Clinical trials: sponsored by University of Pittsburgh
Lung Diseases, Interstitial
Dorothy P. and Richard P. Simmons Center for ILD Research Registry
The purpose of this study is to place past, current, and future medical record information into the UPMC Simmons Center for Interstitial Lung Disease Research Registry.
- Trial name
- ILDRR (NCT00258583)
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- University of Pittsburgh
Sickle Cell Disease
Sickle Cell Disease and CardiovAscular Risk - Red Cell Exchange Trial (SCD-CARRE)
The SCD-CARRE trial is a Phase 3, prospective, randomized, multicenter, controlled, parallel two-arm study aimed to determine if automated exchange blood transfusion and standard of care administered to high mortality risk adult…
- Trial name
- SCD-CARRE (NCT04084080)
- Testing
- Red Blood Cell, Standard of care
- Where
- 23 sites in United States, Brazil and 1 more
- Volunteers
- 173 people
- Sponsor
- University of Pittsburgh
Prostate Cancer
Virtual Reality Headset and/or Aromatherapy for Patients Undergoing a Transperineal Prostate Biopsy
The purpose of this study is to evaluate if a VR headset and/or aromatherapy can be used to reduce patient pain, anxiety, and embarrassment during a transperineal biopsy (TPBx) compared to standard of care (SOC).
- Trial name
- NCT06296147
- Testing
- Virtual Reality Headset, Aromatherapy Patch, Standard of Care
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- University of Pittsburgh
Chronic Kidney Disease Requiring Hemodialysis
Technology Assisted Collaborative Care Intervention to Improve Patient-centered Outcomes in Dialysis Patients
The goal of this study is to learn if a collaborative care intervention of pharmaco-therapy and/or cognitive behavioral therapy (CBT), delivered in a real-world setting, improves symptoms of pain, fatigue and/or depression.
- Trial name
- TACcare 2 0 (NCT06978127)
- Testing
- Technology Assisted Stepped Collaborative Care, Usual Care Arm
- Where
- 2 sites in United States
- Volunteers
- 424 people
- Sponsor
- University of Pittsburgh
Type 1 Diabetes Mellitus
Phipps Conservatory's 5210 Let's Move Pittsburgh and Impact on Youth With T1D
Managing T1D requires a demanding regimen to keep blood sugars in control and stay healthy. Despite recent advances, this remains extremely challenging for children and their families, who usually report having the most…
- Trial name
- NCT07780487
- Testing
- Virtual cooking classes, Routine Diabetes Care
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Pittsburgh
Depression
Cognitive Training as an Adjunct to Ketamine in Real-world Clinics
In a sample of patients already receiving ketamine (or esketamine) treatment as part of their clinical care, this project seeks to test whether we can enhance and/or extend (es)ketamine's rapid effects by introducing helpful…
- Trial name
- NCT06526078
- Testing
- Cognitive Training
- Where
- 3 sites in United States
- Volunteers
- 600 people
- Sponsor
- University of Pittsburgh
Overweight or Obesity, Diabetes Mellitus, Type 2
PA Moves Trial - Patient Participants
The purpose of this study is to address physical inactivity in rural populations in Pennsylvania.
- Conditions
- Overweight or Obesity, Diabetes Mellitus, Type 2, Physical Inactivity
- Trial name
- NCT05227105
- Testing
- Physical Activity, Delayed intervention
- Where
- United States
- Volunteers
- 640 people
- Sponsor
- University of Pittsburgh
Chronic Pain, Opioid Use Disorder
Pain Self-Management and Treatment Engagement for Patients Taking Opioids
The goal of this study is to learn if Pain Self-Management (PSM) can improve chronic pain care in individuals with opioid misuse or opioid use disorder (OUD) The main questions it aims to answer are: Does PSM help participants…
- Conditions
- Chronic Pain, Opioid Use Disorder, Opioid Misuse and Addiction
- Trial name
- TREETOP (NCT06855732)
- Testing
- Usual Care, Pain Self-Management
- Where
- 17 sites in United States
- Volunteers
- 204 people
- Sponsor
- University of Pittsburgh
Arthritis Knee
Functional Recovery After Total Knee Arthroplasty
The goal of this observational study is to learn about patients' recoveries after receiving total knee arthroplasty (TKA). The main questions it aims to answer are: Does robotic-assisted TKA have improved perceived recovery when…
- Trial name
- NCT06821269
- Testing
- Robotic assisted total knee arthroplasty, Manual total knee arthroplasty, Robotic assisted revision total knee arthroplasty
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pittsburgh
Exercise, Healthy
Bone and Body Composition Adaptations to Physical Training
The goal of this clinical trial is to evaluate how different exercise programs alter bone density, structure, and strength in adults.
