Clinical trials: sponsored by University of Rochester
Arrhythmogenic Right Ventricular Cardiomyopathy
Pilot Randomized Trial With Flecainide in ARVC Patients
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is an inherited arrhythmia disorder with high risk of ventricular tachycardia or fibrillation, and implantable cardioverter defibrillator remains as therapy of choice.
- Trial name
- NCT03685149
- Testing
- Flecainide Pill
- Where
- 6 sites in United States
- Volunteers
- 22 people
- Sponsor
- University of Rochester
Chronic Kidney Disease stage3, Chronic Kidney Disease stage4
Study of Sulphoraphane in Chronic Kidney Disease
The purpose of this study is to test the safety of the compound sulforaphane that boosts the activity of antioxidant genes in the body to combat oxidative stress.
- Trial name
- NCT05153174
- Testing
- Sulforaphane
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Rochester
Heart Disease, Ischemic, Hyperlipidemias
Low-Carbohydrate and Plant-Based Dietary Effects on Vascular Health
This is a randomized trial with a crossover design to investigate the short-term effects of two different dietary patterns on markers of vascular health. A low-carbohydrate diet and a whole-food, plant-based diet will be used.
- Conditions
- Heart Disease, Ischemic, Hyperlipidemias, Hypertension
- Trial name
- NCT05414851
- Testing
- Whole-Food, Plant-Based Diet and Low-Carbohydrate Diet
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Rochester
Overweight, Obesity
Deaf Weight Wise 2.0: A Healthy Lifestyle Intervention With Deaf Adults Who Are Overweight or Obese
The purpose of the Deaf Weight Wise 2.0 (DWW 2.0) study is to test an evidence-based, comprehensive program to modify obesity-related health behaviors with Deaf people ages 21 to 70 who use American Sign Language (ASL) as their…
- Trial name
- DWW2 (NCT03060525)
- Testing
- Deaf Weight Wise 2.0
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Mild Traumatic Brain Injury
Enhancing Brain Training With Virtual Reality
The purpose of this study is to evaluate the effectiveness of brain training in a Virtual Reality set up in neurotypical populations as well as in the traumatic brain injury population.
- Trial name
- NCT03582579
- Testing
- Training in Virtual Reality, Training on a computer screen
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Parkinson Disease
Objective, Passive Assessment of LRRK2 Carriers
The goal of this project is to identify objective, sensitive, and convenient measures for assessing early signs of Parkinson's disease in an at-risk population at home.
- Trial name
- OPAL (NCT05287620)
- Testing
- Emerald device
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Rochester
Primary Sjögren Syndrome
Pilot Trial of Ustekinumab for Primary Sjögren's Syndrome
This pilot study will make a preliminary determination of the safety of ustekinumab in patients with Primary Sjogren's Syndrome (PSS) and assess the response of systemic measures of inflammation (biomarkers).
- Trial name
- NCT04093531
- Testing
- Ustekinumab
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Rochester
Prostate Cancer
Cisplatin in Castration Resistant Prostate Cancer
It is hypothesized that treatment with cisplatin will reverse emerging refractoriness to enzalutimide in patients with CRPC by affecting AR function.
- Trial name
- NCT03275857
- Testing
- Cisplatin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Rochester
Respiratory Syncytial Virus Infection
Molecular and Microbiome/Metagenome Correlates of Recurrent Wheeze in RSV Infected Infants
The goal of this observational study is to learn about further wheezing in infants with RSV infection.. The main question it aims to answer is: If infant factors, the infant immune response in the nose and the bacteria that…
- Trial name
- NCT06424795
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Rochester
Chronic Rhinosinusitis With Nasal Polyps
Early-onset Dupilumab Effects in CRSwNP
While it is known that Dupilumab has profound effects in patients with CRSwNP, these are often seen months later after treatment initiation; however, in practice, patients often endorse feeling significantly better within days of…
- Trial name
- NCT06188871
- Testing
- Dupilumab
- Where
- United States
- Sponsor
- University of Rochester
Cancer Survivor, Insomnia
Yoga, Survivorship Health Education, and Cognitive Behavioral Therapy in Reducing Insomnia in Cancer Survivors
This randomized phase III trial compares yoga, survivorship health education program, and cognitive behavioral therapy in reducing sleep disturbance (insomnia) in cancer survivors.
