Clinical trials: sponsored by University of Pittsburgh
Skin Barrier Dysfunction, Healthy Volunteers
Effect of FPP on Cutaneous Barrier Integrity
This pilot study will test how Fermented Papaya Preparation (FPP) impacts overall TEWL of areas that commonly display diminished barrier function, such as the skin from face, arms, and hands.
- Trial name
- FPP OSATO (NCT07725835)
- Testing
- Fermented Papaya Preparation (FPP)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Atrial Fibrillation
PaTH Clinical Data Research Network (CDRN) Atrial Fibrillation (AF) Clinician-Patient Partnership Cohort
The purpose of the PaTH Network AF Clinician-Patient Partnership Cohort is to use clinical data from electronic health records (EHR) and patient reported outcomes (PRO) to answer questions of clinical importance to patients…
- Trial name
- NCT02485288
- Where
- 4 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- University of Pittsburgh
Diabetes Mellitus, Type 2, Lifestyle
Real-time Engagement for Learning to Effectively Control Type 2 Diabetes
The goal of this clinical trial is to learn if a new smartphone app that pairs glucose and exercise data will help adolescents and young adults with type 2 diabetes improve glycemic control.
- Conditions
- Diabetes Mellitus, Type 2, Lifestyle, Hyperglycemia, Physical Inactivity
- Trial name
- REFLECT2D (NCT06375460)
- Testing
- Focused App Prompt, No App Prompt
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Pittsburgh
Cystic Fibrosis, Parenthood Status
Health Outcomes of Parents With Cystic Fibrosis-Aim 2
The goal of this observational prospective study is to determine the health impact of parenthood on United States (US) people with CF in the era of CF transmembrane regulator protein (CFTR) modulators.
- Trial name
- HOPeCF (NCT06296394)
- Testing
- Parenthood
- Where
- 18 sites in United States
- Volunteers
- 146 people
- Sponsor
- University of Pittsburgh
Facial Defect
Autologous Fresh Fat Grafting Followed by Autologous Cryopreserved Fat Grafting
The goal of this clinical trial is to validate the safety and effectiveness of a two-stage approach for minimally invasive craniofacial soft tissue reconstruction using autologous fat grafting in wounded service members and…
- Trial name
- NCT06747715
- Testing
- Serial Fat Grafting Fresh followed by Cryopreserved Fat
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Pittsburgh
Postpartum
Digital Maternal Support Tool Implementation
The goal of this trial is to learn if a smartphone app designed to provide postpartum support is acceptable to new mothers in Pennsylvania.
- Trial name
- NCT07295015
- Testing
- Smartphone application
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pittsburgh
Head and Neck Cancer
Preventing Lymphedema in Patients Undergoing Surgical Treatment for Head and Neck Cancer Through Vein Reconstruction
The goal of this clinical trial is to learn if facial vein reconstruction after neck dissection works to reduce rates of lymphedema in adults getting surgical treatment for head and neck cancer.
- Trial name
- NCT07694726
- Testing
- Facial Vein Reconstruction
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Pittsburgh
Breast Cancer (Advanced/Metastatic), ER Positive
Blood Biomarkers for Breast Cancer Treatment Response
This study looks at whether a simple blood test can help predict how well a breast cancer treatment will work. It follows patients with advanced hormone receptor-positive breast cancer whose cancer has progressed after their…
- Trial name
- TrackER (NCT07860866)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Pittsburgh
Cardiometabolic Health
How Animal and Plant Protein Shakes Change the Body's Nutrient and Health Responses
The goal of this clinical trial is to learn how different protein types affect the body's metabolism and immune system in healthy adults.
- Trial name
- NCT07121010
- Testing
- Animal-Based Protein Smoothie, Plant-Based Protein Smoothie, Plant-Based Protein Smoothie with Leucine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Opioid Overdose, Opioid Use
Machine-Learning Prediction and Reducing Overdoses With EHR Nudges
The goal of this cluster randomized clinical trial is to test a clinician-targeted behavioral nudge intervention in the Electronic Health Record (EHR) for patients who are identified by a machine-learning based risk prediction…
- Conditions
- Opioid Overdose, Opioid Use, Opioid Use Disorder, Opioids
- Trial name
- mPROVEN (NCT06806163)
- Testing
- EHR-Embedded Elevated-Risk Flag, EHR-Embedded Elevated-Risk Flag with Behavioral Nudges, Usual Care
- Where
- United States
- Volunteers
- 1,350 people
- Sponsor
- University of Pittsburgh
Emphysema, Chronic Obstructive Pulmonary Disease
Emphysema Research Registry and Biosample Repository
The Comprehensive Lung Center (CLC) at the University of Pittsburgh Medical Center (UPMC Health System) provides patients with any type of breathing or lung disorder a full range of diagnostic and therapeutic services.
