Clinical trials: sponsored by University of Nebraska
Breast Cancer, Breast Neoplasm Female
Study on Physical Activity's Relationship With Cancer and Cognition
This pilot study tests the effects of aerobic exercise training on cognitive function in breast cancer survivors (BCS). Participants will be randomized to a 12-week walking intervention or usual care.
- Trial name
- SPARCC (NCT03980626)
- Testing
- Walking
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Nebraska
Breast Cancer, Breast Neoplasm Female
High-intensity Exercise After Treatment
This pilot study tests the feasibility and preliminary efficacy of an 8-week, 3-arm pilot exercise trial in which 45 breast cancer survivors will be randomized to high-intensity interval training (HIIT; n=15), moderate-intensity…
- Trial name
- HEAT (NCT04950010)
- Testing
- High-Intensity Interval Training, Moderate-Intensity Exercise
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Nebraska
Cardiac Disease
Impact of High Mechanical Index Ultrasound Impulses on Left Ventricular Stroke Volume With Intravenous Microbubbles
This study will investigate whether applying high mechanical index (MI) impulses from a diagnostic ultrasound transducer when using ultrasound enhancing agent (UEA) microbubble infusion will result in subclinical improvement in…
- Trial name
- MI (NCT05700032)
- Testing
- high MI impulses, low MI impulses
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nebraska
Glenohumeral Dislocation
Time to Diagnosis of Glenohumeral Joint Dislocations in the ED- Traditional Radiography vs. POC Ultrasound
This is study to compare the time to diagnosis of glenohumeral joint dislocation using two imaging methods, traditional x-ray and point-of-care ultrasound.
- Trial name
- NCT05237167
- Testing
- Shoulder reduction
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nebraska
White Spot Lesion
Effectiveness of Resin-Modified Glass Ionomer Varnish in Preventing White Spot Lesions in Fixed Appliance Orthodontia
This is a prospective study to determine the effects of resin-modified glass ionomer (RMGI) on the prevention of white spot lesion (WSL) development during fixed appliance orthodontic treatment.
- Trial name
- NCT03711097
- Testing
- Vanish XT Dental Varnish
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nebraska
Hematologic Neoplasms
Immunological Parameters, Neurocognitive Changes, Activity, & Driving Fitness in Patients Undergoing CAR-T Cell Therapy
Chimeric antigen receptor (CAR) T-cell therapy is a promising new treatment that re-programs patient immune cells to target and destroy cancer cells.
- Trial name
- NCT04275154
- Sponsor
- University of Nebraska
Brain Neoplasms
Multi-modality Localization of Eloquent Brain Function
Accurate identification of areas of eloquent brain function is vital to surgical decision making and to preservation of independence as patients with brain tumors who are higher functioning have better survival outcomes.
- Trial name
- NCT02795338
- Testing
- brain mapping
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nebraska
Atopic Dermatitis
Treatment of Nighttime Pruritus in Atopic Dermatitis
This study will look at melatonin vs. first generation antihistamine vs. placebo in improving nighttime itching in children with atopic dermatitis.
- Trial name
- NCT03688464
- Testing
- Melatonin, Diphenhydramine
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nebraska
Carbon Monoxide Poisoning, Chronic Encephalopathy
Hyperbaric Oxygen for Carbon Monoxide Induced Chronic Encephalopathy
In some patients, a few days or weeks after recovery from carbon monoxide poisoning, new symptoms develop. These can affect mood, ability to think or remember clearly, and movements.
- Trial name
- HACMICE (NCT04118491)
- Sponsor
- University of Nebraska
Amniotic Band Syndrome, Upper Extremity Deformities, Congenital
Assessment of Neural and Motor Performance
The neural basis underlying motor performance in children using a prosthesis has been severely understudied resulting in minimal empirical evidence.
