Clinical trials: open to volunteers, sponsored by University of Pittsburgh
Psychological Distress, Suicidal Ideation
Development and Testing of imHere4U: A Digital Suicide Prevention Intervention for Cyberbullied Adolescents
The objective of this study is to test the feasibility and preliminary efficacy of Flourish (formerly referred to as imHere4U), a digital suicide prevention intervention for cyberbullied adolescents.
- Trial name
- NCT06002191
- Testing
- Flourish, Questionnaires of Online Experiences
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Pittsburgh
Perinatal, Cannabis Use
Feasibility and Acceptability Trial to Reduce Tobacco and Cannabis Use During Pregnancy and Postpartum
Using both tobacco and cannabis during pregnancy is more common in minoritized groups and can make quitting smoking in pregnancy and remaining smoke free postpartum difficult.
- Conditions
- Perinatal, Cannabis Use, Tobacco Use, Smoking Cessation
- Trial name
- PICTURe (NCT07489443)
- Testing
- Perinatal smoking cessation treatment and maintenance sessions
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Pittsburgh
Concussion, Mild, Mild Traumatic Brain Injury (mTBI)
Acceptance and Commitment Therapy Integrated Vestibular Rehabilitation (ACTIVE) RCT
The primary objective of this multi-site randomized clinical trial (RCT) is to compare Acceptance and Commitment Therapy Integrated Rehabilitation (ACT) with usual care rehabilitation (CONTROL) in 250 individuals with…
- Conditions
- Concussion, Mild, Mild Traumatic Brain Injury (mTBI), Psychological Health
- Trial name
- NCT06819904
- Testing
- Acceptance and Commitment Therapy Integrated Rehabilitation (ACT), Usual Care Rehabilitation
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- University of Pittsburgh
Muscle Composition, Obesity
The Effects of Strength Training on Muscle Mass and Mental Health in Adults Taking Obesity Medication
The purpose of this study is to examine the effects of resistance exercise, such as weightlifting, on retention of muscle mass and mental health in individuals taking GLP-1 RAs (an obesity medication).
- Conditions
- Muscle Composition, Obesity, Quality of Life (QOL)
- Trial name
- STRONG (NCT07652333)
- Testing
- Resistance Exercise, GLP-1 RAs
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pittsburgh
Stroke, Cerebellum
Imaging Speech in Neurotypical Adults and Individuals With Cerebellar Stroke
The goal of this research study is to learn how the brain areas that plan and control movement interact with the areas responsible for hearing and perceiving speech in healthy adults and people who have had cerebellar strokes.
- Trial name
- NCT06458153
- Testing
- Neural responses to speech functional localizer, Neural responses to silent articulation, Neural responses to self vs. externally generated speech
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Obesity
A Study to Investigate Why Overweight People Regain Weight After Losing Weight in a Behavioral Weight Loss Program
The goal of this clinical trial is to determine the physiological basis for the differences in weight regain among adults (25-59 years old) with obesity following participation in a behavioral weight loss program.
- Trial name
- POWERS (NCT05748158)
- Testing
- Weight loss
- Where
- 3 sites in United States
- Volunteers
- 205 people
- Sponsor
- University of Pittsburgh
Narrative Medicine
MyPaTH Story Booth
The MyPaTH Story Booth will use an (audio) "document" approach to elicit in depth experiential knowledge or perspectives from patients and caregivers by recording their personal stories.
- Trial name
- NCT03494075
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- University of Pittsburgh
Upper Abdominal Malignancies
Liver Volume Variation Effect on SBRT Planning and Delivery for Upper Abdominal Malignancies
Standard planning constraints for liver SBRT incorporate strict dose-volume limits for normal liver parenchyma to minimize the risk of radiation-induced liver disease.
