Clinical trials: sponsored by University of Pennsylvania
Pancreatic Cancer, Serous Ovarian Cancer
huCART-meso + VCN-01 in Pancreatic and Ovarian Cancer
This is a single-center phase 1 study to evaluate the safety and feasibility of huCART-meso cells given in combination with VCN-01 in patients with unresectable or metastatic pancreatic adenocarcinoma and serous epithelial…
- Trial name
- NCT05057715
- Testing
- VCN-01, huCART-meso Cells
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Pennsylvania
Chemotherapy Resistant Acute Lymphoblastic Leukemia, Refractory Acute Lymphoblastic Leukemia
CART22 Alone or in Combination With huCART19 for ALL
This is a single center, open-label, phase 1 study to determine the safety and feasibility of infusing CART22-65s with or without huCART19 after administration of lymphodepleting chemotherapy in adult patients with relapsed or…
- Trial name
- NCT03620058
- Testing
- CART22-65s cells, huCART19 Cells
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Pennsylvania
HIV Infections, Opioid Use
Evaluation of Neuroinflammation FNOS PET/CT in HIV (+) and (-) Subjects With OUD and Healthy Controls
The purpose of this research is to measure the extent of inflammation in the brain between different groups of participants using a radioactive tracer called [18F]NOS.
- Trial name
- NCT04401917
- Testing
- [18F]NOS
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cognitive Behavioral Therapy, Therapy
AI-Based Fidelity Feedback to Enhance CBT
This study is being conducted together by researchers at the University of Pennsylvania and Lyssn.io, Inc., ("Lyssn"), a technology start-up developing digital tools to support evidence-based psychotherapies (EBPs) for mental…
- Trial name
- AFFECT (NCT05340738)
- Testing
- LyssnCBT
- Where
- United States
- Volunteers
- 448 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Antimicrobial Resistance
Surveillance of Healthcare-associated Infections & Antimicrobial Resistance
The aims of this project, called "Surveillance of Healthcare-associated infections \& Antimicrobial Resistance", or "SHARE", are to 1) enhance laboratory capacity to detect emerging AMR patterns; 2) strengthen hospital…
- Trial name
- NCT05734391
- Testing
- Routine Infection control
- Where
- 2 sites in United States, Botswana
- Volunteers
- 642 people
- Sponsor
- University of Pennsylvania
Crohn Disease
Addressing Disability Effectively With Psychosocial Telemedicine
This multi-site study will be implemented at 5 gastroenterology practices to recruit 420 adults with IBD to complete a baseline survey and enroll those with higher scores on a validated IBD-disability scale into a randomized…
- Trial name
- ADEPT (NCT05635292)
- Testing
- Tele-CBT
- Where
- United States
- Volunteers
- 715 people
- Sponsor
- University of Pennsylvania
Dementia
Evaluation of the PACE/PACENET BHL Caregiver Program
This project will conduct a retrospective clinical database review and a one-time research interview to evaluate outcomes among a sub-set of caregivers (CGs) who were enrolled in the Behavioral Health Laboratory (BHL) Caregiver…
- Trial name
- CREST (NCT02463708)
- Testing
- BHL COTP
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- University of Pennsylvania
Depression, Anxiety
Evaluation of the PACE/PACENET BHL Clinical Program
The SUpporting Seniors Receiving Treatment And INtervention (SUSTAIN) program is a telephone-based clinical service designed to help identify and manage behavioral health issues among PACE/PACENET enrollees.
- Conditions
- Depression, Anxiety, Pain, Chronic
- Trial name
- SUSTAINIV (NCT02463266)
- Testing
- SUSTAIN Monitoring and Care Management
- Where
- United States
- Volunteers
- 4,000 people
- Sponsor
- University of Pennsylvania
Seriously Ill Hospitalized Patients
Comparing Optimized Models of Primary And Specialist Services for Palliative Care
Palliative care (PC) seeks to reduce suffering and improve quality of life for patients with serious illnesses and their families.
- Trial name
- COMPASS-PC (NCT07224594)
- Testing
- Default Order, Accountable Justification, Standardized Usual Care
- Where
- 2 sites in United States
- Volunteers
- 78,302 people
- Sponsor
- University of Pennsylvania
Obsessive - Compulsive Disorder
SONATA Dose Duration LIFU for OCD
This study is testing a new, non-invasive brain stimulation approach for adults with Obsessive Compulsive Disorder (OCD). Researchers are evaluating the safety, tolerability, and target engagement of low-intensity focused…
- Trial name
- NCT07887633
- Testing
- ATTN201 - Low Intensity Focused Ultrasound
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Tobacco Use, Tobacco Use Cessation
Automating Tobacco Cessation in Primary Care
This study focuses on improving how primary care teams identify patients who smoke and offer access to nicotine replacement therapy, or NRT.
