Clinical trials: sponsored by University of Toronto
Domestic Violence, Child Abuse
Cluster RCT of Embedded Parenting Intervention to Prevent Recurrence and Reduce Impairment in Young Children Exposed to Domestic Violence
The current cluster randomized trial examines the efficacy of embedding two different parenting interventions within child protection services for young children (0 to 4) who have been exposed to domestic violence and who are at…
- Trial name
- SafeUnderstood (NCT03198429)
- Testing
- Caring Dads, Mothers in Mind
- Where
- 2 sites in Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Maternal Death Affecting Fetus or Newborn, Delivery Complication
Impact of a Smartphone Intervention on Tanzanian Women's Childbirth Location
This study investigates whether training Community Health Workers (CHW) to use a smartphone-based prenatal counseling application as a "job aid" instead of the existing paper based standard is associated with increased women's…
- Conditions
- Maternal Death Affecting Fetus or Newborn, Delivery Complication, Obstetric Complication, Birth Injuries
- Trial name
- SUSTAIN1 (NCT03161184)
- Testing
- SUSTAIN Smartphone training of CHW (SP+), SUSTAIN Paperbased training of CHW (SOC)
- Volunteers
- 572 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Obesity, Diabetes
The Effects of Carbohydrate Source on Food Intake, Blood Glucose and Gut Hormone Response in Healthy Children
This study will compare the effects of commonly consumed carbohydrate sources such as potatoes, pasta and rice along with a fixed portion of meat on blood glucose, satiety and insulin levels among healthy body weight children.
- Trial name
- NCT02499107
- Testing
- Rice treatment, Pasta treatment, Boiled and mashed potato treatment
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Cholangiocarcinoma
Coregistration of 18F-FDG-PET and MRI in the Staging of Potentially Resectable Hilar Cholangiocarcinoma: a Pilot Study
To evaluate the feasibility and performance of coregistered 18F-FDG-PET/MRI in the staging of potentially respectable hilar cholangiocarcinoma.
- Trial name
- PET/MRCP (NCT00604266)
- Where
- Canada
- Sponsor
- University of Toronto
Skin Infection
Effectiveness of Alcohol Swabs for Preventing Infections During Vaccination
Alcohol is used to disinfect the skin prior to injections in order to prevent infections caused by bacteria on the skin being injected within tissue.
- Trial name
- NCT03131843
- Testing
- Alcohol, No alcohol
- Where
- Canada
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Overweight, Obesity
Meta-analyses of the Effect of 'Catalytic' Doses of Fructose and Its Epimers on Carbohydrate Metabolism
Despite advances in the prevention and treatment of type 2 diabetes, its prevalence continues to rise worldwide. There is a need for new modalities to improve metabolic control in individuals with type 2 diabetes and those who…
- Conditions
- Overweight, Obesity, Dysglycemia, Prediabetes
- Trial name
- NCT02776722
- Testing
- fructose, allulose, tagatose, or sorbose
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Hypertension
Effectiveness of User and Expert Driven Internet-based Lifestyle Interventions on Hypertension Control
Hypertension is a leading risk factor for cardiovascular disease and mortality. Lifestyle counseling is recommended as a first line therapy for reducing blood pressure (BP) and risk for cardiovascular events.
- Trial name
- NCT03111836
- Testing
- Control Group, Expert-Driven Group, User-driven group
- Volunteers
- 129 people
- Sponsor
- University of Toronto
Critical Illness
COGnitive Outcomes and WELLness in Survivors of Critical Illness
As survival rates from critical illness improve, strategies to return patients to their baseline cognitive and functional status are important research priorities.
- Trial name
- COGWELL (NCT02086877)
- Where
- 5 sites in Canada
- Volunteers
- 150 people
- Sponsor
- University of Toronto
Diabetes, Prediabetes
Meta-analyses of Pasta as Part of Low Glycemic Index Diets and Adiposity
Pasta is an important example of a food which can lower the glycemic index (GI) of the diet, a property that has been exploited extensively in studies of low GI dietary patterns.
- Conditions
- Diabetes, Prediabetes, Overweight, Obesity
- Trial name
- NCT02961088
- Testing
- Pasta as part of a low GI/GL diet
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Peripheral Neuropathy, Diabetes Mellitus
IVIg for Demyelination in Diabetes Mellitus
The purpose of this study is to determine whether intravenous immunoglobulin (IVIg) is an effective intervention for patients with diabetes, peripheral neuropathy, and demyelination on nerve conduction studies.
