Clinical trials: sponsored by University of Rochester
Asthma in Children
Telemedicine Enhanced Asthma Management - Uniting Providers
This research study is an innovative school-based program for urban children with moderate to severe persistent or difficult-to-control asthma.
- Trial name
- TEAM-UP (NCT03545906)
- Testing
- TEAM-UP Intervention Group, Enhanced Care Comparison
- Where
- United States
- Volunteers
- 326 people
- Sponsor
- University of Rochester
Neuronal Ceroid Lipofuscinosis, Neuronal Ceroid Lipofuscinosis CLN1
Clinical and Neuropsychological Investigations in Batten Disease
This study aims to assess the natural history of Batten disease (Neuronal Ceroid Lipofuscinosis) by obtaining information about the motor, behavioral, and functional capabilities of individuals with Batten disease.
- Conditions
- Neuronal Ceroid Lipofuscinosis, Neuronal Ceroid Lipofuscinosis CLN1, Neuronal Ceroid Lipofuscinosis CLN2, Neuronal Ceroid Lipofuscinosis CLN3
- Trial name
- NCT01873924
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Rochester
Esophageal Carcinoma
Induction Chemotherapy for Locally Advanced Esophageal Cancer
Evaluate mFOLFOX6 (5-Fluorouracil, Leucovorin and Oxaliplatin) chemotherapy as induction treatment prior to standard neoadjuvant chemoradiation to decrease the rate of distant recurrence among patients with locally advanced…
- Trial name
- NCT03110926
- Testing
- mFOLFOX6, Chemoradiation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Rochester
Head and Neck Cancer
Study of Non-invasive Acupuncture-like Transcutaneous Electrical Nerve Stimulation (Altens) to Help Alleviate Xerostomia After Radiation Therapy for Cancers of the Head and Neck
The purpose of this study would like to learn if acupuncture-like electrical therapy can be used in patients with head and neck cancer who have had radiation treatment to treat dry mouth.
- Trial name
- NCT04805528
- Testing
- Acupuncture-Like Transcutaneous Electrical Stimulation (ALTENS)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Rochester
Head Injuries
Monitoring & Mitigation of Neurologic Injuries to Optimize Resilience After Repetitive Head Impacts
The purpose of this Phase 2, double-arm study is to identify repetitive, non-concussive head impacts that impair neurologic functioning, and to test treatments that can mitigate these effects and return functioning to normal as…
- Trial name
- MONITOR-RHI (NCT06810193)
- Testing
- Aerobic exercise
- Where
- 3 sites in United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Myeloma
Repeated HBO Therapy in Myeloma Patients Undergoing High-Dose Therapy and Auto-HCT
Subjects with multiple myeloma (MM) who are considered eligible for high-dose therapy and autologous stem cell transplantation by the transplant team at WCI will be enrolled in the study.
- Trial name
- NCT04862676
- Testing
- Hyperbaric oxygen
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Rochester
Stage 4 NSCLC, Radiotherapy
Thoracic Radiotherapy for Patients With Metastatic (Stage IV) Non-Small Cell Lung Cancer at High Risk of Symptomatic Progression Within the Thorax
Patients with metastatic non small cell lung cancer with high risk location or size are treated with prophylactic radiation therapy in conjunction with standard of care systemic therapy.
- Trial name
- DRO2301 (NCT06262321)
- Testing
- Prophylactic Palliative Radiotherapy
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Rochester
Schizophrenia, Schizoaffective Disorder
Remediation of Visual Perceptual Impairments in People With Schizophrenia
The purpose of this study is to evaluate the effectiveness of a visual remediation intervention for people with schizophrenia. The intervention targets two visual functions that much research has shown are impaired in many people…
- Trial name
- VRiS (NCT03314129)
- Testing
- UltimEyes, Contour Integration Training, UltimEyes + Contour Integration Training
- Where
- 2 sites in United States
- Volunteers
- 79 people
- Sponsor
- University of Rochester
Asthma
Telemedicine Enhanced Asthma Management Through the Emergency Department
In the US, children from minority ethnic and racial backgrounds suffer disproportionately from asthma and account for substantially more emergency department (ED) visits and hospitalizations than non-minority children.
