Clinical trials: sponsored by University of Rochester
Suicidal Ideation
Home-based tDCS for Prevention of Suicidal Ideation
Risk for suicide is elevated in the period after discharge from hospital among adults with major affective disorder. The primary objective of this study is to investigate the feasibility of delivering tDCS sessions for high-risk…
- Trial name
- NCT05280756
- Testing
- Home-based transcranial direct current stimulation (tDCS)
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Rochester
Fetal Alcohol Spectrum Disorder
Dialectical Behavior Therapy for Adolescents With Fetal Alcohol Spectrum Disorders Feasibility Trial
The purpose of this study is to test the feasibility of dialectical behavior therapy for adolescents (DBT-A) with fetal alcohol spectrum disorders (FASD).
- Trial name
- NCT06747650
- Testing
- Dialectical Behavior Therapy for Adolescents
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Rochester
Social Isolation, Loneliness
Culture and Well-Being for Latinos
The proposed K23 study is an intervention study using an experimental therapeutics approach. This pilot RCT asks: "Does SOCIAL-ENGAGE increase cultural-social engagement and decrease suicide risk among Spanish-speaking adults?"…
- Conditions
- Social Isolation, Loneliness, Suicidal Ideation
- Trial name
- NCT05244733
- Testing
- Social Engage (S-ENGAGE), The Healthy Lifestyles Education Program
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Rochester
Asthma in Children
SMART-School-based Asthma Therapy
The goal of this research trial is to: 1) Develop a SMART-SBAT protocol specifically designed for schools, 2) Evaluate the effectiveness of SMART-SBAT vs.
- Trial name
- NCT06796387
- Testing
- SMART-SBAT, Usual Care
- Volunteers
- 330 people
- Sponsor
- University of Rochester
Substance Use Disorders, Alcohol Use Disorder
A Randomized Controlled Trial of Digital CBT to Treat Addiction: Digital RITch®CBT vs. Standard CBT
Substance Use Disorders continue to increase across the United States with significant adverse effects resulting in more than $700 billion annually (NIDA, 2017) with high co-occurring rates of IPV.
- Conditions
- Substance Use Disorders, Alcohol Use Disorder, Stimulant-Related Disorder
- Trial name
- NCT05943171
- Testing
- Cognitive Behavioral Therapy, Standard CBT
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Cervical Cancers, HPV
Advancing Cervical Cancer Screening Through the Emergency Department - IIS
Cervical cancer screening in the Emergency Department
- Trial name
- NCT06796738
- Testing
- HPV testing
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Rochester
High Blood Pressure, Hypertension
Team-Based Home Blood Pressure Monitoring
The overall goal of this study is to identify and rigorously evaluate strategies for implementing and sustaining team-based home blood pressure monitoring (TB-HBPM) within primary care.
- Trial name
- TB-HBPM (NCT05488795)
- Testing
- Team-Based Home Blood Pressure Monitoring
- Where
- United States
- Volunteers
- 5,760 people
- Sponsor
- University of Rochester
Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8
Vitamin D for Prostate Endocrine Therapy
This phase III trial tests whether high-dose vitamin D works in treating androgen-deprivation therapy (ADT)-induced bone loss in patients with prostate cancer who are undergoing androgen-deprivation therapy.
- Conditions
- Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8, Stage III Prostate Cancer AJCC v8, Stage IVA Prostate Cancer AJCC v8
- Trial name
- ViPER (NCT05838716)
- Testing
- Biospecimen Collection, D Vitamin, Dual X-ray Absorptiometry
- Where
- 51 sites in United States
- Volunteers
- 240 people
- Sponsor
- University of Rochester
Fetal Alcohol Spectrum Disorders
Efficacy Trial of the FMF Connect Mobile Health Intervention
The purpose of this study is to test a new smartphone "app" for parents/caregivers of children with fetal alcohol spectrum disorder (FASD). The app is called Families Moving Forward (FMF) Connect.
- Trial name
- NCT05028517
- Testing
- FMF Connect, Coaching
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Lymphoma, Malignant Solid Neoplasm
Geriatric Evaluation and Management With Survivorship Health Education for Older Survivors of Cancer, GEM-S Trial
This phase III trial compares the effect of geriatric evaluation and management with survivorship health education (GEM-S) to usual care on patient-reported physical function in older survivors of cancer.
- Trial name
- GEM-S (NCT05006482)
- Testing
- Best Practice, Comprehensive Geriatric Assessment, Educational Intervention
- Where
- 45 sites in United States
- Volunteers
- 668 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm
Learning Collaborative Versus Technical Assistance in Delivering a Palliative Care Program to Patients With Advanced Cancer and Their Caregivers
This trial studies the delivery of the ENABLE palliative care program by two different methods called a Virtual Learning Collaborative or Technical Assistance for patients with advanced cancer and their caregivers.