- Conditions
- Peripheral Neuropathy, Diabetes Mellitus, Chronic Inflammatory Demyelinating Polyneuropathy
- Trial name
- IDIDM (NCT02372149)
- Testing
- 10% intravenous immunoglobulin (IVIg), 0.9% sodium chloride
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University of Toronto
Anterior Cruciate Ligament Injury
The Effect of Knee Flexion Angle for Graft Fixation During Single-Bundle Anterior Cruciate Ligament Reconstruction
The purpose of this study is to conduct a randomized controlled trial to determine if the knee flexion angle (KFA) during anterior cruciate ligament reconstruction (ACLR) graft fixation has an effect on postoperative outcomes.
- Trial name
- FIRM (NCT02111759)
- Testing
- knee flexion angle 1, knee flexion angle 2
- Where
- Canada
- Volunteers
- 204 people
- Sponsor
- University of Toronto Orthopaedic Sports Medicine
PreDiabetes, Diabetes Mellitus
Dried Fruit and Postprandial Glycemia Trial
Dried fruits show promising potential for the management of blood glucose. Previous trials have reported beneficial effects of raisins on post-prandial glucose and insulin responses in healthy individuals when compared with white…
- Conditions
- PreDiabetes, Diabetes Mellitus, Dysglycemia
- Trial name
- NCT02960373
- Testing
- White Bread (Control), Dried Fruit - Glycemic Index, Catalytic Fructose Dose Effect
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Hyperlipidemia, Cardiovascular Diseases
Lipoprotein Turnover on Low- and High-MUFA Portfolio Diets
Low and very low carbohydrate diets, such as the Atkins' Diet, have recently gained attention for their potential health benefits from weight loss and have gained some scientific support from a growing number of studies.
- Conditions
- Hyperlipidemia, Cardiovascular Diseases, Diet Therapy
- Trial name
- NCT00430430
- Testing
- High MUFA dietary portfolio, Low MUFA dietary portfolio
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Schistosomiasis Mansoni, HIV
Effect of Schistosomiasis Mansoni on HIV Susceptibility and Female Genital Immunology
The aim of this study is to assess the impact of Schistosoma mansoni infection and its treatment on genital immunology and HIV susceptibility in Ugandan women.
- Trial name
- NCT02878564
- Testing
- Praziquantel
- Where
- Uganda
- Volunteers
- 34 people
- Sponsor
- University of Toronto
Vaccination
To Look or Not to Look at the Needle During Vaccination
It is common for people to advise individuals undergoing vaccination to look away from the needle to make them hurt less and be less scary. However, this advice is not backed up by research evidence.
- Trial name
- NCT02937428
- Testing
- Look away from the needle, Look at the needle
- Where
- Canada
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Anterior Cruciate Ligament (ACL) Tear
Conventional Follow-up Versus Mobile App For Post-Operative ACL Reconstruction Patients
Background: Telemedicine is increasingly used to overcome distance between patients and physicians. Preliminary studies suggest that mobile app follow-up care for ACL reconstruction patients is feasible, can avert in-person…
- Trial name
- NCT02942940
- Testing
- mobile app, conventional in-person
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of Toronto Orthopaedic Sports Medicine
Healthy
Pilot Study to Describe Immune Responses of Healthy Women Following Immunization With Varicella Zoster Virus Vaccine
The re-activating nature of Varicella Zoster Virus (VZV) may allow life long boosting when used as a vaccine vector in conjunction with HIV to generate durable immunity systemically and at the mucosa.
- Trial name
- KAVI-VZV-001 (NCT02514018)
- Testing
- Live-attenuated varicella-zoster virus vaccine
- Where
- Kenya
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Postpartum Women
A Hospital-based Postnatal Parent Education Intervention About Infant Immunizations
Immunization injections are the most common recurring painful medical procedure undertaken in childhood. Numerous evidence-based and feasible interventions are available to mitigate immunization pain, however, there is low uptake…
- Trial name
- IIAP (NCT01937143)
- Testing
- Low intensity intervention, High intensity intervention, Control
- Where
- Canada
- Volunteers
- 3,420 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Type 2 Diabetes
Low Glycemic Index Diet for Type 2 Diabetics
A low glycemic index diet may improve glycemic control and reduce plaque buildup in arteries of those with type 2 diabetes. Subjects will be randomly assigned to receive dietary advice on either a low glycemic index diet, or a…
- Trial name
- NCT01063374
- Testing
- low glycemic diet instruction, high cereal fibre diet instruction
- Where
- 2 sites in Canada
- Volunteers
- 169 people
- Sponsor
- University of Toronto
Body Weight, Obesity
Meta Analysis of the Effect of a Low Glycemic Index Diet and Glycemic Load on Body Weight
A low glycemic index (GI) diet has been associated with improved glycemic control in type 2 diabetes patients and a reduced risk of cardiovascular disease (CVD).
- Conditions
- Body Weight, Obesity, Cardiovascular Diseases, Diabetes Mellitus, Type 2
- Trial name
- NCT02557022
- Testing
- GI and/or GL
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of Toronto