Clinical trials: sponsored by University of Nottingham
Falls
Action Falls for Domiciliary Care
Action Falls is a programme that helps older adults avoid falls and injuries. It finds out why someone might fall and suggests ways to help, like checking their medication and encouraging them to stay active.
- Trial name
- NCT07516054
- Where
- United Kingdom
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Ataxia Telangiectasia
Biomarkers for Babies and Young Children With Ataxia Telangiectasia
The goal of this observational study is to identify progressive changes of quantitative brain and lung imaging, serum and movement-related biomarkers reflecting disease progression in pre-symptomatic infants and very young…
- Trial name
- BOBCAT (NCT07709728)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Osteoarthritis, Fibromyalgia
Assessing Central Aspects of Pain
BACKGROUND: Chronic pain continues for more than 12 weeks despite medication or treatment. Chronic pain is the main symptom of muscle and joint problems, rarely explained by damage to the muscle and joints alone.
- Conditions
- Osteoarthritis, Fibromyalgia, Chronic Low Back Pain, Inflammatory Arthritis
- Trial name
- AsCent (NCT06518278)
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- University of Nottingham
Gastro-Intestinal Disorder, Crohn Disease
NAZA - Nottingham/Astra ZenecA Prospective IBD Cohort Study
The goal of this observational study is to learn about the comparisons of inflammatory markers between IBD and non-IBD (control) participants.
- Conditions
- Gastro-Intestinal Disorder, Crohn Disease, Ulcerative Colitis, Inflammatory Bowel Diseases
- Trial name
- NAZA (NCT06956703)
- Where
- United Kingdom
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Ulcerative Colitis (UC), Crohn's Disease
Stopping PPI Therapy in Inactive IBD
To investigate the feasibility of proton pump inhibitor (PPI) withdrawal in inflammatory bowel disease (IBD); the data collected will provide valuable information to inform a future multi-centre randomised controlled trial.
- Trial name
- STOP-IT (NCT07691138)
- Testing
- Continue PPI Therapy, Withdraw PPI Therapy
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Nottingham
Thoracic Aortic Disease
Accessing the Clarity and Acceptability of Recruitment Materials for a Study on Thoracic Aortic Disease Surveillance
People who are invited to take part in health research are usually given written information, such as invitation letters, and information sheets.
- Trial name
- ACCESS-TAD (NCT07574151)
- Testing
- Acceptability and Clarity
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Cardio Vascular Disease, Dietary Change
Lifestyle Advice in CVD
Individuals living in the UK who are from ethnic minority communities have a higher risk of heart disease and strokes than white individuals. This risk arises from the social determinants of health.
- Conditions
- Cardio Vascular Disease, Dietary Change, Dietary Behaviors, Diet Habits
- Trial name
- NCT07672054
- Testing
- Experience of healthcare
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- University of Nottingham
Ventilation, Mechanical, Ventilation-Associated Pneumonia
Surveillance of Neonatal Endotracheal Tube Colonisation
Babies in neonatal intensive care units (NICUs) sometimes need help breathing using a breathing tube (endotracheal tube, or ETT) connected to a breathing machine (ventilator).
- Trial name
- NETT (NCT07664449)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Psychological Stress, Anxiety
Effects of L-Theanine and Hericium Erinaceus Gummies on Psychological, Cognitive, and Sleep Quality in University Students
The THEA-HEAL Trial is an 8-week randomized controlled study investigating the effects of a daily gummy supplement containing L-theanine and Hericium erinaceus (Lion's mane mushroom) extract on stress, anxiety, cognitive…
- Conditions
- Psychological Stress, Anxiety, Depression, Sleep Quality
- Trial name
- THEA-HEAL (NCT07665840)
- Testing
- gummy intervention
- Where
- Malaysia
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Nottingham Malaysia
Overweight, Obesity
Glycaemic Response of Arabic Bread
Bread remains one of the most widely consumed staple foods worldwide, with wheat flour serving as its traditional foundation. However, the widespread dependence on refined wheat-based bread has paralleled the rising prevalence of…
- Conditions
- Overweight, Obesity, Glycaemic Response
- Trial name
- NCT07652320
- Testing
- Control Bread, Chickpea-Enriched Arabic Bread, Pea-Enriched Arabic Bread
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Surgery, Colorectal Cancer
Postoperative Electrical Muscle Stimulation Two
Undesirable loss of skeletal muscle mass (atrophy) is a common feature of many diseases as well as ageing, bed rest and physical inactivity.