- Trial name
- NCT07735286
- Testing
- Tobacco counseling resources
- Where
- United States
- Volunteers
- 4,800 people
- Sponsor
- University of Pennsylvania
HIV, Intravenous Substance Abuse
Implementing PrEP for Women Who Inject Drugs
Women who inject drugs are among the most vulnerable to acquiring HIV, but very few women who inject drugs are prescribed pre-exposure prophylaxis (PrEP) for HIV prevention largely due to barriers within our healthcare system.
- Conditions
- HIV, Intravenous Substance Abuse, Women's Health, Organization and Administration
- Trial name
- NCT05360849
- Testing
- Practice Facilitation
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Brain Structure, Cognitive Performance
Effects of Long-Duration Spaceflight on General and Spatial Cognition and Its Neural Basis
This study investigates the effects of extended-duration spaceflight (12-month International Space Station missions) on general cognitive performance (measured with the Cognition test battery), spatial cognition, structural and…
- Trial name
- NCT04856410
- Testing
- Spaceflight, Controls
- Where
- 3 sites in United States, Germany
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Alcohol Use Disorder, Ketosis
Effects of Ketones on Brain Energetics and Alcohol Consumption in Alcohol Use Disorder
This is a randomized, double-blind, crossover trial to evaluate the immediate effects of a nutritional ketone supplement, Kenotic compared to placebo on brain function and alcohol consumption in individuals with alcohol use…
- Trial name
- KABA (NCT06807918)
- Testing
- Kenetik, magnetic resonance imaging scan, Alcohol bar lab
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pennsylvania
BRCA1/2 Mutation
INO 5401 Vaccination in BRCA1/2 Mutation Carriers
The research study is being conducted to test an experimental vaccine to potentially prevent cancer for people with BRCA1 or BRCA2 mutations.
- Trial name
- NCT04367675
- Testing
- INO-5401, INO-9012, Cellectra 2000
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Type 2 Diabetes, Type II Diabetes Mellitus
The GRoceries Aimed at Increasing Nutrition Study
Only 2% of Americans meet the recommended levels of whole grain consumption, despite its association with reduced risk of type 2 diabetes.
- Conditions
- Type 2 Diabetes, Type II Diabetes Mellitus, Type II Diabetes, Pre-diabetes
- Trial name
- GRAINS (NCT07167004)
- Testing
- Marketing Nudges Only, Marketing Nudges + Dynamically Adapted Financial Incentives
- Where
- United States
- Volunteers
- 219 people
- Sponsor
- University of Pennsylvania
Anxiety, Depression
Weighted Blankets for Dental Anxiety
The objective of this project is to determine the effectiveness of weighted blankets as an anxiety-reducing intervention for neurotypical adult patients with dental anxiety undergoing routine dental procedures at the University…
- Trial name
- NCT07879846
- Testing
- Blanket at visit 1., No blanket at visit 1, Blanket at visit 2.
- Volunteers
- 50 people
- Sponsor
- University of Pennsylvania
HIV, Hypertension
Tracking Income Dynamics and Everyday Health Study
Among adults with chronic illnesses like hypertension, diabetes, or HIV, adherence to daily oral medications is essential but often below 50%.
- Conditions
- HIV, Hypertension, Hypercholerolemia, Type 2 Diabetes
- Trial name
- TIDES (NCT07862452)
- Testing
- Preventative health review invitation early in SNAP cycle, Financial counseling invitation early in the SNAP cycle, Aim 3 follow-up call early in the SNAP period
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Pennsylvania
End Stage Renal Disease
Light Therapy in End Stage Kidney Disease
The goal of this clinical trial is to test light therapy in patients with end stage kidney disease who are receiving hemodialysis. The main aim is to determine if light therapy decreases fatigue severity.
- Trial name
- NCT06310161
- Testing
- Bright light, Dim Light
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pennsylvania
HIV/AIDS
Enhancing the Organizational Social Context to Improve Viral Suppression and Retention in HIV Care
Despite the widespread use of effective antiretroviral therapy (ART), the HIV epidemic continues to impact racial and ethnic minority populations disproportionately.
- Trial name
- NCT06462807
- Testing
- ARC
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- University of Pennsylvania
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