- Conditions
- Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm, Recurrent Malignant Solid Neoplasm
- Trial name
- NCT04062552
- Testing
- Behavioral, Psychological or Informational Intervention, Educational Intervention, Medical Examination Assessment
- Where
- 113 sites in United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- University of Rochester NCORP Research Base
Advanced Colorectal Carcinoma, Advanced Lung Non-Small Cell Carcinoma
LOTUS-CC: An Observational Research Study to Uncover Subtypes of Cancer Cachexia
This study evaluates cancer-related weight and muscle mass loss, symptoms, and physical function (cachexia) in patients undergoing treatment for colorectal, lung, or pancreatic cancer that cannot be removed by surgery…
- Conditions
- Advanced Colorectal Carcinoma, Advanced Lung Non-Small Cell Carcinoma, Advanced Pancreatic Adenocarcinoma, Stage IV Colorectal Cancer AJCC v8
- Trial name
- LOTUS (NCT06073431)
- Testing
- Biospecimen Collection, Computed Tomography, Electronic Health Record Review
- Where
- 225 sites in United States
- Volunteers
- 800 people
- Sponsor
- University of Rochester
Ridge Preservation, Allografts
Comparison of Two Types of Bone Grafts in Patients Who Need One of Their Front Teeth Removed and Replaced With an Implant
The purpose of this study is to compare two different bone graft materials (freeze-dried bone allograft, FDBA and collagen-enriched bovine xenograft, CEBX) that are routinely used for preserving the remaining bone after…
- Conditions
- Ridge Preservation, Allografts, Extraction, Tooth, Xenograft
- Trial name
- FDBA or CEBX (NCT06722482)
- Testing
- FDBA, CEBX
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Rochester
Trauma
A Trial of Neurofeedback as an Adjunctive Treatment for Youth in Outpatient Mental Health Settings
The purpose of this study is to test the feasibility and effectiveness of a neurofeedback intervention conducted as an adjunctive behavioral health treatment to reduce trauma and affective symptoms in trauma-exposed youth.
- Trial name
- NCT04871009
- Testing
- Neurofeedback Intervention, standard of care
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Rochester
Postoperative Cognitive Decline, Postoperative Delirium
Daridorexant to Prevent Post-cardiotomy Delirium
The goal of this follow-on pilot randomized clinical trial is to obtain additional preliminary data to inform a larger, adequately powered phase 2b trial of daridorexant for the prevention of postoperative delirium after heart…
- Trial name
- NCT07217912
- Testing
- Daridorexant 50 mg
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Rochester
Neuropathy;Peripheral
Exercise and Nutrition Interventions During Chemotherapy K07
Chemotherapy-induced peripheral neuropathy (CIPN) is a highly prevalent and severe side-effect of taxane chemotherapy, often used to treat breast cancer. Unfortunately there are very limited treatments for CIPN.
- Trial name
- NCT03858153
- Testing
- EXCAP Exercise, Nutrition Education
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of Rochester
Social Isolation, Loneliness
Study 1: Social Engage Coaching R61 Phase
The purpose of this study is to test whether an individual coaching program called Social Engage Coaching (or 'Engage Coaching' for short) helps adults age 60 and older feel more connected to other people in ways that matter to…
- Conditions
- Social Isolation, Loneliness, Suicide Ideation, Quality of Life
- Trial name
- R61 Phase (NCT05745493)
- Testing
- Social Engage Coaching (S-ENG)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Rochester
Glioma
Telehealth Visits to Discuss Advanced Directives for Patients Newly Diagnosed With High Grade Glioma
High grade gliomas (HGGs) are rapidly progressive brain tumors resulting in death for most patients between 6 months and 2 years after diagnosis.
- Trial name
- NCT04543201
- Testing
- Early START visit using checklist over telephone or zoom
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Rochester
Breast Cancer
Trial of Neratinib Plus Capecitabine in Subjects With HER2-Negative Metastatic Breast Cancer With Brain Metastases and Abnormally Active HER2 Signaling
The purpose of this research is to look at the safety and effectiveness of a HER2-targeted therapy neratinib when given with capecitabine, a chemotherapy, for breast cancer patients with brain metastases whose tumors were…
- Trial name
- NCT04965064
- Testing
- Capecitabine and Neratinib.
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Rochester
Breast Feeding, Exclusive Breastfeeding
At-the-Breast vs. Expressed Human Milk: Genesis of Infant Nutrition (BEGIN)
The purpose of this study is to define human milk (HM) as an ecosystem which investigators will then combine into temporal models of milk dynamics to accurately describe HM chronobiology.
- Trial name
- BEGIN (NCT06691932)
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of Rochester