Clinical trials: active, sponsored by University of Pennsylvania
Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia
Phase 1 Study of huCART19-IL18-CD428z Cells for the Treatment of Patients With HIV With CD19+ Cancers
This research study is being conducted to evaluate an experimental drug called huCART19-IL18-CD428z cells in patients living with HIV who have been diagnosed with Non-Hodgkin Lymphoma (NHL), Chronic Lymphocytic Leukemia (CLL)…
- Conditions
- Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia, Acute Lymphoblastic Leukemia, Richter's Transformation
- Trial name
- NCT07891468
- Testing
- huCART19-IL18-CD428z cells
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Pennsylvania
Depression, Anxiety
Evaluation of the PACE/PACENET BHL Clinical Program
The SUpporting Seniors Receiving Treatment And INtervention (SUSTAIN) program is a telephone-based clinical service designed to help identify and manage behavioral health issues among PACE/PACENET enrollees.
- Conditions
- Depression, Anxiety, Pain, Chronic
- Trial name
- SUSTAINIV (NCT02463266)
- Testing
- SUSTAIN Monitoring and Care Management
- Where
- United States
- Volunteers
- 4,000 people
- Sponsor
- University of Pennsylvania
Dementia
Evaluation of the PACE/PACENET BHL Caregiver Program
This project will conduct a retrospective clinical database review and a one-time research interview to evaluate outcomes among a sub-set of caregivers (CGs) who were enrolled in the Behavioral Health Laboratory (BHL) Caregiver…
- Trial name
- CREST (NCT02463708)
- Testing
- BHL COTP
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- University of Pennsylvania
BRCA1/2 Mutation
INO 5401 Vaccination in BRCA1/2 Mutation Carriers
The research study is being conducted to test an experimental vaccine to potentially prevent cancer for people with BRCA1 or BRCA2 mutations.
- Trial name
- NCT04367675
- Testing
- INO-5401, INO-9012, Cellectra 2000
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Brain Structure, Cognitive Performance
Effects of Long-Duration Spaceflight on General and Spatial Cognition and Its Neural Basis
This study investigates the effects of extended-duration spaceflight (12-month International Space Station missions) on general cognitive performance (measured with the Cognition test battery), spatial cognition, structural and…
- Trial name
- NCT04856410
- Testing
- Spaceflight, Controls
- Where
- 3 sites in United States, Germany
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
HIV, Intravenous Substance Abuse
Implementing PrEP for Women Who Inject Drugs
Women who inject drugs are among the most vulnerable to acquiring HIV, but very few women who inject drugs are prescribed pre-exposure prophylaxis (PrEP) for HIV prevention largely due to barriers within our healthcare system.
- Conditions
- HIV, Intravenous Substance Abuse, Women's Health, Organization and Administration
- Trial name
- NCT05360849
- Testing
- Practice Facilitation
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Alcohol Use Disorder, Ketosis
Effects of Ketones on Brain Energetics and Alcohol Consumption in Alcohol Use Disorder
This is a randomized, double-blind, crossover trial to evaluate the immediate effects of a nutritional ketone supplement, Kenotic compared to placebo on brain function and alcohol consumption in individuals with alcohol use…
- Trial name
- KABA (NCT06807918)
- Testing
- Kenetik, magnetic resonance imaging scan, Alcohol bar lab
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pennsylvania
Seriously Ill Hospitalized Patients
Comparing Optimized Models of Primary And Specialist Services for Palliative Care
Palliative care (PC) seeks to reduce suffering and improve quality of life for patients with serious illnesses and their families.
- Trial name
- COMPASS-PC (NCT07224594)
- Testing
- Default Order, Accountable Justification, Standardized Usual Care
- Where
- 2 sites in United States
- Volunteers
- 78,302 people
- Sponsor
- University of Pennsylvania
Tobacco Use, Tobacco Use Cessation
Automating Tobacco Cessation in Primary Care
This study focuses on improving how primary care teams identify patients who smoke and offer access to nicotine replacement therapy, or NRT.
