Clinical trials: sponsored by University of Nottingham
Pregnancy Related
Managing Weight in Pregnancy
It is well known that being overweight or obese increases the risk of health problems, and that many people find it difficult to maintain a healthy weight.
- Trial name
- MAGIC (NCT01770522)
- Where
- United Kingdom
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Chronic Liver Disease, Alcohol Use Disorder
Nottingham Community Liver Biomarkers Cohort
Deaths due to advanced liver scarring (liver cirrhosis) continue to increase, and liver disease is now the 3rd leading cause of premature death in the United Kingdom.
- Conditions
- Chronic Liver Disease, Alcohol Use Disorder, Type 2 Diabetes, Persistently Elevated ALT
- Trial name
- NCT02037867
- Testing
- Fibrosis Biomarkers
- Where
- United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- University of Nottingham
Physical Activity, Falls Prevention
Keeping Adults Physically Active Feasibility Study
The Keeping Adults Physically Active (KAPA) feasibility study aimed to examine the feasibility and acceptability of the an intervention designed to encourage the continuation of physical activity following the completion of a…
- Trial name
- KAPA (NCT03824015)
- Testing
- Keeping Adults Physically Active (KAPA) intervention, Usual Care
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Osteoarthritis, Chronic Pain
Mindfulness for Osteoarthritis-related Knee Pain
The purpose of this project is to investigate the feasibility and acceptability of a Mindfulness based intervention for people who are attending secondary care with Osteoarthritis (OA)-related knee pain.
- Trial name
- NCT02595099
- Testing
- Mindfulness training
- Volunteers
- 15 people
- Sponsor
- University of Nottingham
Stroke
Regaining Confidence After Stroke a Feasibility Randomised Controlled Trial
The Regaining Confidence after Stroke Course (RCAS) is a group therapy intervention to evaluate the feasibility of conducting a definitive trial, aimed to facilitate adjustment for people with stroke discharged from…
- Trial name
- RCAS (NCT03807284)
- Testing
- A group psychosocial course
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Healthy
In Vivo Predictive Dissolution 1
This study will: 1. validate MRI motility method with concomitant perfused manometry method in healthy adult participants. 2. measure exploratory endpoints of interest including GI fluid volumes in 21 adult healthy volunteers…
- Trial name
- iPD1 (NCT03191045)
- Testing
- MRI and concomitant perfused manometry of bowel motility
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Prematurity, Transfer Injury
Minimising the Adverse Physiological Effects of Transportation on the Premature Infant
Centralisation of neonatal intensive care has led to an increase in postnatal inter-hospital transfers within the first 72 hours of life.
- Conditions
- Prematurity, Transfer Injury, Brain Injuries, Intraventricular Hemorrhage
- Trial name
- TRiPs (NCT03754439)
- Testing
- Physiological changes to noise and vibration exposure
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Nottingham
Irritable Bowel Syndrome
Carbohydrate Reduction and Impact on Gastrointestinal System
Title : A pilot single blind randomised controlled trial of the effect of a diet low in poorly digested carbohydrates on gastrointestinal form and symptoms in irritable bowel syndrome patients Acronym: CRAIGS Short title…
- Trial name
- CRAIGS (NCT03729622)
- Testing
- Low FODMAP Diet
- Where
- United Kingdom
- Volunteers
- 65 people
- Sponsor
- University of Nottingham
Gastrointestinal Symptoms
Effect of Physical Form of Apples on Gastrointestinal Function and Satiety: a MRI Study
Different physical form of apples had a significant effect on satiety and blood sugar levels which was shown in a 1977 study by Haber and his team (Haber et al.1977).It was suggested that , this effect was due to processing of…
- Trial name
- NCT03714464
- Testing
- Whole apples, Apple puree, Apple Juice
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Idiopathic Pulmonary Fibrosis
Prospective Study of Fibrosis In the Lung Endpoints (PROFILE - Central England)
The overall aim of this study is to develop a test that predicts the prognosis of IPF (Idiopathic Pulmonary Fibrosis) and which could be used to determine whether new treatments for IPF are likely to work.