- Conditions
- Emphysema, Chronic Obstructive Pulmonary Disease, Chronic Bronchitis
- Trial name
- NCT00307281
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Preeclampsia, Hypertensive Disorder of Pregnancy
Eliminating Severe Maternal Morbidity With Heart Health Doulas Trial
This is a single site, single-blinded parallel randomized control trial that investigates a multi-level intervention to improve postpartum blood pressure in women with hypertensive disorder pregnancy.
- Conditions
- Preeclampsia, Hypertensive Disorder of Pregnancy, Toxemia, Pregnancy Complications
- Trial name
- HHD (NCT05655936)
- Testing
- Heart Health Doula Intervention Program, Usual Care
- Where
- United States
- Volunteers
- 454 people
- Sponsor
- University of Pittsburgh
Stage III Colorectal Cancer
Use of ctDNA for Monitoring of Stage III Colorectal Cancer
This observational study will evaluate circulating tumor DNA (ctDNA) as a prognostic marker and as a monitor of disease recurrence in stage III colorectal cancer (CRC).
- Trial name
- NCT02842203
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- University of Pittsburgh
Social Cognition, Personality Disorder
Neurocomputational Dynamics of Cooperation
The purpose of this study is to understand brain function, how people make decisions when they interact with others, and how brain function and behavior relate to personality traits.
- Conditions
- Social Cognition, Personality Disorder, Mental Health, Interpersonal Conflict
- Trial name
- COBRA (NCT07759973)
- Testing
- Social Learning Task Battery, Clinical Cohort, Social Learning Task Battery, Online Cohort
- Where
- United States
- Volunteers
- 1,612 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Violence, Physical, Violence, Non-accidental
Community Resiliency Collective Efficacy Intervention
This study will evaluate, via a cluster-randomized controlled trial, the effectiveness of a community-centered intervention that promotes thriving and resiliency to reduce community violence.
- Conditions
- Violence, Physical, Violence, Non-accidental, Violence, Sexual, Violence, Domestic
- Trial name
- NCT05768217
- Testing
- Community Resiliency Collective Efficacy Intervention (CRCEI), Health Education Sessions
- Where
- United States
- Volunteers
- 4,600 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Mental Health Issue, Teamwork
Team-Focused Implementation in Child Advocacy Centers
Child Advocacy Centers (CACs) are well-positioned to identify children at risk for mental health problems and to facilitate access to evidence-based treatments.
- Trial name
- NCT05679154
- Testing
- Team-focused Implementation, Standard Implementation
- Where
- United States
- Volunteers
- 147 people
- Sponsor
- University of Pittsburgh
Urgency Urinary Incontinence
Investigation of Brain Mechanisms Involved in the Urinary Continence Mechanism Associated With Aging
Urge urinary incontinence (UUI) is a common problem in older people which vastly reduces quality of life, yet the cause and mechanism of disease are not well understood.
- Trial name
- NCT04599088
- Testing
- Brain functional MRI with simplified urodynamics
- Where
- United States
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Chronic Low-back Pain, Myofascial Pain
Ultrasound Imaging for Myofascial Pain
The goal of this observational study is to develop and validate a biomarker for lumbar myofascial pain (MP) based on ultrasound obtained measurements of the lumbar muscles and fascia.
- Trial name
- NCT05928884
- Testing
- There is no intervention. It is a phenotyping study only
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Pyruvate Dehydrogenase Complex Deficiency Disease
Natural History and Advanced Genetic Study of Pyruvate Dehydrogenase Complex Deficiencies
Children and adults with pyruvate dehydrogenase complex deficiency (PDCD) are participating in a research study seeking to better understand the genetic causes, symptoms, usefulness of current treatments, and outcomes for these…
- Trial name
- NCT03056794
- Testing
- No intervention
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Pittsburgh
Chemotherapy-related Cognitive Dysfunction
Telehealth and Memory Study
The overall purpose of this trial is to confirm the efficacy of Memory and Attention Adaptation Training (MAAT), a cognitive-behavioral therapy (CBT) for treatment of chemotherapy-related cognitive dysfunction among (female or…
- Trial name
- TAMS (NCT04586530)
- Testing
- Memory and Attention Adaptation Training (MAAT), Supportive Therapy (ST)
- Where
- 2 sites in United States
- Volunteers
- 194 people
- Sponsor
- University of Pittsburgh