Clinical trials: sponsored by University of Toronto
Tuberculosis (TB)
Research on Key Interventional Technologies for Controlling the Epidemic in High-prevalence Areas of Tuberculosis in Guangxi, China
The goal of this study is to find out if using mobile vans with advanced technology can help reduce tuberculosis (TB) in rural Guangxi, China. The study will also examine how practical and cost-effective this approach is.
- Trial name
- NCT06702774
- Testing
- Active case finding
- Where
- China
- Volunteers
- 43,067 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Noncommunicable Diseases, COVID-19
Interventions to Improve Non-communicable Disease Management During the Pandemic
This randomized controlled trial aims to implement and evaluate a comprehensive package of digital health interventions for integrated COVID-non-communicable diseases (NCDs) care to manage NCDs in primary care facilities in rural…
- Trial name
- NCT05699369
- Testing
- Digital health interventions
- Where
- Pakistan
- Volunteers
- 1,965 people
- Sponsor
- University of Toronto
Healthy Adults
FueL Use During eXercise in Males and Females
This study will investigate whether pre-exercise nutrition influences sex differences in fuel utilization during endurance exercise.
- Trial name
- FLUX (NCT07829237)
- Testing
- Pre-exercise carbohydrate beverage, Pre-exercise protein beverage, Fasted control beverage
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Women
Feasibility of Different Types of Exercise Training in Perimenopausal Females
Throughout the menopause transition, women experience many symptoms (i.e., hot flashes, night sweats) that can significantly reduce their quality of life. Moreover, their risk of heart disease increases substantially.
- Trial name
- POWER (NCT07132385)
- Testing
- Guidelines-based moderate-intensity continuous exercise, High-intensity interval training, Stretching exercise
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Toronto
Type 2 Diabetes
Integrating Educational Videos Into Skills-Based Nutrition Programs to Reduce Type 2 Diabetes Risk in Peel
The goal of this clinical trial is to assess the potential benefits of integrating a video covering topics related to nutrition education, food literacy and type 2 diabetes into Seva Food Banks current programs (Culinary Training…
- Trial name
- NCT07790081
- Testing
- Educational Video
- Where
- Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Coronary Artery Disease
Time Restricted Eating and Cardiac Rehabilitation
This study will use a form of intermittent fasting called time-restricted eating (TRE) where individuals consume ad libitum energy intake within a set window of time, commonly 8 hours, which induces a fasting window of 16 hours…
- Trial name
- TREat-CR (NCT05075317)
- Testing
- Standard cardiac rehabilitation, Time-Restricted Eating
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- University of Toronto
Healthy
Influence of Menstrual Cycle Phase on Adaptations to Sprint Interval Training
Sprint interval training improves endurance performance and induces metabolic adaptations in muscle. Most research demonstrating these responses has been conducted in males, with limited studies evaluating changes to endurance…
- Trial name
- NCT06744517
- Testing
- Sprint Interval Training
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- University of Toronto
Asthma Management, Asthma
eAMS-Eco: Implementation of a Tool for Climate Conscious Inhaler Prescribing
The goal of this study is to determine whether an 'eco' version of the Electronic Asthma Management System (eAMS) can reduce inhaler carbon emissions in primary care, in patients with asthma.
- Conditions
- Asthma Management, Asthma, Computerized Decision Support System, Primary Care
- Trial name
- NCT07638735
- Testing
- Climate-Conscious Clinical Decision Support System for Asthma Management
- Where
- 2 sites in Canada
- Volunteers
- 95 people
- Sponsor
- University of Toronto
Depression / Major Depressive Disorder, Conduct Disorders in Children
Optimizing Treatment for Depressed Parents of Children With Emotional and Behavioural Problems
Standard Behavioral Parent Training (BPT) is often less effective for parents experiencing depression. As such, the Addressing Depression and Positive Parenting Techniques (ADAPT) intervention is a novel BPT tailored to address…
- Conditions
- Depression / Major Depressive Disorder, Conduct Disorders in Children, Disruptive Behaviour in Children, Parenting Intervention
- Trial name
- OPTED (NCT07749521)
- Testing
- ADAPT Treatment, Incredible Years Parenting Program (IYPP)
- Where
- Canada
- Volunteers
- 180 people
- Sponsor
- University of Toronto
Cancer, Sedentary Behaviour
Feasibility of a Habit-Based Intervention to Reduce Sedentary Behaviour in Cancer Survivors
Cancer and its treatments are associated with long-term side effects including lowered physical strength and quality of life. Decreasing sedentary behaviour improves health outcomes in cancer survivors.
- Trial name
- NCT07694479
- Testing
- Sedentary Behaviour Intervention, Active Control Group
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Toronto
Arthroplasty Replacement, Knee, Anesthesia Conduction
Migration Rate for Continuous Adductor Canal Block Catheters After Primary Total Knee Arthroplasty Surgery: a Comparison Between Two Insertion Techniques
Continuous adductor canal block (CACB) is becoming increasingly popular for providing postoperative analgesia following knee arthroplasties.