- Trial name
- BoBCAT (NCT06972862)
- Testing
- Osteogenic Index Optimized Exercise Training Program
- Where
- 2 sites in United States
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Cyclic Vomiting Syndrome
Cortical Excitability in Cyclic Vomiting Syndrome
This exploratory study will determine if there are differences in cortical excitability between patients suffering from cyclic vomiting syndrome (CVS) and healthy control subjects, as assessed by a non-invasive method of brain…
- Trial name
- NCT05256160
- Testing
- TMS Paired-Pulse assessment of cortical excitability, Autonomic activity
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Attention Deficit Hyperactivity Disorder, Sleep Disturbance
Settling Down for Sleep in ADHD: The Impact of Sensory and Arousal Systems on Sleep in ADHD
The goal of this study is test the hypothesis that sleep problems for children with ADHD are linked to sensory over-responsivity, a type of sensory processing difference that causes a person to interpret daily sensory input as…
- Trial name
- NCT06406309
- Testing
- Power Down manipulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pittsburgh
Glaucoma and Ocular Hypertension
Clarifying the Optimal Application of SLT Therapy Trial
The goal of this study is to understand if SLT performed at low energy is as effective as SLT performed at standard energy, and also to see if repeating SLT at low energy once a year will prevent or delay the need for daily eye…
- Trial name
- COAST (NCT04967989)
- Testing
- Low Energy SLT, Standard Energy SLT
- Where
- 29 sites in United States, Canada
- Volunteers
- 790 people
- Sponsor
- University of Pittsburgh
Gestational Diabetes Mellitus in Pregnancy, Pregestational Diabetes Mellitus
Intrapartum Glucose Control and Risk of Neonatal Hypoglycemia
The purpose of this study is to assess whether a liberal intrapartum glycemic target range compared to usual care standard control ranges will lead to a decrease in the rate of neonatal hypoglycemia among pregnant patients in…
- Conditions
- Gestational Diabetes Mellitus in Pregnancy, Pregestational Diabetes Mellitus, Neonatal Hypoglycemia
- Trial name
- NCT06643351
- Testing
- Standard Intrapartum Glucose Target Range, Liberalized Intrapartum Glucose Target Range
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- University of Pittsburgh
Healthy
Characterization of Gastric Evoked Potentials
This is an exploratory study that will determine and standardize how best to record gastric evoked potentials (GEPs) elicited by a non-invasive method of brain stimulation (Transcranial Magnetic Stimulation, TMS), by optimizing…
- Trial name
- NCT05924009
- Testing
- Transcranial Magnetic Stimulation, TMS
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Autism, Sleep Disturbance
The Power Down Pilot Study: A Novel Bedtime Manipulation Protocol
The goal of this pilot intervention study is to examine the feasibility and acceptability of a novel bedtime manipulation protocol called "The Power Down" for autistic youth, ages 6-10.
- Trial name
- NCT06386029
- Testing
- Power Down bedtime manipulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pittsburgh
Nocturia, Insomnia
Addressing Nocturia in Older Women Utilizing Behavioral Sleep Intervention and Brief Mindfulness
The goal of this clinical trial is to examine and compare the effect of behavioral sleep treatment: BBTI (brief behavioral treatment of insomnia) and brief mindfulness (MI), independently and combined vs control on frequency of…
- Trial name
- ANOWSM (NCT07760779)
- Testing
- Brief behavioral treatment of insomnia, MI, Control
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Pittsburgh
Inflamatory Bowel Disease (Crohn's and Ulcerative Colitis)
Inflammatory Bowel Disease (IBD) Research Registry
Patients seen at the Center for Inflammatory Bowel Disease will be asked to provide their written informed consent (authorization) to allow their identifiable medical record information related to their Inflammatory Bowel Disease…
- Trial name
- NCT04243525
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- University of Pittsburgh
Cognitive Ability General, Functional Abilities
Automated IADL Sensing to Refine Measurement of Older Adult Daily Activity
The instrumental activities of daily living (IADL) refer to complex daily activities required for adult independence, such as preparing a meal or taking medications.
- Trial name
- NCT07585864
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Biliary Atresia
Mapping Disease Pathways for Biliary Atresia
This project will primarily evaluate the developmental/genetic basis of biliary atresia, the most common cause of liver failure at birth, and which accounts of half of all liver transplants performed worldwide in children.
- Trial name
- BA (NCT03273049)
- Where
- United States
- Volunteers
- 1,100 people
- Sponsor
- University of Pittsburgh