Clinical trials: sponsored by University of Nottingham
Diverticular Disease
DD Obesity MRI Study
In this study, our novel MRI techniques for studying the small bowel will be applied to patients with diverticular disease. The ratio of visceral to subcutaneous fat will also be determined using MRI measurements.
- Trial name
- DDOMRI (NCT02278770)
- Volunteers
- 58 people
- Sponsor
- University of Nottingham
Osteoarthritis, Pain
fMRI and Central Sensitization in Chronic Knee Osteoarthritis. A Pre and Post TKR Study
Painful osteoarthritis (OA) is the 4th largest cause of disability in the UK. Preoperative temporal summation, a measure of central pain facilitation, has been shown to predict postoperative pain after total knee replacement…
- Conditions
- Osteoarthritis, Pain, Postoperative Pain, Surgery
- Trial name
- NCT03126279
- Testing
- Total Knee Replacement Surgery
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
IOP
Effect of Acetazolamide on Intraocular Pressure After Being in the Trendelenburg Position.
Perioperative vision loss following laparoscopic colorectal surgery is rare but has been reported. Studies show Trendelenburg positioning during surgery can produce a significant rise in the IOP, and this rise is thought to be a…
- Trial name
- TaPPs (NCT03107429)
- Testing
- Acetazolamide, Trendelenburg Position
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Healthy
Ispaghula and Colonic Water Content
Chronic constipation is a phenomenon which affects nearly 20% of the population worldwide. Bulking agents such as ispaghula are used as treatments, but only half of the patients are satisfied with the treatment.
- Trial name
- NCT01805999
- Testing
- 7 g Ispaghula
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Underweight, Malnutrition
Study of Effect of Microfinance on Under 5 Health in Rural India
Investigators propose a feasibility and pilot study for a cluster randomised controlled trial. The proposed trial will evaluate the effects of an economic intervention (microfinance) in self-help groups of poor and marginalised…
- Trial name
- NCT01845545
- Testing
- Early provision of microfinance
- Where
- India
- Volunteers
- 2,469 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Constipation
MRI and Microbiota Analysis in Constipation
The purpose of the study is to test how well magnetic resonance imaging (MRI) can measure whole gut transit time in people with constipation, and how readily it can detect a change in transit time induced by taking a dietary…
- Trial name
- MIMIC (NCT02144376)
- Testing
- Ispaghula, Maltodextrin
- Where
- 2 sites in United Kingdom
- Volunteers
- 24 people
- Sponsor
- University of Nottingham
Insulin Resistance
Role of Preoperative Carbohydrates Drinks, Dichloroacetate and Exercise on Postoperative Muscle Insulin Resistance
The aim of the study is to investigate whether preoperative interventions such as carbohydrate drinks, Dichloroacetate and exercise would inhibit or reverse the changes in molecular mechanisms regulating muscle carbohydrate…
- Trial name
- CARBEX (NCT02469337)
- Testing
- Dichloroacetate, Carbohydrate drinks, Moderate intensity exercise
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Nottingham
Gout
Arthritis Research UK Gout Treatment Trial - Phase 2
The purpose of this study is to determine in community-derived patients with gout the effectiveness, and cost effectiveness, of a nurse-led complex intervention that reflects recommended best practice (including patient…
- Trial name
- NCT01477346
- Testing
- Nurse intervention, Standard care
- Where
- United Kingdom
- Volunteers
- 517 people
- Sponsor
- University of Nottingham
Healthy
Magnetic Resonance Imaging of Motility in Crohn's 1
Crohn's disease (CD) is becoming more common. One of the main features of this disease is weight loss and malnutrition with symptoms such as tummy aches and bloating.
- Trial name
- MIC1 (NCT02717117)
- Testing
- Soup meal
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Infertility, Polycystic Ovarian Syndrome
Letrozole Versus Clomifene Citrate for Ovulation Induction
The primary aim of the study is to assess the efficacy of letrozole as an ovulation induction agent and to test the hypothesis that letrozole will generate better pregnancy rates with fewer multiple pregnancies and higher live…
- Trial name
- NCT00478504
- Testing
- Letrozole, Clomifene citrate
- Where
- United Kingdom
- Volunteers
- 159 people
- Sponsor
- University of Nottingham
Cachexia, Lung Cancer
Is Clarithromycin a Potential Treatment for Cachexia in People With Lung Cancer?
