Clinical trials: sponsored by University of Nottingham
Kidney Injury, Acute, Perfusion Imaging
Validation of Renal Perfusion CEUS Against MRI, and Its Application in Acute Kidney Injury
The purposes of this study is 1. To establish the validity of CEUS to measure renal perfusion by comparing it against ASL-MRI in young and older healthy volunteers, and generate a normative dataset of CEUS measures of renal…
- Conditions
- Kidney Injury, Acute, Perfusion Imaging, Ultrasonography, Kidney Diseases
- Trial name
- NCT04181281
- Testing
- Contrast enhanced ultrasound, Arterial Spin Labelling -Magnetic Resonance Imaging
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
PTSD, Trauma, Psychological
Narrative Exposure Therapy for Adults With Intellectual Disability
The purpose of the study is to identify how Narrative Exposure Therapy (NET) can be adapted for delivery with adults with mild Intellectual Disability (ID) and to explore whether NET can reduce symptoms of traumatic stress in…
- Trial name
- NCT04418752
- Testing
- Psychological therapy
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nottingham
Ascites Hepatic, Cirrhosis and Chronic Liver Disease
Evaluation of 'Melody' Paracentesis Device for Ascites Therapy
Ascites is the accumulation of fluid inside the abdomen. This can happen when the liver fails due to a substantial amount of scarring (cirrhosis).
- Trial name
- EMPATHY (NCT03191851)
- Testing
- standard device, Melody Device, Melody Device with Pump
- Where
- United Kingdom
- Volunteers
- 101 people
- Sponsor
- University of Nottingham
Brain Injuries, Traumatic
The Role of MEG in Assessment and Diagnosis In mTBI
Head injuries are responsible for 1.4 million visits to hospital each year in the United Kingdom (UK). Most patients are allowed home the same day and make a full recovery, but some will have persistent symptoms.
- Trial name
- MEGAbIT (NCT03867513)
- Testing
- Multimodal imaging
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Nottingham
Mild Dementia, Moderate Dementia
iCST Web-application for People With Dementia
In the UK, over 670,000 older people are living with dementia which has a substantial, multi-level impact on society, the person with dementia, and their carers.
- Trial name
- NCT03282877
- Testing
- iCST web-application
- Where
- 4 sites in United Kingdom
- Volunteers
- 43 people
- Sponsor
- University of Nottingham
Multiple Sclerosis
The PrEliMS Feasibility Trial
The PrEliMS study is a mixed-methods feasibility randomised controlled trial of a point of diagnosis intervention programme which aims to provide emotional support for newly diagnosed people with Multiple Sclerosis (MS).
- Trial name
- PrEliMS (NCT03735056)
- Testing
- MS Nurse Support, Peer Support
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Nottingham
Knee Osteoarthritis, Knee Pain Chronic
Effects of Internet / Web-based Exercises on the Population With Knee Arthritis
1. To test whether internet-based exercises reduce the pain in knee OA 2. To check whether internet-based exercises improve the physical activity in the patients with knee OA. 3.
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Sleep Disturbance
- Trial name
- Knee OA (NCT03545048)
- Testing
- Internet based exercises
- Where
- United Kingdom
- Volunteers
- 105 people
- Sponsor
- University of Nottingham
CPPD - Calcium Pyrophosphate Deposition Disease
Perspectives on CPPD Outcome Domains
The purpose of this study is to obtain patient and stakeholder perspectives on what outcome measures should be included in future trials on CPPD (Calcium PyroPhosphate Deposition), a common form of inflammatory arthritis.
- Trial name
- NCT04176003
- Testing
- Qualitative interview, Member checking
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Asthma
Poor Response to Monoclonal Therapy in Asthma
Asthma affects 8% of the entire population. 4-5% of asthma sufferers have severe asthma, characterised by recurrent exacerbations (worsening of symptoms leading to the person having a bout of corticosteroids and/or antibiotics)…
- Trial name
- PROCLAIM (NCT04114396)
- Testing
- Anti-IL5 Antibody, Bronchoscopy
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Dysphagia Following Cerebral Infarction, Dysphagia Following Nontraumatic Intracerebral Hemorrhage
Validation and Reliability Testing of Dysphagia Trained Nurse Assessment
Nurses at Royal Derby Hospital, UK have been trained to use a comprehensive protocol based dysphagia assessment (Dysphagia Trained Nurse Assessment (DTNAx)) to assess all acute stroke patients on admission.
