Clinical trials: sponsored by University of Nottingham
Stroke (CVA) or TIA
Characterising the Neuromuscular Function of Post Stroke Patients
Strokes are a leading cause of death and disability in developed countries, with significant economic and social impacts. Defined by the WHO, strokes cause rapid and lasting disturbances in cerebral function.
- Trial name
- (cSTROKE) (NCT07013188)
- Testing
- Neuromuscular function
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University of Nottingham
Hypertension, Vascular Diseases
The Effect of Chronic Remote Ischaemic Preconditioning on Blood Pressure in Older Adults
The purpose of this study is to assess whether remote ischaemic conditioning, applied chronically, improves vascular health in older adults
- Trial name
- RIPCo (NCT05971407)
- Testing
- Remote Ischaemic Preconditioning
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Multiple Sclerosis
Optimising Access to Vocational Rehabilitation for People With Multiple Sclerosis
People with multiple sclerosis (MS) often leave the workforce prematurely due to MS symptoms and difficulties managing workplace relationships and performance.
- Trial name
- MS_Work_Hub (NCT06966115)
- Testing
- Multiple Sclerosis Vocational Rehabilitation (MSVR)
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Nottingham
Cognitive Impairment
The Effect of Upper Limb Low-intensity Motor Control Training Program on Cognitive Function in Healthy Older Adults
This healthy volunteer intervention study is designed to evaluate the effectiveness of upper limb motor control training (uMCT) on physical and cognitive functions in older adults.
- Trial name
- uMCON (NCT06962722)
- Testing
- Upper limb motor control training (uMCON)
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Depression - Major Depressive Disorder, ANXIETY DISORDERS (or Anxiety and Phobic Neuroses)
Is Betwixt App Effective and Acceptable?
Title Is the Betwixt application effective and acceptable in improving emotion regulation for an adult clinical population? Short title Betwixt: Effective/acceptable clinical population emotion regulation? Chief Investigator…
- Trial name
- NCT06958887
- Testing
- Betwixt app intervention
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- University of Nottingham
Older People
The Effects of Moderate Intensity Cycle Ergometer vs. Treadmill Training on Physiological Resilience in Older Adults
Government guidelines suggest that we should all take part in approximately two and a half hours each week of moderate-intensity aerobic exercise.
- Trial name
- MICeT (NCT06955676)
- Testing
- treadmill exercise, cycle ergometer exercise
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Muscular Atrophy, Immobility Syndrome
Mechanisms of Disuse Atrophy in Human Skeletal Muscle (iMOB)
Loss of muscle can be caused by a variety of stimuli and results in reduced mobility and strength and also impacts whole body health. Whilst it is known that muscles waste the process by which this occurs is not well understood.
- Trial name
- iMOB (NCT04199923)
- Testing
- Single leg immobilisation
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Skeletal Muscle Atrophy
Post-operative Electrical Muscle Stimulation to Stimulate Muscle Protein Synthesis in Humans
Skeletal muscle accounts for approximately 45-55% of total body mass in healthy adults and plays a pivotal role in whole-body metabolic health, locomotion and physical independence.
- Trial name
- PoEMS (NCT05997095)
- Testing
- Neuromuscular electrical stimulation (NMES/0
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Type2 Diabetes, NAFLD
Effects of VLCD and Bariatric Surgery in Patients With Type 2 Diabetes
The investigators are therefore interested to explore the effects of VLCD and different bariatric surgery procedures to changes in the physical deposition of fat in organs which regulate glucose metabolism (i.e.
- Conditions
- Type2 Diabetes, NAFLD, Obesity
- Trial name
- BARIATRICMRI (NCT05092399)
- Testing
- Bariatric Surgery
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- University of Nottingham
Infant, Premature, Discharge
FAcilitating Safe Transition to Home for Preterm Infants: an Observational Study
Finding out what the common discharge barriers are in neonatal units will help design and develop services to facilitate safe, early discharge in preterm babies. This study will have 2 components.
- Trial name
- FAST-Home (NCT05609305)
- Testing
- Discharge
- Where
- United Kingdom
- Volunteers
- 155 people
- Sponsor
- University of Nottingham
Muscle Atrophy, Age-Related Sarcopenia
Impacts of Mechanistic Target of Rapamycin (mTOR) Inhibition on Aged Human Muscle (Rapamune)
As people age, muscle mass and function is lost and exercise training is an important way to reduce the effects of this and remain independent.
