Clinical trials: sponsored by University of Nottingham
Healthy Volunteers
The Relationship Between Cardiac Output and Microvascular Visceral Blood Flow
Although major surgery is often required to treat abdominal problems, there is a significant risk of death or complication following these operations.
- Trial name
- NCT02167178
- Testing
- Administration of 0.9% NaCl solution, Measurement of stroke volume, Measurement of microvascular blood flow
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Healthy Volunteers
The Effect of Phenylephrine and Ephedrine on Microvascular Blood Flow
During operations to treat abdominal problems the blood pressure can fall, resulting in falls in blood flow to the vital organs. This fall can be treated by the administration of drugs that cause constriction of blood vessels.
- Trial name
- NCT02252627
- Testing
- Administration of phenylephrine, Measurement of stroke volume, Contrast enhanced ultrasound scan
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Patients Undergoing Open Resection of Colorectal Tumours
Vascular Changes During Colorectal Surgery
The purpose of this study is to investigate whether increases in the blood flow from the heart (the cardiac output), induced by the administration of intravenous fluids, lead to an increase in the blood flow to the vital organs…
- Trial name
- MaMiFlo (NCT02136277)
- Testing
- Hartmann's solution
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University of Nottingham
Hip Fractures, Anesthesia
Validation of Nexfin Cardiac Output in Elderly Patients With Hip Fracture
Measurement of how much blood the heart pumps may be useful in guiding how much intravenous fluid to give patients during surgery.
- Trial name
- NCT01474824
- Where
- 2 sites in United Kingdom
- Volunteers
- 6 people
- Sponsor
- University of Nottingham
Qualitative, Nicotine Replacement Therapy
Experiences of Pregnant Women Who Use NRT in Pregnancy as Part of a Quit Attempt
This study is largely a qualitative study with a small survey component. The aim of the survey would be to gain a quantitative perspective of how women use NRT after this has been prescribed by stop smoking services (SSS).
- Conditions
- Qualitative, Nicotine Replacement Therapy, Pregnancy
- Trial name
- NCT02125370
- Testing
- Qualitative and survey
- Where
- 2 sites in United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Obesity, Sarcopenia
Effect of Obesity-derived Cytokines on Protein Turnover and Carbohydrate Metabolism in Human Skeletal Muscle
Obesity in humans has been shown to result in the increased release of small inflammatory-inducing proteins, called cytokines, from the fat cells of the body.
- Trial name
- NCT02305069
- Testing
- Pioglitazone, Insulin, Octreotide
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Dehydration
Hydration Amongst Nurses and Doctors Oncall
The main purpose of this study is to assess and compare the hydration status of medical and nursing staff and to investigate the relationship between the hydration status, cognitive function and serum cortisol (marker of stress).
- Trial name
- HANDsOn (NCT02230774)
- Where
- United Kingdom
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Irritable Bowel Syndrome
Small and Large Bowel Transit Tests Using MRI (Study 1)
Irritable bowel syndrome, (IBS) is a common functional disorder of the gut that can be quite disabling to patients. The most common symptoms of IBS are abdominal pain or discomfort along with erratic changes in bowel habit of…
- Trial name
- NCT01534507
- Where
- United Kingdom
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Dehydration
Hydration and Outcome in Older Patients
Dehydration is recognised as a major issue in healthcare. Recovery after illness, extended length of stay, pressure sores and slow tissue recovery can all be impacted by dehydration.
- Trial name
- HOOP (NCT01703715)
- Testing
- The Hydrant
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University of Nottingham
Attention Deficit Hyperactivity Disorder (ADHD)
Self-help in Adjunct to Pharmacotherapy
Therapist-led parenting interventions have been shown to reduce symptoms of attention deficit hyperactivity disorder (ADHD) and are recommended as a first line treatment for school age children with ADHD.
- Trial name
- SHIP (NCT02174952)
- Testing
- Self-help version of the New Forest Parenting Programme
- Volunteers
- 50 people
- Sponsor
- University of Nottingham
Functional Constipation, Irritable Bowel Syndrome Characterized by Constipation
Mode of Action of Moviprep
The University of Nottingham have been developing new, non-invasive magnetic resonance imaging (MRI) techniques to image the bowel.