- Trial name
- NCT03700853
- Testing
- Dysphagia Trained Nurse Assessment (DTNAx)
- Where
- United Kingdom
- Volunteers
- 47 people
- Sponsor
- University of Nottingham
Stroke, Acute, Dysphagia, Oropharyngeal
Feasibility Study of Biofeedback in Dysphagia Therapy Post Stroke
This study will investigate the feasibility of delivering swallowing therapy using surface electromyography as a means of biofeedback to patients with dysphagia in the acute stroke setting.
- Trial name
- NCT03499574
- Testing
- Dysphagia therapy using surface EMG as biofeedback, Usual Care
- Where
- United Kingdom
- Volunteers
- 27 people
- Sponsor
- University of Nottingham
Secondary Progressive Multiple Sclerosis
Acceptance Based Telephone Support When Transitioning to SPMS
What is the purpose of the study? People with Multiple Sclerosis often say that they feel less support is available after they are diagnosed with Secondary Progressive Multiple Sclerosis, compared to before they received this…
- Trial name
- AT-SPMS (NCT04239664)
- Testing
- Acceptance Based Telephone Support (ABS+UC)
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- University of Nottingham
High-Intensity Interval Training
Short-term, Home-based, High-intensity Interval Training (HIT) for Improving Fitness
This study will aim to evaluate the efficacy of a short-term, home-based, high-intensity interval (HIT) programme in improving cardiovascular fitness in healthy volunteers aged 55 and above, with an age-comparison to younger…
- Trial name
- HomeHIT (NCT03473990)
- Testing
- High-intensity interval training
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Asymptomatic Conditions
Assessing the Effect of Lettuce on Intestinal Water Content Through Magnetic Resonance Imaging of the Small Bowel
When patients have bowel surgery they are sometimes left with a stoma, where the small bowel exits onto the wall of the abdomen, not into the colon.
- Trial name
- LETIS (NCT02939716)
- Testing
- Rhubarb, Bread, Lettuce
- Where
- 2 sites in United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Constipation - Functional, Irritable Bowel Syndrome Characterized by Constipation
Reclassifying Constipation Using Imaging and Manometry
Constipation is a common condition in which an individual suffers with hard stools which are infrequent and difficult to pass. It is poorly understood and treatment is often unsatisfactory.
- Trial name
- RECLAIM (NCT03226145)
- Testing
- MRI Motility, High Resolution Manometry, Bisacodyl
- Where
- 3 sites in United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Anesthesia
Gaze Training on Task Performance Regional Anaesthesia
Regional anaesthesia is the performance of spinal, epidural or peripheral nerve blocks to allow patients to undergo surgery awake and to provide post-operative pain relief.
- Trial name
- NCT04426227
- Testing
- Gaze training, Discovery learning
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Asthma Attack
Impact of Asthma Exacerbations
The purpose of the study is to gain a deeper understanding of the impact of asthma attacks on the lives of patients who experience them.
- Trial name
- IMPAX (NCT04410120)
- Testing
- Interview
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Nottingham
Other Postprocedural Cardiac Functional Disturbances, Myocardial Perfusion
Dynamic Effects of Online HDF on Cardiac Function and Myocardial Perfusion Utilising Cardiac MRI (CAMRID)
The purpose of this study is to characterise, in detail, the cardiac structure, function and perfusion of those on haemodialysis and haemodiafiltration, comparing the two modalities to ascertain if haemodiafiltration provides…
- Trial name
- CAMRID (NCT02494843)
- Testing
- online Hemodiafiltration, Hemodialysis
- Volunteers
- 12 people
- Sponsor
- University of Nottingham
Celiac Disease, Coeliac Disease
MAgnetic Resonance Imaging in COeliac Disease
One in 100 people suffers from coeliac disease. It affects the lining of the bowel and causes many symptoms such as diarrhoea, wind, stomach pain, constipation and nausea.
- Conditions
- Celiac Disease, Coeliac Disease, Celiac Sprue, Gluten Enteropathy
- Trial name
- MARCO (NCT02551289)
- Testing
- Gluten free diet
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Smoking Cessation, Pregnancy Related
Effectiveness and Cost-effectiveness of a Tailored Text Message Programme (MiQuit) for Smoking Cessation in Pregnancy
The trial aims to determine whether or not MiQuit (text-message support programme) is effective when offered in addition to standard behavioural support for smoking cessation in pregnancy.
- Trial name
- NCT03231553
- Testing
- MiQuit text message support programme
- Where
- 17 sites in United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- University of Nottingham