- Trial name
- TEAM-ED (NCT02752165)
- Testing
- TEAM-ED, Enhanced Usual Care
- Where
- United States
- Volunteers
- 384 people
- Sponsor
- University of Rochester
Immunization; Infection, Pregnancy Related
VAX-MOM COVID-19: Increasing Maternal COVID-19 Vaccination
COVID-19 infection during pregnancy is associated with increased risk of pre-eclampsia, preterm birth and stillbirth. Pregnant people with COVID-19 have a higher rate of ICU admission and intubation than those who are not…
- Conditions
- Immunization; Infection, Pregnancy Related, COVID-19
- Trial name
- NCT05570630
- Testing
- VAX-MOM COVID-19 Intervention, Standard of Care
- Where
- United States
- Volunteers
- 6,911 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Vaping
Graphic Messages to Prevent E-Cigarette Use Among Black and Latino Adolescents
The aim of this study is to determine if graphic messages prevent future vaping use among African American and Latino adolescents.
- Trial name
- NCT04899999
- Testing
- Financial reward graphic message, Health reward graphic message, Self-efficacy graphic message
- Where
- United States
- Volunteers
- 362 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Smoking Cessation
Advancing Smoking Cessation Among Transgender
In partnership with a Community Advisory Board, the investigators developed TRANSformá tu salud (Spanish for TRANSform your health), a culturally adapted smoking cessation intervention for transgender and gender diverse…
- Trial name
- NCT07099287
- Testing
- TRANSform your health
- Where
- Argentina
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Persistent Atrial Fibrillation
Hybrid Ablation Plus Medical Therapy for Persistent Atrial Fibrillation
This clinical trial is designed to compare two management strategies for the treatment of asymptomatic/subclinical atrial fibrillation after ablation based on data from the Biotronik ICM (BioMonitor3® or future generation of…
- Trial name
- NCT04190186
- Testing
- Insertable Cardiac Monitor
- Where
- 4 sites in United States
- Volunteers
- 55 people
- Sponsor
- University of Rochester
Polypharmacy
Deprescribing for Older Adults After Hospital Discharge in Home Health Care
The purpose of this study is to examine the feasibility of providing a medication optimization program to improve patient health outcomes during the transition from hospital to home.
- Trial name
- NCT05630144
- Testing
- HomeMed
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Rochester
Cancer-related Problem/Condition, Cognitive Impairment
Memory and Attention Adaptation Training-Geriatrics (MAAT-G) Phase II
Cancer-related cognitive dysfunction (CRCD) affects up to 75% of patients receiving chemotherapy and older adults are at greater risk of developing CRCD, which can negatively affect their functional independence and quality of…
- Trial name
- NCT04669301
- Testing
- MAAT-G, Supportive therapy (time and attention control)
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Rochester
POSTOPERATIVE DELIRIUM, POSTOPERATIVE COGNITIVE DECLINE
Daridorexant to Prevent Delirium After Heart Surgery
The goal of this phase 2 clinical trial is to demonstrate the feasibility of the current study methods and obtain preliminary data for an adequately powered trial of daridorexant with the aim of preventing delirium after heart…
- Trial name
- NCT06630390
- Testing
- Daridorexant 50 mg
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Rochester
Social Isolation, Loneliness
Mindfulness to Reduce Loneliness in Older Caregivers
The objective of this pilot study is to provide initial evidence of the role of mindfulness training in improving social disconnectedness - including social isolation and feelings of loneliness - in older caregivers for family…
- Trial name
- NCT04560088
- Testing
- Mindfulness, Breathing
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Rochester
Nephrectomy
Efficacy of IV Acetaminophen Versus Oral Acetaminophen
The aim of this study is to determine whether intravenous acetaminophen compared to enteric acetaminophen offers increased efficacy in patients who are scheduled for laparoscopic donor nephrectomy and for patients scheduled for…
- Trial name
- NCT03365622
- Testing
- acetaminophen
- Where
- United States
- Volunteers
- 214 people
- Sponsor
- University of Rochester
Vision
Eye Movements, Visual Perception and Attention
During visual fixation, small eye movements of which we are usually not aware, prevent the maintenance of a steady direction of gaze.
- Trial name
- NCT03884985
- Testing
- Visual stimulation
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Ischemic and Non-ischemic Cardiomyopathy
OptiVol for Precision Medical Management of Heart Failure
This clinical study is designed to show that a multidisciplinary team following a pre-specified standard of care medication decision model based on data from an implanted cardioverter device will increase the rate of change in…
- Trial name
- (OPTIMED-HF) (NCT04206501)
- Testing
- Medtronic ICD with Opti Vol-Monitor
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Rochester