Clinical trials: sponsored by University of Minnesota
Healthy
Effect of Aspirin on Gut Microbiome
Regular use of aspirin may reduce the incidence of colorectal cancer (CRC). However, it is unclear through which mechanism aspirin exerts its effect, in whom it decreases CRC risk and in whom it causes side effects.
- Trial name
- ASMIC (NCT02761486)
- Testing
- Aspirin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Marijuana Dependence
Hormones and Reduction in Co-users of Marijuana and Nicotine
The purpose of this study is to examine the role of progesterone (a naturally occurring hormone found in both men and women) on reducing marijuana use.
- Trial name
- NCT02579421
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Pulmonary Arterial Hypertension
Beta-blockers in Pulmonary Arterial Hypertension
The investigators will conduct a, randomized, phase 2, placebo-controlled, double-blinded, crossover trial of carvedilol in 26 PAH patients with World Health Organization functional class II or III symptoms and RV ejection…
- Trial name
- NCT02507011
- Testing
- Carvedilol
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Minnesota
Cryptococcal Meningitis, Fungal Meningitis
Adjunctive Sertraline for the Treatment of HIV-Associated Cryptococcal Meningitis
This is a phase III trial to determine whether adjunctive sertraline will lead to improved survival 18-week survival. There was an initial phase I/II unmasked dose finding pharmacokinetic study of CSF concentrations in 172…
- Trial name
- ASTRO-CM (NCT01802385)
- Testing
- Sertraline
- Where
- 2 sites in Uganda
- Volunteers
- 460 people
- Sponsor
- University of Minnesota
Cryptococcal Meningitis, HIV Infections
Cryptococcal Optimal ART Timing Trial
The Cryptococcal Optimal ART Timing (COAT) trial seeks to determine after cryptococcal meningitis (CM) whether early initiation of antiretroviral therapy (ART) prior to hospital discharge results in superior survival compared to…
- Conditions
- Cryptococcal Meningitis, HIV Infections, AIDS
- Trial name
- COAT (NCT01075152)
- Testing
- efavirenz, nucleoside
- Where
- 3 sites in South Africa, Uganda
- Volunteers
- 177 people
- Sponsor
- University of Minnesota
Cryptococcosis, Cryptococcal Infections
Cryptococcal Antigen Screening Plus Sertraline
Cryptococcal meningitis or "Crypto" is a life threatening fungal infection around the brain that requires hospitalization for treatment for 14 days and then continued therapy.
- Conditions
- Cryptococcosis, Cryptococcal Infections, AIDS-Related Opportunistic Infections
- Trial name
- C-ASSERT (NCT03002012)
- Testing
- Sertraline, Fluconazole
- Where
- Uganda
- Volunteers
- 22 people
- Sponsor
- University of Minnesota
HIV Infections
Investigating the Anti-Human Immunodeficiency Virus (HIV) & Anti-inflammatory Effect of Chloroquine
Summary: Chloroquine is a medication that in laboratory settings has significant anti-HIV effects in HIV infected T-cells. Chloroquine has been used safely for over 60 years for malaria treatment and prevention, and it also has…
- Trial name
- NCT00308620
- Testing
- chloroquine phosphate
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Minnesota
Cryptococcal Meningitis, Cryptococcus Neoformans
Operational Research for Cryptococcal Antigen Screening
This will be a stepped wedge randomized trial design to evaluate the implementation of cryptococcal antigen (CRAG) screening and preemptive anti-fungal therapy of HIV-infected persons entering antiretroviral therapy (ART)…
- Conditions
- Cryptococcal Meningitis, Cryptococcus Neoformans, Cryptococcosis
- Trial name
- ORCAS (NCT01535469)
- Testing
- Fluconazole
- Where
- 2 sites in Uganda
- Volunteers
- 3,049 people
- Sponsor
- University of Minnesota
Lyme Disease
Passive Prophylaxis of Lyme Disease Using Permethrin Treated Clothes
Hypothesis: Does treatment of lower extremity clothing with permethrin prevent Lyme disease? This is a double-blind, randomized clinical trial using permethrin treatment of clothing to prevent Lyme disease.
- Trial name
- NCT00958139
- Testing
- Permethrin
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Acute Myeloid Leukemia, Myelodysplastic Syndrome
NK Cell Based Non-Myeloablative Transplantation in Acute Myeloid Diseases
This is a phase II multi-institutional therapeutic study of NK-cell based nonmyeloablative haploidentical transplantation for the treatment of high-risk acute myeloid diseases. Enrollment will use a two-stage design.