- Trial name
- NCT06355895
- Testing
- Standardized high-carbohydrate meal
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Pittsburgh
Cancer
Dietary Interventions in Cancer Patients Treated With Immune Checkpoint Inhibitors
This pilot trial will study the potential impact of two distinct dietary interventions with sequential use of high-fermented foods and high-fiber supplements on the gut microbiome and antitumor immunity in patients with melanoma…
- Trial name
- NCT06475807
- Testing
- High-fermented food, High fiber supplementation
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Pittsburgh
Type 1 Diabetes
School Partnered Collaborative Care (SPACE) Intervention for Children With Type 1 Diabetes
This is a pilot trial of a school-partnered collaborative care (SPACE) model for pediatric type 1 diabetes. The trial will investigate the feasibility and acceptability of SPACE for children with type 1 diabetes in the school…
- Trial name
- SPACE (NCT06420661)
- Testing
- SPACE for T1D, Enhanced usual care
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pittsburgh
People Who Use Opioids/People With Opioid Use Disorder (OUD)
Prescribe to Prevent HIV: A Hybrid Trial Helping Addiction Clinics Prevent HIV & Infections Through Safer Drug Use Support
In the U.S., an estimated 3.6 million people who inject drugs (PWID) face a growing yet preventable health crisis, with rising cases of serious injection-related infections (SIRI), including HIV, due to limited access to two…
- Trial name
- P2PH (NCT07073924)
- Testing
- Implementation strategy bundle
- Where
- 4 sites in United States
- Volunteers
- 536 people
- Sponsor
- University of Pittsburgh
Shoulder Dislocation, Glenohumeral Dislocation
Open Versus Arthroscopic Stabilization of Shoulder Instability With Subcritical Bone Loss: The OASIS Trial
This clinical trial will determine the outcome trajectories of common surgeries (arthroscopic Bankart repair with remplissage of a Hill-Sachs lesion, open Bankart, Latarjet) with post-operative rehabilitation and identification…
- Conditions
- Shoulder Dislocation, Glenohumeral Dislocation, Anterior Shoulder Dislocation
- Trial name
- OASIS (NCT04809064)
- Testing
- Arthroscopic Bankart repair procedure, Open Bankart, Latarjet
- Where
- 15 sites in United States
- Volunteers
- 450 people
- Sponsor
- University of Pittsburgh
Non-healing Wound
Mechanisms Underlying Impaired Diabetic Wound Healing
The overall aim of this research is to utilize wound derived inflammatory cells from diabetic versus non diabetic human chronic wounds to understand mechanisms that are responsible for disregulated inflammation in individuals…
- Trial name
- WoundVAC (NCT00777712)
- Testing
- Blood draw
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- University of Pittsburgh
Tobacco Dependence
Effect of Yoga on Reducing Craving in Tobacco Dependent Individuals
Yoga is a culturally acceptable practice that can reduce craving and help people quit tobacco. There is a need to evaluate the feasibility of implementation of a well- designed yoga protocol to address craving in individuals who…
- Trial name
- NCT06488443
- Testing
- Yoga, WHO 5As model intervention
- Where
- India
- Volunteers
- 96 people
- Sponsor
- University of Pittsburgh
Alcohol Use Disorder (AUD)
Effectiveness of Nurse-Conducted Brief Intervention (NCBI) Supplemented With Mobile for Preventing Alcohol Use Disorders
The study is aimed to find out that combining Nurse-Conducted Brief Intervention (NCBI) with a Smart Mobile is better than Nurse-Conducted Brief Intervention (NCBI) only in preventing relapse among Alcohol Use Disorder patients.
- Trial name
- NCT06652802
- Testing
- Nurse-Conducted Brief Intervention (NCBI). supplemented with mobile based application., Nurse-Conducted Brief Intervention (NCBI)
- Volunteers
- 74 people
- Sponsor
- University of Pittsburgh
Suicide and Depression, Adolescent Behavior
Clinical Trial for Integrated Care to Help At Risk Teen (iCHART) Intervention
This protocol will test the effectiveness of an intervention, iCHART (integrated Care to Help At-Risk Teens) and facilitate recruitment for other studies in the larger ETUDES Center grant, which are focused on treatment…
- Trial name
- NCT05748730
- Testing
- iCHART, Treatment As Usual
- Where
- 13 sites in United States
- Volunteers
- 900 people
- Sponsor
- University of Pittsburgh
Emotion Regulation
Testing an Intergenerational Model of Suicide Risk in Mother-child Dyads
The investigators are interested in learning more about how the role of mothers' emotions has on the transmission of suicide risk to children.
- Trial name
- NCT06463054
- Testing
- Dialectical Behavior Therapy Skills Group Training, Safety Planning Intervention
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Pittsburgh
Anhedonia, Depression and Suicide Ideation
Get ActivE Study for At-risk Youth
The study will adapt and deploy a digital Behavioral Activation app with mobile sensing, supported by health coaches, that encourages youth to engage in positive activities.
- Trial name
- GetActivE (NCT06829953)
- Testing
- GET ActivE, Treatment As Usual
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- University of Pittsburgh
Depression, Suicidal Ideation
Social Media Intervention for Online Victimized Youth
This feasibility pilot trial seeks to examine the feasibility and target engagement of a coping skills and psychoeducational intervention delivered via an automated conversational chatbot named SMILEY in reducing frequency and…
- Trial name
- SMILEY (NCT06835985)
- Testing
- Chatbot Intervention, Brief Psychoeducation
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- University of Pittsburgh
Sleep Disturbance, Sleep
Transdiagnostic Sleep and Circadian Intervention + Bright Light in Adolescents With Elevated Depression (TranS-C+BL)
The goal of this clinical trial is to adapt a sleep intervention for individuals representative of all demographic groups, including those who are at the highest risk for suicidal behavior.
- Conditions
- Sleep Disturbance, Sleep, Depression, Suicide
- Trial name
- NCT06963463
- Testing
- TranS-C, Sleep Feedback
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- University of Pittsburgh