Clinical trials: sponsored by University of Nottingham
Acceptance and Commitment Therapy, Dementia
ACT for People With Dementia Experiencing Psychological Distress
Introduction: People with dementia have a high prevalence of psychological distress but are under-served with evidence-based psychological interventions.
- Trial name
- NCT04630912
- Testing
- Acceptance and Commitment Therapy
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- University of Nottingham
Osteoarthritis, Pain
An Investigation Into the Role of Walking in Treating the Symptoms of Knee Osteoarthritis: The WalkOut Study
There are over 8.75 million people in the United Kingdom with osteoarthritis in their knees. The effect of this condition can be debilitating. Symptoms are due to wear and tear of the knee joint.
- Conditions
- Osteoarthritis, Pain, Arthritis, Gonarthritis
- Trial name
- WalkOut (NCT02748291)
- Testing
- Walking, Department of Health Physical Activity Guidelines
- Where
- United Kingdom
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Emergency, Pain
Tissue Interface Pressures in Athlete Medical Extraction
This study aims to establish clinical evidence for the use of scoop stretchers in the sports setting for spinal immobilisation and transport compared to the traditionally used long back boards through measuring tissue interface…
- Conditions
- Emergency, Pain, Medical Device Discomfort
- Trial name
- NCT02770638
- Testing
- Scoop Stretcher, Long Back Spinal board
- Where
- United Kingdom
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Asthma Attack
Asthma: Phenotyping Exacerbations 3
Exacerbations of asthma (asthma attacks) are very common in the UK. They are frightening for patients, expensive for the health service, and occasionally lead to avoidable deaths.
- Trial name
- APEX3 (NCT05446090)
- Testing
- Spirometry including peak flow, Fractional Exhaled Nitric Oxide (FeNO), Forced Oscillation Technique (FOT)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Nottingham
Dementia
Sharing the Outcome of a Memory Assessment
The purpose of this study is to establish the acceptability of a guide developed to improve people's experiences of dementia assessment outcome appointments in comparison to a standard consultation.
- Trial name
- NCT04935060
- Testing
- A guide to inform the process of delivering the outcomes of a dementia assessment, Usual Care
- Where
- 2 sites in United Kingdom
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Brain Cancer
Controlling Coordination After Childhood Cerebellar Cancer, a Pilot Study
Posterior fossa tumours (PFT) account for 2/3 of childhood brain cancers. They can be highly malignant requiring combined chemotherapy and radiotherapy post-surgery for a >50% chance of cure.
- Trial name
- 5C-pilot (NCT04501731)
- Testing
- Transcranial Magnetic Stimulation (TMS), Magnetic Resonance Imaging (MRI), Motor assessment
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Chronic Obstructive Pulmonary Disease, Alpha 1-Antitrypsin Deficiency
Functional and Structural Lung Imaging in Chronic Obstructive Pulmonary Disease
This study aims to use novel proton-based MRI techniques to assess lung function and structure in healthy volunteers and patients with chronic obstructive pulmonary disease (COPD) and alpha-1-anti-trypsin deficiency (A1ATD).
- Trial name
- FASTCOPD (NCT04966221)
- Testing
- Lung MRI scan
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Diabetes, Foot Ulcer
Adherence to Activity Limitations in Diabetes
This study aims to develop and test a theory-based motivation communication training programme for healthcare professionals working with diabetic foot ulcer patients.
- Trial name
- NCT03853941
- Testing
- Intervention
- Where
- United Kingdom
- Volunteers
- 49 people
- Sponsor
- University of Nottingham
Traumatic Stress Disorder, Cancer
Narrative Exposure Therapy to Reduce Symptoms of Traumatic Stress in Cancer Survivors
The main purpose of the study is to evaluate the feasibility, acceptability, and potential effectiveness of NET in reducing symptoms of traumatic stress (e.g., hyperarousal, avoidance, and intrusion) in cancer patients who are…
- Trial name
- NCT05272553
- Testing
- Narrative Exposure Therapy
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Cancer, Lung, Respiratory Disease
Yorkshire Enhanced Stop Smoking Study
Lung cancer rates are higher in Yorkshire than the rest of the UK, and this is due to higher rates of smoking. Deaths from lung cancer can be reduced using regular lung scans (screening) and by helping people stop smoking.
- Conditions
- Cancer, Lung, Respiratory Disease, Heart Diseases
- Trial name
- YESS (NCT03750110)
- Testing
- Intervention, Usual Care
- Where
- United Kingdom
- Volunteers
- 1,001 people
- Sponsor
- University of Nottingham
Frailty, Frailty Syndrome
Characterising Frailty Using Magnetic Resonance Imaging
Ageing is associated with the development of various negative conditions, such as frailty. Defined as a decreased ability to combat negative stressors (e.g.