- Trial name
- NCT01370213
- Testing
- Preparative Regimen, NK Cells, Interleukin-2
- Where
- 4 sites in United States
- Volunteers
- 25 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Kidney Cancer, Leukemia
Allogeneic Bone Marrow Transplantation Using Less Intensive Therapy
RATIONALE: A peripheral stem cell transplant may be able to replace blood-forming cells that were destroyed by chemotherapy and radiation therapy, or that have become cancer.
- Conditions
- Kidney Cancer, Leukemia, Lymphoma, Multiple Myeloma
- Trial name
- NCT00303719
- Testing
- anti-thymocyte globulin, cyclophosphamide, cyclosporine
- Where
- United States
- Volunteers
- 342 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
PANS, PANDAS
Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS): Clinical Characterization and Prospective Course
This study is a brief (3 month) longitudinal study following children between the ages of 4-16 years old who have been diagnosed with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS).
- Trial name
- NCT04382716
- Testing
- No intervention
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Minnesota
Peripheral Artery Disease
Community Walking Exercise for Patients With Peripheral Artery Disease
The primary aim of the study is to determine the effect of a community-based walking exercise program with detailed training, monitoring, and coaching (TMC) exercise components enhanced by community-based participatory research…
- Trial name
- GAIT (NCT02075502)
- Testing
- Exercise therapy, lower extremity ET, peripheral open intervention
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Minnesota
Metastatic Prostate Cancer
Phase II Study of Sipuleucel-T and Indoximod for Patients With Refractory Metastatic Prostate Cancer
This is a randomized, double blind, multi-institutional phase II therapeutic study of Indoximod or placebo after the completion of standard of care sipuleucel-T (Provenge®) in men with asymptomatic or minimally symptomatic…
- Trial name
- NCT01560923
- Testing
- Indoximod, Sipuleucel-T
- Where
- 4 sites in United States
- Volunteers
- 47 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Obesity Complicating Childbirth
Pregnancy Weight Tracking Pilot Project
This pilot study will examine perceptions about daily weighing for pregnant women with overweight or obesity by testing the feasibility, acceptability, and preliminary efficacy of daily weighing for reducing excess gestational…
- Trial name
- PTRK (NCT03652766)
- Testing
- Daily Weight Tracking
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Adolescent Depression
An Adaptive Treatment Strategy for Adolescent Depression-Continuation
Aim 1: Assess the feasibility and acceptability of the personalized continuation treatment strategy. Aim 2: Estimate variances of primary and secondary outcomes with the continuation treatment.
- Trial name
- PTAD GIA (NCT02017535)
- Testing
- Fluoxetine, Interpersonal Psychotherapy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Minnesota
Hurler Syndrome
Administration of IV Laronidase Post Bone Marrow Transplant in Hurler
This is a single center pilot study in which Laronidase will be given weekly for two years in patients with Hurler syndrome, also known as mucopolysaccharide IH (MPS I, Hurler syndrome), that have previously been treated with an…
- Trial name
- NCT01173016
- Testing
- Laronidase
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Diffuse Intrinsic Pontine Glioma
Imiquimod/Brain Tumor Initiating Cell (BTIC) Vaccine in Brain Stem Glioma
This is a pilot/feasibility study. The study design represents a modification of current standard of care for Diffuse Intrinsic Pontine Glioma (DIPG) (5580 cGY involved field radiation), with the final two doses of radiation…
- Trial name
- NCT01400672
- Testing
- Tumor Lysate Vaccine, Imiquimod, Radiation therapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Heart Failure
Stem Cell Therapy in Patients With Severe Heart Failure & Undergoing Left Ventricular Assist Device Placement
The purpose of this study is to determine if the delivery of cells just after implantation of left ventricular assist device will help to improve the pumping function of your heart and minimize heart enlargement in the future.
- Trial name
- ASSURANCE (NCT00869024)
- Testing
- Intramyocardial Delivery of Bone Marrow Derived Mononuclear Cells
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Minnesota
Stroke
Correlation Analysis Between Brain Lesions and Sensorimotor Impairments in Individuals With Stroke (Preliminary Study)
The objective of the preliminary study is: 1. To identify correlations between brain lesions and sensorimotor impairments in stroke. 2.
- Trial name
- NCT02465281
- Testing
- Device: 3T scanner with MRI-compatible robot
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
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