Clinical trials: open to volunteers, sponsored by University of Nebraska
Healthy Young Adults
Development of a Real-time Controller to Estimate Walking Performance Using a Bilateral Ankle Exoskeleton
This study is developing and testing a new controller for a robotic ankle exoskeleton (Biomotum) that can adjust itself in real time to better support people while they walk.
- Trial name
- NCT07393971
- Testing
- Adaptive Torque Control System for Ankle Exoskeleton
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Diffuse Large B-Cell Lymphoma
MRD-Adapted Low-Dose Radiation Therapy During Frontline Chemoimmunotherapy for Diffuse Large B-Cell Lymphoma
This prospective Phase IIA feasibility study evaluates a minimal residual disease (MRD)-adapted treatment strategy in patients with diffuse large B-cell lymphoma (DLBCL) receiving frontline R-chemoimmunotherapy.
- Trial name
- MRD-XRT (NCT07517705)
- Testing
- Low-Dose Radiation Therapy (LDRT), Standard Frontline Chemoimmunotherapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Nebraska
Breast Cancer by AJCC V8 Anatomic Stage, Breast Cancer
De-escalation of Axillary Dissection for Node-positive Breast Cancer
Recent studies have demonstrated the safety of de-escalation of nodal surgery for clinically node-positive breast cancer patients after a favorable response to neoadjuvant systemic therapy (NST).
- Trial name
- NCT07856160
- Testing
- TAD, ALND
- Volunteers
- 20 people
- Sponsor
- University of Nebraska
Prostate Cancer, Prostate Adenocarcinoma
Whole Versus Partial Gland Boost During Prostate SBRT
The purpose of this randomized phase II trial is to compare dose escalation of the prostate versus the dominant intra-prostatic lesion in a reduced fraction radiation therapy regimen.
- Trial name
- NCT07574489
- Testing
- Prostate stereotactic body radiotherapy with whole gland boost, Prostate stereotactic body radiotherapy with DIL boost
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- University of Nebraska
Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
Testosterone-Informed De-Escalation in Metastatic Prostate Cancer (TIDE PC)
The purpose of this study is to use androgen deprivation therapy (ADT) intermittently in hopes of reducing side effects from ADT and reducing unnecessary dosing of ADT in adult men with a prolonged response to frontline therapy…
- Trial name
- NCT07904026
- Testing
- Androgen Deprivation Therapy (ADT), Androgen Receptor Pathway Inhibitors (ARPIs)
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Nebraska
Stress
Intranasal Oxytocin Intervention for Caregivers to Persons With Dementia
More than 15 million family caregivers provide support for individuals with Alzheimer's disease (AD) or related dementias. This number is expected to grow with the increasing population of persons with dementia (PWD).
- Trial name
- NCT06364228
- Testing
- Oxytocin Intranasal Spray 12 International Unit (12IU), Oxytocin Intranasal Spray 24 International Unit (24IU), Functional MRI
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Congenital Heart Disease (CHD)
Butyric Acid Supplementation for Gut Improvement After Cardiac Surgery in Kids
Butyric acid has been shown to promote gut health and improve the microbiome in multiple adult studies. In preliminary studies in older children with inflammatory bowel disease, butyric acid was shown to be safe.
- Trial name
- BASICS-Kids (NCT06882772)
- Testing
- 2 mL SunButyrate-TG, 4 mL SunButyrate-TG
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- University of Nebraska
ACDF Surgery
Post-operative Outcomes of Anterior Cervical Discectomy and Fusion Surgery With and Without Drain Placement
Anterior Cervical Discectomy and Fusion (ACDF) is a widely performed surgical procedure used to treat cervical spondylosis and cervical disc herniations with cervical nerve root compression and or cervical spinal cord compression…
- Trial name
- NCT06938607
- Testing
- Drain
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- University of Nebraska
Hypertensive Disorders of Pregnancy (HDP), Hypertension, Pregnancy Induced
Community Support and Mobile Apps to Help Black Women Control High Blood Pressure After Pregnancy
The goal of this randomized clinical trial is to evaluate the effectiveness of a collaborative care intervention, consisting of remote blood pressure monitoring and support from community health workers, in improving blood…
- Conditions
- Hypertensive Disorders of Pregnancy (HDP), Hypertension, Pregnancy Induced, Severe Maternal Morbidity, Postpartum Hypertension
- Trial name
- PRIME CARE (NCT07606027)
- Testing
- Collaborative care, Standard of Care (SOC)
- Volunteers
- 404 people
- Sponsor
- University of Nebraska
Stress and Performance, Pilot Stress
The Investigators Want to See if There is a Correlation Between Stress and the Microbiome for Pilots and Astronauts and if There is a Way to Optimize This Balance for Pilots so That They Can Maximize Aerodynamic Decision Making on the Flight Deck.
The investigators are going to test the bacteria growing in your intestine to see if it influences your ability to manage stress while flying an airplane.
