Clinical trials: sponsored by University of Minnesota
Parkinson's Disease (PD), Deep Brain Stimulation
Coordinated Reset Deep Brain Stimulation for Parkinson's Disease
Deep brain stimulation (DBS) is a surgical implant procedure for the treatment of Parkinson's Disease (PD) utilizing medical devices approved by the FDA.
- Trial name
- CR DBS PD (NCT07340073)
- Testing
- DBS
- Volunteers
- 24 people
- Sponsor
- University of Minnesota
Preterm Birth, Very Preterm Infant
NICU-to-Home Dyadic Support for Very Preterm Infants and Families
This feasibility study will evaluate delivery of the Supporting Play Exploration and Early Development Intervention after neonatal intensive care unit discharge for very preterm infants and their families.
- Conditions
- Preterm Birth, Very Preterm Infant, Infant Development, Neonatal Intensive Care Unit
- Trial name
- MN-SPEEDI (NCT07820462)
- Testing
- Homebased SPEEDI, Telehealth SPEEDI
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Minnesota
Type 2 Diabetes Mellitus, Acute Kidney Injury
Clinical Decision Support for SGLT2i After AKI in Type 2 Diabetes
This pilot study will evaluate the feasibility of using a clinical decision support(CDS) message to support consideration of SGLT2 inhibitor prescribing in patients with type 2 diabetes who recently had acute kidney injury.
- Conditions
- Type 2 Diabetes Mellitus, Acute Kidney Injury, Chronic Kidney Diseases, SGLT2 Inhibitor Use
- Trial name
- NCT07868666
- Testing
- Clinical Decision Support Message
- Volunteers
- 250 people
- Sponsor
- University of Minnesota
Healthy
State Dependence of Prefrontal Transcranial Magnetic Stimulation
The study will examine whether the benefits of brain stimulation on mental functioning can be enhanced if an individual is actively engaging the target brain networks while receiving brain stimulation.
- Trial name
- NCT05962385
- Testing
- Brain state while receiving TMS
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Congenital Heart Disease, Cardiac Output
UltraTrac for Cardiac Output Monitoring in Congenital Heart Disease
This pilot feasibility study will evaluate UltraTrac, an investigational noninvasive wearable device for continuous cardiac output monitoring, in patients with congenital heart disease.
- Conditions
- Congenital Heart Disease, Cardiac Output, Hemodynamic Monitoring, Pediatric Heart Disease
- Trial name
- UltraTrac (NCT07866573)
- Testing
- UltraTrac
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Minnesota
Symptomatic Bradycardia, Cognitive Function
PACE Cognition Proof-of-Concept Study
This proof-of-concept study will evaluate whether physiologic pacemaker programming improves cognitive function and health status in patients with symptomatic bradycardia who require permanent pacemaker implantation.
- Conditions
- Symptomatic Bradycardia, Cognitive Function, Pacemaker, Health Status
- Trial name
- NCT07769424
- Testing
- Physiologic Pacemaker Programming, Standard Pacemaker Programming
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- University of Minnesota
Lennox Gastaut Syndrome (LGS), Epilepsy
Sleep-Driven Adaptive Neuromodulation in Lennox-Gastaut Syndrome
The goal of this clinical trial is to explore a new type of personalized brain stimulation that works during day time and night time hours using the Medtronic Percept Deep Brain Stimulation (DBS) device in patients with…
- Trial name
- ADAPT LGS (NCT07568860)
- Testing
- Personalized Adaptive Deep Brain Stimulation Therapy, Conventional Non-Personalized Deep Brain Stimulation Therapy
- Volunteers
- 4 people
- Sponsor
- University of Minnesota
Grip Strength, Hand Strength
Tyrannosaurus Flex: Finding the "Fair-ly Normal" Grip
The purpose of this study is to evaluate the performance of the Dinomometer and establish normative data to inform clinical standards and benchmarks for therapeutic practice.
- Trial name
- NCT07735195
- Testing
- Dinomometer
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Kidney Transplant; Complications, CMV
CMVIG Prophylaxis in Belatacept Conversion Kidney Transplant Recipients
The purpose of this study is to study how CMVIG interacts with the body and to see if it might work to prevent kidney transplant patients from becoming infected with CMV.