- Conditions
- Frailty, Frailty Syndrome, Frail Elderly Syndrome
- Trial name
- PHENOFRIM (NCT04612686)
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Gastrointestinal Ulcer Haemorrhage, Bacterial Infection Due to Helicobacter Pylori (H. Pylori)
Helicobacter Eradication Aspirin Trial
HEAT (Helicobacter Eradication Aspirin Trial) is a large simple double-blind placebo controlled outcomes study of Helicobacter pylori (H. pylori) eradication to prevent ulcer bleeding in aspirin users.
- Trial name
- HEAT (NCT01506986)
- Testing
- Lansoprazole 30mg, Clarithromycin 500mg, Metronidazole 400mg
- Where
- 6 sites in United Kingdom
- Volunteers
- 30,024 people
- Sponsor
- University of Nottingham
Retinal Imaging
Hand-held Optical Coherence Tomography Feasibility Older Hip Fracture
Assessment of the feasibility of achieving retinal imaging in older people with recent hips fracture surgery using hand held optical coherence tomography device
- Trial name
- NCT04041336
- Testing
- Optical coherence tomography
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Nottingham
Magnetic Resonance Imaging, Hip Fractures
fMRI Feasibility Older Hip Fracture Surgery
An assessment of the feasibility of structural and functional magnetic resonance imaging (MRI) brain scans in older people who have recovered from and older people who never had delirium after hip fracture surgery
- Conditions
- Magnetic Resonance Imaging, Hip Fractures, Postoperative Delirium
- Trial name
- NCT05081726
- Testing
- Functional MRI
- Volunteers
- 10 people
- Sponsor
- University of Nottingham
Glycaemic Response in Healthy Participants
Effect of Consuming Products Containing Rare Sugars Alongside Sucrose on Glycaemic Response in Healthy Adults
Food manufacturers are being tasked to reduce the added sugar content of products. Rare, but natural sugars, may serve as useful sweeteners as they are low-calorie, safe, sweet and have a mild taste.
- Trial name
- NCT05353712
- Testing
- SUCROSE, CONTROL, ARA20
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Inflammatory Disease, Rheumatoid Arthritis
Vaccination Perception in Inflammatory Conditions - Flu, Pneumonia and COVID-19
People with inflammatory diseases are often treated with medications that act to suppress the immune-system, increasing the risk of catching infections.
- Conditions
- Inflammatory Disease, Rheumatoid Arthritis, Psoriatic Arthritis, Systemic Lupus Erythematosus
- Trial name
- OPINION (NCT05115370)
- Testing
- Semi-structured qualitative interview
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
FMD
Effects of Five Days of Physical Inactivity on Endothelial Function in Healthy Humans
Physical inactivity is a significant predictor of major non-communicable diseases such as type 2 diabetes (7%), cardiovascular disease (6%), musculoskeletal disorders and some types of cancer, and has been proposed to be the 4th…
- Trial name
- NCT04199949
- Testing
- Inactivity
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Asthma, Chronic Obstructive Pulmonary Disease
Clinic Versus Home Spirometry
The study aims to assess the differences between spirometry performed with the NuvoAir Air Next spirometer in the clinic setting with both direct and virtual supervision via a video call, and in the home setting with virtual…
- Trial name
- COMPAIR (NCT05219773)
- Testing
- NuvoAir Air Next spirometer
- Where
- 3 sites in United Kingdom
- Volunteers
- 68 people
- Sponsor
- University of Nottingham
Barrett's Oesophagus, Oesophageal Varices
The Accuracy and Acceptability of Magnet Assisted Capsule Endoscopy in the Diagnosis of Esophageal Pathology: a Pilot Study
A pilot study to assess the accuracy and acceptability of a magnet assisted capsule endoscopy in detecting esophageal pathology compared to standard endoscopy.
- Trial name
- MACE (NCT02852161)
- Testing
- Magnet assissted capsule endoscopy
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Nottingham
Non-Alcoholic Fatty Liver Disease, Insulin Resistance
Effects of Carnitine Supplementation on Liver and Muscle
It will be evaluated whether carnitine, a dietary supplement, reduces liver fat and improves metabolism in individuals who have a high concentration of fat within their liver.
- Trial name
- ECLIPSE (NCT03439917)
- Testing
- L-Carnitine tartrate, Meal Replacement Drink, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Nottingham