- Conditions
- Surgery, Colorectal Cancer, Muscle Atrophy, Cancer Gi
- Trial name
- POEMS2 (NCT06964438)
- Testing
- Neuromuscular Electrical Stimulation, Protein supplement drink
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- University of Nottingham
Obesity
MRI Based Study to Assess Brain-gut Axis in Obesity
The mechanism of neural communication between the brain and gut in the regulation of food intake is complex and not fully understood.
- Trial name
- BGImaging (NCT05437653)
- Testing
- Nutritional Drink A, Nutritional Drink B
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Cognitive Enhancement
Transcranial Focused Ultrasound Stimulation to Enhance Cognition in Healthy Participants
This study examines the impact of theta-burst transcranial focused ultrasound stimulation (tFUS) on cognitive performance in healthy participants, specifically focusing on both acute and post-stimulation effects on visual working…
- Trial name
- NCT06829368
- Testing
- Transcranial Focused Ultrasound Stimulation
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Frozen Shoulder
Exploring the Link Between Menopause, Glucose Control, and Frozen Shoulder in Women
Background Frozen shoulder (FS) is a common condition and affects how the shoulder moves, making it very stiff and sore. The shoulder joint becomes inflamed and tightened due to scarring in the joint called fibrosis.
- Trial name
- MENO-FROST (NCT07603089)
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Patient Safety
Clinical Experience of Maintaining Patient Safety in Hospital
The key purpose of the study is to establish what the barriers to preventing accidental falls in hospital are, what interventions are perceived to work best in preventing falls and what could help.
- Trial name
- CEMPSIH (NCT06738316)
- Testing
- Simulation
- Where
- 3 sites in United Kingdom
- Volunteers
- 53 people
- Sponsor
- University of Nottingham
Healthcare Access, Experience
Learning Differences in Medical Education
A learning difference or disability is a reduction in intellectual ability (GMC, 2024). It causes lifelong difficulty with everyday activities. Different individuals require different levels of support.
- Conditions
- Healthcare Access, Experience, Learning Disabilities
- Trial name
- NCT07585708
- Testing
- Experience of healthcare
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- University of Nottingham
Type 1 Diabetes Mellitis
Diathermy On Diabetes Glucose Monitoring Effectiveness
The goal of this observational study is to investigate if diathermy (a surgical tool that uses electrical energy to control bleeding) has any affect on the accuracy and functioning of continuous glucose monitoring systems in…
- Trial name
- DODGE (NCT07583238)
- Where
- United Kingdom
- Volunteers
- 126 people
- Sponsor
- University of Nottingham
X-linked Hypophosphatemia (XLH)
Effective Dosing of Burosumab in XLH
X-linked hypophosphataemia (XLH) is a rare, hereditary condition. The genetic defect leads to low blood phosphate levels and vitamin D suppression. Phosphate is required for strong bones and teeth and to store energy in cells.
- Trial name
- NCT07183579
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Nottingham
Major Depressive Disorder, Depression Moderate
Exercise Recovery From Persistent Depression: A Thematic Analysis
Depression is a leading cause of disability worldwide and poses a large economic burden in the UK. There is evidence that exercise is beneficial in the management of depression and NICE now recommends group exercise programs as a…
- Conditions
- Major Depressive Disorder, Depression Moderate, Depression Severe
- Trial name
- NCT05539495
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Nottingham
Cystic Fibrosis (CF)
Proof of Principle Study for an Efficacy Trial of Linaclotide for Cystic Fibrosis
Linaclotide is a medicine used to treat constipation and irritable bowel syndrome with constipation (IBS-C). It works by acting on the surface of the gut lining, where it increases the movement of salt and water into the bowel.
- Trial name
- MODEL (NCT07569419)
- Testing
- Linaclotide 290 micrograms
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Nottingham