- Trial name
- PROFILE (NCT01134822)
- Where
- United Kingdom
- Volunteers
- 330 people
- Sponsor
- University of Nottingham
Laparoscopic Training
Simulating Laparoscopy With an Eye Patch
Comparison of laparoscopic training simulator v use of eye patch (to simulate loss of dept perception) to investigate acquisition of laparoscopic skills.
- Trial name
- LapACQ (NCT03407235)
- Testing
- Computerized Laparoscopic Trainer, Box trainer with eye patch
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Parkinson Disease
Nigrosomal Iron Imaging in Parkinson's Disease
Prospective observational study to compare sensitivity of 3T functional Magnetic Resonance Imaging (3T fMRI) at diagnosing Parkinson's Disease (PD) against the benchmark DaTScan diagnostic test and clinical diagnosis at follow up.
- Trial name
- N3iPD (NCT03022357)
- Testing
- Patient assessment, DATScan, Orbital X-Ray
- Where
- 3 sites in United Kingdom
- Volunteers
- 145 people
- Sponsor
- University of Nottingham
Multiple Sclerosis
Baseline Cortical Haemodynamics in MS
This study will provide information on cortical haemodynamics in MS patients to address the discrepancies reported in previous literature, allowing further insight into the role of haemodynamics in the disease.
- Trial name
- CortHaem (NCT02481882)
- Testing
- Magnetic Resonance Imaging, Prohance (Gadoteridol)
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Hearing Loss
Feasibility of an Online Rehabilitation Program
The study will assess the feasibility of conducting a full-scale clinical trial of the effectiveness of an online rehabilitation program for adults living with hearing loss.
- Trial name
- NCT03408535
- Testing
- Eriksholm Guide to Better Hearing
- Where
- United Kingdom
- Volunteers
- 83 people
- Sponsor
- University of Nottingham
Stroke
Remote Ischaemic Conditioning After Stroke Trial (ReCAST-2)
Stroke has an enormous impact on both individual and society. Novel treatments are required to relieve this burden and remote ischaemic conditioning (RIC) is one such approach.
- Trial name
- ReCAST-2 (NCT02779712)
- Testing
- Remote ischaemic conditioning
- Where
- 2 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Nottingham
Perianal Fistula
MR Assessment of Perianal Crohn's Disease
Perianal Crohn's disease (pCD) is the commonest form of fistulising Crohn's disease, with up to 38% of patients affected and with 30% of them experiencing recurring disease symptoms.
- Trial name
- MAP (NCT03325582)
- Where
- 3 sites in United Kingdom
- Volunteers
- 25 people
- Sponsor
- University of Nottingham
Cancer
Preoperative HIIT in Elderly Cancer Patients
This randomized control trial will determine the effect of short term high intensity interval training (HIIT) on physical fitness, in an elderly patient group with active cancer, prior to surgical resection.
- Trial name
- eHIITCa (NCT02671617)
- Testing
- High intensity interval training (HIIT)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Nottingham
Sarcopenia, Aged
HIT Training in the Frail Elderly.
This pilot study aims to investigate whether high intensity interval training can result in rapid improvements in physical fitness amongst the frail elderly (over 70 years old).
- Conditions
- Sarcopenia, Aged, Exercise, Preoperative Care
- Trial name
- eHIT (NCT03138265)
- Testing
- HIIT Device: ergometer
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Chronic Oedema, Obesity
Prevalence of Chronic Oedema in Obese Patients
Persistent swelling (chronic oedema), e.g. of the legs, is quite a common condition, which can cause a number of problems, including infections (cellulitis) in the swollen area and ulceration.
- Trial name
- NCT03154593
- Testing
- Stage 2 - Bariatric Surgery
- Where
- United Kingdom
- Volunteers
- 78 people
- Sponsor
- University of Nottingham
COPD With Hyperinflation, Diaphragmatic Weakness
Upright MRI in Lung Disease
The diaphragm is the main muscle assisting breathing. This study aims to assess the use of MRI in patients with diaphragmatic weakness and patients with Chronic Obstructive Pulmonary Disease (COPD) who have hyperinflation.
- Trial name
- NCT03531775
- Testing
- Upright MRI
- Where
- 2 sites in United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Nottingham