Clinical trials: sponsored by University of Nottingham
Anosmia, Parosmia
Multimodal Chewing Gum Flavour Training to Aid Flavour Perception Recovery - a Pilot Study.
Olfactory training is developed for people who have partly or completely lost their sense of smell (olfactory dysfunction). Participants expose themselves to odours twice daily for usually 12 weeks or longer.
- Conditions
- Anosmia, Parosmia, Phantosmia, Dysgeusia
- Trial name
- FITS (NCT07498062)
- Testing
- Flavour impairment training using chewing gum group (FIT), Olfactory training group (OT), Waiting list control group
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Nottingham
Autism Disorders and Maternal Stress, Autism
CFT Guided Self-help Intervention: Parents of Autistic Children
This research will aim to test how practical, achievable and effective a brief, guided, self-help compassion focused intervention is for parents of autistic children aged 6-17 years old.
- Conditions
- Autism Disorders and Maternal Stress, Autism, Autism Disorder, Autism Spectrum Disorder
- Trial name
- CFT-GSH-PAC (NCT07498049)
- Testing
- Guided, self-help compassion-focused intervention for parents of autistic children
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Immune-Mediated Hepatitis
Checkpoint Inhibitor-induced Liver Injury
In this multi-center prospective observational study, the investigators plan to identify the incidence and risk factors for checkpoint inhibitor-induced liver injury and characterize biochemical, genetic, immunological, and…
- Trial name
- ChILI (NCT04476563)
- Testing
- Obtaining biological samples
- Where
- United Kingdom
- Volunteers
- 160 people
- Sponsor
- University of Nottingham
Mentalisation, Mentalization
Mentalization-Based Therpay With Older Adults
The investigators would like to find out if Mentalization-Based Therapy (MBT) is effective for people aged 60+ who struggle in relationships.
- Conditions
- Mentalisation, Mentalization, Later Life, Older Adults
- Trial name
- NCT07065071
- Testing
- Mentalization-Based Therapy
- Where
- United Kingdom
- Volunteers
- 3 people
- Sponsor
- University of Nottingham
Dementia, Hip Fracture
Communication for Early Mobilisation of People Living With Dementia Following Surgery for Hip Fracture
This goal of this study is to identify ways that healthcare professionals communicate that are effective in helping a person living with dementia to stand or walk after surgery for a broken hip (hip fracture).
- Conditions
- Dementia, Hip Fracture, Early Mobilisation, Communication Research
- Trial name
- VOICE-HF (NCT07418268)
- Volunteers
- 200 people
- Sponsor
- University of Nottingham
Tinnitus
WHITBY: Working Towards Better Healthcare Interventions for Tinnitus: a Brain Stimulation studY
Tinnitus - the awareness of sound without any outside source - affects around 15% of people and can cause anxiety and depression. Treatment options are limited and do not address tinnitus directly (e.g., reduce its loudness).
- Trial name
- WHITBY (NCT06628414)
- Testing
- transcranial Direct Current Stimulation
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Nottingham
Healthcare Inequities, Health Intervention
Ethnic Minorities Experiences of Healthcare Intervention
As ethnic diversity in Britain continues to grow, so do the health needs in a society with many different ethnic backgrounds, including the need for personalised healthcare.
- Conditions
- Healthcare Inequities, Health Intervention, Study Focus is Healthcare Interventions and Health Inequalities
- Trial name
- EM (NCT07211698)
- Testing
- Qualitative study - Phase 1, Qualitative study - Phase 2
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Stroke, Trauma
Focused Ultrasound Stimulation of the Cerebellum to Induce Changes in Cognition and Brain Activity
The goal of this preclinical study is to assess the effects of focused ultrasound stimulation to the cerebellum on brain dynamics and cognition in healthy volunteers aged 18 to 40.
- Conditions
- Stroke, Trauma, Cognition, Agency
- Trial name
- FUSCBM (NCT07389447)
- Testing
- Focused ultrasound, EEG
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Psychosis, Schizophrenia and Other Psychotic Disorders
What is the Feasibility of Narrative Exposure Therapy (NET) for People Experiencing Psychosis?
The goal of this interventional study is to evaluate the feasibility of Narrative Exposure Therapy (NET) for people experiencing psychosis.
