Clinical trials: sponsored by University of Toronto
Diabetes
A Series of Systematic Reviews and Meta-analyses of the Effect of Vegetarian/Vegan Diets on Cardiometabolic Risk
Vegetarian and vegan diets have been shown to reduce chronic disease risk, including diabetes and cardiovascular disease, as well as several cardiometabolic risk factors.
- Trial name
- NCT02600377
- Testing
- Vegetarian diet
- Volunteers
- 1 people
- Sponsor
- University of Toronto
Hypertension
Dietary Approach to Stop Hypertension With Sodium (Na) Reduction for Chinese Canadians
The study examined the feasibility of the Dietary Approach to Stop Hypertension with Sodium (Na) Reduction for Chinese Canadian (DASHNa-CC) intervention and its potential effects on blood pressure, health-related quality of life…
- Trial name
- DASHNa-CC (NCT02579746)
- Testing
- DASHNa-CC, usual care
- Volunteers
- 60 people
- Sponsor
- University of Toronto
Obesity
Role of Colonic Short Chain Fatty Acids in Obesity
The excess production of colonic short-chain-fatty-acids (SCFA) has been implicated in the promotion of obesity, but colonic fermentation of dietary-fiber to SCFA may also play a role in preventing diabetes.
- Trial name
- NCT02562014
- Testing
- Glucose, Inulin, Resistant Starch
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Type 2 Diabetes Mellitus, Vitamin D Deficiency
Effect of Vitamin D Supplementation on Glucose Tolerance in Subjects at Risk for Diabetes With Low Vitamin D.
Type 2 diabetes (T2D) is an increasingly common and serious condition. Studies show that low vitamin D levels are associated with increased diabetes risk and that vitamin D may protect against diabetes by reducing chronic…
- Trial name
- EVIDENCE (NCT01726777)
- Testing
- Control, Vitamin D
- Where
- 3 sites in Canada
- Volunteers
- 71 people
- Sponsor
- University of Toronto
Routine Infant Immunizations, Pain Management
Speed of Injection and Pain During Routine Infant Vaccinations
Vaccine injections are a significant source of pain for infants. Altering the injection speed when administering vaccines may be an effective intervention and is feasible (cost neutral).
- Trial name
- NCT02504398
- Testing
- Fast injection speed by immunizer, Slow injection speed by immunizer
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Postpartum Depression
Postpartum Depression Prevention Trial
The primary objective of this study is to evaluate the effect of peer (mother-to-mother) support on the prevention of postpartum depression among mothers identified as high-risk.
- Trial name
- NCT00604604
- Testing
- Peer support
- Where
- 7 sites in Canada
- Volunteers
- 702 people
- Sponsor
- University of Toronto
Retinal Detachment
Study Trial of Dexamethasone Use for Alleviation of Symptoms After Scleral Buckle Eye Surgery
Dexamethasone is a medication that has been shown to have clear anti-nausea, anti-inflammatory, and painkilling properties. Dexamethasone is currently used to manage postoperative symptoms of a variety of surgical procedures.
- Trial name
- NCT01326585
- Testing
- Dexamethasone Sodium Phosphate Injection, Saline Injection
- Where
- 2 sites in Canada
- Sponsor
- University of Toronto
Obstructive Sleep Apnea
SIESTA: Home Sleep Study With ApneaDx™ for the Diagnosis of Obstructive Sleep Apnea
The SIESTA Home Sleep Study is a pragmatic, multi-centre randomized single-blinded two arm trial, assisted by a Decision Analytic Model, primarily designed to assess the accuracy, effectiveness and cost-effectiveness of…
- Trial name
- NCT02003729
- Testing
- Portable Sleep Monitor
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- University of Toronto
Graves Ophthalmopathy
Use of Botox in the Management of Thyroid Related Upper Eyelid Retraction
Currently there are few therapeutic options for the treatment of lid retraction secondary to thyroid orbitopathy (TO) during the active stages of the disease.
- Trial name
- NCT01272414
- Testing
- Botulinum Toxin Type A, Saline injection
- Where
- Canada
- Sponsor
- University of Toronto
Neuropathic Pain, Orofacial Pain
Pregabalin and Orofacial Neuropathic Pain
The purpose of this study is to determine whether pregabalin can decrease pain and improve quality of life in patients who have nerve pain on the mouth or the face
- Trial name
- Pregabalin-Dao (NCT00852436)
- Testing
- pregabalin
- Where
- 2 sites in Canada
- Volunteers
- 1 people
- Sponsor
- University of Toronto
Health Behavior
Experiences With a Genetic Test for Personalized Nutrition Test for Personalized Nutrition
The investigators will use a web-based survey to collect data on individual attitudes and self-reported health behaviour changes following genetic testing for personalized nutrition.