- Trial name
- NCT07096453
- Testing
- Cytogam
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Pain, Procedural Pain
E-MOHS Trial of TENS and Vibration During Local Anesthesia
The E-MOHS Trial is a randomized controlled trial evaluating whether active vibration plus transcutaneous electrical nerve stimulation reduces pain during local anesthetic infiltration in adults undergoing Mohs micrographic…
- Conditions
- Pain, Procedural Pain, Local Anesthesia, Mohs Surgery
- Trial name
- E-MOHS (NCT07852455)
- Testing
- Active Vibration:TENS
- Where
- 3 sites in United States
- Volunteers
- 90 people
- Sponsor
- University of Minnesota
Lymphatic Diseases, Hematopoietic Malignancy
Infusion of Cell Populations From Unlicensed Umbilical Cord Blood Units
For the next 5-10 years or possibly longer, a high proportion of the Cord Blood Banks (CBB) inventory worldwide will be composed of unlicensed umbilical cord blood (UCB) units.
- Trial name
- NCT01451502
- Testing
- Umbilical Cord Blood (UCB)
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
CKD
Effects of Dietary Phosphorus on Phosphorus and Calcium Whole-Body Balance and Kinetics in Moderate CKD
The aim of the study is to look at the effects of dietary phosphorus on phosphorous and calcium whole-body balance and kinetics in moderate chronic kidney disease (CKD).
- Trial name
- NCT06712719
- Testing
- LP then HP, HP then LP
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Minnesota
Histoplasmosis
Histoplasmosis Induction and Consolidation Therapy Factorial Randomized Clinical Trial (Histo-FACT)
The purpose of the study is threefold: 1. Assess the safety and efficacy of a single high-dose intravenous (LAmB 10mg/kg) compared to the SOC daily dosing (3mg/kg) of the same medication for induction therapy in moderate to…
- Trial name
- NCT07261150
- Testing
- LAmB B, Posaconazole, World Health Organization (WHO)-recommended SOC
- Where
- 2 sites in United States, Brazil
- Volunteers
- 664 people
- Sponsor
- University of Minnesota
Traumatic Brain Injury, Venous Thromboembolism
Evaluation of the SCALED (SCaling AcceptabLE cDs)
This project will adapt a currently deployed Clinical Decision Support (CDS) system to deliver a VTE prevention guideline for adult patients with traumatic brain injury (TBI).
- Trial name
- NCT05628207
- Testing
- Observational, Observational-control
- Where
- United States
- Volunteers
- 15,000 people
- Sponsor
- University of Minnesota
Diabetic Foot Ulcer, Diabetes Mellitus
Total Contact Soft Cast in Diabetic Foot Ulcers
To determine the effectiveness, compliance, patient tolerance, ease of use and safety of total contact soft cast in diabetic foot ulcers.
- Conditions
- Diabetic Foot Ulcer, Diabetes Mellitus, Foot Ulcer, Foot Ulcer, Diabetic
- Trial name
- NCT04210089
- Testing
- Total Contact Soft Cast, Cam Boot
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Minnesota
Schizophrenia, Schizoaffective Disorder
NEURO-COGS: Neurometabolic Mechanisms of Cognitive Training in Schizophrenia
This study will examine brain metabolic and excitatory/inhibitory mechanisms related to cognitive and visual functioning in adults with schizophrenia and healthy control participants.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Cognitive Impairment, Visual Impairment
- Trial name
- NCT07788755
- Testing
- Perceptual Discrimination Training, Cognitive Control Training
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Healthy Volunteers
Sustained Release Oral Formulation For Treatment Of Parkinsons Disease
LD/CD (medications to treat Parkinson's disease) will be delivered using an assembly of nested sachets made of permeable material.
- Trial name
- NCT07709741
- Testing
- Formulation A, Formulation B, Formulation C
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cervical Dystonia
Effect of Vibro-tactile Stimulation Intensity on Head Posture in Cervical Dystonia
The primary goal of this clinical trial is to examine the effects of cervical vibrotactile stimulation intensity on abnormal head posture in people with cervical dystonia.
- Trial name
- (CD-VTS) (NCT07245615)
- Testing
- cervical vibrotactile stimulation
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
NASH - Nonalcoholic Steatohepatitis
Vertical Sleeve Gastrectomy and Lifestyle Modification for the Treatment of Non-Alcoholic Steatohepatitis
Participants meeting study entry criteria are randomized with equal probability to one of two study groups: (1) Lifestyle modification or (2) Vertical Sleeve Gastrectomy (VSG) with Iifestyle modification, followed for 12 months.
- Trial name
- NCT03587831
- Testing
- Vertical Sleeve Gastrectomy, Lifestyle Modification Counseling
- Where
- 4 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Metastatic Breast Cancer, Ovarian Cancer
Assessing the Time Demands of Cancer
A total of 80 individuals receiving treatment for metastatic breast or advanced stage ovarian cancer will be asked to complete a baseline survey and install the mobile app on their smartphone; carry the smartphone for 28…
- Trial name
- NCT05708703
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
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