interventional phase 2A trial to evaluate the safety profile and potential efficacy of multi-dosing of mesenchymal stromal cells (MSC) for patients with SARS-CoV-2…
- Conditions
- Acute Respiratory Distress Syndrome, ARDS (Moderate or Severe), COVID-19 Pneumonia
- Trial name
- NCT04466098
- Testing
- Mesenchymal stromal cells
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
SRP, Minocycline HCl Microspheres
Scaling and Root Planing (SRP) With and Without Minocycline HCl Microspheres, 1 mg
The primary goal of this study is to investigate the qualitative and quantitative effects of scaling and root planing (SRP) with and without minocycline HCL microspheres, 1 mg on periodontal pathogens and overall bacterial load.
- Conditions
- SRP, Minocycline HCl Microspheres, Biomarkers
- Trial name
- NCT03762915
- Testing
- minocycline HCl microspheres
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Premature Birth
Nasogastric/Orogastric Tube Placement Confirmation in Neonates Utilizing Self-contained pH Device, a Feasibility Study
This study is looking at using a self-contained pH device that will assist in confirming placement of a nasogastric or orogastric tube placed in the stomach of hospitalized infants.
- Trial name
- NCT06274944
- Testing
- nasogastric tube placement pH confirmation device
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Minnesota
Spasticity
Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment of Post-Stroke Spasticity
Spasticity is a common complication of stroke affecting quality of life. Spasticity involves exaggerated stretch reflexes that create stiffness in muscles with associated loss of motion and functional control.
- Trial name
- NCT02268461
- Testing
- repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Minnesota
Chronic Pancreatitis, Diabetes Mellitus
Intra-Portal Alone Versus Intra- and Extra-Portal Transplantation of Pancreatic Islets After Total Pancreatectomy for Chronic Pancreatitis
Randomized pilot trial of patients (n=30) undergoing Total Pancreatectomy and Islet AutoTransplant (TPIAT). Patients with islet harvest of greater than 5000 islet equivalents/kg body weight will be randomized to receive a portion…
- Conditions
- Chronic Pancreatitis, Diabetes Mellitus, Islet Cell Transplantation
- Trial name
- iSite (NCT03779139)
- Testing
- Intrahepatic islets and islets in the omental pouch, Intrahepatic islets alone, Normal Volunteers
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
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