This study aims to identify if clarithromycin (CLM) has potential as a widely available and inexpensive treatment for cachexia (the loss of muscle mass) in people with non-small cell lung cancer (NSCLC).
- Trial name
- NCT02416570
- Testing
- Clarithromycin
- Volunteers
- 1 people
- Sponsor
- University of Nottingham
Malaria, Pneumonia
A Comparison of Diagnostic Approaches for Malaria and Pneumonia
This research investigates the diagnostic accuracy of various diagnostic approaches for malaria and pneumonia in under-five children presenting to primary healthcare centres in Benin City, Nigeria.
- Trial name
- NCT02482116
- Testing
- malaria or pneumonia diagnosis
- Where
- Nigeria
- Volunteers
- 1,000 people
- Sponsor
- University of Nottingham
Reversible Cerebral Vasoconstriction Syndrome
Perfusion MRI in Reversible Cerebral Vasoconstriction Syndrome
This study aims to quantify perfusion, assess arterial vasoconstriction, and confirm reversibility using 3T ASL-MRI and MRA in 10 patients with suspected RCVS.
- Trial name
- NCT02756416
- Testing
- MRI brain, ASL-MRI brain, MRA brain
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University of Nottingham
Anxiety, Depression
ACT for Distress in Head and Neck Cancer Patients
Title: Acceptance and Commitment therapy for Individuals with Head and Neck Cancer Experiencing Psychological Distress. Head and neck cancer (HNC) patients are particularly vulnerable to experiencing psychological distress .
- Trial name
- NCT02840071
- Testing
- Psychological therapy
- Where
- 2 sites in United Kingdom
- Volunteers
- 3 people
- Sponsor
- University of Nottingham
Attention Deficit Hyperactivity Disorder (ADHD)
Assessing QbTest Utility in ADHD: A Randomised Controlled Trial
Attention Deficit/Hyperactivity Disorder (ADHD)is one of the most common mental health disorders of childhood. Children with ADHD often have poor attention, are restless and hyperactive and show impulsive behaviour.
- Trial name
- AQUA2 (NCT02209116)
- Testing
- Qb Test
- Where
- 9 sites in United Kingdom
- Volunteers
- 267 people
- Sponsor
- University of Nottingham
Healthy
Assessment of Millet, Oat and Rye Porridge Breakfasts Glucose and Gastric Emptying
Breakfast porridges are made from milled grains and are commonly eaten worldwide. Traditionally different grains are used in different countries.
- Trial name
- AMORE (NCT02653274)
- Testing
- Breakfast porridge
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Septicaemia, Deformity of Spine
The Paediatric Refill Study (PRefill)
2 recent national reports 'Why Children Die' and 'Are we there yet?'identified deficiencies in recognising and managing sick children.
- Conditions
- Septicaemia, Deformity of Spine, Trauma
- Trial name
- PRefill (NCT02208817)
- Where
- United Kingdom
- Volunteers
- 75 people
- Sponsor
- University of Nottingham
Autism Spectrum Disorder (ASD)
Efficacy of Training Programme to Reduce Stress
This study aims to reduce stress in mothers of children with autism in Saudi Arabia. The researcher has designed a training programme for mothers whose children are young and just in their early stage at the autism organisations…
- Trial name
- NCT02384486
- Testing
- Training to Reduce Stress in Mothers of Children with (ASD), Nothing (treatment as usual)
- Where
- Saudi Arabia
- Volunteers
- 67 people
- Sponsor
- University of Nottingham
Post-infective Bowel Dysfunction, Functional Gastrointestinal Disorders
Campylobacter Enteritis and PI-BD: Dietary Reduction in Carbohydrates
The purpose of the study is explore the issues that relate to testing a particular dietary treatment, the low FODMAP diet, in a randomised trial using an appropriate control diet with which to compare it.
- Trial name
- CEDRIC (NCT02232373)
- Testing
- low FODMAP dietary advice, Maltodextrin, Oligofructose
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- University of Nottingham
Irritable Bowel Syndrome
Fructose and Fructans in Irritabla Bowel Syndrome
The purpose of the study is to investigate if patients with Irritable Bowel Syndrome (IBS) who also report bloating are more likely to report clinically important gastrointestinal symptoms after consuming fructose or fructans…
- Trial name
- FABS (NCT01776853)
- Testing
- Glucose, Fructose, Fructans
- Where
- United Kingdom
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Nottingham