Clinical trials: sponsored by University of Nottingham
Insulin Resistance
The Effects of Cocoa Flavanols on Insulin Resistance in an 'At-risk' Population
The aim of the current study is to investigate the ability of antioxidants found in cocoa ('flavanols') to increase the body's sensitivity to the hormone insulin.
- Trial name
- NCT01201590
- Testing
- High Flavanol Cocoa, Low Flavanol Cocoa
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Sarcopenia
Assessing the Impact of "Super-whey" vs. Isonitrogenous Whey on Muscle Protein Synthesis
Skeletal muscle accounts for approximately 45-55% of total body mass in healthy adults and plays a pivotal role in whole-body metabolic health, locomotion and physical independence.
- Trial name
- ARLA-WHEY (NCT05701202)
- Testing
- Super-Whey protein, Isonitrogenous whey protein
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Post-Traumatic Stress Disorder in Children, Post-Traumatic Stress Disorder in Adolescence
Video NET With CYP Who Witnessed Domestic Violence
Research suggests that children and young people (CYP) who witness domestic violence are susceptible to develop Post-traumatic stress (PTS).
- Conditions
- Post-Traumatic Stress Disorder in Children, Post-Traumatic Stress Disorder in Adolescence, Post-Traumatic Stress Disorder Complex, Domestic Violence
- Trial name
- NCT04866511
- Testing
- Narrative Exposure Therapy
- Where
- 2 sites in United Kingdom
- Volunteers
- 5 people
- Sponsor
- University of Nottingham
Crohn Disease
Non-invasive Approaches to Identify the Cause of Fatigue in Inflammatory Bowel Disease Patients.
Crohn's disease (CD) presents with severe symptoms, but fatigue is a very predominant symptom that negatively impacts upon quality of life.
- Trial name
- IBD Fatigue (NCT03670693)
- Testing
- Muscle strength and fatigue assessment, Dual-energy X-ray absorptiometry (DEXA scan), Supine cardiorespiratory fitness assessment
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
COPD, IPF
Functional MR Lung Imaging Using Hyperpolarised 129Xe
The aim of this study is to investigate the potential value of a novel imaging technique (hyperpolarized 129Xe lung imaging) in the diagnosis and assessment of lung disease in patients with COPD and IPF.
- Trial name
- NCT02976935
- Testing
- hyperpolarised 129 Xenon
- Where
- United Kingdom
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Patient Safety, Inappropriate Prescribing
A Randomised Pilot Study of the REVISiT Intervention
In 2012, the General Medical Council (GMC) funded PRACtICe (PRevalence And Causes of prescrIbing errors in general practiCe) study, reported that 1 in 20 prescriptions in general practice were found to have a prescribing or…
- Conditions
- Patient Safety, Inappropriate Prescribing, Medication Errors
- Trial name
- NCT04586595
- Testing
- REVISiT intervention
- Where
- 4 sites in United Kingdom
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Pain, Opioid Use
The Experiences of People Prescribed Opioid Pain Medicines
Opioids are morphine-type medicines which come from the opium poppy or are similar-to morphine. They are very effective for short-term pain, cancer pain, and pain at the end of life.
- Trial name
- NCT04888897
- Where
- United Kingdom
- Volunteers
- 619 people
- Sponsor
- University of Nottingham
Inflammatory Bowel Diseases, Sarcopenia
Phenotyping of Adult Crohn's Focusing on Sarcopenia
Inflammatory bowel disease (IBD) includes two idiopathic chronic relapsing and remitting inflammatory conditions affecting the gastrointestinal (GI) tract: Crohn's disease (CD) and ulcerative colitis (UC)Malnutrition and…
- Conditions
- Inflammatory Bowel Diseases, Sarcopenia, Digestive System Disease, Nutrition, Healthy
- Trial name
- PACS (NCT05572203)
- Testing
- Intrinsically labelled protein
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Parkinson Disease, Progression, Disease
Neuromelanin MRI: A Progression Marker in Early PD
Prospective observational study to qualify NM-MRI as progression marker in early Parkinson's.
- Trial name
- InsIghtPD (NCT05631158)
- Testing
- MRI
- Where
- United Kingdom
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Eczema
Barrier Enhancement for Eczema Prevention
The primary objective is to determine whether advising parents to apply emollient (moisturiser) to their child's skin for the first year of life in addition to best practice infant skin care advice can prevent or delay the onset…
- Trial name
- BEEP (NCT04680520)
- Testing
- Experimental (Doublebase Gel® or Diprobase Cream®), Best practice skin care advice booklet
- Where
- 16 sites in United Kingdom
- Volunteers
- 1,394 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Arthroplasty Complications, Fibrosis
Physiotherapy for Arthrofibrosis Following Knee Replacement.