- Conditions
- Cancer Survivor, Insomnia, Malignant Neoplasm
- Trial name
- YOCAS-II (NCT02613364)
- Testing
- Behavioral Intervention, Cognitive Intervention, Educational Intervention
- Where
- 16 sites in United States
- Volunteers
- 746 people
- Sponsor
- University of Rochester NCORP Research Base
Cervical Cancer
Increasing Cervical Cancer Screening Uptake Among Emergency Department Patients
Invasive cervical cancer is preventable with adequate screening but screening rates are considerably below national goals. Emergency departments care for a disproportionate number of women who are not up to date with recommended…
- Trial name
- NCT04374760
- Testing
- SMS-intervention
- Where
- 2 sites in United States
- Volunteers
- 1,116 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Chronic Kidney Diseases
Effects of a Whole-food, Plant-based Nutrition Program on BP and Potassium in Subjects With CKD
The purpose of this study is to determine if an educational program emphasizing a whole food plant based diet favorably impacts blood pressure while not significantly increasing blood potassium levels, by comparing a group of…
- Trial name
- NCT06343129
- Testing
- Dietary education program
- Where
- 2 sites in United States
- Volunteers
- 43 people
- Sponsor
- University of Rochester
Suicide, Attempted
Network Health Intervention for Adolescents Leaving Acute Psychiatric Care
The purpose of this pilot study is to refine and then assess the feasibility, acceptability, and target engagement of Acute Youth Connect - a network health intervention for adolescents leaving acute psychiatric care with…
- Trial name
- NCT05340296
- Testing
- Acute Youth Connect
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Rochester
Brain Injuries, Malaria
An MRI Ancillary Study of a Malaria Fever Investigation
This study will seek consent from parents of children enrolled in the Malaria FEVER study to obtain neuroimaging and 12-month neuropsychiatric outcomes data and kidney function on their child.
- Conditions
- Brain Injuries, Malaria, MRI Imaging, Neurocognitive Deficits
- Trial name
- MRIA (NCT05746819)
- Testing
- Aggressive antipyretics therapy of fever vs usual care in the Malaria RCT study
- Where
- 2 sites in Malawi, Zambia
- Volunteers
- 181 people
- Sponsor
- University of Rochester
Smoking Cessation
Mobile Cessation Support for Latino Smokers
The primary aim of this study is to examine the efficacy of Decídetexto, an innovative mobile smoking cessation intervention that incorporates two elements: 1) a tablet-based e-Health platform that collects personal…
- Trial name
- NCT03586596
- Testing
- The Decídetext program, Standard Care Control
- Where
- 3 sites in United States
- Volunteers
- 457 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Cancer-Related Cognitive Difficulties, Cancer-Related Cognitive Impairment
An Online Cognitive Assessment in Cancer Patients
The purpose of this study is to test the feasibility (acceptability and usability) and usefulness of the CAMPFIRE (Cognitive Assessment and Monitoring Platform for Integrative Research) system, a patient-facing portal able to…
- Trial name
- CAMPFIRE (NCT04667689)
- Testing
- CAMPFIRE Online Cognitive Assessment for Cancer Patients
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Rochester
Chronic Lymphocytic Leukemia (CLL), Waldenstrom Macroglobulinemia (WM)
Serologic Response to SHINGRIX Vaccine in Patients With CLL and WM Treated With BTK Inhibitors
The primary objective of the study is to assess the capability of a patient with Chronic Lymphocytic Leukemia (CLL) or Waldenström Macroglobulinemia (WM) to generate an immune response to the Shingrix vaccine under first-line BTK…
- Trial name
- NCT03771157
- Testing
- Shingrix vaccine
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Rochester
Parkinson Disease, Parkinson Disease Psychosis
Characterization and Progression of Minor Phenomena in Parkinson's Disease (PD)
Parkinson's disease psychosis encompasses a range of symptoms, including minor phenomena, frank hallucinations, and delusions. Minor phenomena include passage hallucinations (fleeting sense of a person, animal or object passing…
- Conditions
- Parkinson Disease, Parkinson Disease Psychosis, Hallucinations, Delusion
- Trial name
- NCT05240339
- Testing
- Observation of minor phenomena
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Rochester
Malaria, Seizures
Aggressive Antipyretics for Fever Reduction in CNS Malaria
The study will examine whether prophylactic and scheduled treatment with acetaminophen and ibuprofen can decrease the maximum temperature experienced during the acute illness in children with CNS malaria.
- Conditions
- Malaria, Seizures, Coma, Parasitemia
- Trial name
- NCT03399318
- Testing
- Acetaminophen, Ibuprofen
- Where
- 3 sites in Malawi, Zambia
- Volunteers
- 256 people
- Sponsor
- University of Rochester