Clinical trials: sponsored by University of Nottingham
Constipation, Diet Modification
Effect of Kiwifruit on Gastrointestinal Fluid Distribution and Transit in Healthy Volunteers
Constipation is a widespread and common problem in which a person finds it difficult and/or painful to open their bowels. The current treatment is the use of medications called laxatives.
- Trial name
- KIWI (NCT03303417)
- Testing
- MRI Scan, Kiwifruit, calorie-matched sugar drink
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Obesity
Cellodextrin Tolerability Study
This is an initial pilot study to assess and investigate if any adverse symptoms occur (and also the severity of any symptoms) after consuming a food-grade Cellodextrin preparation.
- Trial name
- CELLDEX (NCT02621086)
- Testing
- Cellodextrin
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Insulin Resistance
Skeletal Muscle Protein Metabolism and Insulin Sensitivity in Overweight Individuals: Effects of Meals With Various Fatty Acid Compositions
The aim of the study will investigate whether impairment in the action of insulin to promote the use of glucose in skeletal muscle (insulin resistance) as a result of oral ingestion of a liquid meal rich in saturated fat is…
- Trial name
- NCT03146286
- Testing
- Saturated fat, Fish Oil
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Perioperative Hypertension, Hypertension
Exploring Time-efficient Strategies to Improve Fitness for Surgery in Older Adults
The incidence of conditions requiring surgical intervention increases with age, however there is a reported decline in the rates of elective surgical procedures in those over 65.
- Trial name
- eHHH (NCT03019146)
- Testing
- HIIT, HOLD, HUG
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Stroke
Bayraktutan Dunhill Medical Trust EPC Study
Stroke is a life-threatening medical condition that occurs due to a sudden disruption of blood supply to the brain. Although it may affect all age groups including children, the elderly are at a greater risk of having strokes.
- Trial name
- NCT02980354
- Where
- 2 sites in United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Familial Hypercholesterolemia
Improving Identification of Familial Hypercholesterolaemia in Primary Care (FAMCAT)
Multi-centre, non-randomised, non-controlled quasi-experimental study with nested qualitative study and economic appraisal. Improving the identification of patients at high risk of cardiovascular disease in primary care, caused…
- Trial name
- FAMCAT (NCT03934320)
- Testing
- FAMCAT
- Where
- United Kingdom
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Overweight and Obesity
The Effect of Very Low Calorie Diet With and Without Exercise on Muscle Synthesis in Middle-aged Overweight Male.
The aims of this project are: to investigate the impact of VLCD on control of muscle protein synthesis, muscle structure and function, cardiac function (ejection fraction), vascular function (blood flow and capillary function)…
- Trial name
- VLCDex (NCT03116256)
- Testing
- Very low calorie diet (VLCD), High intensity interval training (HIIT), Resistance exercise training (RET)
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Depression
Social Connectedness Group Intervention in Depression
This study evaluates the feasibility of the Groups for Health (G4H) intervention for adults accessing support for depression in the UK.
- Trial name
- G4H-A (NCT03446963)
- Testing
- Groups for Health
- Where
- United Kingdom
- Volunteers
- 29 people
- Sponsor
- University of Nottingham
Osteoarthritis, Knee
Ibuprofen Gel or Capsaicin Cream for my Painful Knee Osteoarthritis?
Despite evidence that topical non-steroidal anti-inflammatory drugs (NSAIDs) and capsaicin are effective in osteoarthritis (OA), it is still unclear why they work for some people but not others.
- Trial name
- NCT03146689
- Testing
- Topical NSAID, Topical Capsaicin
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Nottingham
Crohn's Disease
Reduced Appetite in Crohn's Disease: The Role of the Brain in the Control of Food Intake
Crohn's disease (CD) is becoming more common, specifically in the western world. One of the main features of this disease is weight loss and malnutrition. Although clinically common, these problems are not well understood.