- Trial name
- NCT01622972
- Testing
- Polyethyleneglycol
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Chronic Obstructive Pulmonary Disease
The Effect of Statins in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Chronic obstructive pulmonary disease (COPD) is a condition of the lungs which results in breathing difficulties due to the lungs becoming inflamed and the airways narrowed.
- Trial name
- NCT01151306
- Testing
- Simvastatin, Lactose tablet
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University of Nottingham
Asthma
Predicting Steroid Response Using Exhaled Nitric Oxide
Asthma affects 6% of the UK population and costs the NHS 1 billion pounds per year. £473 million alone is spent on inhaled steroid treatment which is designed to reduce inflammation in the breathing tubes.
- Trial name
- PCR (NCT01308411)
- Testing
- 50% step down reduction in inhaled corticosteroid dose
- Where
- United Kingdom
- Volunteers
- 191 people
- Sponsor
- University of Nottingham
Asthma
Small Particle Steroids in Refractory Asthma
The purpose of this study is to determine whether an inhaled steroid with a small particle size can be an additional treatment option in patients with refractory eosinophilic asthma.
- Trial name
- SPIRA (NCT01171365)
- Testing
- Ciclesonide
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Nottingham
Depression
Exercise for Depression in Young People
Exercise as an adjunct to routine treatment may be useful for helping young people recover from distressing mental health problems, but they seldom get sufficient support to help them to exercise.
- Trial name
- HEALTH (NCT01474837)
- Testing
- Intervention: Exercise and motivational interviewing
- Where
- United Kingdom
- Volunteers
- 86 people
- Sponsor
- University of Nottingham
Old Age (Focus; Not a Recognized Condition)
Dysfunction of Nutritive Blood Flow as a Determinant of Anabolic Resistance With Age; the Role of Amino Acids in Modulating Muscle Metabolism
The investigators plan to measure changes in muscle protein metabolism in response to feeding, comparing between a single large essential amino acid (EAA) feed (the normal building blocks of protein) and the provision of the same…
- Trial name
- Ajinomoto1A (NCT01735539)
- Testing
- 15g EAA bolus, 4 x 3.75g Mixed EAA Pulses, 15g EAA Bolus supplemented with 3g Arginine
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Old Age
Modulation of Muscle Protein Metabolism by Essential Amino Acids
The investigators plan to explore the ability of amino acids, the building blocks of proteins in our bodies and in the food we eat, to stimulate muscles to grow and stay strong.
- Trial name
- Aj1B (NCT01890369)
- Testing
- 15g Mixed Essential Amino Acids, 3g Leucine, 15g Mixed Essential Amino Acid REFEED
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Osteoarthritis of the Knee
Measures of Pain Relevant to Knee Osteoarthritis
The aim is to improve understanding of the assessment of pain experience in patients with osteoarthritis (OA) of the knee. The current study will be divided into two parts.
- Trial name
- NCT01310257
- Testing
- Questionnaires
- Where
- 3 sites in United Kingdom
- Volunteers
- 448 people
- Sponsor
- University of Nottingham
Evidence of Adaptation to Dietary Exposure to Fructans
Pilot Study of the Effect of Fructans on Fermentation in the Colon & Transit
Some carbohydrates (complex sugars) which are found in grains, fruit and vegetables, cannot be digested by humans. When eaten they pass through the small bowel to the large bowel, or colon.
- Trial name
- PERFECT (NCT01963364)
- Testing
- Inulin challenge, oligofructose supplement
- Where
- 2 sites in United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Irritable Bowel Syndrome With Diarrhoea
Mesalazine for the Treatment of Diarrhoea-predominant Irritable Bowel Syndrome (IBS-D)
The purpose of the trial is to define the clinical benefit and possible mediators of the benefit of mesalazine in Irritable Bowel Syndrome (IBS) with diarrhoea.
- Trial name
- MIBS (NCT01316718)
- Testing
- Mesalazine
- Where
- United Kingdom
- Volunteers
- 108 people
- Sponsor
- University of Nottingham