- Trial name
- NCT04241588
- Testing
- 3D Printed Upper-limb Prosthesis, Control
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nebraska
Coronary Microvascular Disease, Cardiac Pacemaker Syndrome
The Effects of Trans Venous Cardiac Pacing on Coronary Microvascular Function and Hemodynamics
The study will examine role of transvenous pacing on coronary microcirculation.
- Trial name
- NCT03917251
- Testing
- Coronary flow and pressure measurement in patients with ventricular pacing
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nebraska
Pediatric Obesity
Packaging Building Healthy Families for Community Implementation
There is a large body of literature regarding efficacious intervention strategies for treating childhood obesity. Unfortunately, the degree to which efficacious programs have been packaged for translation in micropolitan and…
- Trial name
- NECORD (NCT04719442)
- Testing
- Building Healthy Families
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nebraska
Leukemia
Donor Enriched Activated NK Cell Infusion Post Haploidentical Stem Cell Transplant for Refractory Myeloid Malignancies
Patients with relapse refractory myeloid malignancies have no therapeutic options for long term remission. Some success has been achieved in treating patients with refractory relapsed acute myeloid leukemia (AML) in using…
- Trial name
- NCT05375253
- Testing
- Donor Enriched Activated Natural Killer Cell Infusion
- Sponsor
- University of Nebraska
Gait Disorders, Neurologic
Variable Visual Stimulus as a Novel Approach for Gait Rehabilitation
Deterioration in walking performance as a result of disease or simply as a result of aging is a serious threat to independence in older adults.
- Trial name
- VISNA (NCT03737331)
- Testing
- Fractal visual cueing, Periodic visual cueing, Random visual cueing
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Headache Disorders
Capsaicin in Treatment of Rhinogenic Headache
Description: Capsaicin (8- methyl-N-vanillyl-6-nonenamide) has been demonstrated to have a therapeutic effect in idiopathic rhinitis.
- Trial name
- NCT03330639
- Testing
- Capsaicin
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nebraska
UVeitis, Glaucoma
Factors Affecting Aqueous Humor Outflow Facility in Patients with Uveitis
Objective: To determine the clinical variables that influence aqueous outflow facility (Co) and intraocular pressure (IOP) in uveitis. Uveitic glaucoma is potentially blinding and occurs in 17-46% of chronic uveitis patients.
- Trial name
- NCT02613442
- Sponsor
- University of Nebraska
Peripheral Artery Disease, Peripheral Arterial Disease
Effects of Tetrahydrobiopterin (BH4) on Leg Blood Flow and Exercise Capacity in Patients With Peripheral Artery Disease
Nitric oxide has been shown to be an important regulator within the cardiovascular system, responsible for regulation of blood flow, blood pressure and vascular growth.
- Trial name
- NCT03493412
- Testing
- Sapropterin Dihydrochloride (BH4, tetrahydrobiopterin)
- Sponsor
- University of Nebraska
Periodontitis, Adult, Inflammation Gum
Effect of Local Cannabidiol on Clinical and Inflammatory Outcomes in Periodontal Maintenance Patients.
This study will determine if cannabidiol (CBD) has any effect on local inflammation in periodontal maintenance patients. Many successful therapies exist for the active, untreated periodontal patient.
- Trial name
- NCT05646459
- Testing
- cannabidiol, floss, proxabrush
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nebraska
Ankle Sprains, Ankle Injuries and Disorders
Agreement Between Clinician and Instrumented Laxity Assessment
Ankle injuries are the most common acute injury to the active population. It is important to ensure best practices and techniques used in clinics for evaluation are validated and consistent.
- Trial name
- NCT03309098
- Testing
- Ligmaster Arthrometer Assessment
- Sponsor
- University of Nebraska
Chronic Kidney Diseases
Pilot Study- Treat to Target Vitamin D in End Stage Renal Disease
Feasibility of dose adjustment to reach a 6 month 25-hydroxy vitamin D level of 35-50 ng/ml in end stage renal disease patients
- Trial name
- NCT04167111
- Testing
- Cholecalciferol
- Sponsor
- University of Nebraska