This research aims to develop an optimal physiotherapy intervention for people with arthrofibrosis (stiffness due to scar tissue) after total knee replacement (TKR). We will develop an optimal intervention by conducting: 1.
- Conditions
- Arthroplasty Complications, Fibrosis, Knee Joint Contracture
- Trial name
- ReSTART (NCT05459259)
- Testing
- Interviews and Delphi Survey
- Where
- United Kingdom
- Volunteers
- 145 people
- Sponsor
- University of Nottingham
Dementia
Preliminary Randomised Evaluation of Singing in Dementia
Background and study aims Dementia affects about 800,000 people in the UK, with the number expected to rise. As well as searching for medical treatments for dementia, there is a need for helpful social activities to support…
- Trial name
- PRESIDE (NCT05573750)
- Testing
- Singing group
- Where
- 2 sites in United Kingdom
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Stroke, Acute
Desmopressin for Reversal of Antiplatelet Drugs in Stroke Due to Haemorrhage
Haemorrhagic stroke, an emergency caused by bleeding in the brain, often leads to death or long-term disability. A quarter of these patients are taking blood-thinning drugs (antiplatelet drugs, such as aspirin) because they are…
- Trial name
- DASH (NCT03696121)
- Testing
- Desmopressin Injection, Normal saline
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- University of Nottingham
Type 2 Diabetes Mellitus in Obese
Glucagon-like Peptide-1 Agonism With Very Low Calorie Diets
The very-low calorie diet (VLCD) is a highly effective and safe way to rapidly lose significant amounts of weight and dramatically improve blood sugar control in a short period of time (typically 8-12 weeks).
- Trial name
- SemVLCD (NCT05606471)
- Testing
- Semaglutide Pen Injector [Ozempic], Very-low Calorie Diet
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- University of Nottingham
Metabolic Disturbance, Obesity
The Effect of Irregular Meal Pattern Providing Hypo-energetic Diet on Energy Expenditure and Metabolism
In this study we will compare the effect of two different meal patterns. Firstly, participants will consume a diet providing their estimated energy requirement for a 7 day standardisation period (6 meals per day).
- Trial name
- NCT05569837
- Testing
- Regular meal pattern, Irregular meal pattern
- Where
- United Kingdom
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Crohn Disease
ProteIn Nutrition in Crohn's Disease
Muscles are essential for good quality of life. The investigators have shown that when children with Crohn's disease eat protein, only very little of it enters the muscles, leading to poor muscle growth and fatigue.
- Trial name
- PINC (NCT05572008)
- Testing
- Protein nutrition in paediatric Crohn's disease
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Enteral Nutrition
Comparison of an Alginate Containing Enteral Feed and an Alginate Free Enteral Feed.
When patients cannot eat and drink enough a tube can be placed through their nostril, down the back of their throat into their stomach and used to give their nutrition as a liquid feed.
- Trial name
- AlgiNG (NCT04113200)
- Testing
- MerMed One, Nutricomp Soy Fibre
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Nitrogen Balance
The Effect of Irregular Meal Pattern on Nitrogen Balance in Healthy Normal-weight Women
Nitrogen balance (NB) is defined as the net difference between the intake of nitrogen (input) and its excretion (output). NB was considered as an indicator of the catabolic stress level.
- Trial name
- NCT05226650
- Testing
- Regular meal pattern, Irregular meal pattern
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Multiple Sclerosis
Who Benefits Most From Cognitive Rehabilitation for Multiple Sclerosis?
Over the last 20 years, there have been many studies investigating the efficacy of attention and memory rehabilitation for people with multiple sclerosis (MS) however, there appears to be a lack of conclusive evidence regarding…
- Trial name
- NCT05509426
- Testing
- Cognitive Rehabilitation
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- University of Nottingham
Tinnitus
MaST: MEG and Brain Stimulation in Tinnitus
Tinnitus is the awareness of a sound in the ear or head without any outside source. It affects around 15% of people in the UK. About 20% of people with tinnitus experience symptoms that negatively affect their quality of life…
- Trial name
- MaST (NCT04978142)
- Testing
- transcranial Direct Current Stimulation (tDCS)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Nottingham