- Trial name
- NCT07735286
- Testing
- Tobacco counseling resources
- Where
- United States
- Volunteers
- 4,800 people
- Sponsor
- University of Pennsylvania
Firearm Safety, Firearm Safety Storage
Firearm Secure Storage Device Distribution RCT
This study aims to learn how to best promote safe firearm storage in the community. Firearm injuries are a major public health concern, and securely storing firearms can help prevent accidental injuries, suicide, and unauthorized…
- Trial name
- NCT07886983
- Testing
- Cable locks, Lock box, Lock box and cable locks
- Volunteers
- 1,858 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Obsessive - Compulsive Disorder
SONATA Dose Duration LIFU for OCD
This study is testing a new, non-invasive brain stimulation approach for adults with Obsessive Compulsive Disorder (OCD). Researchers are evaluating the safety, tolerability, and target engagement of low-intensity focused…
- Trial name
- NCT07887633
- Testing
- ATTN201 - Low Intensity Focused Ultrasound
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Type 2 Diabetes, Type II Diabetes Mellitus
The GRoceries Aimed at Increasing Nutrition Study
Only 2% of Americans meet the recommended levels of whole grain consumption, despite its association with reduced risk of type 2 diabetes.
- Conditions
- Type 2 Diabetes, Type II Diabetes Mellitus, Type II Diabetes, Pre-diabetes
- Trial name
- GRAINS (NCT07167004)
- Testing
- Marketing Nudges Only, Marketing Nudges + Dynamically Adapted Financial Incentives
- Where
- United States
- Volunteers
- 219 people
- Sponsor
- University of Pennsylvania
HIV/AIDS
Enhancing the Organizational Social Context to Improve Viral Suppression and Retention in HIV Care
Despite the widespread use of effective antiretroviral therapy (ART), the HIV epidemic continues to impact racial and ethnic minority populations disproportionately.
- Trial name
- NCT06462807
- Testing
- ARC
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- University of Pennsylvania
Suicide
Army-SPRING Army-Suicide Prevention Research
Every unit in the Connecticut Army National Guard has a Suicide Intervention Officer to provide suicide intervention education awareness for their unit, monitor for soldiers in crisis and connect soldiers with helping resources…
- Trial name
- NCT06547008
- Testing
- Army-SPRING, Risk Reduction Group (Control)
- Where
- 3 sites in United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
HIV, Hypertension
Tracking Income Dynamics and Everyday Health Study
Among adults with chronic illnesses like hypertension, diabetes, or HIV, adherence to daily oral medications is essential but often below 50%.
- Conditions
- HIV, Hypertension, Hypercholerolemia, Type 2 Diabetes
- Trial name
- TIDES (NCT07862452)
- Testing
- Preventative health review invitation early in SNAP cycle, Financial counseling invitation early in the SNAP cycle, Aim 3 follow-up call early in the SNAP period
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Pennsylvania
Anxiety, Depression
Weighted Blankets for Dental Anxiety
The objective of this project is to determine the effectiveness of weighted blankets as an anxiety-reducing intervention for neurotypical adult patients with dental anxiety undergoing routine dental procedures at the University…
- Trial name
- NCT07879846
- Testing
- Blanket at visit 1., No blanket at visit 1, Blanket at visit 2.
- Volunteers
- 50 people
- Sponsor
- University of Pennsylvania
Neurodegenerative Disease
PET Tau - Neurodegenerative Disease Imaging
The purpose of this study is to measure the amount of a protein in the brain known as tau using an imaging procedure called Positron Emission Tomography (PET/CT).
- Trial name
- NCT03143374
- Testing
- 18F-AV-1451
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Pulmonary Hypertension
Understanding the Effects of Pulmonary Arterial Hypertension on Lean Muscle Mass
Patients with pulmonary arterial hypertension (PAH) are at increased risk of muscle loss and decreased physical activity. This study will aim to (1) understand the way in which muscle loss occurs in PAH, particularly the role of…
- Trial name
- MUSCLE UP-PH (NCT07132788)
- Testing
- blood draw, Short Performance Physical Battery, Grip strength test
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of Pennsylvania
Renal Insufficiency, Chronic
SDCC - Prospective Cohort Study of Chronic Renal Insufficiency
Chronic kidney disease (CKD) is a silent epidemic affecting more than 37 million Americans. The burden of morbidity and mortality associated with CKD derives from its frequent progression to end-stage kidney disease (ESKD) and…
- Trial name
- CRIC (NCT00304148)
- Where
- 12 sites in United States
- Volunteers
- 5,499 people
- Sponsor
- University of Pennsylvania
Myeloma
Study of Belantamab Mafodotin as Pre- and Post-autologous Stem Cell Transplant and Maintenance for Multiple Myeloma
This is a single-institution, single-arm, phase 2 study in which belantamab mafodotin (GSK2857916), an antibody-drug conjugate targeting B-cell maturation antigen (BCMA), will be administered to patients with multiple myeloma…
- Trial name
- NCT04680468
- Testing
- Belantamab mafodotin
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Pennsylvania