- Trial name
- NCT02772458
- Testing
- Dodecanoate acid and saline
- Where
- 2 sites in United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Impaired Cognition, Quality of Life
The Assessment of the Feasibility of a Home Based Exercise Programme in the Older Patient Following Major Surgery
The primary aim of this study is to establish if it is possible for patients who have undergone major body surgery to complete a home based exercise training program and complete the assessments required to measure physical and…
- Conditions
- Impaired Cognition, Quality of Life, Surgery, Delirium
- Trial name
- POETold (NCT03064308)
- Testing
- Exercise Programme
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- University of Nottingham
Constipation, Diet Modification
A Study of the Effect of Bran, Psyllium and Nopal on Intestinal Water Content Using Magnetic Resonance Imaging
This study will compare 3 food products (bran, psyllium and nopal) on intestinal water content measured via MRI.
- Trial name
- NOPAL (NCT03263065)
- Testing
- Bran, Nopal, Psyllium
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Mild Dementia, Moderate Dementia
Touchscreen Technology and Art for People With Dementia in Care Homes
The prevalence of dementia is rapidly growing worldwide, affecting 46.8 million people in 2015. The 2014 Alzheimer's Society report estimated that 311,730 people with dementia were living in care homes in the United Kingdom (UK).
- Trial name
- NCT03773016
- Testing
- Art apps
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Nottingham
Hypoxia
Planetary Habitat Simulation: Nutrition Studies
A loss of body weight has been documented in lowland-living individuals when exposed to hypoxic environments, such as at high altitude, or under laboratory conditions.
- Trial name
- PlanHab (NCT02293772)
- Testing
- Hypoxic ambulatory, Hypoxic Bedrest, Normoxic Bedrest
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Hypoxia, Bone Resorption
Planetary Habitat Simulation: Bone Metabolism Studies
Bone losses are well known to occur in response to unloading (in microgravity or during immobilisation) and in patients with chronic obstructive airway disease (COPD).
- Trial name
- PlanHab (NCT02637921)
- Testing
- Hypoxia, Ambulatory, Normoxia
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Insulin Resistance, Age Problems
Investigating the Effects of Beta-Hydroxy-Beta-Methylbutyrate on Glucose Handling in Older and Younger Men.
This study intends to examine the effect of a commercially available nutritional supplement, Beta-hydroxy-beta-methylbutyrate(HMB) on whole-body responses to a sugar load.
- Trial name
- NCT03018496
- Testing
- Beta-Hydroxy-Beta-Methylbutyrate
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Cardiorespiratory Fitness
Can 2 Weeks of High Intensity Interval Training in Healthy 65-85 Year-olds Improve Cardiorespiratory Fitness?
The incidence of conditions requiring surgical intervention increases with age, however there is a reported decline in the rates of elective surgical procedures in those over 65.
- Trial name
- 2WkHIT (NCT03331679)
- Testing
- HIIT
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Sarcopenia, Muscle Hypotrophy
Systemic Hormones and Muscle Protein Synthesis
This study evaluates the effect of increase in testosterone levels in older males and the effects of decrease in testosterone levels in young males on muscle protein synthesis.
- Conditions
- Sarcopenia, Muscle Hypotrophy, Muscle Atrophy
- Trial name
- NCT03054168
- Testing
- Sustanon 250, Zoladex
- Where
- United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
NAFLD
Fighting Fatty Liver in India
This study aims to build capacity in India by: 1. Developing tailored protocol methodologies for research including technical capability in imaging (MRI/S protocols \& customised software), dietary intervention delivery, dietary…
- Trial name
- FFL (NCT03844165)
- Testing
- Diet change (red rice), Yoga
- Where
- India
- Volunteers
- 84 people
- Sponsor
- University of Nottingham
Pregnancy Related
Managing Weight in Pregnancy
It is well known that being overweight or obese increases the risk of health problems, and that many people find it difficult to maintain a healthy weight.
- Trial name
- MAGIC (NCT01770522)
- Where
- United Kingdom
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- University of Nottingham