Clinical trials: sponsored by University of Toronto
Hypertension in Type 2 Diabetes, Diabetes Mellitus Type 2
The SWITCH (Substitution of High With Low Ultra-processed Soy Protein Foods In a Guideline-based Diet inTervention for Cardiometabolic Health) Trial
This is a randomized, controlled, parallel study with 3 experimental arms aimed to assess the effect of a digital dietary intervention (web-based app, online behavior change curriculum) enhanced with 10 servings of vegetables and…
- Conditions
- Hypertension in Type 2 Diabetes, Diabetes Mellitus Type 2, Dyslipidemia, Hypertension
- Trial name
- SWITCH (NCT06907862)
- Testing
- Reference Treatment, Control, Active Treatment
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- University of Toronto
Anxiety, Panic Disorder
Investigation of Pathogenic Gut Microbiota Patterns in Anxiety, Depression and Panic Disorders
This study aims to investigate the etiology of anxiety, depression, and panic disorders, providing new evidence and insights into the root causes and effective treatments, potentially offering a novel approach to achieving…
- Conditions
- Anxiety, Panic Disorder, Mood Disorders, Depression
- Trial name
- NCT07268729
- Testing
- H pylori stool test, Bacterial stool analysis
- Where
- Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Diabete Mellitus, Loneliness
The Impact of Social Worker Referrals on Diabetes and Loneliness
The goal of this clinical trial is to learn if referral to a social worker (social prescribing) can help reduce loneliness and improve blood sugar control (A1C) in older adults with diabetes.
- Trial name
- NCT07486050
- Testing
- Social worker referral to address loneliness, Continue Primary care
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- University of Toronto
Hiv
The T Cell Activator of Cell Killing ("TACK") IT ON" STUDY
Antiretroviral therapy or ART blocks HIV replication reducing plasma viral loads to undetectable levels but has no effect on persistently infected cells in the body, called the virus reservoir.
- Trial name
- "TACKITON (NCT06823596)
- Testing
- Efavirenz 600mg
- Where
- 2 sites in Canada
- Volunteers
- 26 people
- Sponsor
- University of Toronto
Dairy Consumption, Metabolic Health
The Effect of Dairy Intake on Body Weight and Composition and Metabolic Health in Adolescents and Seniors
The goal of this study is to examine how regular dairy intake affects body weight, body composition, and metabolic health in overweight and obese adolescents (ages 15-18) and older adults (ages 60-80) over six months.
- Conditions
- Dairy Consumption, Metabolic Health, Obesity Prevention
- Trial name
- NCT06879652
- Testing
- Counselling to follow Canada's Food Guide and 3 daily servings of Dairy (long-term study), Dairy (short-term study), Counselling to follow Canada's Food Guide (long-term study)
- Where
- 2 sites in Canada
- Volunteers
- 240 people
- Sponsor
- University of Toronto
Healthy, Omega 3
Observing Metabolism of EPA With Consideration of Genetics And Sex
The goal of this clinical study is to learn how fast EPA is converted to other molecules, including DHA, with consideration of biological sex and genetics in healthy humans.
- Conditions
- Healthy, Omega 3, Metabolism, Lipids
- Trial name
- OMEGA (NCT06975241)
- Testing
- EPA 2.4g/day
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Consent of Patients, Coercion to Participate in Research
Coercion in Same-Day Research Consent
As a result of their unique practice patterns, many specialist physicians typically only meet patients on the date of an intervention such as surgery.
- Trial name
- NCT07380035
- Testing
- Invitation to Consent to Trial Participation
- Where
- Canada
- Volunteers
- 114 people
- Sponsor
- University of Toronto
Protein Metabolism
Validating IAAO for Muscle Outcomes
Consuming dietary protein stimulates whole-body and muscle protein synthesis, the latter of which is typically measured using invasive primed constant infusions of stable isotopes with concurrent muscle biopsies.
- Trial name
- VIM (NCT07317921)
- Testing
- Protein + Stable Isotope Tracer Beverage
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Arthroplasties, Knee Replacement, Nerve Block
Post-Operative Urinary Retention on Revision Knee Arthroplasty: the Role of Intrathecal Morphine
Revision total knee arthroplasty (rTKA) is a frequently performed procedure. Adequate pain management is an important feature, especially for fast-track and Enhanced Recovery After Surgery (ERAS) programs.
- Conditions
- Arthroplasties, Knee Replacement, Nerve Block, Urinary Retention Postoperative, Anesthesia, Spinal
- Trial name
- POURRKA (NCT07050277)
- Testing
- Intrathecal Morphine, No Intrathecal Morphine
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Female Sex Hormones, Menstrual Cycle
Menstrual Cycle vs. Oral Contraceptives: Effects on Muscle Protein Metabolism After Resistance Exercise
The muscles of the body are constantly breaking down old proteins and building new ones. These two processes, protein breakdown and protein synthesis, together are known as protein turnover.