- Trial name
- NCT07237529
- Testing
- Narrative Exposure Therapy (NET)
- Volunteers
- 1 people
- Sponsor
- University of Nottingham
Tinnitus
Blinding and Adverse Effects of Ultrasonic Vagus Nerve Stimulation (U-VNS) in Tinnitus
The vagus nerve is a large nerve that runs from the gut to the brain. It consists of two main sections, left and right, and comprises a series of branches. One of these branches runs through the ear.
- Trial name
- BLAST II (NCT07291648)
- Testing
- Device: Ultrasound Vagus Nerve Stimulation (U-VNS)
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Nottingham
Accidental Falls, Fall Prevention
Technology Supported Improvement, Management and Prevention of Accidental Falls in Hospitals
The student will observe fall prevention systems in practice in 2 different hospitals considering how fall prevention technology influences staff behaviour and patients safety in the context of accidental falls in hospital.
- Trial name
- TechSIMPAFiH (NCT07355556)
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Acquired Brain Injury
Family-Centred ACT After Paediatric ABI
Children and young people with acquired brain injury (ABI) commonly experience long-term emotional, behavioural, and participation difficulties that can affect quality of life for both them and their families.
- Trial name
- FamilyCARE-ABI (NCT07303075)
- Testing
- Acceptance and Commitment Therapy (DNA-V)
- Volunteers
- 6 people
- Sponsor
- University of Nottingham
Chronic Pain, Pain, Chronic
Pain at Work Toolkit in Employees With Chronic Pain
This project will test the feasibility and acceptability of the Pain at Work (PAW) Toolkit which aims to help employees self-manage chronic or persistent pain at work.
- Trial name
- PAW (NCT05838677)
- Testing
- Pain at Work Toolkit, Active control
- Where
- United Kingdom
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Healthy Participants
Non-invasive Ultrasonic Auricular Vagus Nerve Stimulation
The Vagus nerve, one of 12 cranial nerves that connect the brain to the human body, controls specific involuntary functions such as breathing, heart rate, the digestive system and the immune system, and it is crucial to unlocking…
- Trial name
- SONIC (NCT07283913)
- Testing
- Ultrasound Vagus Nerve Stimulation (U-VNS)
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Chronic Knee Pain, Fibromyalgia
Investigating the Role of Central Pain Hypersensitivity in Skeletal Muscle Neural Drive
Background: pain lasting for 12 weeks or beyond, which is often referred to as chronic pain, is common for people living with musculoskeletal conditions (e.g. arthritis, low back pain and fibromyalgia).
- Trial name
- Pain-Drive (NCT07281651)
- Testing
- Central Pain Hypersensitivity
- Where
- United Kingdom
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Low Back Pain, Chronic
A Combined Exercise Programme Involving Strengthening, Flexibility and Aerobic Exercise for Lower Back Pain
This randomised controlled trial will evaluate the effectiveness of different exercise modalities for individuals with low back pain.
- Trial name
- NCT06921694
- Testing
- Runner group, Swim/Cycle Group
- Where
- United Kingdom
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Obesity
Effect of Oral Feeding on Gastric Emptying, Gut Blood Flow, and Hormone Responses in Obese and Healthy Weight Subjects
Obesity is a complicated condition that is poorly understood. The aim of this study is to increase our knowledge of how the condition may arise, and what makes obese people remain obese.
- Trial name
- NCT03860623
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Sedentary Behavior, Metabolic Syndrome
Multi-organ Responses to CHronic Physical Activity and INactivity
Life expectancy has been increasing for the last 150 years, but the maintenance of health has not kept pace with increased lifespan, and on average, UK adults spend the last decade of life in poor-health, with major consequences…
- Conditions
- Sedentary Behavior, Metabolic Syndrome, Age-related Cognitive Decline, Age-Related Sarcopenia
- Trial name
- CHAIN (NCT06377254)
- Testing
- Decreased Physical Activity, Increased Physical activity
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Blood Pressure
Effects of Dietary Nitrate and Vitamin C Co-supplementation on Blood Pressure and Endothelial Function in Overweight Individuals
The investigators have shown in two short-term studies in healthy, young participants that the combined supplementation of inorganic nitrate with vitamin C has beneficial effects on blood pressure and blood vessel wall stiffness.
- Trial name
- NCT07242066
- Testing
- Beetroot juice plus vitamin C tablet
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Insulin Resistance, Obesity
The Effects of Orange Juice on Insulin Sensitivity and Plasma Lipids
The aim of this study is primarily to investigate the ability of antioxidants found in orange juice (OJ) to increase the body's sensitivity to the hormone insulin.
- Trial name
- NCT01201603
- Testing
- orange juice
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Nottingham