- Trial name
- Rapamune (NCT05414292)
- Testing
- Rapamune (sirolimus) 1Mg Tablet, Unilateral resistance exercise training
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Chronic Kidney Diseases
National Unified Renal Translation Research Enterprise - Chronic Kidney Disease
Chronic Kidney Disease (CKD) affects around 10% of the adult population and is associated with an increased risk of heart attack, stroke and end stage kidney disease (ESKD).
- Trial name
- NURTuRE-CKD (NCT04084145)
- Where
- 2 sites in United Kingdom
- Volunteers
- 3,004 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Infertility, Subfertility
The Accuracy of Endometrial Ultrasound to Predict Implantation
To measure the accuracy of different ultrasound endometrial patterns to predict successful embryo implantation during assisted conception; in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI).
- Trial name
- NCT03860636
- Testing
- Endometrial Pattern on Ultrasound at ET, Endometrial Pattern on Ultrasound at HCG, Endometrial Pattern on Ultrasound at TVOR
- Where
- United Kingdom
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Irritable Bowel Syndrome
Effect of MethylceIlulose or Psyllium on Fermentation of Inulin Assessed Using a Gas Sensing Capsule
The investigators plan to measure the local (in vivo) production of hydrogen when methylcellulose is ingested, to see if the investigators can show a shift of the site of fermentation to the distal colon.
- Trial name
- REALISTIC (NCT06551948)
- Testing
- psyllium, methylcellulose, maltodextrin
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Healthy
Very Low-calorie Diet & Cardiometabolic Health
To investigate the effects of a short-term (1-week) nutritional intervention in healthy individuals using very low-calorie (fasting-mimicking) diets with different protein content on markers of cardiometabolic health and…
- Trial name
- NCT06560996
- Testing
- Very low calorie diet with low protein content (VLCD-LP group), Very low calorie diet with high protein content (VLCD-HP group)
- Where
- Switzerland
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Dysphagia, Stroke
Swallow Training with Biofeedback in Acute Post Stroke Dysphagia
About 50% of people who have a stroke experience difficulty swallowing. There is a growing evidence base showing that swallowing therapy can help to improve swallowing, but we don't know which type or how much therapy is most…
- Trial name
- ssSIP (NCT05744245)
- Testing
- Swallow Strength and Skill Training
- Where
- United Kingdom
- Volunteers
- 34 people
- Sponsor
- University of Nottingham
Pain, Chronic, Pain
Understanding and Managing Pain for Thalidomide Survivors
Aim: To explore the pain experience of Thalidomide survivors and propose an effective pain management service, tailored to meet the unique needs of this population.
- Trial name
- TRIUMPH-TS (NCT06398132)
- Testing
- Usual Care
- Where
- United Kingdom
- Volunteers
- 73 people
- Sponsor
- University of Nottingham
Older Adult
High-intensity Interval Training Combined with Muscle-strength Training in Older Women
Women generally live longer than men but often experience a faster muscle mass loss due to inactivity, which can lead to weakness and disability. Despite these risks, women, particularly older women, are less active than men.
- Trial name
- NCT06825130
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Healthy
Muscle Mass, Quality, and the Menopause: Sex-specific Strategies to Mitigate Sarcopenia in Ageing Populations
Aging causes muscles to often become smaller and weaker resulting in physical frailty and functional impairments, such as difficulty raising from a chair, dressing, and preparing meals.
- Trial name
- NCT06806501
- Testing
- Unilateral Resistance Exercise
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Sucrase Isomaltase Deficiency
Genetic Carbohydrate Maldigestion As Model to Study Food Hypersensitivity Mechanism (WORK PACKAGE 2)
Irritable bowel syndrome (IBS) affects one in seven people with gastrointestinal (GI) symptoms that are detected without an established underlying organic cause.
- Trial name
- GenMalCarb2 (NCT06770907)
- Testing
- Blood, stool and saliva collection, Questionnaire completion, Magnetic Resonance Imaging (MRI) and Breath test
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Nottingham