- Trial name
- NCT07829159
- Testing
- Flight simulator
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Pregnancy
Comparison of Beta-hCG Levels When Using Venous Puncture Blood and Peripheral Finger Stick Blood
The objective of his study is to quantitatively evaluate a patient's pregnancy status using their beta-hCG levels when using venipuncture blood vs peripheral blood.
- Trial name
- P-Beta-H (NCT07493720)
- Testing
- Beta-hCG
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Nebraska
Cerebral Palsy Children, Healthy Adults
Evaluating the Effects of an Electrical Stimulator on Improving the Walking Ability of Children With Cerebral Palsy
The goal of this study is to see if gentle electrical stimulation can help children with cerebral palsy (CP) walk more easily. This stimulation, called neuromuscular electrical stimulation (NMES), sends small pulses to muscles to…
- Trial name
- CP (NCT06811545)
- Testing
- Neuromuscular Electrical Stimulation (NMES)
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Implementation Science, Delirium
Behavioral Economic & Staffing Strategies in the ICU
The overarching goal of this study is to support the "real world" assessment of strategies used to foster adoption of several highly efficacious evidence-based practices in healthcare systems that provide care to critically ill…
- Conditions
- Implementation Science, Delirium, Critical Illness, Mechanical Ventilation Complication
- Trial name
- BEST-ICU (NCT06184945)
- Testing
- Realtime audit and feedback, RN Implementation Facilitator
- Where
- 3 sites in United States
- Volunteers
- 16,500 people
- Sponsor
- University of Nebraska
Prostate Cancer
HRT-PC Trial: Hormone Recovery After Treatment for Prostate Cancer Trial. An Open-label Phase II Study of Clomiphene Citrate in Patients With Persistent Hypogonadism After ADT for Treatment of Localized Prostate Cancer
The purpose of this phase II trial is to assess the clinical utility of clomiphene citrate for the augmentation of testosterone in prostate cancer survivors who complete androgen deprivation therapy (ADT), including the efficacy…
- Trial name
- NCT07882862
- Testing
- Clomiphene Citrate 25mg
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- University of Nebraska
Amniotic Band Syndrome, Upper Extremity Deformities, Congenital
The Influence of 3D Printed Prostheses on Neural Activation Patterns
The neural basis underlying motor performance in children using a prosthesis has been severely understudied resulting in minimal empirical evidence.
- Trial name
- NCT04110730
- Testing
- 3D Printed Upper-limb Prosthesis, Home Intervention
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Dyspnea, Chronic Obstructive Pulmonary Disease
The Increase of Lung Capacity Using the Lung Master (Pulmonary Exerciser)
Investigators are studying how a device called The Lung Master device can help people breathe better. The investigational device increases the amount of air our lungs can hold, which is important for overall lung health.
- Conditions
- Dyspnea, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT06524856
- Testing
- Lung Master (Pulmonary Exerciser)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Diabetes
Feasibility and Performance of Continuous Glucose Monitoring to Guide Computerized Insulin Infusion Therapy in Non-ICU Patients Receiving Corticosteroid Therapy and Specialized Nutrition
The objective of this pilot study is to assess the feasibility and performance of real-time CGM for titrating CII via: (1) evaluation of CGM glucose accuracy in oncology and post-transplant population receiving IV insulin…
- Trial name
- NCT07194642
- Testing
- Dexcom G7 CGM
- Volunteers
- 80 people
- Sponsor
- University of Nebraska
Prostate Cancer
Abi/Pred + ADT vs ADT in PSMA-Positive, Conventionally Node-Negative Prostate Cancer
The advent of PSMA-PET has improved sensitivity and specificity in staging prostate cancer, particularly in intermediate- and high-risk disease.
- Trial name
- NCT07237269
- Testing
- Androgen Deprivation Therapy (ADT), Abiraterone, Prednisone
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- University of Nebraska
Motor Function
Feasibility Study of the Flash-Sole: A Wearable Midsole With Soft Actuators for Walking Assistance
The goal of this clinical trial is to test a new shoe device called Flash-Sole. The Flash-Sole is designed to help support the ankle while walking. It was developed by researchers at the University of Nebraska at Omaha.
- Trial name
- FLASHSOLE (NCT07507006)
- Testing
- Flash-Sole midsole device
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Hematological Malignancies, Graft-versus-Host Disease (GVHD)
Optimizing GVHD Prophylaxis After Allogeneic Hematopoietic Cell Transplantation
This study will compare post-transplant health-related quality of life following the use of standard versus attenuated dose of post-transplant cyclophosphamide in addition to two-drug graft-versus-host disease (GVHD) prophylaxis…
- Trial name
- PTCYGVHD (NCT06799195)
- Testing
- Attenuated-dose Cyclophosphamide, High-dose Cyclophosphamide, Sirolimus
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- University of Nebraska