- Conditions
- Female Sex Hormones, Menstrual Cycle, Oral Contraceptives, Protein Metabolism
- Trial name
- MCOC (NCT07258576)
- Testing
- Protein Beverage, Stable Isotope Tracer [D5]phenylalanine, Stable Isotope Tracer [13C]phenylalanine
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Breast Cancer, Insulin Resistance
Alternative Physical Activity Strategies for Breast Cancer Survivors
The primary aim of this study is to compare the acute glycemic effects of two novel, alternative physical activity (PA) strategies (dispersed post-meal PA, PA snacks) to a no PA condition and to exercise sessions representing the…
- Conditions
- Breast Cancer, Insulin Resistance, Cardiometabolic Risk Factors
- Trial name
- PACE (NCT06633380)
- Testing
- Standard Physical Activity - Fasted, Standard Physical Activity - Post-Meal, Dispersed Physical Activity
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Breast Cancer, Cardiovascular Risk
Time Restricted Eating in Survivors Trial 2.0
After chemotherapy, older breast cancer survivors experience a faster decline in brain function. This can make it harder to enjoy life, stay social, and maintain independence.
- Conditions
- Breast Cancer, Cardiovascular Risk, Cognitive Function, Physical Function
- Trial name
- TEST2 (NCT07259434)
- Testing
- Time Restricted Eating, Healthy Eating Education
- Where
- Canada
- Volunteers
- 152 people
- Sponsor
- University of Toronto
HIV Infections
Vaccines in a Time of Dual Pandemic: COVID-19 Vaccine in People With HIV
This is a prospective, non-randomized observational study to examine SARS-CoV-2 vaccine immunogenicity, immune activation and HIV reservoirs in people with HIV infection in comparison with HIV-negative individuals, in those aged…
- Trial name
- NCT06731127
- Where
- Canada
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Cardiovascular Diseases, Cardiovascular Risk Factors
The Effect of a Digital Heart Health App and Lifestyle Intervention for Heart Disease in Primary Care.
Despite the availability of medications, many people around the world continue to live with long-term health problems like heart disease, stroke and diabetes. In Canada, heart disease is a leading cause of death.
- Conditions
- Cardiovascular Diseases, Cardiovascular Risk Factors, Dyslipidemia, Cholesterol
- Trial name
- CHEAP (NCT06919302)
- Testing
- Digital Heart Health Program
- Where
- Canada
- Volunteers
- 1,100 people
- Sponsor
- University of Toronto
Nutrition, Healthy
A Dose Response Investigation of Docosahexaenoic Acid (DHA)
Docosahexaenoic acid (DHA) is an omega-3 polyunsaturated fatty acid (n-3 PUFA), commonly consumed from fish, that regulates many critical functions within the body including the brain, eye, and heart.
- Trial name
- DRI-DHA (NCT06294067)
- Testing
- docosahexaenoic acid (DHA)
- Where
- Canada
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Breast Cancer Females
Short-term Impacts of Endocrine Therapy on Cardiovascular and Brain Health Outcomes in Breast Cancer
Aromatase inhibitors are the most used endocrine therapy for hormone-positive breast cancer. While there is a clear linear relationship between the duration of aromatase inhibitor use and the cumulative incidence of…
- Trial name
- STRIVE (Acute) (NCT06781762)
- Testing
- N/A (Usual Care)
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Metabolic Disturbance
Remote Time-restricted EAting DeliverY
This study will evaluate the implementation and effectiveness of free-living TRE on biological and behavioural breast cancer risk factors.
- Trial name
- READY (NCT05454943)
- Testing
- Standardized TRE Protocol, Personalized TRE Protocol, External Support for TRE
- Where
- Canada
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Metabolic Disturbance, Sedentary Behavior
Multiple Risk Factor Intervention Trial in Breast Cancer Survivors
This study aims to produce new evidence on the efficacy of exercise and diet for cardiometabolic risk reduction in BC survivors.
- Conditions
- Metabolic Disturbance, Sedentary Behavior, Breast Cancer Female
- Trial name
- MsFITBC (NCT06454864)
- Testing
- Guidelines-based healthy eating, Guidelines-based physical activity, Stretching exercise
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- University of Toronto
Breast Cancer
Cardio-Oncology Rehabilitation Exercise
Women with breast cancer who are referred to the cardiac rehabilitation program at the Toronto Rehabilitation Institute will be invited to enrol in this observational study.
- Trial name
- CORE (NCT05522959)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of Toronto
Cancer, Exercise
Behaviour Change for Cancer Survivors Trial
This study will be a two-arm RCT, to examine the effects of an entirely virtual, 6-month supervised PA program plus standard exercise counselling (PA+EC) versus a supervised PA plus motivationally-enhanced behavioral counselling…
- Trial name
- BOOST-Up (NCT06624930)
- Testing
- Behavioural Counselling, Exercise Counselling
- Where
- Canada
- Volunteers
- 236 people
- Sponsor
- University of Toronto