- Trial name
- NCT02440698
- Testing
- Genetic test for personalized nutrition
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Osteoporosis
Nitrates and Bone Turnover; Nitrates and Bone Turnover Bisphosphonate Sub-Study
Purpose: NABT: To compare five widely available nitrate formulations: (1) 15 of nitroglycerin (NTG) ointment, (2) 0.3 mg and (3) 0.6 mg of sublingual NTG, (4) 20 mg of isosorbide mononitrate (an oral tablet), and (5) 160 mg of…
- Trial name
- NABT;NABT-B (NCT01387672)
- Testing
- Nitrates (NABT Main trial)
- Where
- Canada
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Evidence-Based Medicine
Using a Systematic Review in Clinical Decision Making: a Pilot Parallel, Randomized Controlled Trial
The purpose of this pilot study is to determine the feasibility of running a full-scale trial that compares two formats of a shortened systematic review to a full-length systematic review to be used in clinical decision-making.
- Trial name
- NCT02414360
- Testing
- Shortened Format, Full Length
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Respiratory Distress Syndrome, Adult, Ventilator-Induced Lung Injury
Esophageal Pressure-Guided Optimal PEEP/mPaw in CMV and HFOV: The EPOCH Study
The use of positive end-expiratory pressure (PEEP) has been shown to prevent the cycling end-expiratory collapse during mechanical ventilation and to maintain alveolar recruitment, keeping lung portions open, increasing the…
- Trial name
- EPOCH (NCT02342756)
- Testing
- Targeting transpulmonary pressure to avoid VILI
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- University of Toronto
Parkinson's Disease
L-dopa Versus Dopamine Agonists After Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease
Deep Brain Stimulation (DBS) of the Subthalamic nucleus (STN) is an established treatment for patients with advanced Parkinson's disease (PD).
- Trial name
- NCT02347059
- Testing
- L-dopa, Dopamine Agonists (pramipexole, ropirinole)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Toronto
Safer Sex
A Group-level Intervention to Reduce HIV/STI Risk for Women Who Have Sex With Women in Calgary and Toronto
The limited research that exists suggests that lesbian, bisexual and queer (LBQ) women are at similar risk for sexually transmitted infections (STI) as heterosexual women.
- Trial name
- NCT02067845
- Testing
- Adapted Many Men, Many Voices (3MV) group level intervention, A group-based HIV/STI prevention intervention for women who have sex with women
- Where
- 2 sites in Canada
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Glaucoma
Prospective Randomized Study Comparing Ex-PRESS to Trabeculectomy
Prospective randomized study comparing guarded Ex-PRESS to trabeculectomy. Primary outcome: IOP and success (complete success defined as IOP between 5-18 mmHg and 20% reduction from baseline without medication or additional…
- Trial name
- NCT01263561
- Testing
- ExPRESS shunt, trabeculectomy
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- University of Toronto
Breast Neoplasm
GenetiKiT: Evaluation of an Educational Intervention on the Delivery of Genetics Services by Family Physicians
There is an urgent need for a knowledge translation strategy to facilitate the integration of genetics into family medicine, to improve the low knowledge base of most Canadian family physicians, ensure that the needs are met of…
- Trial name
- NCT00295529
- Testing
- Multifaceted educational intervention
- Where
- Canada
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Respiratory Distress Syndrome, Adult
Strategies for Optimal Lung Ventilation in ECMO for ARDS: The SOLVE ARDS Study
Due to lack of studies on mechanical ventilation strategies in patients with severe Acute Respiratory Distress Syndrome (ARDS) supported with Veno-Venous Extra-Corporeal Membrane Oxygenation (VV ECMO), ventilator settings in this…
- Trial name
- SOLVE ARDS (NCT01990456)
- Testing
- PHASE 1: impact of tidal ventilation on VILI, PHASE 2: impact of PEEP on VILI
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Toronto
Aneuploidy, Pregnancy
The Effect of Co Enzyme Q10 Together With Fertility Drugs on Pregnancy Outcome of in Vitro Fertilization
The goal of our research is to increase live birth rates in infertile women and to reduce the incidence of aneuploidy leading to miscarriage and trisomies.
- Conditions
- Aneuploidy, Pregnancy, Miscarriage
- Trial name
- CoQ10-IVF (NCT01048385)
- Testing
- Coenzyme Q10 concomitant treatment
- Where
- Canada
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Toronto