- Trial name
- ISAFExOOPS (NCT07681622)
- Testing
- ISAFE technique for adductor canal catheter insertion, OOPS technique
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Diabetes Mellitus, Type 2, Obesity
Time-restricted Eating, Window Timing, Type 2 Diabetes Status and Sex on Glycemic Control
This study will evaluate the effectiveness of time-restricted eating (TRE), which is a form of intermittent fasting. When performing TRE, individuals consume all of their calories within a specific time window and then only…
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Prediabetic State, Hyperglycemia
- Trial name
- NCT06118931
- Testing
- Early (7:00 - 16:00) TRE, Mid (9:30 - 18:30) TRE, Late (12:00 - 21:00) TRE
- Where
- Canada
- Volunteers
- 123 people
- Sponsor
- University of Toronto
Respiratory Depression, Opioids
Transcutaneous Electrical Stimulation for Apnea Detected by Capnography
After surgery, patients often recover in a special area called the Post Anesthesia Care Unit (PACU). Patients may receive pain medications either during the surgery or afterward in the PACU.
- Trial name
- TESCapno (NCT06823661)
- Testing
- transcutaneous electrical nerve stimulation (TENS)
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- University of Toronto
Developmental Language Disorder, Language Delay
Using Neuroimaging and Behavioral Assessments to Understand Late Talking
Late talkers (LT), representing 10-20% of children under 3, demonstrate hallmark syntax and vocabulary deficits similar to preschoolers with developmental language disorder.
- Conditions
- Developmental Language Disorder, Language Delay, Language Development
- Trial name
- NCT06156865
- Testing
- Intervention to address late talking
- Where
- 2 sites in Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Knee Arthroplasty, Total, Anesthesia, Regional
Continuous Adductor Canal Block in Outpatient Total Knee Arthroplasty
Total knee arthroplasty (TKA) is a frequent performed surgery. Many institutions are implementing outpatient programs for this surgery and adequate pain management is an important feature.
- Conditions
- Knee Arthroplasty, Total, Anesthesia, Regional, Acute Pain
- Trial name
- NCT05100706
- Testing
- Continuous adductor canal block (CACB)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Toronto
Arthroplasty, Replacement, Hip
Low Concentration Local Anesthesia Fascia Iliaca Block for Total Hip Arthroplasty
Fascia iliaca compartment block (FICB) is a documented option for postoperative analgesia for total hip arthroplasty (THA) surgery.
- Trial name
- HALF (NCT06102811)
- Testing
- Low Concentration Local Anesthetic Fascia Iliaca Compartment Block, High Concentration Local Anesthetic Fascia Iliaca Compartment Block
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Toronto
Stroke
Stroke Motor Recovery for the Hand and Fingers
The goal of this clinical trial is to compare two rehabilitation methods to improve finger movements in people who have had a stroke.
- Trial name
- NCT06604143
- Testing
- Quality Training, Goal Training
- Where
- 5 sites in Canada
- Volunteers
- 40 people
- Sponsor
- University of Toronto
Cancer, Breast, Cancer, Ovarian
Family History App in Personalized Medicine
A complete family history (FH) may identify persons at high risk for certain conditions. They can be offered genetic testing and life-saving screening and treatment.
- Conditions
- Cancer, Breast, Cancer, Ovarian, Cancer, Colorectal, Cancer, Prostate
- Trial name
- FHAMe (NCT04726319)
- Testing
- FHAMe Intervention
- Where
- Canada
- Volunteers
- 627 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Polypharmacy, Inappropriate Prescribing
SPIDER: A Research & QI Collaboration Supporting Practices in Improving Care for Complex Elderly Patients
Elders living with multiple chronic conditions often take many drugs (polypharmacy); some of the drugs may not benefit them or may be harmful.
- Conditions
- Polypharmacy, Inappropriate Prescribing, Aged, Primary Health Care
- Trial name
- SPIDER (NCT03689049)
- Testing
- SPIDER, Usual Care
- Where
- 9 sites in Canada
- Volunteers
- 104 people
- Sponsor
- University of Toronto Practice Based Research Network
Schizophrenia Spectrum & Other Psychotic Disorders
REFLECT: A Novel Group-Based Compassion-Focussed Cognitive Behavioural Approach to Core Beliefs in Psychosis
The current study is an open-label, proof-of-concept, pilot trial examining the feasibility, safety, and preliminary efficacy of a 6-week group therapy intervention targeting core beliefs related to symptoms of psychosis.
- Trial name
- REFLECT (NCT07569471)
- Testing
- REFLECT: REFlecting on and Learning to Evaluate Core beliefs in real Time
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- University of Toronto